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NRDC-201 ,NRDC ,O43847
  • Uniprot Accession= O43847
  • Ensembl Transcript= ENST00000352171.12
  • Uniprot Name= NRDC
  • Name= Nardilysin
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 14
GO term GO name GO namespace GO def
GO:0004222 metalloendopeptidase activity molecular_function Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0046872 metal ion binding molecular_function Binding to a metal ion. [GOC:ai]
GO:0048408 epidermal growth factor binding molecular_function Binding to epidermal growth factor. [GOC:dgh]
GO:0006508 proteolysis biological_process The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
GO:0031643 positive regulation of myelination biological_process Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons. [GOC:mah]
GO:0050772 positive regulation of axonogenesis biological_process Any process that activates or increases the frequency, rate or extent of axonogenesis. [GOC:ai]
GO:0051044 positive regulation of membrane protein ectodomain proteolysis biological_process Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. [GOC:ai]
GO:0052548 regulation of endopeptidase activity biological_process Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. [GOC:ai, GOC:hjd]
GO:0120163 negative regulation of cold-induced thermogenesis biological_process Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis. [PMID:27876809]
GO:0005739 mitochondrion cellular_component A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0009986 cell surface cellular_component The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
GO:0030425 dendrite cellular_component A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]