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OMA1-201 ,OMA1 ,Q96E52
  • Uniprot Accession= Q96E52
  • Ensembl Transcript= ENST00000371226.8
  • Uniprot Name= OMA1
  • Name= Metalloendopeptidase OMA1, mitochondrial
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 22
GO term GO name GO namespace GO def
GO:0004222 metalloendopeptidase activity molecular_function Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
GO:0008289 lipid binding molecular_function Binding to a lipid. [GOC:ai]
GO:0046872 metal ion binding molecular_function Binding to a metal ion. [GOC:ai]
GO:0002024 diet induced thermogenesis biological_process The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signaling in the sympathetic nervous system. [PMID:12161655]
GO:0006006 glucose metabolic process biological_process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. [ISBN:0198506732]
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins biological_process The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. [GOC:jl]
GO:0006629 lipid metabolic process biological_process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma]
GO:0010637 negative regulation of mitochondrial fusion biological_process Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment. [GOC:dph, GOC:tb]
GO:0016540 protein autoprocessing biological_process Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. [GOC:ai, PMID:9335337]
GO:0031638 zymogen activation biological_process The proteolytic processing of an inactive enzyme to an active form. [GOC:hjd]
GO:0033108 mitochondrial respiratory chain complex assembly biological_process The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex. [GOC:mah]
GO:0034982 mitochondrial protein processing biological_process The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import. [GOC:curators]
GO:0042407 cristae formation biological_process The assembly of cristae, the inwards folds of the inner mitochondrial membrane. [GOC:jl, ISBN:0198506732]
GO:0043065 positive regulation of apoptotic process biological_process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
GO:0097009 energy homeostasis biological_process Any process involved in the balance between food intake (energy input) and energy expenditure. [GOC:yaf, PMID:15919751]
GO:0120162 positive regulation of cold-induced thermogenesis biological_process Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809]
GO:0140467 integrated stress response signaling biological_process The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. [PMID:27629041]
GO:0140468 HRI-mediated signaling biological_process A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. [PMID:27629041]
GO:1903850 regulation of cristae formation biological_process Any process that modulates the frequency, rate or extent of cristae formation. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012]
GO:0005758 mitochondrial intermembrane space cellular_component The region between the inner and outer lipid bilayers of the mitochondrial envelope. [GOC:mah]
GO:0005743 mitochondrial inner membrane cellular_component The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]
GO:0031966 mitochondrial membrane cellular_component Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. [GOC:mah, NIF_Subcellular:sao1045389829]