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OTUD7B-202 ,OTUD7B ,Q6GQQ9
  • Uniprot Accession= Q6GQQ9
  • Ensembl Transcript= ENST00000581312.6
  • Uniprot Name= OTUD7B
  • Name= OTU domain-containing protein 7B
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 22
GO term GO name GO namespace GO def
GO:0003677 DNA binding molecular_function Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
GO:0004843 cysteine-type deubiquitinase activity molecular_function An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:jh2, PMID:30783221]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0008234 cysteine-type peptidase activity molecular_function Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
GO:0008270 zinc ion binding molecular_function Binding to a zinc ion (Zn). [GOC:ai]
GO:1990380 K48-linked deubiquitinase activity molecular_function Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin. [GOC:bf, GOC:PARL, PMID:22970133]
GO:0000122 negative regulation of transcription by RNA polymerase II biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
GO:0001701 in utero embryonic development biological_process The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. [GOC:go_curators, GOC:mtg_sensu]
GO:0002250 adaptive immune response biological_process An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). [GO_REF:0000022, GOC:add, ISBN:0781735149]
GO:0002385 mucosal immune response biological_process An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract. [GO_REF:0000022, GOC:jal, ISBN:0781735149]
GO:0006508 proteolysis biological_process The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
GO:0032717 negative regulation of interleukin-8 production biological_process Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production. [GOC:mah]
GO:0035871 protein K11-linked deubiquitination biological_process A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein. [GOC:sp, PMID:21596315]
GO:0043124 negative regulation of canonical NF-kappaB signal transduction biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
GO:0070536 protein K63-linked deubiquitination biological_process A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. [GOC:mah, PMID:19202061, PMID:19214193]
GO:0071108 protein K48-linked deubiquitination biological_process A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. [GOC:mah]
GO:1900181 negative regulation of protein localization to nucleus biological_process Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. [GOC:TermGenie]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process biological_process The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism. [GOC:mah]
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding molecular_function Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein. [GOC:mah, PMID:15556404, PMID:17525341]