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PCSK9-201 ,PCSK9 ,Q8NBP7
  • Uniprot Accession= Q8NBP7
  • Ensembl Transcript= ENST00000302118.5
  • Uniprot Name= PCSK9
  • Name= Proprotein convertase subtilisin/kexin type 9
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 57
GO term GO name GO namespace GO def
GO:0003723 RNA binding molecular_function Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
GO:0004252 serine-type endopeptidase activity molecular_function Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0019871 sodium channel inhibitor activity molecular_function Binds to and stops, prevents, or reduces the activity of a sodium channel. [GOC:mah]
GO:0030169 low-density lipoprotein particle binding molecular_function Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. [GOC:mah]
GO:0030547 signaling receptor inhibitor activity molecular_function Binds to and modulates the activity of a signaling receptor. [GOC:ceb]
GO:0034185 apolipoprotein binding molecular_function Binding to an apolipoprotein, the protein component of a lipoprotein complex. [GOC:BHF, GOC:rl]
GO:0034189 very-low-density lipoprotein particle binding molecular_function Binding to a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. [GOC:BHF, GOC:mah]
GO:0034190 apolipoprotein receptor binding molecular_function Binding to an apolipoprotein receptor. [GOC:BHF, GOC:rl]
GO:0043621 protein self-association molecular_function Binding to a domain within the same polypeptide. [GOC:jl]
GO:0050750 low-density lipoprotein particle receptor binding molecular_function Binding to a low-density lipoprotein receptor. [GOC:ai]
GO:0070326 very-low-density lipoprotein particle receptor binding molecular_function Binding to a very-low-density lipoprotein receptor. [GOC:BHF, GOC:mah]
GO:0001822 kidney development biological_process The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544]
GO:0001889 liver development biological_process The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. [GOC:add, ISBN:068340007X]
GO:0001920 negative regulation of receptor recycling biological_process Any process that stops, prevents, or reduces the rate of receptor recycling. [GOC:add]
GO:0002091 negative regulation of receptor internalization biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization. [GOC:hjd]
GO:0002092 positive regulation of receptor internalization biological_process Any process that activates or increases the frequency, rate or extent of receptor internalization. [GOC:hjd]
GO:0006641 triglyceride metabolic process biological_process The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. [ISBN:0198506732]
GO:0006644 phospholipid metabolic process biological_process The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732]
GO:0006915 apoptotic process biological_process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
GO:0007041 lysosomal transport biological_process The directed movement of substances into, out of or within a lysosome. [GOC:ai]
GO:0008203 cholesterol metabolic process biological_process The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. [ISBN:0198506732]
GO:0009267 cellular response to starvation biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. [GOC:jl]
GO:0010469 regulation of signaling receptor activity biological_process Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. [GOC:dph, GOC:tb]
GO:0010989 negative regulation of low-density lipoprotein particle clearance biological_process Any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:dph, GOC:tb]
GO:0016540 protein autoprocessing biological_process Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. [GOC:ai, PMID:9335337]
GO:0022008 neurogenesis biological_process Generation of cells within the nervous system. [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
GO:0030182 neuron differentiation biological_process The process in which a relatively unspecialized cell acquires specialized features of a neuron. [GOC:mah]
GO:0032802 low-density lipoprotein particle receptor catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:mah]
GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process biological_process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors. [GOC:mah]
GO:0032869 cellular response to insulin stimulus biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]
GO:0042157 lipoprotein metabolic process biological_process The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. [ISBN:0198506732]
GO:0042632 cholesterol homeostasis biological_process Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators]
GO:0043523 regulation of neuron apoptotic process biological_process Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis]
GO:0043525 positive regulation of neuron apoptotic process biological_process Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. [GOC:go_curators, GOC:mtg_apoptosis]
GO:1905596 negative regulation of low-density lipoprotein particle receptor binding biological_process Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein particle receptor binding. [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
GO:1905598 negative regulation of low-density lipoprotein receptor activity biological_process Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein receptor activity. [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
GO:1905601 negative regulation of receptor-mediated endocytosis involved in cholesterol transport biological_process Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport. [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640]
GO:2000650 negative regulation of sodium ion transmembrane transporter activity biological_process Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity. [GOC:obol]
GO:0005576 extracellular region cellular_component The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
GO:0005615 extracellular space cellular_component That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0005764 lysosome cellular_component A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732]
GO:0005765 lysosomal membrane cellular_component The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
GO:0005769 early endosome cellular_component A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]
GO:0005770 late endosome cellular_component A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]
GO:0005783 endoplasmic reticulum cellular_component The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
GO:0005788 endoplasmic reticulum lumen cellular_component The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684]
GO:0005794 Golgi apparatus cellular_component A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0009986 cell surface cellular_component The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
GO:0030134 COPII-coated ER to Golgi transport vesicle cellular_component A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport). [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]
GO:0031232 extrinsic component of external side of plasma membrane cellular_component The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region. [GOC:dos, GOC:mah]
GO:0036020 endolysosome membrane cellular_component The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. [GOC:pde]
GO:0048471 perinuclear region of cytoplasm cellular_component Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
GO:1990667 PCSK9-AnxA2 complex cellular_component A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and annexin A2 (AnxA2). [GOC:BHF, GOC:nc, PMID:22848640]
GO:1990666 PCSK9-LDLR complex cellular_component A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway. [GOC:BHF, GOC:nc, PMID:18250299, PMID:24440079]