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PEAR1-201 ,PEAR1 ,Q5VY43
  • Uniprot Accession= Q5VY43
  • Ensembl Transcript= ENST00000292357.8
  • Uniprot Name= PEAR1
  • Name= Platelet endothelial aggregation receptor 1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 9
GO term GO name GO namespace GO def
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0038023 signaling receptor activity molecular_function Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling]
GO:0010572 positive regulation of platelet activation biological_process Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. [GOC:dph, GOC:sl, GOC:tb]
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction biological_process An intracellular signaling cassette that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway. [PMID:20517722, PMID:22952397]
GO:0043654 recognition of apoptotic cell biological_process The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis. [GOC:rk, PMID:15536015]
GO:0070527 platelet aggregation biological_process The adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:BHF, GOC:vk]
GO:0001891 phagocytic cup cellular_component An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome. [PMID:10358769]
GO:0030027 lamellipodium cellular_component A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. [ISBN:0815316194]
GO:0016020 membrane cellular_component A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]