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PEX14-201 ,PEX14 ,O75381
  • Uniprot Accession= O75381
  • Ensembl Transcript= ENST00000356607.9
  • Uniprot Name= PEX14
  • Name= Peroxisomal membrane protein PEX14
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 28
GO term
GO name
GO namespace
GO def
GO:0007031 peroxisome organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. [GOC:mah]
GO:0003714 transcription corepressor activity molecular_function A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
GO:0005102 signaling receptor binding molecular_function Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0008017 microtubule binding molecular_function Binding to a microtubule, a filament composed of tubulin monomers. [GOC:krc]
GO:0008320 protein transmembrane transporter activity molecular_function Enables the transfer of a protein from one side of a membrane to the other. [GOC:jl]
GO:0030674 protein-macromolecule adaptor activity molecular_function The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. [GOC:bf, GOC:mah, GOC:vw]
GO:0042802 identical protein binding molecular_function Binding to an identical protein or proteins. [GOC:jl]
GO:0048487 beta-tubulin binding molecular_function Binding to the microtubule constituent protein beta-tubulin. [GOC:krc]
GO:0016558 protein import into peroxisome matrix biological_process The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix. [ISBN:0716731363, PMID:11687502, PMID:11988772]
GO:0016560 protein import into peroxisome matrix, docking biological_process The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane. [PMID:11687502, PMID:11988772, PMID:14754507]
GO:0016561 protein import into peroxisome matrix, translocation biological_process The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation. [PMID:11687502]
GO:0032091 negative regulation of protein binding biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. [GOC:mah]
GO:0034453 microtubule anchoring biological_process Any process in which a microtubule is maintained in a specific location in a cell. [GOC:mah]
GO:0034614 cellular response to reactive oxygen species biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. [GOC:mah]
GO:0036250 peroxisome transport along microtubule biological_process The directed movement of a peroxisome along a microtubule, mediated by motor proteins. [GOC:pm, PMID:21525035]
GO:0043433 negative regulation of DNA-binding transcription factor activity biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:jl]
GO:0044721 protein import into peroxisome matrix, substrate release biological_process The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane. [PMID:21976670]
GO:0045892 negative regulation of DNA-templated transcription biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
GO:0065003 protein-containing complex assembly biological_process The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. [GOC:jl]
GO:0005778 peroxisomal membrane cellular_component The lipid bilayer surrounding a peroxisome. [GOC:mah]
GO:0001650 fibrillar center cellular_component A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. [PMID:10754561]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005777 peroxisome cellular_component A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0016020 membrane cellular_component A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
GO:0032991 protein-containing complex cellular_component A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]
GO:1990429 peroxisomal importomer complex cellular_component A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners. [PMID:12667447, PMID:20154681, PMID:22375831]