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PFDN2-201 ,PFDN2 ,Q9UHV9
  • Uniprot Accession= Q9UHV9
  • Ensembl Transcript= ENST00000368010.4
  • Uniprot Name= PFDN2
  • Name= Prefoldin subunit 2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 16
GO term GO name GO namespace GO def
GO:0001540 amyloid-beta binding molecular_function Binding to an amyloid-beta peptide/protein. [GOC:hjd]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0044183 protein folding chaperone molecular_function Binding to a protein or a protein-containing complex to assist the protein folding process. [GOC:mtg_cambridge_2009]
GO:0051082 unfolded protein binding molecular_function Binding to an unfolded protein. [GOC:ai]
GO:0006457 protein folding biological_process The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. [GOC:go_curators, GOC:rb]
GO:0050821 protein stabilization biological_process Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai]
GO:0051495 positive regulation of cytoskeleton organization biological_process Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:ai]
GO:0061077 chaperone-mediated protein folding biological_process The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. [GOC:dph, GOC:vw]
GO:1905907 negative regulation of amyloid fibril formation biological_process Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation. [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0005739 mitochondrion cellular_component A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0016272 prefoldin complex cellular_component A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics. [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]
GO:0101031 protein folding chaperone complex cellular_component A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins. [GOC:bhm, PMID:21855797]
GO:1990062 RPAP3/R2TP/prefoldin-like complex cellular_component A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity. [GOC:pr, PMID:20453924, PMID:21925213, PMID:22418846]