| GO term | GO name | GO namespace | GO def |
| GO:0030097 | hemopoiesis | biological_process | The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. [GOC:dgh, ISBN:0198506732] |
| GO:0000287 | magnesium ion binding | molecular_function | Binding to a magnesium (Mg) ion. [GOC:ai] |
| GO:0002020 | protease binding | molecular_function | Binding to a protease or a peptidase. [GOC:hjd] |
| GO:0004672 | protein kinase activity | molecular_function | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction |
| GO:0004674 | protein serine/threonine kinase activity | molecular_function | Catalysis of the reactions |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0005524 | ATP binding | molecular_function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| GO:0010857 | calcium-dependent protein kinase activity | molecular_function | Calcium-dependent catalysis of the reaction |
| GO:0016301 | kinase activity | molecular_function | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [ISBN:0198506732] |
| GO:0016504 | peptidase activator activity | molecular_function | Binds to and increases the activity of a peptidase. [GOC:ai] |
| GO:0031625 | ubiquitin protein ligase binding | molecular_function | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp] |
| GO:0043422 | protein kinase B binding | molecular_function | Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism. [GOC:jl, http://www.heartandmetabolism.org/] |
| GO:0044877 | protein-containing complex binding | molecular_function | Binding to a macromolecular complex. [GOC:jl] |
| GO:0055131 | C3HC4-type RING finger domain binding | molecular_function | Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence |
| GO:0106310 | protein serine kinase activity | molecular_function | Catalysis of the reactions |
| GO:1904841 | TORC2 complex binding | molecular_function | Binding to a TORC2 complex. [GOC:TermGenie, PMID:20660630] |
| GO:0000422 | autophagy of mitochondrion | biological_process | The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions. [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344] |
| GO:0000423 | mitophagy | biological_process | The selective autophagy process in which a mitochondrion is degraded by macroautophagy. [PMID:15798367] |
| GO:0001934 | positive regulation of protein phosphorylation | biological_process | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd] |
| GO:0002082 | regulation of oxidative phosphorylation | biological_process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. [GOC:dph] |
| GO:0002931 | response to ischemia | biological_process | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. [GOC:hjd] |
| GO:0006468 | protein phosphorylation | biological_process | The process of introducing a phosphate group on to a protein. [GOC:hb] |
| GO:0006511 | ubiquitin-dependent protein catabolic process | biological_process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. [GOC:go_curators] |
| GO:0006979 | response to oxidative stress | biological_process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:jl, PMID:12115731] |
| GO:0007005 | mitochondrion organization | biological_process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] |
| GO:0010310 | regulation of hydrogen peroxide metabolic process | biological_process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. [PMID:14765119] |
| GO:0010629 | negative regulation of gene expression | biological_process | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018] |
| GO:0010821 | regulation of mitochondrion organization | biological_process | Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. [GOC:dph, GOC:tb] |
| GO:0010952 | positive regulation of peptidase activity | biological_process | Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. [GOC:dph, GOC:tb] |
| GO:0014046 | dopamine secretion | biological_process | The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone. [GOC:ef] |
| GO:0016239 | positive regulation of macroautophagy | biological_process | Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation. [GOC:go_curators, PMID:9412464] |
| GO:0016242 | negative regulation of macroautophagy | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy. [GOC:go_curators] |
| GO:0016567 | protein ubiquitination | biological_process | The process in which one or more ubiquitin groups are added to a protein. [GOC:ai] |
| GO:0018105 | peptidyl-serine phosphorylation | biological_process | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. [RESID:AA0037] |
| GO:0022904 | respiratory electron transport chain | biological_process | A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. [GOC:mtg_electron_transport, ISBN:0716720094] |
| GO:0031396 | regulation of protein ubiquitination | biological_process | Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah] |
| GO:0031398 | positive regulation of protein ubiquitination | biological_process | Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah] |
| GO:0032148 | activation of protein kinase B activity | biological_process | Any process that initiates the activity of the inactive enzyme protein kinase B. [GOC:pg] |
| GO:0032226 | positive regulation of synaptic transmission, dopaminergic | biological_process | Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. [GOC:mah] |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation | biological_process | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah] |
| GO:0033603 | positive regulation of dopamine secretion | biological_process | Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine. [GOC:sl] |
| GO:0034599 | cellular response to oxidative stress | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:mah] |
| GO:0035307 | positive regulation of protein dephosphorylation | biological_process | Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein. [GOC:bf] |
| GO:0035556 | intracellular signal transduction | biological_process | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] |
| GO:0036289 | peptidyl-serine autophosphorylation | biological_process | The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein. [GOC:pm] |
| GO:0038203 | TORC2 signaling | biological_process | A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components. [GOC:lb] |
| GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | biological_process | Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl] |
| GO:0043254 | regulation of protein-containing complex assembly | biological_process | Any process that modulates the frequency, rate or extent of protein complex assembly. [GOC:jl] |
| GO:0043524 | negative regulation of neuron apoptotic process | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis] |
| GO:0045727 | positive regulation of translation | biological_process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. [GOC:dph, GOC:go_curators, GOC:tb] |
| GO:0046329 | negative regulation of JNK cascade | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf] |
| GO:0050821 | protein stabilization | biological_process | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. [GOC:ai] |
| GO:0051443 | positive regulation of ubiquitin-protein transferase activity | biological_process | Any process that activates, maintains or increases the rate of ubiquitin transferase activity. [GOC:ai, GOC:tb] |
| GO:0051881 | regulation of mitochondrial membrane potential | biological_process | Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:ai] |
| GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | biological_process | Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai] |
| GO:0061136 | regulation of proteasomal protein catabolic process | biological_process | Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. [GOC:dph, GOC:tb] |
| GO:0071456 | cellular response to hypoxia | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:mah] |
| GO:0072655 | establishment of protein localization to mitochondrion | biological_process | The directed movement of a protein to the mitochondrion or a part of the mitochondrion. [GOC:mah] |
| GO:0072656 | maintenance of protein location in mitochondrion | biological_process | Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere. [GOC:mah] |
| GO:0090200 | positive regulation of release of cytochrome c from mitochondria | biological_process | Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb] |
| GO:0090258 | negative regulation of mitochondrial fission | biological_process | Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. [GOC:sl, GOC:tb] |
| GO:0097237 | cellular response to toxic substance | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:pr] |
| GO:0098779 | positive regulation of mitophagy in response to mitochondrial depolarization | biological_process | Any process that activates or increases the frequency, rate or extent of mitophagy in response to mitochondrial depolarization. [GOC:PARL, PMID:18200046, PMID:23985961] |
| GO:0099074 | mitochondrion to lysosome vesicle-mediated transport | biological_process | Vesicle-mediated transport of cargo from the mitochondrion to the lysosome, mediated by a mitochondrion-derived vesicle. [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655] |
| GO:1900407 | regulation of cellular response to oxidative stress | biological_process | Any process that modulates the frequency, rate or extent of cellular response to oxidative stress. [GOC:mah, GOC:TermGenie] |
| GO:1901525 | negative regulation of mitophagy | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of mitophagy. [GOC:TermGenie] |
| GO:1902803 | regulation of synaptic vesicle transport | biological_process | Any process that modulates the frequency, rate or extent of synaptic vesicle transport. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112] |
| GO:1902902 | negative regulation of autophagosome assembly | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly. [GO_REF:0000058, GOC:als, GOC:autophagy, GOC:TermGenie, PMID:21975012] |
| GO:1902958 | positive regulation of mitochondrial electron transport, NADH to ubiquinone | biological_process | Any process that activates or increases the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone. [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063] |
| GO:1903146 | regulation of autophagy of mitochondrion | biological_process | Any process that modulates the frequency, rate or extent of mitochondrion degradation by an autophagic process. [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391] |
| GO:1903214 | regulation of protein targeting to mitochondrion | biological_process | Any process that modulates the frequency, rate or extent of protein targeting to mitochondrion. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] |
| GO:1903298 | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24553947] |
| GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15790595] |
| GO:1903384 | negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of a hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23261939] |
| GO:1903751 | negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide. [GO_REF:0000058, GOC:TermGenie, PMID:18681888] |
| GO:1903852 | positive regulation of cristae formation | biological_process | Any process that activates or increases the frequency, rate or extent of cristae formation. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012] |
| GO:1903955 | positive regulation of protein targeting to mitochondrion | biological_process | Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24270810] |
| GO:1904544 | positive regulation of free ubiquitin chain polymerization | biological_process | Any process that activates or increases the frequency, rate or extent of free ubiquitin chain polymerization. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806] |
| GO:1904881 | cellular response to hydrogen sulfide | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24012591] |
| GO:2000377 | regulation of reactive oxygen species metabolic process | biological_process | Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah] |
| GO:2000378 | negative regulation of reactive oxygen species metabolic process | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah] |
| GO:2001171 | positive regulation of ATP biosynthetic process | biological_process | Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process. [GOC:obol] |
| GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis] |
| GO:0005634 | nucleus | cellular_component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| GO:0005737 | cytoplasm | cellular_component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| GO:0005739 | mitochondrion | cellular_component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| GO:0005741 | mitochondrial outer membrane | cellular_component | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai] |
| GO:0005743 | mitochondrial inner membrane | cellular_component | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai] |
| GO:0005758 | mitochondrial intermembrane space | cellular_component | The region between the inner and outer lipid bilayers of the mitochondrial envelope. [GOC:mah] |
| GO:0005783 | endoplasmic reticulum | cellular_component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| GO:0005829 | cytosol | cellular_component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| GO:0005856 | cytoskeleton | cellular_component | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. [GOC:mah, PMID:16959967, PMID:27419875] |
| GO:0016020 | membrane | cellular_component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| GO:0030424 | axon | cellular_component | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732] |
| GO:0030426 | growth cone | cellular_component | The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468] |
| GO:0044297 | cell body | cellular_component | The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. [GOC:go_curators] |
| GO:0048471 | perinuclear region of cytoplasm | cellular_component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
| GO:0097413 | Lewy body | cellular_component | Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein. [NIF_Subcellular:sao4933778419] |
| GO:0097449 | astrocyte projection | cellular_component | A prolongation or process extending from the soma of an astrocyte and wrapping around neurons. [NIF_Subcellular:sao1630537580] |
| GO:0000785 | chromatin | cellular_component | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130] |
| GO:0042981 | regulation of apoptotic process | biological_process | Any process that modulates the occurrence or rate of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| GO:0090141 | positive regulation of mitochondrial fission | biological_process | Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. [GOC:ascb_2009, GOC:dph, GOC:tb] |