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PIP5K1A-202 ,PIP5K1A ,Q99755
  • Uniprot Accession= Q99755
  • Ensembl Transcript= ENST00000368888.9
  • Uniprot Name= PIP5K1A
  • Name= Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 33
GO term GO name GO namespace GO def
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex cellular_component A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. [PMID:14749727]
GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity molecular_function Catalysis of the reaction
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0005524 ATP binding molecular_function Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity molecular_function Catalysis of the reaction
GO:0019900 kinase binding molecular_function Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. [GOC:jl]
GO:0052742 phosphatidylinositol kinase activity molecular_function Catalysis of the reaction
GO:0052810 1-phosphatidylinositol-5-kinase activity molecular_function Catalysis of the reaction
GO:0006650 glycerophospholipid metabolic process biological_process The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. [ISBN:0198506732]
GO:0006661 phosphatidylinositol biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [ISBN:0198506732]
GO:0006909 phagocytosis biological_process A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. [ISBN:0198506732]
GO:0007165 signal transduction biological_process The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
GO:0008654 phospholipid biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. [ISBN:0198506732]
GO:0010761 fibroblast migration biological_process Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. [GOC:BHF, GOC:dph, GOC:tb]
GO:0016310 phosphorylation biological_process The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. [ISBN:0198506732]
GO:0016477 cell migration biological_process The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
GO:0030036 actin cytoskeleton organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:dph, GOC:jl, GOC:mah]
GO:0030216 keratinocyte differentiation biological_process The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb]
GO:0048041 focal adhesion assembly biological_process The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. [GOC:jid, GOC:mah]
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction biological_process Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
GO:0060326 cell chemotaxis biological_process The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [GOC:dph]
GO:0072659 protein localization to plasma membrane biological_process A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. [GOC:mah]
GO:0090630 activation of GTPase activity biological_process Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. [GOC:dph, GOC:mah, GOC:tb]
GO:0097178 ruffle assembly biological_process The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42. [GOC:yaf, http:en.wikipedia.org/wiki/Membrane_ruffling, PMID:12556481]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0005925 focal adhesion cellular_component A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]
GO:0016607 nuclear speck cellular_component A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. [http://www.cellnucleus.com/]
GO:0030027 lamellipodium cellular_component A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. [ISBN:0815316194]
GO:0032587 ruffle membrane cellular_component The portion of the plasma membrane surrounding a ruffle. [GOC:mah]
GO:0046854 phosphatidylinositol phosphate biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. [ISBN:0198506732]