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PLA2G4A-201 ,PLA2G4A ,P47712
  • Uniprot Accession= P47712
  • Ensembl Transcript= ENST00000367466.4
  • Uniprot Name= PLA2G4A
  • Name= Cytosolic phospholipase A2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 41
GO term
GO name
GO namespace
GO def
GO:0004622 lysophospholipase activity molecular_function Catalysis of the reaction
GO:0004623 phospholipase A2 activity molecular_function Catalysis of the reaction
GO:0005509 calcium ion binding molecular_function Binding to a calcium ion (Ca2+). [GOC:ai]
GO:0005544 calcium-dependent phospholipid binding molecular_function Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. [GOC:jl]
GO:0008374 O-acyltransferase activity molecular_function Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. [GOC:ai]
GO:0010314 phosphatidylinositol-5-phosphate binding molecular_function Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. [GOC:bf, GOC:tair_curators]
GO:0032266 phosphatidylinositol-3-phosphate binding molecular_function Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775]
GO:0047498 calcium-dependent phospholipase A2 activity molecular_function Catalysis of the reaction
GO:0047499 calcium-independent phospholipase A2 activity molecular_function Catalysis of the reaction
GO:0070273 phosphatidylinositol-4-phosphate binding molecular_function Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. [GOC:bf, GOC:mah]
GO:0102545 phosphatidyl phospholipase B activity molecular_function Catalysis of the reaction
GO:1902387 ceramide 1-phosphate binding molecular_function Binding to ceramide 1-phosphate. [GOC:TermGenie, PMID:23863933]
GO:0001516 prostaglandin biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. [GOC:ai]
GO:0002827 positive regulation of T-helper 1 type immune response biological_process Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response. [GOC:add]
GO:0006071 glycerol metabolic process biological_process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. [GOC:ai, ISBN:0198506732]
GO:0006640 monoacylglycerol biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. [ISBN:0198506732]
GO:0006663 platelet activating factor biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli. [ISBN:0198547684]
GO:0006690 icosanoid metabolic process biological_process The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. [GOC:ma]
GO:0010572 positive regulation of platelet activation biological_process Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. [GOC:dph, GOC:sl, GOC:tb]
GO:0019369 arachidonic acid metabolic process biological_process The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [ISBN:0198506732]
GO:0019370 leukotriene biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. [GOC:go_curators]
GO:0032308 positive regulation of prostaglandin secretion biological_process Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell. [GOC:mah]
GO:0034478 phosphatidylglycerol catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. [GOC:mah]
GO:0034638 phosphatidylcholine catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:jp]
GO:0036151 phosphatidylcholine acyl-chain remodeling biological_process Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. [GOC:mw, PMID:18195019, PMID:18458083]
GO:0042127 regulation of cell population proliferation biological_process Any process that modulates the frequency, rate or extent of cell proliferation. [GOC:jl]
GO:0043032 positive regulation of macrophage activation biological_process Any process that stimulates, induces or increases the rate of macrophage activation. [GOC:jl]
GO:0050482 arachidonic acid secretion biological_process The controlled release of arachidonic acid from a cell or a tissue. [GOC:ai]
GO:0051649 establishment of localization in cell biological_process Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. [GOC:ai, GOC:dos, GOC:dph, GOC:tb]
GO:0071236 cellular response to antibiotic biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. [GOC:mah]
GO:0000139 Golgi membrane cellular_component The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
GO:0005635 nuclear envelope cellular_component The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). [ISBN:0198547684]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0005743 mitochondrial inner membrane cellular_component The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]
GO:0005789 endoplasmic reticulum membrane cellular_component The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0043231 intracellular membrane-bounded organelle cellular_component Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
GO:0046475 glycerophospholipid catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. [ISBN:0198506732]
GO:0005783 endoplasmic reticulum cellular_component The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005794 Golgi apparatus cellular_component A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]