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PLEKHN1-203 ,PLEKHN1 ,Q494U1
  • Uniprot Accession= Q494U1
  • Ensembl Transcript= ENST00000379410.8
  • Uniprot Name= PLEKHN1
  • Name= Pleckstrin homology domain-containing family N member 1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 12
GO term GO name GO namespace GO def
GO:0001786 phosphatidylserine binding molecular_function Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. [ISBN:0198506732, PMID:12000961]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0070300 phosphatidic acid binding molecular_function Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. [CHEBI:16337, GOC:jp, ISBN:0198506732]
GO:1901612 cardiolipin binding molecular_function Binding to cardiolipin. [GOC:kmv, GOC:TermGenie]
GO:1901981 phosphatidylinositol phosphate binding molecular_function Binding to phosphatidylinositol phosphate. [GOC:TermGenie, PMID:23445487]
GO:0001666 response to hypoxia biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd]
GO:0043065 positive regulation of apoptotic process biological_process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
GO:0061158 3'-UTR-mediated mRNA destabilization biological_process An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. [GOC:dph, GOC:jh]
GO:0005739 mitochondrion cellular_component A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
GO:0005856 cytoskeleton cellular_component A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. [GOC:mah, PMID:16959967, PMID:27419875]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0031966 mitochondrial membrane cellular_component Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. [GOC:mah, NIF_Subcellular:sao1045389829]