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POU2F1-212 ,POU2F1 ,P14859
  • Uniprot Accession= P14859
  • Ensembl Transcript= ENST00000541643.7
  • Uniprot Name= POU2F1
  • Name= POU domain, class 2, transcription factor 1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 17
GO term GO name GO namespace GO def
GO:0045892 negative regulation of DNA-templated transcription biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding molecular_function Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding molecular_function Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene. [GOC:pg, GOC:txnOH, PMID:12381658]
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific molecular_function A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]
GO:0003677 DNA binding molecular_function Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0043565 sequence-specific DNA binding molecular_function Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. [GOC:jl]
GO:0045944 positive regulation of transcription by RNA polymerase II biological_process Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
GO:1902895 positive regulation of miRNA transcription biological_process Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription. [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0005783 endoplasmic reticulum cellular_component The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
GO:0043231 intracellular membrane-bounded organelle cellular_component Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
GO:0000785 chromatin cellular_component The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]
GO:0090575 RNA polymerase II transcription regulator complex cellular_component A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. [GOC:tb]
GO:0006357 regulation of transcription by RNA polymerase II biological_process Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]