| GO term | GO name | GO namespace | GO def |
| GO:0000976 | transcription cis-regulatory region binding | molecular_function | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. [GOC:txnOH] |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | molecular_function | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018] |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | molecular_function | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018] |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | molecular_function | A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018] |
| GO:0003677 | DNA binding | molecular_function | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw] |
| GO:0003700 | DNA-binding transcription factor activity | molecular_function | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [GOC:txnOH-2018] |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0016922 | nuclear receptor binding | molecular_function | Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand. [PMID:7776974] |
| GO:0050692 | DNA binding domain binding | molecular_function | Binding to a protein's DNA binding domain (DBD). [PMID:9682036] |
| GO:0050693 | LBD domain binding | molecular_function | Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket. [PMID:9682036] |
| GO:1990837 | sequence-specific double-stranded DNA binding | molecular_function | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl] |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |
| GO:0001822 | kidney development | biological_process | The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544] |
| GO:0001889 | liver development | biological_process | The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. [GOC:add, ISBN:068340007X] |
| GO:0001938 | positive regulation of endothelial cell proliferation | biological_process | Any process that activates or increases the rate or extent of endothelial cell proliferation. [GOC:add] |
| GO:0001946 | lymphangiogenesis | biological_process | Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. [GOC:dph, PMID:11596157] |
| GO:0002088 | lens development in camera-type eye | biological_process | The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. [GOC:dph, ISBN:0582064333] |
| GO:0002194 | hepatocyte cell migration | biological_process | The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes. [CL:0000182, PMID:9794819] |
| GO:0006366 | transcription by RNA polymerase II | biological_process | The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382] |
| GO:0007405 | neuroblast proliferation | biological_process | The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. [GOC:ai, GOC:mtg_sensu, GOC:sart] |
| GO:0007406 | negative regulation of neuroblast proliferation | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts. [GOC:ai] |
| GO:0007420 | brain development | biological_process | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] |
| GO:0007623 | circadian rhythm | biological_process | Any biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:bf, GOC:go_curators] |
| GO:0008284 | positive regulation of cell population proliferation | biological_process | Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators] |
| GO:0008285 | negative regulation of cell population proliferation | biological_process | Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators] |
| GO:0010468 | regulation of gene expression | biological_process | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018] |
| GO:0010595 | positive regulation of endothelial cell migration | biological_process | Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. [GOC:BHF, GOC:dph, GOC:tb] |
| GO:0010631 | epithelial cell migration | biological_process | The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism. [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb] |
| GO:0021516 | dorsal spinal cord development | biological_process | The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11179871] |
| GO:0021542 | dentate gyrus development | biological_process | The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] |
| GO:0021707 | cerebellar granule cell differentiation | biological_process | The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] |
| GO:0021915 | neural tube development | biological_process | The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] |
| GO:0030240 | skeletal muscle thin filament assembly | biological_process | The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle. [GOC:ef, GOC:mah, GOC:mtg_muscle] |
| GO:0030324 | lung development | biological_process | The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. [GOC:jid, UBERON:0002048] |
| GO:0030910 | olfactory placode formation | biological_process | The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity. [GOC:dgh] |
| GO:0031016 | pancreas development | biological_process | The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones. [GOC:cvs] |
| GO:0031667 | response to nutrient levels | biological_process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. [GOC:mah] |
| GO:0042752 | regulation of circadian rhythm | biological_process | Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:dph, GOC:jl, GOC:tb] |
| GO:0043049 | otic placode formation | biological_process | The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain. [GOC:go_curators, PMID:12668634] |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:jl] |
| GO:0045071 | negative regulation of viral genome replication | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication. [GOC:go_curators] |
| GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | biological_process | Any process that activates or increases the frequency, rate or extent of CDK activity. [GOC:go_curators, GOC:pr] |
| GO:0045787 | positive regulation of cell cycle | biological_process | Any process that activates or increases the rate or extent of progression through the cell cycle. [GOC:go_curators] |
| GO:0045892 | negative regulation of DNA-templated transcription | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH] |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | biological_process | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH] |
| GO:0046619 | lens placode formation involved in camera-type eye formation | biological_process | Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles. [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] |
| GO:0048664 | neuron fate determination | biological_process | The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed. [GOC:dph] |
| GO:0048845 | venous blood vessel morphogenesis | biological_process | The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart. [GOC:dsf, PMID:16740480] |
| GO:0055005 | ventricular cardiac myofibril assembly | biological_process | The process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. [GOC:devbiol] |
| GO:0055009 | atrial cardiac muscle tissue morphogenesis | biological_process | The process in which the anatomical structure of cardiac atrium muscle is generated and organized. [GOC:devbiol] |
| GO:0055010 | ventricular cardiac muscle tissue morphogenesis | biological_process | The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. [GOC:devbiol] |
| GO:0060042 | retina morphogenesis in camera-type eye | biological_process | The process in which the anatomical structure of the retina is generated and organized. [GOC:bf, GOC:dph, GOC:mtg_sensu] |
| GO:0060059 | embryonic retina morphogenesis in camera-type eye | biological_process | The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage. [GOC:dgh, GOC:dph] |
| GO:0060214 | endocardium formation | biological_process | Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. [GOC:bf, GOC:dph, PMID:17722983] |
| GO:0060298 | positive regulation of sarcomere organization | biological_process | Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. [GOC:BHF, GOC:dph, GOC:tb] |
| GO:0060412 | ventricular septum morphogenesis | biological_process | The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. [GOC:dph] |
| GO:0060414 | aorta smooth muscle tissue morphogenesis | biological_process | The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. [GOC:bf, GOC:dgh, GOC:dph, Wikipedia:Aorta] |
| GO:0060421 | positive regulation of heart growth | biological_process | Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. [GOC:BHF, GOC:dph, GOC:tb] |
| GO:0060836 | lymphatic endothelial cell differentiation | biological_process | The process in which a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels. [GOC:dph, GOC:sdb_2009, GOC:tb] |
| GO:0060837 | blood vessel endothelial cell differentiation | biological_process | The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels. [GOC:dph, GOC:sdb_2009, GOC:tb] |
| GO:0060838 | lymphatic endothelial cell fate commitment | biological_process | The commitment of a venous blood vessel endothelial cell to a lymphatic endothelial cell fate and its capacity to differentiate into a lymphatic endothelial cell. [GOC:dph, GOC:sdb_2009, GOC:tb] |
| GO:0061114 | branching involved in pancreas morphogenesis | biological_process | The process in which the branches of the pancreas are generated and organized. [GOC:dph] |
| GO:0070309 | lens fiber cell morphogenesis | biological_process | The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. [GOC:mah, PMID:7693735] |
| GO:0070365 | hepatocyte differentiation | biological_process | The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver. [CL:0000182, PMID:7588884] |
| GO:0070858 | negative regulation of bile acid biosynthetic process | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. [GOC:BHF, GOC:mah] |
| GO:0072574 | hepatocyte proliferation | biological_process | The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. [CL:0000182, GOC:BHF, GOC:mah] |
| GO:0090425 | acinar cell differentiation | biological_process | The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini. [GOC:dph, GOC:tb] |
| GO:0097150 | neuronal stem cell population maintenance | biological_process | Any process in by an organism or tissue maintains a population of neuronal stem cells. [CL:0000047, GOC:dos, GOC:yaf, PMID:11399758] |
| GO:1901978 | positive regulation of cell cycle checkpoint | biological_process | Any process that activates or increases the frequency, rate or extent of cell cycle checkpoint. [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116] |
| GO:2000179 | positive regulation of neural precursor cell proliferation | biological_process | Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. [GOC:dph, GOC:yaf] |
| GO:2000979 | positive regulation of forebrain neuron differentiation | biological_process | Any process that activates or increases the frequency, rate or extent of forebrain neuron differentiation. [GOC:obol] |
| GO:0005634 | nucleus | cellular_component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| GO:0005654 | nucleoplasm | cellular_component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| GO:0005737 | cytoplasm | cellular_component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| GO:0005829 | cytosol | cellular_component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| GO:0000785 | chromatin | cellular_component | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130] |
| GO:0006357 | regulation of transcription by RNA polymerase II | biological_process | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |