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PTPN14-201 ,PTPN14 ,Q15678
  • Uniprot Accession= Q15678
  • Ensembl Transcript= ENST00000366956.10
  • Uniprot Name= PTPN14
  • Name= Tyrosine-protein phosphatase non-receptor type 14
  • Chromosome= chr1
  • Driver status= Compendium
  • Number of GO Term: 12
GO term GO name GO namespace GO def
GO:0003712 transcription coregulator activity molecular_function A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]
GO:0004725 protein tyrosine phosphatase activity molecular_function Catalysis of the reaction
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0030971 receptor tyrosine kinase binding molecular_function Binding to a receptor that possesses protein tyrosine kinase activity. [GOC:mah]
GO:0001946 lymphangiogenesis biological_process Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. [GOC:dph, PMID:11596157]
GO:0006470 protein dephosphorylation biological_process The process of removing one or more phosphoric residues from a protein. [GOC:hb]
GO:0008285 negative regulation of cell population proliferation biological_process Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
GO:0046825 regulation of protein export from nucleus biological_process Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm. [GOC:bf]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0005856 cytoskeleton cellular_component A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. [GOC:mah, PMID:16959967, PMID:27419875]