| GO term | GO name | GO namespace | GO def |
| GO:0030033 | microvillus assembly | biological_process | Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. [GOC:mah, ISBN:0815316194] |
| GO:0003925 | G protein activity | molecular_function | A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP). [PMID:16923326, PMID:24470015] |
| GO:0005085 | guanyl-nucleotide exchange factor activity | molecular_function | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782] |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0031267 | small GTPase binding | molecular_function | Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782] |
| GO:0044877 | protein-containing complex binding | molecular_function | Binding to a macromolecular complex. [GOC:jl] |
| GO:0007399 | nervous system development | biological_process | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh] |
| GO:0010976 | positive regulation of neuron projection development | biological_process | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:dph, GOC:tb] |
| GO:0016079 | synaptic vesicle exocytosis | biological_process | Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft. [GOC:jid, GOC:lmg] |
| GO:0032486 | Rap protein signal transduction | biological_process | An intracellular signaling cassette in which a small monomeric GTPase of the Rap subfamily relays a signal. [GOC:mah] |
| GO:0038180 | nerve growth factor signaling pathway | biological_process | The series of molecular signals initiated by nerve growth factor (NGF) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, PMID:11520933] |
| GO:0043547 | positive regulation of GTPase activity | biological_process | Any process that activates or increases the activity of a GTPase. [GOC:jl, GOC:mah] |
| GO:0045860 | positive regulation of protein kinase activity | biological_process | Any process that activates or increases the frequency, rate or extent of protein kinase activity. [GOC:go_curators] |
| GO:0061028 | establishment of endothelial barrier | biological_process | The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. [GOC:dph] |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | biological_process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah] |
| GO:0071320 | cellular response to cAMP | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. [GOC:mah] |
| GO:0072659 | protein localization to plasma membrane | biological_process | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. [GOC:mah] |
| GO:0098696 | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane | biological_process | Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane. [GOC:dos] |
| GO:1901888 | regulation of cell junction assembly | biological_process | Any process that modulates the frequency, rate or extent of cell junction assembly. [GOC:TermGenie] |
| GO:1990090 | cellular response to nerve growth factor stimulus | biological_process | A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. [PMID:22399805, Wikipedia:Nerve_growth_factor] |
| GO:2001214 | positive regulation of vasculogenesis | biological_process | Any process that activates or increases the frequency, rate or extent of vasculogenesis. [GOC:obol] |
| GO:0098978 | glutamatergic synapse | cellular_component | A synapse that uses glutamate as a neurotransmitter. [GOC:dos] |
| GO:0005737 | cytoplasm | cellular_component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| GO:0005769 | early endosome | cellular_component | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] |
| GO:0005770 | late endosome | cellular_component | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062] |
| GO:0005829 | cytosol | cellular_component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| GO:0005886 | plasma membrane | cellular_component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| GO:0010008 | endosome membrane | cellular_component | The lipid bilayer surrounding an endosome. [GOC:mah] |
| GO:0030054 | cell junction | cellular_component | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264] |
| GO:0035579 | specific granule membrane | cellular_component | The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549] |
| GO:0043005 | neuron projection | cellular_component | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/] |
| GO:0048471 | perinuclear region of cytoplasm | cellular_component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
| GO:0070062 | extracellular exosome | cellular_component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| GO:0070161 | anchoring junction | cellular_component | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. [ISBN:0815332181] |
| GO:0097225 | sperm midpiece | cellular_component | The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. [GOC:cjm, MP:0009831] |
| GO:0098793 | presynapse | cellular_component | The part of a synapse that is part of the presynaptic cell. [GOC:dos] |
| GO:0032045 | guanyl-nucleotide exchange factor complex | cellular_component | A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase. [GOC:mah] |
| GO:2000301 | negative regulation of synaptic vesicle exocytosis | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis. [GOC:obol] |
| GO:0003924 | GTPase activity | molecular_function | Catalysis of the reaction |
| GO:0019003 | GDP binding | molecular_function | Binding to GDP, guanosine 5'-diphosphate. [GOC:ai] |
| GO:0005525 | GTP binding | molecular_function | Binding to GTP, guanosine triphosphate. [GOC:ai] |