| GO term | GO name | GO namespace | GO def |
| GO:0000781 | chromosome, telomeric region | cellular_component | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). [GOC:elh] |
| GO:0016605 | PML body | cellular_component | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. [GOC:ma, PMID:10944585] |
| GO:0035861 | site of double-strand break | cellular_component | A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408] |
| GO:0003684 | damaged DNA binding | molecular_function | Binding to damaged DNA. [GOC:jl] |
| GO:0003697 | single-stranded DNA binding | molecular_function | Binding to single-stranded DNA. [GOC:elh, GOC:vw, PMID:22976174] |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0019899 | enzyme binding | molecular_function | Binding to an enzyme, a protein with catalytic activity. [GOC:jl] |
| GO:0019903 | protein phosphatase binding | molecular_function | Binding to a protein phosphatase. [GOC:jl] |
| GO:0031625 | ubiquitin protein ligase binding | molecular_function | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp] |
| GO:0098505 | G-rich strand telomeric DNA binding | molecular_function | Binding to G-rich, single-stranded, telomere-associated DNA. [PMID:11349150] |
| GO:0000723 | telomere maintenance | biological_process | Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] |
| GO:0000724 | double-strand break repair via homologous recombination | biological_process | The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. [GOC:elh, PMID:10357855] |
| GO:0006260 | DNA replication | biological_process | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. [GOC:mah] |
| GO:0006284 | base-excision repair | biological_process | In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. [ISBN:0815316194] |
| GO:0006289 | nucleotide-excision repair | biological_process | A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). [PMID:10197977] |
| GO:0006298 | mismatch repair | biological_process | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. [ISBN:0198506732, PMID:11687886] |
| GO:0010569 | regulation of double-strand break repair via homologous recombination | biological_process | Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. [GOC:dph, GOC:jp, GOC:tb] |
| GO:0031571 | mitotic G1 DNA damage checkpoint signaling | biological_process | A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint. [GOC:mtg_cell_cycle] |
| GO:0034502 | protein localization to chromosome | biological_process | Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. [GOC:mah] |
| GO:2000001 | regulation of DNA damage checkpoint | biological_process | Any process that modulates the frequency, rate or extent of a DNA damage checkpoint. [GOC:obol] |
| GO:0005634 | nucleus | cellular_component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| GO:0005654 | nucleoplasm | cellular_component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| GO:0005662 | DNA replication factor A complex | cellular_component | A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. [PMID:9242902] |
| GO:0016604 | nuclear body | cellular_component | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182] |
| GO:0000785 | chromatin | cellular_component | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130] |
| GO:0042162 | telomeric DNA binding | molecular_function | Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. [GOC:jl, SO:0000624] |