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S100A9-201 ,S100A9 ,P06702
  • Uniprot Accession= P06702
  • Ensembl Transcript= ENST00000368738.4
  • Uniprot Name= S100A9
  • Name= Protein S100-A9
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 52
GO term GO name GO namespace GO def
GO:0005509 calcium ion binding molecular_function Binding to a calcium ion (Ca2+). [GOC:ai]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0008017 microtubule binding molecular_function Binding to a microtubule, a filament composed of tubulin monomers. [GOC:krc]
GO:0008270 zinc ion binding molecular_function Binding to a zinc ion (Zn). [GOC:ai]
GO:0016209 antioxidant activity molecular_function Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. [ISBN:0198506732]
GO:0035662 Toll-like receptor 4 binding molecular_function Binding to a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response. [GOC:BHF, PMID:18304834]
GO:0050544 arachidonic acid binding molecular_function Binding to arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [GOC:ai]
GO:0050786 RAGE receptor binding molecular_function Binding to a RAGE receptor, the receptor for advanced glycation end-products. [GOC:ai]
GO:0002523 leukocyte migration involved in inflammatory response biological_process The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
GO:0006914 autophagy biological_process The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation. [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]
GO:0006915 apoptotic process biological_process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process biological_process Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
GO:0006954 inflammatory response biological_process The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
GO:0007267 cell-cell signaling biological_process Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah]
GO:0010976 positive regulation of neuron projection development biological_process Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:dph, GOC:tb]
GO:0030307 positive regulation of cell growth biological_process Any process that activates or increases the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
GO:0030593 neutrophil chemotaxis biological_process The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:jl, ISBN:0198506732]
GO:0032119 sequestering of zinc ion biological_process The process of binding or confining zinc ions such that they are separated from other components of a biological system. [GOC:mah]
GO:0034121 regulation of toll-like receptor signaling pathway biological_process Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway. [GOC:add, PMID:16551253, PMID:17328678]
GO:0035606 peptidyl-cysteine S-trans-nitrosylation biological_process Transfer of a nitric oxide (NO) group from one cysteine residue to another. [PMID:19854201, PMID:20972425, PMID:20972426]
GO:0035821 modulation of process of another organism biological_process The process in which an organism effects a change in the structure or processes of another organism. [GOC:bf]
GO:0042742 defense response to bacterium biological_process Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. [GOC:jl]
GO:0045087 innate immune response biological_process Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
GO:0050729 positive regulation of inflammatory response biological_process Any process that activates or increases the frequency, rate or extent of the inflammatory response. [GOC:ai]
GO:0050832 defense response to fungus biological_process Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. [GOC:ai]
GO:0051092 positive regulation of NF-kappaB transcription factor activity biological_process Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]
GO:0051493 regulation of cytoskeleton organization biological_process Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. [GOC:ai]
GO:0060264 regulation of respiratory burst involved in inflammatory response biological_process Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide biological_process An immune response against microbes mediated by anti-microbial peptides in body fluid. [PMID:15761415, PMID:24287494]
GO:0070488 neutrophil aggregation biological_process The adhesion of one neutrophil to one or more other neutrophils via adhesion molecules. [GOC:sl, PMID:12972508]
GO:0098869 cellular oxidant detoxification biological_process Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide. [GOC:dos, GOC:vw]
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway biological_process Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]
GO:0005576 extracellular region cellular_component The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
GO:0005615 extracellular space cellular_component That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0005856 cytoskeleton cellular_component A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. [GOC:mah, PMID:16959967, PMID:27419875]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0034774 secretory granule lumen cellular_component The volume enclosed by the membrane of a secretory granule. [GOC:rph]
GO:0062023 collagen-containing extracellular matrix cellular_component An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617]
GO:0070062 extracellular exosome cellular_component A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
GO:1990660 calprotectin complex cellular_component A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. [GOC:bhm, PMID:25417112]
GO:1990662 S100A9 complex cellular_component A protein complex composed of a S100A9 dimer and capable of binding to toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Transports arachidonic acid between the cytosol and the NADPH oxidase complex at the plasma membrane in neutrophils as part of an inflammatory signal cascade leading to an oxidative burst. Complexes with microtubules to increase cell motility. [GOC:bhm, PMID:15642721]
GO:0018119 peptidyl-cysteine S-nitrosylation biological_process The covalent addition of a nitric oxide (NO) group to the sulphur (S) atom of a cysteine residue in a protein, to form peptidyl-S-nitrosyl-L-cysteine. [RESID:AA0230]
GO:0002544 chronic inflammatory response biological_process Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response. [GO_REF:0000022, GOC:jal, ISBN:0781735149]
GO:0035425 autocrine signaling biological_process Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type. [GOC:bf, ISBN:3527303782]
GO:0032496 response to lipopolysaccharide biological_process Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464]
GO:0043542 endothelial cell migration biological_process The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. [GOC:go_curators]
GO:0045113 regulation of integrin biosynthetic process biological_process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. [GOC:go_curators]
GO:0014002 astrocyte development biological_process The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. [GOC:dgh, GOC:ef]
GO:0048306 calcium-dependent protein binding molecular_function Binding to a protein or protein complex in the presence of calcium. [GOC:jid, PMID:10485905]