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SETDB1-201 ,SETDB1 ,Q15047
  • Uniprot Accession= Q15047
  • Ensembl Transcript= ENST00000271640.9
  • Uniprot Name= SETDB1
  • Name= Histone-lysine N-methyltransferase SETDB1
  • Chromosome= chr1
  • Driver status= Census, Compendium
  • Number of GO Term: 19
GO term GO name GO namespace GO def
GO:0003677 DNA binding molecular_function Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
GO:0003682 chromatin binding molecular_function Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0008270 zinc ion binding molecular_function Binding to a zinc ion (Zn). [GOC:ai]
GO:0046974 histone H3K9 methyltransferase activity molecular_function Catalysis of the reaction
GO:0140947 histone H3K9me2 methyltransferase activity molecular_function Catalysis of the reaction
GO:0140948 histone H3K9 monomethyltransferase activity molecular_function Catalysis of the reaction
GO:0140949 histone H3K9 trimethyltransferase activity molecular_function Catalysis of the reaction
GO:1990841 promoter-specific chromatin binding molecular_function Binding to a section of chromatin that is associated with gene promoter sequences of DNA. [PMID:19948729]
GO:0032259 methylation biological_process The process in which a methyl group is covalently attached to a molecule. [GOC:mah]
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate. [GOC:go_curators]
GO:0090309 positive regulation of DNA methylation-dependent heterochromatin formation biological_process Any process that increases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation. [GOC:BHF]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0005694 chromosome cellular_component A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. [ISBN:0198547684]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0043231 intracellular membrane-bounded organelle cellular_component Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
GO:0010629 negative regulation of gene expression biological_process Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
GO:0070828 heterochromatin organization biological_process Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin. [GOC:mah]