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SMYD2-201 ,SMYD2 ,Q9NRG4
  • Uniprot Accession= Q9NRG4
  • Ensembl Transcript= ENST00000366957.10
  • Uniprot Name= SMYD2
  • Name= N-lysine methyltransferase SMYD2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 21
GO term GO name GO namespace GO def
GO:0000993 RNA polymerase II complex binding molecular_function Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. [GOC:txnOH]
GO:0002039 p53 binding molecular_function Binding to one of the p53 family of proteins. [GOC:hjd]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0016278 lysine N-methyltransferase activity molecular_function Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. [GOC:mah]
GO:0016279 protein-lysine N-methyltransferase activity molecular_function Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. [PMID:12054878]
GO:0046872 metal ion binding molecular_function Binding to a metal ion. [GOC:ai]
GO:0046975 histone H3K36 methyltransferase activity molecular_function Catalysis of the reaction
GO:0140938 histone H3 methyltransferase activity molecular_function Catalysis of the reaction
GO:0140999 histone H3K4 trimethyltransferase activity molecular_function Catalysis of the reaction
GO:0000122 negative regulation of transcription by RNA polymerase II biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
GO:0006338 chromatin remodeling biological_process A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
GO:0007507 heart development biological_process The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:jid, UBERON:0000948]
GO:0008285 negative regulation of cell population proliferation biological_process Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
GO:0018026 peptidyl-lysine monomethylation biological_process The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine. [RESID:AA0076]
GO:0018027 peptidyl-lysine dimethylation biological_process The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. [RESID:AA0075]
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator biological_process Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. [GOC:jl]
GO:1901796 regulation of signal transduction by p53 class mediator biological_process Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. [GOC:TermGenie]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]