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SPTA1-208 ,SPTA1 ,P02549
  • Uniprot Accession= P02549
  • Ensembl Transcript= ENST00000643759.2
  • Uniprot Name= SPTA1
  • Name= Spectrin alpha chain, erythrocytic 1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 24
GO term GO name GO namespace GO def
GO:0005200 structural constituent of cytoskeleton molecular_function The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. [GOC:mah]
GO:0005509 calcium ion binding molecular_function Binding to a calcium ion (Ca2+). [GOC:ai]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0002260 lymphocyte homeostasis biological_process The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262]
GO:0006779 porphyrin-containing compound biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. [GOC:jl, ISBN:0198506732, Wikipedia:Porphyrin#Natural_formation]
GO:0007009 plasma membrane organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. [GOC:dph, GOC:jl, GOC:mah]
GO:0007015 actin filament organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. [GOC:mah]
GO:0008360 regulation of cell shape biological_process Any process that modulates the surface configuration of a cell. [GOC:dph, GOC:go_curators, GOC:tb]
GO:0030097 hemopoiesis biological_process The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. [GOC:dgh, ISBN:0198506732]
GO:0042102 positive regulation of T cell proliferation biological_process Any process that activates or increases the rate or extent of T cell proliferation. [GOC:ai]
GO:0051693 actin filament capping biological_process The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. [ISBN:071673706X]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0009898 cytoplasmic side of plasma membrane cellular_component The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]
GO:0014731 spectrin-associated cytoskeleton cellular_component The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane. [GOC:mtg_muscle, PMID:15970557]
GO:0015629 actin cytoskeleton cellular_component The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. [GOC:jl, ISBN:0395825172, ISBN:0815316194]
GO:0030424 axon cellular_component The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732]
GO:0032437 cuticular plate cellular_component A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted. [PMID:12485990, PMID:2592408, PMID:8071151]
GO:0008091 spectrin cellular_component Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins. [GOC:curators, ISBN:0815316194]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0051015 actin filament binding molecular_function Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. [ISBN:0198506732]
GO:0030054 cell junction cellular_component A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264]
GO:0042995 cell projection cellular_component A prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
GO:0030036 actin cytoskeleton organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:dph, GOC:jl, GOC:mah]
GO:0030864 cortical actin cytoskeleton cellular_component The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. [GOC:mah]