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SZT2-210 ,SZT2 ,Q5T011
  • Uniprot Accession= Q5T011
  • Ensembl Transcript= ENST00000634258.3
  • Uniprot Name= SZT2
  • Name= KICSTOR complex protein SZT2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 16
GO term GO name GO namespace GO def
GO:0061700 GATOR2 complex cellular_component A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins. [GOC:krc, GOC:rb, PMID:23723238, PMID:25934700]
GO:1990130 GATOR1 complex cellular_component A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins. [GOC:krc, GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:25934700, PMID:28199306, PMID:29199950]
GO:0003674 molecular_function molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. [GOC:pdt]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0007417 central nervous system development biological_process The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. [GOC:bf, GOC:jid, ISBN:0582227089]
GO:0009791 post-embryonic development biological_process The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. [GOC:go_curators]
GO:0021540 corpus callosum morphogenesis biological_process The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
GO:0034198 cellular response to amino acid starvation biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. [GOC:ecd]
GO:0042149 cellular response to glucose starvation biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. [GOC:jl]
GO:0043473 pigmentation biological_process The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. [GOC:jl]
GO:0061462 protein localization to lysosome biological_process A process in which a protein is transported to, or maintained in, a location within a lysosome. [GOC:dph]
GO:1901668 regulation of superoxide dismutase activity biological_process Any process that modulates the frequency, rate or extent of superoxide dismutase activity. [GOC:TermGenie]
GO:1904262 negative regulation of TORC1 signaling biological_process Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling. [GO_REF:0000058, GOC:TermGenie, PMID:25366275]
GO:0005765 lysosomal membrane cellular_component The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
GO:0005777 peroxisome cellular_component A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
GO:0140007 KICSTOR complex cellular_component A protein complex that regulates the TORC1 signaling pathway in response to nutrients. The KICSTOR complex is composed of KPTN, ITFG2, C12orf66 and SZT2. [PMID:28199306]