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TGFBR3-201 ,TGFBR3 ,Q03167
  • Uniprot Accession= Q03167
  • Ensembl Transcript= ENST00000212355.9
  • Uniprot Name= TGFBR3
  • Name= Transforming growth factor beta receptor type 3
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 64
GO term GO name GO namespace GO def
GO:0046328 regulation of JNK cascade biological_process Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. [GOC:bf]
GO:0070372 regulation of ERK1 and ERK2 cascade biological_process Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:add, ISBN:0121245462, ISBN:0896039986]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0050431 transforming growth factor beta binding molecular_function Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. [ISBN:0198506732]
GO:0004888 transmembrane signaling receptor activity molecular_function Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. [GOC:go_curators, Wikipedia:Transmembrane_receptor]
GO:0005024 transforming growth factor beta receptor activity molecular_function Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction
GO:0005114 type II transforming growth factor beta receptor binding molecular_function Binding to a type II transforming growth factor beta receptor. [GOC:ceb, GOC:mah, PMID:11252892]
GO:0005160 transforming growth factor beta receptor binding molecular_function Binding to a transforming growth factor beta receptor. [GOC:ai]
GO:0005539 glycosaminoglycan binding molecular_function Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. [GOC:jl, ISBN:0198506732]
GO:0008201 heparin binding molecular_function Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:jl, ISBN:0198506732]
GO:0015026 coreceptor activity molecular_function Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. [GOC:go_curators]
GO:0017134 fibroblast growth factor binding molecular_function Binding to a fibroblast growth factor. [PMID:9806903]
GO:0030165 PDZ domain binding molecular_function Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. [GOC:go_curators, Pfam:PF00595]
GO:0036122 BMP binding molecular_function Binding to a member of the bone morphogenetic protein (BMP) family. [GOC:BHF, PMID:9660951]
GO:0046332 SMAD binding molecular_function Binding to a SMAD signaling protein. [GOC:ai]
GO:0048185 activin binding molecular_function Binding to activin, a dimer of inhibin-beta subunits. [GOC:jid, GOC:mah]
GO:0070123 transforming growth factor beta receptor activity, type III molecular_function Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors. [GOC:BHF, GOC:mah, PMID:9759503]
GO:0001666 response to hypoxia biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:hjd]
GO:0001837 epithelial to mesenchymal transition biological_process A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:dph, PMID:14701881]
GO:0001889 liver development biological_process The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. [GOC:add, ISBN:068340007X]
GO:0003007 heart morphogenesis biological_process The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:dph, GOC:isa_complete]
GO:0003150 muscular septum morphogenesis biological_process The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum. [GOC:mtg_heart]
GO:0003151 outflow tract morphogenesis biological_process The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. [GOC:mtg_heart, UBERON:0004145]
GO:0003223 ventricular compact myocardium morphogenesis biological_process The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized. [GOC:mtg_heart]
GO:0006955 immune response biological_process Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add]
GO:0007179 transforming growth factor beta receptor signaling pathway biological_process The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:mah, GOC:signaling]
GO:0007181 transforming growth factor beta receptor complex assembly biological_process The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex. [GOC:jl, Reactome:R-HSA-170840, Wikipedia:TGF_beta_signaling_pathway]
GO:0010628 positive regulation of gene expression biological_process Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
GO:0016477 cell migration biological_process The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
GO:0030336 negative regulation of cell migration biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. [GOC:go_curators]
GO:0030509 BMP signaling pathway biological_process The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, ISBN:0878932437, PMID:17428827]
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway biological_process Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity. [GOC:go_curators]
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. [GOC:mah]
GO:0031100 animal organ regeneration biological_process The regrowth of a lost or destroyed animal organ. [GOC:mah]
GO:0032354 response to follicle-stimulating hormone biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. [GOC:mah]
GO:0034695 response to prostaglandin E biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. [GOC:BHF, GOC:vk]
GO:0034699 response to luteinizing hormone biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus. [GOC:BHF, GOC:vk]
GO:0035556 intracellular signal transduction biological_process The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
GO:0043124 negative regulation of canonical NF-kappaB signal transduction biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
GO:0050680 negative regulation of epithelial cell proliferation biological_process Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. [GOC:ai]
GO:0055010 ventricular cardiac muscle tissue morphogenesis biological_process The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. [GOC:devbiol]
GO:0060038 cardiac muscle cell proliferation biological_process The expansion of a cardiac muscle cell population by cell division. [GOC:dph, GOC:rph, PMID:11161571]
GO:0060045 positive regulation of cardiac muscle cell proliferation biological_process Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. [GOC:dph, GOC:rph]
GO:0060216 definitive hemopoiesis biological_process A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood. [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691]
GO:0060317 cardiac epithelial to mesenchymal transition biological_process A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:dph, PMID:16314491, PMID:1996351]
GO:0060318 definitive erythrocyte differentiation biological_process Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis. [GOC:add, GOC:BHF, GOC:dph]
GO:0060347 heart trabecula formation biological_process The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. [GOC:dph]
GO:0060391 positive regulation of SMAD protein signal transduction biological_process Any process that increases the rate, frequency or extent of SMAD protein signal transduction. [GOC:BHF, GOC:dph, GOC:tb]
GO:0060392 negative regulation of SMAD protein signal transduction biological_process Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. [GOC:BHF, GOC:dph, GOC:tb]
GO:0060412 ventricular septum morphogenesis biological_process The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. [GOC:dph]
GO:0060939 epicardium-derived cardiac fibroblast cell development biological_process The process whose specific outcome is the progression of an epicardial-derived cardiac fibroblast over time, from its formation to the mature state. A epicardial-derived cardiac fibroblast is a connective tissue cell of the heart that arises from the epicardium and secretes an extracellular matrix rich in collagen and other macromolecules. [GOC:mtg_heart]
GO:0060979 vasculogenesis involved in coronary vascular morphogenesis biological_process The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes. [GOC:mtg_heart]
GO:0061384 heart trabecula morphogenesis biological_process The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. [GOC:dph]
GO:0062009 secondary palate development biological_process The biological process whose specific outcome is the progression of the secondary palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The secondary palate is the part of the palate formed from the fusion of the two palatine shelves, extensions of the maxillary prominences. [PMID:28784960]
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis biological_process Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
GO:1901202 negative regulation of extracellular matrix assembly biological_process Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly. [GOC:BHF, GOC:TermGenie]
GO:0005615 extracellular space cellular_component That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0009897 external side of plasma membrane cellular_component The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]
GO:0009986 cell surface cellular_component The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
GO:0070062 extracellular exosome cellular_component A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
GO:0034673 inhibin-betaglycan-ActRII complex cellular_component A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B. [GOC:BHF, PMID:10746731]
GO:0043235 receptor complex cellular_component Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway biological_process Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway. [GOC:mah]