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TLR5-206 ,TLR5 ,O60602
  • Uniprot Accession= O60602
  • Ensembl Transcript= ENST00000642603.2
  • Uniprot Name= TLR5
  • Name= Toll-like receptor 5
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 12
GO term GO name GO namespace GO def
GO:0032757 positive regulation of interleukin-8 production biological_process Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. [GOC:mah]
GO:0004888 transmembrane signaling receptor activity molecular_function Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. [GOC:go_curators, Wikipedia:Transmembrane_receptor]
GO:0005149 interleukin-1 receptor binding molecular_function Binding to an interleukin-1 receptor. [GOC:go_curators]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0038187 pattern recognition receptor activity molecular_function Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response. [GOC:ar, GOC:bf]
GO:0034146 toll-like receptor 5 signaling pathway biological_process The series of molecular signals initiated by a ligand binding to toll-like receptor 5. [GOC:add, PMID:16551253, PMID:17328678]
GO:0045087 innate immune response biological_process Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
GO:0071260 cellular response to mechanical stimulus biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. [GOC:mah]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0006954 inflammatory response biological_process The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
GO:0038023 signaling receptor activity molecular_function Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling]
GO:0002224 toll-like receptor signaling pathway biological_process The series of molecular signals initiated by a ligand binding to a toll-like receptor of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]