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UFC1-201 ,UFC1 ,Q9Y3C8
  • Uniprot Accession= Q9Y3C8
  • Ensembl Transcript= ENST00000368003.6
  • Uniprot Name= UFC1
  • Name= Ubiquitin-fold modifier-conjugating enzyme 1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 9
GO term GO name GO namespace GO def
GO:0034976 response to endoplasmic reticulum stress biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. [GOC:cjm, GOC:mah]
GO:0071569 protein ufmylation biological_process Covalent attachment of the ubiquitin-like protein UFM1 to another protein. [GOC:vw, PMID:20018847]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0061657 UFM1 conjugating enzyme activity molecular_function Isoenergetic transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both the X-UFM1 and Y-UFM1 linkages are thioester bonds between the C-terminal amino acid of UFM1 and a sulfhydryl side group of a cysteine residue. [GOC:dph]
GO:0007420 brain development biological_process The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
GO:0061709 reticulophagy biological_process The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions. [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]
GO:1990592 protein K69-linked ufmylation biological_process A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein. [PMID:25219498]
GO:0070062 extracellular exosome cellular_component A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
GO:0071568 UFM1 transferase activity molecular_function Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages. [GOC:sp, PMID:20018847]