Filter in search result
Please select a valid state.
USP21-203 ,USP21 ,Q9UK80
  • Uniprot Accession= Q9UK80
  • Ensembl Transcript= ENST00000368002.8
  • Uniprot Name= USP21
  • Name= Ubiquitin carboxyl-terminal hydrolase 21
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 13
GO term GO name GO namespace GO def
GO:0003713 transcription coactivator activity molecular_function A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
GO:0004843 cysteine-type deubiquitinase activity molecular_function An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:jh2, PMID:30783221]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0008234 cysteine-type peptidase activity molecular_function Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
GO:0019784 deNEDDylase activity molecular_function An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated. [GOC:mah, PMID:25628956]
GO:0046872 metal ion binding molecular_function Binding to a metal ion. [GOC:ai]
GO:0006508 proteolysis biological_process The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
GO:0045815 transcription initiation-coupled chromatin remodeling biological_process An epigenetic mechanism of regulation of gene expression that involves chromatin remodeling to capacitate gene expression by either modifying the chromatin fiber, the nucleosomal histones, or the DNA. [PMID:34414474]
GO:0045893 positive regulation of DNA-templated transcription biological_process Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]