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VAV3-202 ,VAV3 ,Q9UKW4
  • Uniprot Accession= Q9UKW4
  • Ensembl Transcript= ENST00000370056.9
  • Uniprot Name= VAV3
  • Name= Guanine nucleotide exchange factor VAV3
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 28
GO term GO name GO namespace GO def
GO:0008361 regulation of cell size biological_process Any process that modulates the size of a cell. [GOC:go_curators]
GO:0005085 guanyl-nucleotide exchange factor activity molecular_function Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]
GO:0005096 GTPase activator activity molecular_function Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. [GOC:mah]
GO:0005154 epidermal growth factor receptor binding molecular_function Binding to an epidermal growth factor receptor. [GOC:ai]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0046872 metal ion binding molecular_function Binding to a metal ion. [GOC:ai]
GO:0001525 angiogenesis biological_process Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
GO:0006906 vesicle fusion biological_process Fusion of the membrane of a transport vesicle with its target membrane. [GOC:jid]
GO:0006974 DNA damage response biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. [GOC:go_curators]
GO:0007229 integrin-mediated signaling pathway biological_process The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
GO:0007264 small GTPase-mediated signal transduction biological_process An intracellular signaling cassette in which a small monomeric GTPase relays a signal. [GOC:mah]
GO:0009410 response to xenobiotic stimulus biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
GO:0030032 lamellipodium assembly biological_process Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. [GOC:mah, ISBN:0815316194]
GO:0030168 platelet activation biological_process A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. [http://www.graylab.ac.uk/omd/]
GO:0030593 neutrophil chemotaxis biological_process The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:jl, ISBN:0198506732]
GO:0030890 positive regulation of B cell proliferation biological_process Any process that activates or increases the rate or extent of B cell proliferation. [GOC:mah]
GO:0038095 Fc-epsilon receptor signaling pathway biological_process The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. [GOC:phg, PMID:12413516, PMID:15048725]
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis biological_process An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes. [GOC:phg, PMID:12488490, PMID:15466916]
GO:0043087 regulation of GTPase activity biological_process Any process that modulates the rate of GTP hydrolysis by a GTPase. [GOC:jl, GOC:mah]
GO:0045785 positive regulation of cell adhesion biological_process Any process that activates or increases the frequency, rate or extent of cell adhesion. [GOC:go_curators]
GO:0050853 B cell receptor signaling pathway biological_process The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. [GOC:add]
GO:0051056 regulation of small GTPase mediated signal transduction biological_process Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. [GOC:go_curators]
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction biological_process Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0001772 immunological synapse cellular_component An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. [GOC:mgi_curators, PMID:11244041, PMID:11376300]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0016477 cell migration biological_process The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]