| GO term | GO name | GO namespace | GO def |
| GO:0003714 | transcription corepressor activity | molecular_function | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867] |
| GO:0048018 | receptor ligand activity | molecular_function | The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands). [GOC:kv, GOC:molecular_function_refactoring, GOC:pdt] |
| GO:0001658 | branching involved in ureteric bud morphogenesis | biological_process | The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. [GOC:dph, PMID:16916378] |
| GO:0001822 | kidney development | biological_process | The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544] |
| GO:0001837 | epithelial to mesenchymal transition | biological_process | A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:dph, PMID:14701881] |
| GO:0001838 | embryonic epithelial tube formation | biological_process | The morphogenesis of an embryonic epithelium into a tube-shaped structure. [GOC:dph, ISBN:0824072820] |
| GO:0001889 | liver development | biological_process | The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. [GOC:add, ISBN:068340007X] |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | biological_process | The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. [GOC:ceb] |
| GO:0008584 | male gonad development | biological_process | The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. [GOC:jid] |
| GO:0008585 | female gonad development | biological_process | The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. [GOC:dph, GOC:jid, GOC:tb] |
| GO:0009267 | cellular response to starvation | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. [GOC:jl] |
| GO:0010629 | negative regulation of gene expression | biological_process | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018] |
| GO:0010894 | negative regulation of steroid biosynthetic process | biological_process | Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [GOC:BHF, GOC:tb] |
| GO:0022407 | regulation of cell-cell adhesion | biological_process | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. [GOC:isa_complete] |
| GO:0030237 | female sex determination | biological_process | The specification of female sex of an individual organism. [GOC:mah, ISBN:0198506732] |
| GO:0030325 | adrenal gland development | biological_process | The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. [GOC:dgh] |
| GO:0030336 | negative regulation of cell migration | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. [GOC:go_curators] |
| GO:0030501 | positive regulation of bone mineralization | biological_process | Any process that activates or increases the frequency, rate or extent of bone mineralization. [GOC:go_curators] |
| GO:0032349 | positive regulation of aldosterone biosynthetic process | biological_process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. [GOC:mah] |
| GO:0032967 | positive regulation of collagen biosynthetic process | biological_process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. [GOC:mah] |
| GO:0033080 | immature T cell proliferation in thymus | biological_process | The expansion of an immature T cell population by cell division in the thymus. [GOC:add, ISBN:0781735149] |
| GO:0035567 | non-canonical Wnt signaling pathway | biological_process | A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via effectors other than beta-catenin. [PMID:37804416] |
| GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. [GOC:go_curators] |
| GO:0042445 | hormone metabolic process | biological_process | The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. [GOC:jl] |
| GO:0043410 | positive regulation of MAPK cascade | biological_process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators] |
| GO:0045596 | negative regulation of cell differentiation | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. [GOC:go_curators] |
| GO:0045669 | positive regulation of osteoblast differentiation | biological_process | Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. [GOC:go_curators] |
| GO:0045836 | positive regulation of meiotic nuclear division | biological_process | Any process that activates or increases the frequency, rate or extent of meiosis. [GOC:go_curators] |
| GO:0045892 | negative regulation of DNA-templated transcription | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH] |
| GO:0045893 | positive regulation of DNA-templated transcription | biological_process | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH] |
| GO:0048599 | oocyte development | biological_process | The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. [GOC:go_curators] |
| GO:0051145 | smooth muscle cell differentiation | biological_process | The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. [CL:0000192, GOC:ai] |
| GO:0051496 | positive regulation of stress fiber assembly | biological_process | Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. [GOC:ai] |
| GO:0051894 | positive regulation of focal adhesion assembly | biological_process | Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. [GOC:ai] |
| GO:0060008 | Sertoli cell differentiation | biological_process | The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. [GOC:dph] |
| GO:0060070 | canonical Wnt signaling pathway | biological_process | A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [PMID:11532397, PMID:19619488] |
| GO:0060126 | somatotropin secreting cell differentiation | biological_process | The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin. [GOC:dph] |
| GO:0060129 | thyroid-stimulating hormone-secreting cell differentiation | biological_process | The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a thyroid-stimulating hormone-secreting cell. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid-stimulating hormone, thyrotrophin. [GOC:dph] |
| GO:0060231 | mesenchymal to epithelial transition | biological_process | A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. [GOC:ascb_2009, GOC:dph, GOC:tb] |
| GO:0060748 | tertiary branching involved in mammary gland duct morphogenesis | biological_process | The branching process in which the mammary gland ducts form tertiary branches off of the secondary branches as part of diestrus and pregnancy. [GOC:dph, PMID:18614704] |
| GO:0061045 | negative regulation of wound healing | biological_process | Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. [GOC:dph] |
| GO:0061180 | mammary gland epithelium development | biological_process | The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. [GOC:dph, GOC:yaf] |
| GO:0061184 | positive regulation of dermatome development | biological_process | Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. [GOC:BHF, GOC:dph] |
| GO:0061205 | paramesonephric duct development | biological_process | The process whose specific outcome is the progression of the paramesonephric duct over time, from its formation to the mature structure. Mullerian ducts (or paramesonephric ducts) are paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, cervix, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin. [GOC:dph, GOC:yaf] |
| GO:0061369 | negative regulation of testicular blood vessel morphogenesis | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis in the testicle. [GOC:BHF, GOC:dph] |
| GO:0071560 | cellular response to transforming growth factor beta stimulus | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. [GOC:ecd, PMID:15451575] |
| GO:0072033 | renal vesicle formation | biological_process | The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. [GOC:mtg_kidney_jan10] |
| GO:0072034 | renal vesicle induction | biological_process | Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the renal vesicle. [GOC:mtg_kidney_jan10] |
| GO:0072162 | metanephric mesenchymal cell differentiation | biological_process | The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state. [GOC:mtg_kidney_jan10] |
| GO:0072174 | metanephric tubule formation | biological_process | The developmental process pertaining to the initial formation of a metanephric tubule. [GOC:mtg_kidney_jan10] |
| GO:0072273 | metanephric nephron morphogenesis | biological_process | The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros. [GOC:mtg_kidney_jan10] |
| GO:0097190 | apoptotic signaling pathway | biological_process | The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis] |
| GO:0140013 | meiotic nuclear division | biological_process | One of the two nuclear divisions that occur as part of the meiotic cell cycle. [PMID:9334324] |
| GO:1904238 | pericyte cell differentiation | biological_process | The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell. [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:23868830] |
| GO:2000019 | negative regulation of male gonad development | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of male gonad development. [GOC:obol, GOC:yaf] |
| GO:2000066 | positive regulation of cortisol biosynthetic process | biological_process | Any process that activates or increases the frequency, rate or extent of cortisol biosynthetic process. [GOC:obol, GOC:yaf] |
| GO:2000180 | negative regulation of androgen biosynthetic process | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of androgen biosynthetic process. [GOC:dph, GOC:yaf] |
| GO:2000225 | negative regulation of testosterone biosynthetic process | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of testosterone biosynthetic process. [GOC:obol, GOC:yaf] |
| GO:2001234 | negative regulation of apoptotic signaling pathway | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. [GOC:mtg_apoptosis] |
| GO:0005576 | extracellular region | cellular_component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| GO:0005615 | extracellular space | cellular_component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| GO:0005737 | cytoplasm | cellular_component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| GO:0005788 | endoplasmic reticulum lumen | cellular_component | The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684] |
| GO:0005796 | Golgi lumen | cellular_component | The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. [GOC:mah] |
| GO:0005886 | plasma membrane | cellular_component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| GO:0009986 | cell surface | cellular_component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| GO:0030666 | endocytic vesicle membrane | cellular_component | The lipid bilayer surrounding an endocytic vesicle. [GOC:mah] |
| GO:0031012 | extracellular matrix | cellular_component | A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324] |
| GO:0070062 | extracellular exosome | cellular_component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| GO:0005125 | cytokine activity | molecular_function | The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. [ISBN:0198599471, PMID:11530802] |
| GO:0030182 | neuron differentiation | biological_process | The process in which a relatively unspecialized cell acquires specialized features of a neuron. [GOC:mah] |
| GO:0045165 | cell fate commitment | biological_process | The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate. [ISBN:0716731185] |
| GO:0005109 | frizzled binding | molecular_function | Binding to a frizzled (fz) receptor. [GOC:ceb] |