| GO term | GO name | GO namespace | GO def |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0008009 | chemokine activity | molecular_function | The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine] |
| GO:0042379 | chemokine receptor binding | molecular_function | Binding to a chemokine receptor. [GOC:ai] |
| GO:0042803 | protein homodimerization activity | molecular_function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| GO:0001916 | positive regulation of T cell mediated cytotoxicity | biological_process | Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. [GOC:add, ISBN:0781735149] |
| GO:0002690 | positive regulation of leukocyte chemotaxis | biological_process | Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. [GOC:add] |
| GO:0002725 | negative regulation of T cell cytokine production | biological_process | Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production. [GOC:add] |
| GO:0002726 | positive regulation of T cell cytokine production | biological_process | Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. [GOC:add] |
| GO:0002826 | negative regulation of T-helper 1 type immune response | biological_process | Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response. [GOC:add] |
| GO:0007165 | signal transduction | biological_process | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11] |
| GO:0007267 | cell-cell signaling | biological_process | Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. [GOC:dos, GOC:mah] |
| GO:0009615 | response to virus | biological_process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. [GOC:hb] |
| GO:0010820 | positive regulation of T cell chemotaxis | biological_process | Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. [GOC:BHF, GOC:dph, GOC:tb] |
| GO:0030593 | neutrophil chemotaxis | biological_process | The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:jl, ISBN:0198506732] |
| GO:0032689 | negative regulation of type II interferon production | biological_process | Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383] |
| GO:0032703 | negative regulation of interleukin-2 production | biological_process | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. [GOC:mah] |
| GO:0032733 | positive regulation of interleukin-10 production | biological_process | Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. [GOC:mah] |
| GO:0035782 | mature natural killer cell chemotaxis | biological_process | The directed movement of a mature natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). A mature natural killer cell is a natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class and other stress related molecules. [CL:0000824, GOC:BHF] |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:jl] |
| GO:0045892 | negative regulation of DNA-templated transcription | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH] |
| GO:0050727 | regulation of inflammatory response | biological_process | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. [GOC:ai] |
| GO:0051209 | release of sequestered calcium ion into cytosol | biological_process | The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment. [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929] |
| GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | biological_process | Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. [GOC:ai] |
| GO:0071353 | cellular response to interleukin-4 | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. [GOC:mah] |
| GO:0071560 | cellular response to transforming growth factor beta stimulus | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. [GOC:ecd, PMID:15451575] |
| GO:0071636 | positive regulation of transforming growth factor beta production | biological_process | Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta. [GOC:mah] |
| GO:0071663 | positive regulation of granzyme B production | biological_process | Any process that activates or increases the frequency, rate, or extent of production of granzyme B. [GOC:mah] |
| GO:0090023 | positive regulation of neutrophil chemotaxis | biological_process | Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. [GOC:dph, GOC:tb] |
| GO:2000412 | positive regulation of thymocyte migration | biological_process | Any process that activates or increases the frequency, rate or extent of thymocyte migration. [GOC:mah] |
| GO:2000503 | positive regulation of natural killer cell chemotaxis | biological_process | Any process that activates or increases the frequency, rate or extent of natural killer cell chemotaxis. [GOC:BHF] |
| GO:2000513 | positive regulation of granzyme A production | biological_process | Any process that activates or increases the frequency, rate or extent of granzyme A production. [GOC:obol] |
| GO:2000518 | negative regulation of T-helper 1 cell activation | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell activation. [GOC:obol] |
| GO:2000538 | positive regulation of B cell chemotaxis | biological_process | Any process that activates or increases the frequency, rate or extent of B cell chemotaxis. [GOC:obol] |
| GO:2000553 | positive regulation of T-helper 2 cell cytokine production | biological_process | Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production. [GOC:obol] |
| GO:2000556 | positive regulation of T-helper 1 cell cytokine production | biological_process | Any process that activates or increases the frequency, rate or extent of T-helper 1 cell cytokine production. [GOC:obol] |
| GO:2000558 | positive regulation of immunoglobulin production in mucosal tissue | biological_process | Any process that activates or increases the frequency, rate or extent of immunoglobulin production in mucosal tissue. [GOC:obol] |
| GO:2000562 | negative regulation of CD4-positive, alpha-beta T cell proliferation | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation. [GOC:obol] |
| GO:2000563 | positive regulation of CD4-positive, alpha-beta T cell proliferation | biological_process | Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation. [GOC:obol] |
| GO:2000566 | positive regulation of CD8-positive, alpha-beta T cell proliferation | biological_process | Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation. [GOC:obol] |
| GO:0005576 | extracellular region | cellular_component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| GO:0005615 | extracellular space | cellular_component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| GO:0048245 | eosinophil chemotaxis | biological_process | The movement of an eosinophil in response to an external stimulus. [GOC:jid, PMID:11292027, PMID:12391252] |
| GO:0071346 | cellular response to type II interferon | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. [GOC:mah] |
| GO:0048247 | lymphocyte chemotaxis | biological_process | The directed movement of a lymphocyte in response to an external stimulus. [GOC:hjd, GOC:jid, PMID:12391252] |
| GO:0006954 | inflammatory response | biological_process | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] |
| GO:0070098 | chemokine-mediated signaling pathway | biological_process | The series of molecular signals initiated by a chemokine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling] |
| GO:0002548 | monocyte chemotaxis | biological_process | The movement of a monocyte in response to an external stimulus. [GOC:add, PMID:11696603, PMID:15173832] |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | biological_process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. [GOC:mah] |
| GO:0071347 | cellular response to interleukin-1 | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. [GOC:mah] |
| GO:0071356 | cellular response to tumor necrosis factor | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. [GOC:mah] |
| GO:0007186 | G protein-coupled receptor signaling pathway | biological_process | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] |
| GO:0048020 | CCR chemokine receptor binding | molecular_function | Binding to a CCR chemokine receptor. [GOC:ai] |
| GO:0043547 | positive regulation of GTPase activity | biological_process | Any process that activates or increases the activity of a GTPase. [GOC:jl, GOC:mah] |