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YTHDF2-201 ,YTHDF2 ,Q9Y5A9
  • Uniprot Accession= Q9Y5A9
  • Ensembl Transcript= ENST00000373812.8
  • Uniprot Name= YTHDF2
  • Name= YTH domain-containing family protein 2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 36
GO term
GO name
GO namespace
GO def
GO:0045948 positive regulation of translational initiation biological_process Any process that activates or increases the frequency, rate or extent of translational initiation. [GOC:go_curators]
GO:0003723 RNA binding molecular_function Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0062153 C5-methylcytidine-containing RNA reader activity molecular_function A protein adaptor that recognizes and binds an RNA molecule modified by C5-methylcytidine. [PMID:28418038]
GO:1990247 N6-methyladenosine-containing RNA reader activity molecular_function A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs. [PMID:22575960, PMID:24284625]
GO:0001556 oocyte maturation biological_process A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/]
GO:0006402 mRNA catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. [ISBN:0198506732]
GO:0006959 humoral immune response biological_process An immune response mediated through a body fluid. [GOC:hb, ISBN:0198506732]
GO:0007049 cell cycle biological_process The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. [GOC:go_curators, GOC:mtg_cell_cycle]
GO:0007276 gamete generation biological_process The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. [GOC:ems, GOC:mtg_sensu]
GO:0007284 spermatogonial cell division biological_process The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes). [GOC:bf, GOC:pr, ISBN:0879694238]
GO:0030155 regulation of cell adhesion biological_process Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. [GOC:mah]
GO:0034063 stress granule assembly biological_process The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. [GOC:mah, PMID:17392519]
GO:0043488 regulation of mRNA stability biological_process Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. [GOC:jl]
GO:0045087 innate immune response biological_process Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
GO:0045746 negative regulation of Notch signaling pathway biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway. [GOC:go_curators]
GO:0048598 embryonic morphogenesis biological_process The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. [GOC:jid, GOC:mtg_sensu]
GO:0050767 regulation of neurogenesis biological_process Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. [GOC:ai]
GO:0060339 negative regulation of type I interferon-mediated signaling pathway biological_process Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. [GOC:dph]
GO:0061157 mRNA destabilization biological_process Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns. [GOC:dph, GOC:jh]
GO:0070925 organelle assembly biological_process The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. [GOC:mah]
GO:0071425 hematopoietic stem cell proliferation biological_process The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. [CL:0000037, GOC:add, GOC:BHF, GOC:mah, GOC:rl]
GO:0098508 endothelial to hematopoietic transition biological_process The generation of hematopoietic stem cells from hemogenic endothelial cells by a process that includes tight-junction dissolution and loss of cell polarity followed by delamination from the endothelium. [PMID:20154732, PMID:22521721]
GO:1902036 regulation of hematopoietic stem cell differentiation biological_process Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation. [GOC:TermGenie, PMID:23403623]
GO:1903538 regulation of meiotic cell cycle process involved in oocyte maturation biological_process Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25212395]
GO:1903679 positive regulation of cap-independent translational initiation biological_process Any process that activates or increases the frequency, rate or extent of cap-independent translational initiation. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11959995]
GO:2000232 regulation of rRNA processing biological_process Any process that modulates the frequency, rate or extent of rRNA processing. [GOC:mah]
GO:2000737 negative regulation of stem cell differentiation biological_process Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. [GOC:obol]
GO:0000932 P-body cellular_component A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. [GOC:clt, PMID:12730603]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0010494 cytoplasmic stress granule cellular_component A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]
GO:0034451 centriolar satellite cellular_component A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. [GOC:BHF, PMID:10579718, PMID:12403812]
GO:0036464 cytoplasmic ribonucleoprotein granule cellular_component A ribonucleoprotein granule located in the cytoplasm. [GOC:bf, GOC:PARL, PMID:15121898]
GO:0003729 mRNA binding molecular_function Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. [GOC:kmv, GOC:pr, SO:0000234]