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ARHGEF11-201 ,ARHGEF11 ,O15085
  • Number of Interaction partner in intact: 18
  • Number of Interaction partner in biogrid: 36
  • Number of Interaction partner in hippie: 82
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABCA1-202 ABCA1 O95477 Phospholipid-transporting ATPase ABCA1 chr9 Not Cancer Driver No 1 hippie 202 247 25 25 31
ABL1-201 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 Census, Compendium Yes 1 hippie 106 609 53 53 2
ARAP2-201 ARAP2 Q8WZ64 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 chr4 Not Cancer Driver No 1 hippie, biogrid 200 449 56 56 0
ARHGEF11-201 ARHGEF11 O15085 Rho guanine nucleotide exchange factor 11 chr1 Not Cancer Driver No 1 hippie 170 1038 113 113 0
ARHGEF12-202 ARHGEF12 Q9NZN5 Rho guanine nucleotide exchange factor 12 chr11 Census, Compendium Yes 1 hippie, biogrid 141 974 103 103 0
ARHGEF40-201 ARHGEF40 Q8TER5 Rho guanine nucleotide exchange factor 40 chr14 Not Cancer Driver No 1 hippie, biogrid 127 784 55 55 0
ARRB2-201 ARRB2 P32121 Beta-arrestin-2 chr17 Not Cancer Driver No 1 hippie 39 122 19 19 0
BCAR1-201 BCAR1 P56945 Breast cancer anti-estrogen resistance protein 1 chr16 Not Cancer Driver No 1 hippie 88 681 64 64 0
CDC42-208 CDC42 P60953 Cell division control protein 42 homolog chr1 Not Cancer Driver No 2 intact, hippie 21 23 1 1 1
CGN-201 CGN Q9P2M7 Cingulin chr1 Not Cancer Driver No 1 hippie, biogrid 113 1182 111 111 0
COMMD9-201 COMMD9 Q9P000 COMM domain-containing protein 9 chr11 Not Cancer Driver No 1 hippie, biogrid 14 0 0 0 0
COPS5-201 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 Not Cancer Driver No 1 hippie 27 32 4 4 0
CRK-201 CRK P46108 Adapter molecule crk chr17 Not Cancer Driver No 1 hippie 24 197 19 19 0
DAAM1-202 DAAM1 Q9Y4D1 Disheveled-associated activator of morphogenesis 1 chr14 Not Cancer Driver No 1 intact, hippie 47 392 11 11 0
DISC1-209 DISC1 Q9NRI5 Disrupted in schizophrenia 1 protein chr1 Not Cancer Driver No 1 intact, hippie 106 520 65 65 0
ELAVL1-201 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 54 43 5 5 0
ENST00000695856 CDC42 P60953 Cell division control protein 42 homolog chr1 Not Cancer Driver No 2 intact, hippie 21 23 1 1 1
ESR1-201 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 intact, hippie 92 198 19 19 2
ESR2-202 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 69 92 10 10 1
FAM124B-203 FAM124B Q9H5Z6 Protein FAM124B chr2 Not Cancer Driver No 1 hippie, biogrid 56 195 7 7 0
FYN-202 FYN P06241 Tyrosine-protein kinase Fyn chr6 Not Cancer Driver No 1 hippie 64 71 11 11 0
GNA12-201 GNA12 Q03113 Guanine nucleotide-binding protein subunit alpha-12 chr7 Not Cancer Driver No 1 hippie 30 20 0 0 0
GNA13-201 GNA13 Q14344 Guanine nucleotide-binding protein subunit alpha-13 chr17 Compendium Yes 1 hippie 45 32 4 4 0
GNAQ-201 GNAQ P50148 Guanine nucleotide-binding protein G(q) subunit alpha chr9 Census, Compendium Yes 1 hippie 82 14 1 1 1
GRB2-202 GRB2 P62993 Growth factor receptor-bound protein 2 chr17 Not Cancer Driver No 1 intact, hippie 21 10 0 0 0
GSK3A-201 GSK3A P49840 Glycogen synthase kinase-3 alpha chr19 Not Cancer Driver No 1 intact, hippie 33 180 5 5 0
GSK3B-201 GSK3B P49841 Glycogen synthase kinase-3 beta chr3 Not Cancer Driver No 1 intact, hippie 34 148 6 6 0
HNRNPCL2-202 HNRNPCL2 B2RXH8 Heterogeneous nuclear ribonucleoprotein C-like 2 chr1 Not Cancer Driver No 1 intact, hippie 0 199 0 0 0
HOOK3-201 HOOK3 Q86VS8 Protein Hook homolog 3 chr8 Census Yes 1 hippie 65 493 44 44 0
IFT57-201 IFT57 Q9NWB7 Intraflagellar transport protein 57 homolog chr3 Not Cancer Driver No 1 hippie 36 219 18 18 0
INA-201 INA Q16352 Alpha-internexin chr10 Not Cancer Driver No 1 hippie, biogrid 51 257 35 35 0
ISCA2-204 ISCA2 Q86U28 Iron-sulfur cluster assembly 2 homolog, mitochondrial chr14 Not Cancer Driver No 1 hippie, biogrid 7 38 0 0 1
KRT19-201 KRT19 P08727 Keratin, type I cytoskeletal 19 chr17 Not Cancer Driver No 1 hippie, biogrid 42 165 18 18 0
LARP1-204 LARP1 Q6PKG0 La-related protein 1 chr5 Not Cancer Driver No 1 hippie 100 815 75 75 0
LONP2-201 LONP2 Q86WA8 Lon protease homolog 2, peroxisomal chr16 Not Cancer Driver No 1 hippie, biogrid 85 163 21 21 0
LPAR1-205 LPAR1 Q92633 Lysophosphatidic acid receptor 1 chr9 Not Cancer Driver No 1 hippie 55 21 5 5 0
LPAR2-201 LPAR2 Q9HBW0 Lysophosphatidic acid receptor 2 chr19 Not Cancer Driver No 1 hippie 35 2 0 0 0
LRCH3-203 LRCH3 Q96II8 DISP complex protein LRCH3 chr3 Not Cancer Driver No 1 hippie, biogrid 71 418 38 38 0
MAP1A-201 MAP1A P78559 Microtubule-associated protein 1A chr15 Not Cancer Driver No 1 hippie 273 2451 234 234 0
MAP1B-201 MAP1B P46821 Microtubule-associated protein 1B chr5 Not Cancer Driver No 1 hippie 169 1949 166 166 0
MPRIP-202 MPRIP Q6WCQ1 Myosin phosphatase Rho-interacting protein chr17 Not Cancer Driver No 1 hippie, biogrid 87 736 72 72 0
MTX2-201 MTX2 O75431 Metaxin-2 chr2 Not Cancer Driver No 1 hippie, biogrid 23 0 0 0 0
MYO5A-204 MYO5A Q9Y4I1 Unconventional myosin-Va chr15 Census, Compendium Yes 1 hippie, biogrid 159 499 53 53 0
MZT2B-201 MZT2B Q6NZ67 Mitotic-spindle organizing protein 2B chr2 Not Cancer Driver No 1 hippie, biogrid 9 113 9 9 0
NCK1-207 NCK1 P16333 Cytoplasmic protein NCK1 chr3 Not Cancer Driver No 1 intact, hippie 41 111 15 15 0
NOA1-201 NOA1 Q8NC60 Nitric oxide-associated protein 1 chr4 Not Cancer Driver No 1 hippie, biogrid 55 228 20 20 0
NTRK1-206 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 133 57 8 8 23
NUP98-203 NUP98 P52948 Nuclear pore complex protein Nup98-Nup96 chr11 Census Yes 1 hippie 161 1012 78 78 0
NUPR1-201 NUPR1 O60356 Nuclear protein 1 chr16 Not Cancer Driver No 1 hippie 10 82 10 10 0
PAK4-203 PAK4 O96013 Serine/threonine-protein kinase PAK 4 chr19 Not Cancer Driver No 4 intact, hippie, biogrid 46 344 27 27 0
PAK5-201 PAK5 Q9P286 Serine/threonine-protein kinase PAK 5 chr20 Not Cancer Driver No 1 intact, hippie 186 410 105 105 0
PDF-201 PDF Q9HBH1 Peptide deformylase, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 2 8 0 0 0
PFN1-201 PFN1 P07737 Profilin-1 chr17 Not Cancer Driver No 1 hippie, biogrid 13 7 1 1 3
PIK3R1-211 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 Census, Compendium Yes 1 intact, hippie 122 271 50 50 2
PLCG1-202 PLCG1 P19174 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 chr20 Census, Compendium Yes 1 hippie 129 187 15 15 0
PLEKHG4B-201 PLEKHG4B Q96PX9 Pleckstrin homology domain-containing family G member 4B chr5 Not Cancer Driver No 1 intact, hippie, biogrid 174 712 80 80 0
PLXNB1-201 PLXNB1 O43157 Plexin-B1 chr3 Not Cancer Driver No 2 intact, hippie 173 687 52 52 0
PLXNB2-201 PLXNB2 O15031 Plexin-B2 chr22 Not Cancer Driver No 1 hippie 206 307 25 25 0
PLXNB3-201 PLXNB3 Q9ULL4 Plexin-B3 chrX Not Cancer Driver No 2 intact, hippie 168 358 30 30 0
POTEE-205 POTEE Q6S8J3 POTE ankyrin domain family member E chr2 Not Cancer Driver No 1 hippie, biogrid 228 465 75 75 0
PPIE-201 PPIE Q9UNP9 Peptidyl-prolyl cis-trans isomerase E chr1 Not Cancer Driver No 1 hippie, biogrid 35 102 11 11 0
PPP1R9B-202 PPP1R9B Q96SB3 Neurabin-2 chr17 Not Cancer Driver No 1 hippie, biogrid 37 698 27 27 0
PTPRF-201 PTPRF P10586 Receptor-type tyrosine-protein phosphatase F chr1 Not Cancer Driver No 1 hippie 201 696 70 70 0
RAC1-201 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 Census, Compendium Yes 1 hippie 61 2 0 0 6
RFXANK-201 RFXANK O14593 DNA-binding protein RFXANK chr19 Not Cancer Driver No 1 intact, hippie 13 122 4 4 1
RHOA-202 RHOA P61586 Transforming protein RhoA chr3 Census, Compendium Yes 3 hippie, biogrid 92 46 12 12 2
RHOB-201 RHOB P62745 Rho-related GTP-binding protein RhoB chr2 Not Cancer Driver No 2 hippie, biogrid 50 20 1 1 0
RHOC-202 RHOC P08134 Rho-related GTP-binding protein RhoC chr1 Not Cancer Driver No 2 hippie, biogrid 23 53 4 4 0
RPRD1A-202 RPRD1A Q96P16 Regulation of nuclear pre-mRNA domain-containing protein 1A chr18 Not Cancer Driver No 1 hippie, biogrid 34 86 14 14 0
RPS6KA1-204 RPS6KA1 Q15418 Ribosomal protein S6 kinase alpha-1 chr1 Not Cancer Driver No 1 hippie 71 178 22 22 0
S100A13-205 S100A13 Q99584 Protein S100-A13 chr1 Not Cancer Driver No 1 hippie, biogrid 8 6 0 0 0
S100A2-202 S100A2 P29034 Protein S100-A2 chr1 Not Cancer Driver No 1 hippie, biogrid 12 6 0 0 0
SLC1A6-204 SLC1A6 P48664 Excitatory amino acid transporter 4 chr19 Not Cancer Driver No 1 hippie 148 51 18 18 0
SSBP1-201 SSBP1 Q04837 Single-stranded DNA-binding protein, mitochondrial chr7 Not Cancer Driver No 1 hippie, biogrid 20 0 0 0 6
TFB1M-201 TFB1M Q8WVM0 Dimethyladenosine transferase 1, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 38 26 2 2 0
TIGD3-201 TIGD3 Q6B0B8 Tigger transposable element-derived protein 3 chr11 Not Cancer Driver No 1 hippie, biogrid 63 99 19 19 0
TMOD1-201 TMOD1 P28289 Tropomodulin-1 chr9 Not Cancer Driver No 1 hippie, biogrid 31 195 22 22 0
TMOD2-201 TMOD2 Q9NZR1 Tropomodulin-2 chr15 Not Cancer Driver No 1 hippie, biogrid 22 216 15 15 0
TRIM25-201 TRIM25 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 chr17 Not Cancer Driver No 1 hippie 45 226 11 11 0
TRMT61A-202 TRMT61A Q96FX7 tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A chr14 Not Cancer Driver No 3 intact, hippie, biogrid 13 74 6 6 0
VIRMA-201 VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 157 634 73 73 0
WDR59-201 WDR59 Q6PJI9 GATOR complex protein WDR59 chr16 Not Cancer Driver No 1 hippie, biogrid 98 204 28 28 0