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CTPS1-217 ,CTPS1 ,P17812
  • Number of Interaction partner in intact: 27
  • Number of Interaction partner in biogrid: 28
  • Number of Interaction partner in hippie: 142
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AAR2-201 AAR2 Q9Y312 Protein AAR2 homolog chr20 Not Cancer Driver No 1 hippie 45 28 5 5 0
ACO1-201 ACO1 P21399 Cytoplasmic aconitate hydratase chr9 Not Cancer Driver No 1 hippie 75 44 10 10 0
ANKRD55-201 ANKRD55 Q3KP44 Ankyrin repeat domain-containing protein 55 chr5 Not Cancer Driver No 1 hippie 72 340 48 48 0
ARRB2-201 ARRB2 P32121 Beta-arrestin-2 chr17 Not Cancer Driver No 1 hippie 39 122 19 19 0
AURKA-208 AURKA O14965 Aurora kinase A chr20 Not Cancer Driver No 1 hippie 25 180 17 17 0
BCAR3-201 BCAR3 O75815 Breast cancer anti-estrogen resistance protein 3 chr1 Not Cancer Driver No 1 hippie 74 397 34 34 0
BCL2L14-203 BCL2L14 Q9BZR8 Apoptosis facilitator Bcl-2-like protein 14 chr12 Not Cancer Driver No 1 hippie 20 40 4 4 0
BIRC3-201 BIRC3 Q13489 Baculoviral IAP repeat-containing protein 3 chr11 Census, Compendium Yes 1 hippie 53 98 10 10 0
BRCA1-203 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 Census, Compendium Yes 1 hippie 167 1466 127 127 34
BRD7-201 BRD7 Q9NPI1 Bromodomain-containing protein 7 chr16 Compendium Yes 1 hippie 58 485 33 33 0
CALCOCO2-201 CALCOCO2 Q13137 Calcium-binding and coiled-coil domain-containing protein 2 chr17 Not Cancer Driver No 1 hippie 31 213 13 13 0
CAND1-208 CAND1 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 chr12 Not Cancer Driver No 1 hippie 118 88 6 6 0
CDK2-201 CDK2 P24941 Cyclin-dependent kinase 2 chr12 Not Cancer Driver No 1 hippie 17 0 0 0 0
CFTR-201 CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 Not Cancer Driver No 2 intact, hippie 216 145 9 9 130
CIC-206 CIC Q96RK0 Protein capicua homolog chr19 Census, Compendium Yes 1 hippie 216 1552 207 207 0
CLNS1A-204 CLNS1A P54105 Methylosome subunit pICln chr11 Not Cancer Driver No 1 hippie 12 170 9 9 0
COPS5-201 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 Not Cancer Driver No 1 hippie 27 32 4 4 0
CS-201 CS O75390 Citrate synthase, mitochondrial chr12 Not Cancer Driver No 1 hippie 38 13 2 2 0
CSAG2-202 CSAG3 Q9Y5P2 Chondrosarcoma-associated gene 2/3 protein chrX Not Cancer Driver No 1 hippie 0 68 0 0 0
CSAG3-201 CSAG3 Q9Y5P2 Chondrosarcoma-associated gene 2/3 protein chrX Not Cancer Driver No 1 hippie 0 67 0 0 0
CSNK1E-203 CSNK1E P49674 Casein kinase I isoform epsilon chr22 Not Cancer Driver No 1 hippie 44 133 13 13 0
CTBP2-205 CTBP2 P56545 C-terminal-binding protein 2 chr10 Not Cancer Driver No 1 hippie, biogrid 36 94 4 4 0
CTPS1-217 CTPS1 P17812 CTP synthase 1 chr1 Not Cancer Driver No 2 intact, hippie 43 83 4 4 0
CTPS2-201 CTPS2 Q9NRF8 CTP synthase 2 chrX Not Cancer Driver No 2 hippie, biogrid 39 65 7 7 0
CUL1-201 CUL1 Q13616 Cullin-1 chr7 Not Cancer Driver No 1 intact, hippie 127 65 9 9 0
CUL2-203 CUL2 Q13617 Cullin-2 chr10 Not Cancer Driver No 1 intact, hippie 64 66 2 2 0
CUL3-201 CUL3 Q13618 Cullin-3 chr2 Census, Compendium Yes 1 intact, hippie 98 168 18 18 3
CUL4B-231 CUL4B Q13620 Cullin-4B chrX Not Cancer Driver No 1 intact, hippie 83 207 23 23 2
CUL5-201 CUL5 Q93034 Cullin-5 chr11 Not Cancer Driver No 1 intact, hippie 69 5 1 1 0
CYLD-203 CYLD Q9NQC7 Ubiquitin carboxyl-terminal hydrolase CYLD chr16 Census, Compendium Yes 1 hippie 76 213 21 21 3
DCTPP1-201 DCTPP1 Q9H773 dCTP pyrophosphatase 1 chr16 Not Cancer Driver No 1 hippie 12 88 7 7 0
DDRGK1-201 DDRGK1 Q96HY6 DDRGK domain-containing protein 1 chr20 Not Cancer Driver No 1 hippie 26 181 19 19 0
DDX3X-244 DDX3X O00571 ATP-dependent RNA helicase DDX3X chrX Census, Compendium Yes 1 hippie 91 302 32 32 18
DFFA-202 DFFA O00273 DNA fragmentation factor subunit alpha chr1 Not Cancer Driver No 1 hippie 37 115 14 14 0
EFTUD2-202 EFTUD2 Q15029 116 kDa U5 small nuclear ribonucleoprotein component chr17 Compendium Yes 1 hippie 100 179 22 22 3
EGLN3-201 EGLN3 Q9H6Z9 Prolyl hydroxylase EGLN3 chr14 Not Cancer Driver No 1 hippie 21 13 0 0 0
EIF4B-201 EIF4B P23588 Eukaryotic translation initiation factor 4B chr12 Not Cancer Driver No 1 hippie, biogrid 80 588 76 76 0
ENST00000635511 PCLAF Q15004 PCNA-associated factor chr15 Not Cancer Driver No 1 hippie 0 0 0 0 0
ERCC2-204 ERCC2 P18074 General transcription and DNA repair factor IIH helicase subunit XPD chr19 Census, Compendium Yes 1 hippie, biogrid 103 5 0 0 30
ESR2-202 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 69 92 10 10 1
FAM107A-201 FAM107A O95990 Actin-associated protein FAM107A chr3 Not Cancer Driver No 1 hippie 19 140 18 18 0
FBXO32-203 FBXO32 Q969P5 F-box only protein 32 chr8 Not Cancer Driver No 1 hippie 31 0 0 0 1
FBXO6-201 FBXO6 Q9NRD1 F-box only protein 6 chr1 Not Cancer Driver No 1 hippie 25 27 3 3 0
GABARAP-201 GABARAP O95166 Gamma-aminobutyric acid receptor-associated protein chr17 Not Cancer Driver No 1 hippie 7 12 0 0 0
GABARAPL1-201 GABARAPL1 Q9H0R8 Gamma-aminobutyric acid receptor-associated protein-like 1 chr12 Not Cancer Driver No 1 hippie 10 10 1 1 0
GABARAPL2-201 GABARAPL2 P60520 Gamma-aminobutyric acid receptor-associated protein-like 2 chr16 Not Cancer Driver No 1 hippie 4 2 1 1 0
GINS3-201 GINS3 Q9BRX5 DNA replication complex GINS protein PSF3 chr16 Not Cancer Driver No 1 hippie 25 14 1 1 0
GMPS-203 GMPS P49915 GMP synthase [glutamine-hydrolyzing] chr3 Census, Compendium Yes 1 hippie, biogrid 67 76 7 7 0
GRN-201 GRN P28799 Progranulin chr17 Not Cancer Driver No 1 hippie 64 29 4 4 1
GSK3B-201 GSK3B P49841 Glycogen synthase kinase-3 beta chr3 Not Cancer Driver No 1 hippie 34 148 6 6 0
H2AC14-201 H2AC14 Q99878 Histone H2A type 1-J chr6 Not Cancer Driver No 1 intact 18 56 2 2 0
HDAC2-205 HDAC2 Q92769 Histone deacetylase 2 chr6 Not Cancer Driver No 1 hippie 34 145 11 11 0
HLA-B-249 HLA-B P01889 HLA class I histocompatibility antigen, B alpha chain chr6 Compendium Yes 1 hippie 49 169 18 18 0
HLA-C-201 HLA-C P10321 HLA class I histocompatibility antigen, C alpha chain chr6 Not Cancer Driver No 1 hippie 36 175 14 14 0
HSD17B10-201 HSD17B10 Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 chrX Not Cancer Driver No 1 intact, hippie, biogrid 18 15 3 3 11
IKBKE-203 IKBKE Q14164 Inhibitor of nuclear factor kappa-B kinase subunit epsilon chr1 Not Cancer Driver No 1 intact, hippie 90 76 10 10 0
IMPDH1-208 IMPDH1 P20839 Inosine-5'-monophosphate dehydrogenase 1 chr7 Not Cancer Driver No 1 hippie, biogrid 60 12 1 1 7
IMPDH2-201 IMPDH2 P12268 Inosine-5'-monophosphate dehydrogenase 2 chr3 Not Cancer Driver No 1 hippie, biogrid 52 6 1 1 0
KDF1-201 KDF1 Q8NAX2 Keratinocyte differentiation factor 1 chr1 Not Cancer Driver No 1 hippie, biogrid 43 279 35 35 0
KIF23-201 KIF23 Q02241 Kinesin-like protein KIF23 chr15 Not Cancer Driver No 1 hippie 74 561 45 45 1
LCA5-201 LCA5 Q86VQ0 Lebercilin chr6 Not Cancer Driver No 1 intact, hippie 67 599 55 55 0
LRRK2-201 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 402 91 13 13 20
MAGEL2-201 MAGEL2 Q9UJ55 MAGE-like protein 2 chr15 Not Cancer Driver No 1 hippie 157 1010 104 104 0
MAP1LC3A-201 MAP1LC3A Q9H492 Microtubule-associated proteins 1A/1B light chain 3A chr20 Not Cancer Driver No 1 hippie 19 24 1 1 0
MAP1LC3B-201 MAP1LC3B Q9GZQ8 Microtubule-associated proteins 1A/1B light chain 3B chr16 Not Cancer Driver No 1 intact, hippie 4 17 0 0 0
MAP2K3-202 MAP2K3 P46734 Dual specificity mitogen-activated protein kinase kinase 3 chr17 Not Cancer Driver No 1 hippie 74 76 19 19 0
MCM2-201 MCM2 P49736 DNA replication licensing factor MCM2 chr3 Not Cancer Driver No 1 hippie 77 277 33 33 1
MECOM-217 MECOM Q03112 Histone-lysine N-methyltransferase MECOM chr3 Census, Compendium Yes 1 hippie 225 751 120 120 3
MTREX-201 MTREX P42285 Exosome RNA helicase MTR4 chr5 Not Cancer Driver No 1 hippie 85 160 11 11 0
MYC-206 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 72 325 41 41 0
NAA40-202 NAA40 Q86UY6 N-alpha-acetyltransferase 40 chr11 Not Cancer Driver No 1 hippie 16 31 1 1 0
NEDD8-201 NEDD8 Q15843 NEDD8 chr14 Not Cancer Driver No 1 hippie 9 36 4 4 0
NEK7-202 NEK7 Q8TDX7 Serine/threonine-protein kinase Nek7 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 18 23 0 0 0
NMD3-201 NMD3 Q96D46 60S ribosomal export protein NMD3 chr3 Not Cancer Driver No 1 hippie, biogrid 47 104 13 13 0
NR2C2-206 NR2C2 P49116 Nuclear receptor subfamily 2 group C member 2 chr3 Not Cancer Driver No 1 hippie 41 187 13 13 0
NTRK1-206 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 133 57 8 8 23
OFD1-201 OFD1 O75665 Centriole and centriolar satellite protein OFD1 chrX Not Cancer Driver No 1 hippie 77 476 25 25 5
OTUB1-208 OTUB1 Q96FW1 Ubiquitin thioesterase OTUB1 chr11 Not Cancer Driver No 1 intact, hippie 25 34 3 3 0
PAPSS1-201 PAPSS1 O43252 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 chr4 Not Cancer Driver No 1 hippie 66 83 9 9 0
PCLAF-201 PCLAF Q15004 PCNA-associated factor chr15 Not Cancer Driver No 1 hippie 15 112 16 16 0
PDCD10-201 PDCD10 Q9BUL8 Programmed cell death protein 10 chr3 Not Cancer Driver No 1 hippie, biogrid 25 25 3 3 0
PIH1D1-201 PIH1D1 Q9NWS0 PIH1 domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie 24 160 13 13 0
PINK1-201 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 Not Cancer Driver No 1 hippie 46 99 8 8 24
PINX1-201 PINX1 Q96BK5 PIN2/TERF1-interacting telomerase inhibitor 1 chr8 Not Cancer Driver No 1 hippie 37 329 38 38 0
PKM-202 PKM P14618 Pyruvate kinase PKM chr15 Not Cancer Driver No 1 hippie 53 58 11 11 0
PLCG1-202 PLCG1 P19174 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 chr20 Census, Compendium Yes 1 hippie, biogrid 129 187 15 15 0
PLD6-201 PLD6 Q8N2A8 Mitochondrial cardiolipin hydrolase chr17 Not Cancer Driver No 1 biogrid 20 24 3 3 0
PLEKHA4-201 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 115 690 110 110 0
POLR1C-210 POLR1C O15160 DNA-directed RNA polymerases I and III subunit RPAC1 chr6 Not Cancer Driver No 1 hippie, biogrid 22 28 1 1 12
PPEF1-204 PPEF1 O14829 Serine/threonine-protein phosphatase with EF-hands 1 chrX Not Cancer Driver No 1 intact, hippie 84 66 5 5 0
PPP5C-201 PPP5C P53041 Serine/threonine-protein phosphatase 5 chr19 Not Cancer Driver No 1 hippie 58 73 10 10 0
PRKAB1-201 PRKAB1 Q9Y478 5'-AMP-activated protein kinase subunit beta-1 chr12 Not Cancer Driver No 1 intact, hippie 21 125 11 11 0
PRMT1-202 PRMT1 Q99873 Protein arginine N-methyltransferase 1 chr19 Not Cancer Driver No 1 hippie, biogrid 37 18 0 0 0
PRMT5-202 PRMT5 O14744 Protein arginine N-methyltransferase 5 chr14 Not Cancer Driver No 1 hippie, biogrid 62 72 3 3 0
PRPF8-201 PRPF8 Q6P2Q9 Pre-mRNA-processing-splicing factor 8 chr17 Not Cancer Driver No 1 hippie 202 226 24 24 6
PSMA3-201 PSMA3 P25788 Proteasome subunit alpha type-3 chr14 Not Cancer Driver No 1 hippie 15 30 1 1 0
PTBP3-204 PTBP3 O95758 Polypyrimidine tract-binding protein 3 chr9 Not Cancer Driver No 1 intact, hippie 39 114 8 8 0
PUS7-202 PUS7 Q96PZ0 Pseudouridylate synthase 7 homolog chr7 Not Cancer Driver No 1 hippie, biogrid 49 163 15 15 1
RAD21-201 RAD21 O60216 Double-strand-break repair protein rad21 homolog chr8 Census, Compendium Yes 1 hippie 84 421 56 56 3
RAF1-201 RAF1 P04049 RAF proto-oncogene serine/threonine-protein kinase chr3 Census, Compendium Yes 1 intact 64 169 30 30 18
RBM28-201 RBM28 Q9NW13 RNA-binding protein 28 chr7 Not Cancer Driver No 1 hippie, biogrid 71 513 51 51 1
RBM39-201 RBM39 Q14498 RNA-binding protein 39 chr20 Compendium Yes 1 hippie 53 228 16 16 0
RECQL4-209 RECQL4 O94761 ATP-dependent DNA helicase Q4 chr8 Census, Compendium Yes 1 hippie 105 612 54 54 1
RIN3-201 RIN3 Q8TB24 Ras and Rab interactor 3 chr14 Not Cancer Driver No 1 intact, hippie 64 420 31 31 0
RNF123-201 RNF123 Q5XPI4 E3 ubiquitin-protein ligase RNF123 chr3 Not Cancer Driver No 1 hippie 126 220 23 23 0
RPGRIP1L-212 RPGRIP1L Q68CZ1 Protein fantom chr16 Not Cancer Driver No 1 intact, hippie 127 587 73 73 8
RTF2-202 RTF2 Q9BY42 Replication termination factor 2 chr20 Not Cancer Driver No 1 hippie 35 171 17 17 0
RUNX1-202 RUNX1 Q01196 Runt-related transcription factor 1 chr21 Census, Compendium Yes 1 hippie 62 361 46 46 2
SNAI1-201 SNAI1 O95863 Zinc finger protein SNAI1 chr20 Not Cancer Driver No 1 hippie 41 98 8 8 0
SNU13-202 SNU13 P55769 NHP2-like protein 1 chr22 Not Cancer Driver No 1 hippie 12 2 0 0 0
SNX2-201 SNX2 O60749 Sorting nexin-2 chr5 Not Cancer Driver No 1 hippie, biogrid 34 218 9 9 0
SNX3-201 SNX3 O60493 Sorting nexin-3 chr6 Not Cancer Driver No 1 hippie 16 37 3 3 0
SPRTN-202 SPRTN Q9H040 DNA-dependent metalloprotease SPRTN chr1 Not Cancer Driver No 1 hippie 53 254 26 26 1
SQSTM1-202 SQSTM1 Q13501 Sequestosome-1 chr5 Not Cancer Driver No 1 hippie 41 271 24 24 30
STAU1-207 STAU1 O95793 Double-stranded RNA-binding protein Staufen homolog 1 chr20 Not Cancer Driver No 1 hippie 54 458 45 45 0
STRAP-202 STRAP Q9Y3F4 Serine-threonine kinase receptor-associated protein chr12 Not Cancer Driver No 1 hippie, biogrid 33 40 4 4 0
SUMO1-203 SUMO1 P63165 Small ubiquitin-related modifier 1 chr2 Not Cancer Driver No 1 hippie 10 76 7 7 0
SUMO2-202 SUMO2 P61956 Small ubiquitin-related modifier 2 chr17 Not Cancer Driver No 1 hippie 8 70 6 6 0
SUMO3-201 SUMO3 P55854 Small ubiquitin-related modifier 3 chr21 Not Cancer Driver No 1 hippie 6 86 4 4 0
TIFAB-201 TIFAB Q6ZNK6 TRAF-interacting protein with FHA domain-containing protein B chr5 Not Cancer Driver No 1 intact, hippie 27 26 4 4 0
TIGD3-201 TIGD3 Q6B0B8 Tigger transposable element-derived protein 3 chr11 Not Cancer Driver No 2 intact, hippie, biogrid 63 99 19 19 0
TMPO-202 TMPO P42166 Lamina-associated polypeptide 2, isoform alpha chr12 Not Cancer Driver No 1 hippie 50 414 32 32 0
TPTEP2-CSNK1E-201 CSNK1E P49674 Casein kinase I isoform epsilon chr22 Not Cancer Driver No 1 hippie 44 133 13 13 0
TRAF6-202 TRAF6 Q9Y4K3 TNF receptor-associated factor 6 chr11 Not Cancer Driver No 1 intact, hippie, biogrid 51 62 5 5 0
TRIM25-201 TRIM25 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 chr17 Not Cancer Driver No 1 hippie 45 226 11 11 0
TRIM28-201 TRIM28 Q13263 Transcription intermediary factor 1-beta chr19 Not Cancer Driver No 1 hippie 67 431 32 32 0
TRMT1-202 TRMT1 Q9NXH9 tRNA (guanine(26)-N(2))-dimethyltransferase chr19 Not Cancer Driver No 1 hippie, biogrid 68 200 21 21 0
TSN-201 TSN Q15631 Translin chr2 Not Cancer Driver No 1 hippie, biogrid 21 0 0 0 0
TTC4-201 TTC4 O95801 Tetratricopeptide repeat protein 4 chr1 Not Cancer Driver No 1 hippie, biogrid 36 101 10 10 0
TUBGCP3-201 TUBGCP3 Q96CW5 Gamma-tubulin complex component 3 chr13 Not Cancer Driver No 1 hippie 70 157 12 12 0
TXNIP-204 TXNIP Q9H3M7 Thioredoxin-interacting protein chr1 Not Cancer Driver No 1 hippie 46 77 10 10 0
UBA1-201 UBA1 P22314 Ubiquitin-like modifier-activating enzyme 1 chrX Not Cancer Driver No 1 hippie 82 166 14 14 4
UBA6-201 UBA6 A0AVT1 Ubiquitin-like modifier-activating enzyme 6 chr4 Not Cancer Driver No 2 hippie, biogrid 106 90 7 7 0
UBR5-207 UBR5 O95071 E3 ubiquitin-protein ligase UBR5 chr8 Census, Compendium Yes 1 hippie 260 1299 135 135 0
UBXN1-202 UBXN1 Q04323 UBX domain-containing protein 1 chr11 Not Cancer Driver No 1 hippie 30 271 29 29 0
UFL1-201 UFL1 O94874 E3 UFM1-protein ligase 1 chr6 Not Cancer Driver No 1 hippie 77 141 19 19 0
USP11-201 USP11 P51784 Ubiquitin carboxyl-terminal hydrolase 11 chrX Not Cancer Driver No 1 hippie 104 211 21 21 0
VCL-201 VCL P18206 Vinculin chr10 Not Cancer Driver No 1 hippie 83 680 60 60 2
VIRMA-201 VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 157 634 73 73 0
WDR36-203 WDR36 Q8NI36 WD repeat-containing protein 36 chr5 Not Cancer Driver No 1 hippie, biogrid 82 89 5 5 2
WWOX-214 WWOX Q9NZC7 WW domain-containing oxidoreductase chr16 Not Cancer Driver No 1 hippie 50 109 7 7 3
YWHAB-201 YWHAB P31946 14-3-3 protein beta/alpha chr20 Not Cancer Driver No 1 intact, hippie 19 110 3 3 0
YWHAG-201 YWHAG P61981 14-3-3 protein gamma chr7 Not Cancer Driver No 2 intact, hippie 21 78 4 4 3
YWHAQ-201 YWHAQ P27348 14-3-3 protein theta chr2 Not Cancer Driver No 1 hippie 23 41 2 2 0
YWHAZ-207 YWHAZ P63104 14-3-3 protein zeta/delta chr8 Not Cancer Driver No 1 intact, hippie 19 81 7 7 0