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ECM1-202 ,ECM1 ,Q16610
  • Number of Interaction partner in intact: 18
  • Number of Interaction partner in biogrid: 61
  • Number of Interaction partner in hippie: 114
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
A1CF-201 A1CF Q9NQ94 APOBEC1 complementation factor chr10 Census Yes 1 hippie 108 63 12 12 0
ACTN3-203 ACTN3 Q08043 Alpha-actinin-3 chr11 Not Cancer Driver No 1 hippie 0 137 0 0 0
AHDC1-217 AHDC1 Q5TGY3 Transcription factor Gibbin chr1 Not Cancer Driver No 1 hippie, biogrid 117 1472 113 113 3
ALDH3A1-201 ALDH3A1 P30838 Aldehyde dehydrogenase, dimeric NADP-preferring chr17 Not Cancer Driver No 1 hippie, biogrid 55 36 5 5 0
AMTN-201 AMTN Q6UX39 Amelotin chr4 Not Cancer Driver No 1 hippie, biogrid 29 128 21 21 0
APP-201 APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 94 419 52 52 12
ATN1-202 ATN1 P54259 Atrophin-1 chr12 Not Cancer Driver No 1 hippie 111 1176 109 109 5
ATP23-201 ATP23 Q9Y6H3 Mitochondrial inner membrane protease ATP23 homolog chr12 Not Cancer Driver No 1 hippie 16 25 4 4 0
ATP6AP2-217 ATP6AP2 O75787 Renin receptor chrX Not Cancer Driver No 1 hippie, biogrid 36 0 0 0 2
BCAS2-201 BCAS2 O75934 Pre-mRNA-splicing factor SPF27 chr1 Not Cancer Driver No 1 hippie 23 55 4 4 0
BNIP3L-201 BNIP3L O60238 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like chr8 Not Cancer Driver No 1 hippie 12 177 10 10 0
BUB1B-201 BUB1B O60566 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta chr15 Census Yes 1 hippie, biogrid 69 484 26 26 7
CA8-201 CA8 P35219 Carbonic anhydrase-related protein chr8 Not Cancer Driver No 2 hippie, biogrid 44 35 2 2 1
CCDC51-201 CCDC51 Q96ER9 Mitochondrial potassium channel chr3 Not Cancer Driver No 2 intact, hippie, biogrid 37 138 15 15 0
CCNC-210 CCNC P24863 Cyclin-C chr6 Census Yes 1 hippie, biogrid 23 33 1 1 0
CD274-202 CD274 Q9NZQ7 Programmed cell death 1 ligand 1 chr9 Census Yes 1 hippie 26 54 9 9 0
CDK10-202 CDK10 Q15131 Cyclin-dependent kinase 10 chr16 Not Cancer Driver No 1 hippie, biogrid 36 30 6 6 0
CDKL3-201 CDKL3 Q8IVW4 Cyclin-dependent kinase-like 3 chr5 Not Cancer Driver No 1 hippie, biogrid 43 278 25 25 0
CFAP298-201 CFAP298 P57076 Cilia- and flagella-associated protein 298 chr21 Not Cancer Driver No 2 intact, hippie 18 111 5 5 0
CFI-201 CFI P05156 Complement factor I chr4 Not Cancer Driver No 2 intact, hippie, biogrid 67 5 0 0 13
COL6A1-201 COL6A1 P12109 Collagen alpha-1(VI) chain chr21 Not Cancer Driver No 1 hippie, biogrid 68 436 23 23 12
COX20-203 COX20 Q5RI15 Cytochrome c oxidase assembly protein COX20, mitochondrial chr1 Not Cancer Driver No 1 intact, hippie, biogrid 10 30 4 4 1
CPTP-201 CPTP Q5TA50 Ceramide-1-phosphate transfer protein chr1 Not Cancer Driver No 1 hippie 12 4 0 0 0
CSNK1D-202 CSNK1D P48730 Casein kinase I isoform delta chr17 Not Cancer Driver No 1 hippie, biogrid 38 133 13 13 2
CTU1-201 CTU1 Q7Z7A3 Cytoplasmic tRNA 2-thiolation protein 1 chr19 Not Cancer Driver No 1 hippie, biogrid 5 60 1 1 0
CTU2-202 CTU2 Q2VPK5 Cytoplasmic tRNA 2-thiolation protein 2 chr16 Not Cancer Driver No 1 hippie, biogrid 36 137 6 6 0
CUL1-201 CUL1 Q13616 Cullin-1 chr7 Not Cancer Driver No 1 intact, hippie, biogrid 127 65 9 9 0
CYLD-203 CYLD Q9NQC7 Ubiquitin carboxyl-terminal hydrolase CYLD chr16 Census, Compendium Yes 1 hippie 76 213 21 21 3
CYSRT1-201 CYSRT1 A8MQ03 Cysteine-rich tail protein 1 chr9 Not Cancer Driver No 1 hippie 4 99 3 3 0
DDIAS-211 DDIAS Q8IXT1 DNA damage-induced apoptosis suppressor protein chr11 Not Cancer Driver No 1 hippie 92 370 45 45 0
DDX39B-202 DDX39B Q13838 Spliceosome RNA helicase DDX39B chr6 Not Cancer Driver No 1 hippie 36 34 6 6 0
DPPA4-201 DPPA4 Q7L190 Developmental pluripotency-associated protein 4 chr3 Not Cancer Driver No 1 intact, hippie, biogrid 76 183 39 39 0
DTX2-206 DTX2 Q86UW9 Probable E3 ubiquitin-protein ligase DTX2 chr7 Not Cancer Driver No 1 hippie 59 295 26 26 0
DYRK3-203 DYRK3 O43781 Dual specificity tyrosine-phosphorylation-regulated kinase 3 chr1 Not Cancer Driver No 1 hippie, biogrid 54 193 11 11 0
E2F6-202 E2F6 O75461 Transcription factor E2F6 chr2 Not Cancer Driver No 1 hippie, biogrid 7 105 2 2 0
EEF1A2-201 EEF1A2 Q05639 Elongation factor 1-alpha 2 chr20 Not Cancer Driver No 1 hippie 58 121 17 17 3
ENKD1-201 ENKD1 Q9H0I2 Enkurin domain-containing protein 1 chr16 Not Cancer Driver No 1 hippie 28 308 25 25 0
ENST00000658393 RNASEH1 O60930 Ribonuclease H1 chr2 Not Cancer Driver No 1 hippie, biogrid 25 124 15 15 2
ERCC3-201 ERCC3 P19447 General transcription and DNA repair factor IIH helicase subunit XPB chr2 Census, Compendium Yes 1 hippie, biogrid 67 208 14 14 2
ESR2-202 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 69 92 10 10 1
FASLG-202 FASLG P48023 Tumor necrosis factor ligand superfamily member 6 chr1 Not Cancer Driver No 1 hippie 51 94 15 15 1
FASTK-201 FASTK Q14296 Fas-activated serine/threonine kinase chr7 Not Cancer Driver No 1 hippie, biogrid 56 143 13 13 0
FBLN1-202 FBLN1 P23142 Fibulin-1 chr22 Compendium Yes 1 hippie 98 22 1 1 0
FKBP6-201 FKBP6 O75344 Inactive peptidyl-prolyl cis-trans isomerase FKBP6 chr7 Not Cancer Driver No 1 hippie 60 17 1 1 0
FN1-203 FN1 P02751 Fibronectin chr2 Compendium Yes 1 hippie, biogrid 289 1249 137 137 8
FRMD1-201 FRMD1 Q8N878 FERM domain-containing protein 1 chr6 Not Cancer Driver No 1 intact, hippie, biogrid 74 266 37 37 0
FRS3-202 FRS3 O43559 Fibroblast growth factor receptor substrate 3 chr6 Not Cancer Driver No 1 hippie 64 390 48 48 0
FTH1-201 FTH1 P02794 Ferritin heavy chain chr11 Not Cancer Driver No 1 hippie, biogrid 18 57 7 7 0
FXR1-202 FXR1 P51114 RNA-binding protein FXR1 chr3 Not Cancer Driver No 1 hippie 63 312 40 40 0
GBP2-201 GBP2 P32456 Guanylate-binding protein 2 chr1 Not Cancer Driver No 1 intact 55 135 12 12 0
GCM2-201 GCM2 O75603 Chorion-specific transcription factor GCMb chr6 Not Cancer Driver No 1 hippie 74 274 41 41 7
GCN1-201 GCN1 Q92616 Stalled ribosome sensor GCN1 chr12 Not Cancer Driver No 1 intact 255 117 13 13 0
GLYR1-201 GLYR1 Q49A26 Cytokine-like nuclear factor N-PAC chr16 Not Cancer Driver No 1 hippie, biogrid 55 201 17 17 0
GMCL1-201 GMCL1 Q96IK5 Germ cell-less protein-like 1 chr2 Not Cancer Driver No 3 intact, hippie, biogrid 23 80 2 2 0
GNE-205 GNE Q9Y223 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase chr9 Not Cancer Driver No 1 hippie 61 15 1 1 34
GPANK1-203 GPANK1 O95872 G patch domain and ankyrin repeat-containing protein 1 chr6 Not Cancer Driver No 1 hippie 30 297 25 25 0
GRN-201 GRN P28799 Progranulin chr17 Not Cancer Driver No 1 hippie 64 29 4 4 1
HECW2-212 HECW2 Q9P2P5 E3 ubiquitin-protein ligase HECW2 chr2 Not Cancer Driver No 1 hippie 272 848 157 157 4
HIBADH-201 HIBADH P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial chr7 Not Cancer Driver No 1 hippie, biogrid 20 7 0 0 0
HOXC8-201 HOXC8 P31273 Homeobox protein Hox-C8 chr12 Not Cancer Driver No 1 hippie 26 139 12 12 0
HSPG2-203 HSPG2 P98160 Basement membrane-specific heparan sulfate proteoglycan core protein chr1 Compendium Yes 1 hippie 414 1724 160 160 1
IL2RB-201 IL2RB P14784 Interleukin-2 receptor subunit beta chr22 Not Cancer Driver No 1 hippie 66 184 26 26 1
IRAK3-201 IRAK3 Q9Y616 Interleukin-1 receptor-associated kinase 3 chr12 Not Cancer Driver No 1 hippie 76 79 10 10 0
ITGB4-201 ITGB4 P16144 Integrin beta-4 chr17 Not Cancer Driver No 1 hippie 203 756 72 72 14
KLHL38-202 KLHL38 Q2WGJ6 Kelch-like protein 38 chr8 Not Cancer Driver No 1 hippie 91 3 2 2 0
KRTAP5-3-201 KRTAP5-3 Q6L8H2 Keratin-associated protein 5-3 chr11 Not Cancer Driver No 1 hippie 1 0 0 0 0
KRTAP9-3-201 KRTAP9-3 Q9BYQ3 Keratin-associated protein 9-3 chr17 Not Cancer Driver No 1 hippie 10 0 0 0 0
LCE2A-201 LCE2A Q5TA79 Late cornified envelope protein 2A chr1 Not Cancer Driver No 1 hippie 0 0 0 0 0
LIN7A-204 LIN7A O14910 Protein lin-7 homolog A chr12 Not Cancer Driver No 1 hippie 62 127 22 22 0
LMO4-202 LMO4 P61968 LIM domain transcription factor LMO4 chr1 Not Cancer Driver No 1 hippie 29 11 1 1 0
MAP3K7-204 MAP3K7 O43318 Mitogen-activated protein kinase kinase kinase 7 chr6 Not Cancer Driver No 1 hippie, biogrid 74 333 42 42 6
MAPK1-201 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 Census, Compendium Yes 1 hippie, biogrid 52 2 0 0 6
MAPK3-201 MAPK3 P27361 Mitogen-activated protein kinase 3 chr16 Not Cancer Driver No 1 hippie, biogrid 32 49 3 3 0
MCL1-202 MCL1 Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 chr1 Not Cancer Driver No 2 hippie, biogrid 27 204 19 19 0
MKRN3-201 MKRN3 Q13064 Probable E3 ubiquitin-protein ligase makorin-3 chr15 Not Cancer Driver No 1 hippie 168 201 88 88 4
MMRN1-201 MMRN1 Q13201 Multimerin-1 chr4 Not Cancer Driver No 2 intact, hippie, biogrid 174 375 59 59 0
MRPL39-202 MRPL39 Q9NYK5 Large ribosomal subunit protein mL39 chr21 Not Cancer Driver No 1 hippie, biogrid 25 38 2 2 0
MYC-206 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 72 325 41 41 0
NFX1-203 NFX1 Q12986 Transcriptional repressor NF-X1 chr9 Not Cancer Driver No 1 hippie 89 492 28 28 0
NHLRC2-201 NHLRC2 Q8NBF2 NHL repeat-containing protein 2 chr10 Not Cancer Driver No 1 hippie 53 103 8 8 0
NPPA-202 NPPA P01160 Natriuretic peptides A chr1 Not Cancer Driver No 2 intact, hippie, biogrid 21 72 13 13 1
NSG2-201 NSG2 Q9Y328 Neuronal vesicle trafficking-associated protein 2 chr5 Not Cancer Driver No 1 hippie 26 43 6 6 0
PAK2-201 PAK2 Q13177 Serine/threonine-protein kinase PAK 2 chr3 Compendium Yes 1 hippie, biogrid 61 242 31 31 1
PI4K2A-201 PI4K2A Q9BTU6 Phosphatidylinositol 4-kinase type 2-alpha chr10 Not Cancer Driver No 1 hippie, biogrid 32 130 4 4 0
PI4KA-201 PI4KA P42356 Phosphatidylinositol 4-kinase alpha chr22 Not Cancer Driver No 1 hippie, biogrid 198 142 10 10 7
PLCZ1-201 PLCZ1 Q86YW0 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 chr12 Not Cancer Driver No 1 intact, hippie, biogrid 121 37 19 19 1
PRKAG1-206 PRKAG1 P54619 5'-AMP-activated protein kinase subunit gamma-1 chr12 Not Cancer Driver No 1 hippie, biogrid 27 25 2 2 0
PRKAR2B-201 PRKAR2B P31323 cAMP-dependent protein kinase type II-beta regulatory subunit chr7 Not Cancer Driver No 1 hippie 43 127 5 5 0
RBFOX1-211 RBFOX1 Q9NWB1 RNA binding protein fox-1 homolog 1 chr16 Compendium Yes 1 intact, hippie, biogrid 139 182 72 72 0
RERE-204 RERE Q9P2R6 Arginine-glutamic acid dipeptide repeats protein chr1 Not Cancer Driver No 1 hippie 154 1307 131 131 0
RNASEH1-201 RNASEH1 O60930 Ribonuclease H1 chr2 Not Cancer Driver No 1 hippie, biogrid 25 125 15 15 2
RNGTT-202 RNGTT O60942 mRNA-capping enzyme chr6 Not Cancer Driver No 1 hippie 47 112 7 7 0
RNPC3-201 RNPC3 Q96LT9 RNA-binding region-containing protein 3 chr1 Not Cancer Driver No 1 hippie, biogrid 19 315 12 12 1
SAMD11-202 SAMD11 Q96NU1 Sterile alpha motif domain-containing protein 11 chr1 Not Cancer Driver No 1 hippie 54 579 36 36 0
SARAF-201 SARAF Q96BY9 Store-operated calcium entry-associated regulatory factor chr8 Not Cancer Driver No 1 hippie, biogrid 23 75 8 8 0
SGTB-201 SGTB Q96EQ0 Small glutamine-rich tetratricopeptide repeat-containing protein beta chr5 Not Cancer Driver No 1 hippie 19 114 8 8 0
SH2D3A-201 SH2D3A Q9BRG2 SH2 domain-containing protein 3A chr19 Not Cancer Driver No 1 hippie, biogrid 52 308 30 30 0
SLC35F2-204 SLC35F2 Q8IXU6 Solute carrier family 35 member F2 chr11 Not Cancer Driver No 1 hippie, biogrid 37 12 0 0 0
SLC9A5-201 SLC9A5 Q14940 Sodium/hydrogen exchanger 5 chr16 Not Cancer Driver No 1 hippie, biogrid 89 307 24 24 0
SNRPC-201 SNRPC P09234 U1 small nuclear ribonucleoprotein C chr6 Not Cancer Driver No 1 hippie 9 143 8 8 0
SNTG1-213 SNTG1 Q9NSN8 Gamma-1-syntrophin chr8 Not Cancer Driver No 1 hippie, biogrid 172 3 1 1 0
SRPK1-204 SRPK1 Q96SB4 SRSF protein kinase 1 chr6 Not Cancer Driver No 1 hippie 52 329 21 21 0
SRRT-213 SRRT Q9BXP5 Serrate RNA effector molecule homolog chr7 Not Cancer Driver No 1 hippie, biogrid 96 596 68 68 0
STX17-201 STX17 P56962 Syntaxin-17 chr9 Not Cancer Driver No 1 hippie, biogrid 24 81 6 6 0
TBC1D22B-201 TBC1D22B Q9NU19 TBC1 domain family member 22B chr6 Not Cancer Driver No 2 intact, hippie, biogrid 43 206 23 23 0
TEFM-205 TEFM Q96QE5 Transcription elongation factor, mitochondrial chr17 Not Cancer Driver No 1 hippie, biogrid 19 26 3 3 0
TGM2-201 TGM2 P21980 Protein-glutamine gamma-glutamyltransferase 2 chr20 Not Cancer Driver No 1 hippie, biogrid 82 108 19 19 0
TRIM68-201 TRIM68 Q6AZZ1 E3 ubiquitin-protein ligase TRIM68 chr11 Not Cancer Driver No 1 hippie, biogrid 56 37 7 7 0
UBQLN1-202 UBQLN1 Q9UMX0 Ubiquilin-1 chr9 Not Cancer Driver No 1 hippie 40 545 38 38 0
UBQLN2-201 UBQLN2 Q9UHD9 Ubiquilin-2 chrX Not Cancer Driver No 1 hippie 64 581 61 61 8
VHL-201 VHL P40337 von Hippel-Lindau disease tumor suppressor chr3 Census, Compendium Yes 1 hippie, biogrid 85 117 15 15 84
XRN1-201 XRN1 Q8IZH2 5'-3' exoribonuclease 1 chr3 Not Cancer Driver No 1 intact 167 578 50 50 0
YAF2-203 YAF2 Q8IY57 YY1-associated factor 2 chr12 Not Cancer Driver No 1 hippie, biogrid 22 169 22 22 0
YES1-201 YES1 P07947 Tyrosine-protein kinase Yes chr18 Not Cancer Driver No 1 hippie, biogrid 48 63 9 9 0
ZDHHC19-201 ZDHHC19 Q8WVZ1 Palmitoyltransferase ZDHHC19 chr3 Not Cancer Driver No 1 hippie, biogrid 40 35 9 9 0
ZIC1-201 ZIC1 Q15915 Zinc finger protein ZIC 1 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 172 246 102 102 1
ZSCAN12-203 ZSCAN12 O43309 Zinc finger and SCAN domain-containing protein 12 chr6 Not Cancer Driver No 1 intact, hippie, biogrid 33 262 19 19 0