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ENST00000676884 ,PSEN2 ,P49810
  • Number of Interaction partner in intact: 36
  • Number of Interaction partner in biogrid: 9
  • Number of Interaction partner in hippie: 108
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AAMP-201 AAMP Q13685 Angio-associated migratory cell protein chr2 Not Cancer Driver No 1 hippie 24 126 7 7 0
ACTG1-205 ACTG1 P63261 Actin, cytoplasmic 2 chr17 Not Cancer Driver No 1 hippie 67 42 11 11 15
AK2-214 AK2 P54819 Adenylate kinase 2, mitochondrial chr1 Not Cancer Driver No 1 intact, hippie 17 76 8 8 2
ALG5-201 ALG5 Q9Y673 Dolichyl-phosphate beta-glucosyltransferase chr13 Not Cancer Driver No 1 hippie, biogrid 32 0 0 0 2
AP1G1-201 AP1G1 O43747 AP-1 complex subunit gamma-1 chr16 Not Cancer Driver No 1 hippie 77 144 20 20 5
APBA1-201 APBA1 Q02410 Amyloid-beta A4 precursor protein-binding family A member 1 chr9 Not Cancer Driver No 1 hippie 117 558 78 78 0
APBA2-213 APBA2 Q99767 Amyloid-beta A4 precursor protein-binding family A member 2 chr15 Not Cancer Driver No 1 hippie 151 429 98 98 0
APBA3-201 APBA3 O96018 Amyloid-beta A4 precursor protein-binding family A member 3 chr19 Not Cancer Driver No 1 hippie 35 309 30 30 0
APH1A-203 APH1A Q96BI3 Gamma-secretase subunit APH-1A chr1 Not Cancer Driver No 1 hippie 29 0 0 0 0
APH1B-201 APH1B Q8WW43 Gamma-secretase subunit APH-1B chr15 Not Cancer Driver No 1 hippie 15 0 0 0 0
APP-201 APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 2 intact, hippie 94 419 52 52 12
ART3-203 ART3 Q13508 Ecto-ADP-ribosyltransferase 3 chr4 Not Cancer Driver No 1 hippie, biogrid 35 82 6 6 0
AURKA-208 AURKA O14965 Aurora kinase A chr20 Not Cancer Driver No 1 hippie 25 180 17 17 0
BAK1-201 BAK1 Q16611 Bcl-2 homologous antagonist/killer chr6 Not Cancer Driver No 1 hippie 25 58 5 5 0
BCL2-201 BCL2 P10415 Apoptosis regulator Bcl-2 chr18 Census, Compendium Yes 1 hippie 21 73 5 5 0
BCL2L1-201 BCL2L1 Q07817 Bcl-2-like protein 1 chr20 Not Cancer Driver No 1 intact, hippie 22 55 2 2 0
CAPN1-201 CAPN1 P07384 Calpain-1 catalytic subunit chr11 Not Cancer Driver No 1 hippie 51 32 0 0 1
CASP1-212 CASP1 P29466 Caspase-1 chr11 Not Cancer Driver No 2 intact, hippie 54 88 12 12 0
CASP3-201 CASP3 P42574 Caspase-3 chr4 Census Yes 1 hippie 19 64 1 1 0
CASP6-201 CASP6 P55212 Caspase-6 chr4 Not Cancer Driver No 1 hippie 19 24 4 4 0
CASP7-203 CASP7 P55210 Caspase-7 chr10 Not Cancer Driver No 1 hippie 28 75 7 7 0
CASP8-218 CASP8 Q14790 Caspase-8 chr2 Census, Compendium Yes 1 hippie 116 106 11 11 1
CEP55-201 CEP55 Q53EZ4 Centrosomal protein of 55 kDa chr10 Not Cancer Driver No 1 hippie 34 264 15 15 0
CFLAR-201 CFLAR O15519 CASP8 and FADD-like apoptosis regulator chr2 Not Cancer Driver No 1 hippie 31 44 1 1 0
CHKA-201 CHKA P35790 Choline kinase alpha chr11 Not Cancer Driver No 1 hippie 31 121 2 2 3
CIB1-201 CIB1 Q99828 Calcium and integrin-binding protein 1 chr15 Not Cancer Driver No 1 hippie 16 6 1 1 0
CLK1-201 CLK1 P49759 Dual specificity protein kinase CLK1 chr2 Not Cancer Driver No 1 hippie 51 131 16 16 0
COX4I1-201 COX4I1 P13073 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial chr16 Not Cancer Driver No 1 intact 13 5 1 1 1
CSNK1A1-202 CSNK1A1 P48729 Casein kinase I isoform alpha chr5 Not Cancer Driver No 1 hippie 34 46 2 2 0
CSNK1D-202 CSNK1D P48730 Casein kinase I isoform delta chr17 Not Cancer Driver No 1 hippie 38 133 13 13 2
CSNK2A1-201 CSNK2A1 P68400 Casein kinase II subunit alpha chr20 Not Cancer Driver No 1 hippie 47 75 6 6 4
CTNNB1-201 CTNNB1 P35222 Catenin beta-1 chr3 Census, Compendium Yes 1 hippie 363 288 291 291 11
CTNND2-201 CTNND2 Q9UQB3 Catenin delta-2 chr5 Census Yes 1 hippie 338 841 228 228 6
DLK1-202 DLK1 P80370 Protein delta homolog 1 chr14 Not Cancer Driver No 1 hippie, biogrid 67 0 0 0 0
DNAJB1-201 DNAJB1 P25685 DnaJ homolog subfamily B member 1 chr19 Census, Compendium Yes 1 intact, hippie 26 196 20 20 0
DOCK3-201 DOCK3 Q8IZD9 Dedicator of cytokinesis protein 3 chr3 Not Cancer Driver No 1 hippie 269 458 51 51 0
DYNC1H1-201 DYNC1H1 Q14204 Cytoplasmic dynein 1 heavy chain 1 chr14 Not Cancer Driver No 1 intact, hippie 371 495 47 47 21
ECD-201 ECD O95905 Protein ecdysoneless homolog chr10 Not Cancer Driver No 1 hippie 44 257 15 15 0
ECSIT-202 ECSIT Q9BQ95 Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial chr19 Not Cancer Driver No 1 hippie 50 146 25 25 0
EID1-201 EID1 Q9Y6B2 EP300-interacting inhibitor of differentiation 1 chr15 Not Cancer Driver No 1 intact, hippie 14 159 11 11 0
ELAVL1-201 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 54 43 5 5 0
ELL2-201 ELL2 O00472 RNA polymerase II elongation factor ELL2 chr5 Not Cancer Driver No 1 intact, hippie 68 425 49 49 0
ENST00000676884 PSEN2 P49810 Presenilin-2 chr1 Not Cancer Driver No 1 hippie 0 0 0 0 0
ERGIC3-202 ERGIC3 Q9Y282 Endoplasmic reticulum-Golgi intermediate compartment protein 3 chr20 Not Cancer Driver No 1 hippie, biogrid 32 23 1 1 0
EVI5L-201 EVI5L Q96CN4 EVI5-like protein chr19 Not Cancer Driver No 1 hippie 55 381 21 21 0
EXOC6-201 EXOC6 Q8TAG9 Exocyst complex component 6 chr10 Not Cancer Driver No 1 intact, hippie 57 104 8 8 0
FAF2-201 FAF2 Q96CS3 FAS-associated factor 2 chr5 Not Cancer Driver No 1 hippie, biogrid 36 171 11 11 0
FBXL12-201 FBXL12 Q9NXK8 F-box/LRR-repeat protein 12 chr19 Not Cancer Driver No 1 hippie 32 0 0 0 0
FHL2-211 FHL2 Q14192 Four and a half LIM domains protein 2 chr2 Not Cancer Driver No 1 hippie 17 0 0 0 0
FKBP8-206 FKBP8 Q14318 Peptidyl-prolyl cis-trans isomerase FKBP8 chr19 Not Cancer Driver No 1 hippie 50 161 19 19 0
FLNA-202 FLNA P21333 Filamin-A chrX Census Yes 1 intact, hippie 314 1460 162 162 29
FLNB-201 FLNB O75369 Filamin-B chr3 Not Cancer Driver No 1 intact, hippie 257 1187 123 123 19
FOXD4L6-201 FOXD4L6 Q3SYB3 Forkhead box protein D4-like 6 chr9 Not Cancer Driver No 1 intact, hippie 6 217 2 2 0
FTL-201 FTL P02792 Ferritin light chain chr19 Not Cancer Driver No 1 intact, hippie 15 36 6 6 2
GCDH-201 GCDH Q92947 Glutaryl-CoA dehydrogenase, mitochondrial chr19 Not Cancer Driver No 1 hippie 48 37 3 3 51
GFAP-214 GFAP P14136 Glial fibrillary acidic protein chr17 Not Cancer Driver No 1 hippie 45 290 27 27 41
HLA-DMB-258 HLA-DMB P28068 HLA class II histocompatibility antigen, DM beta chain chr6 Not Cancer Driver No 1 intact, hippie 32 41 6 6 0
HNRNPLL-209 HNRNPLL Q8WVV9 Heterogeneous nuclear ribonucleoprotein L-like chr2 Not Cancer Driver No 1 intact, hippie 25 149 9 9 0
HPS1-203 HPS1 Q92902 BLOC-3 complex member HPS1 chr10 Not Cancer Driver No 1 hippie 56 154 13 13 0
ICAM5-201 ICAM5 Q9UMF0 Intercellular adhesion molecule 5 chr19 Not Cancer Driver No 1 hippie 80 422 38 38 0
IFIT3-202 IFIT3 O14879 Interferon-induced protein with tetratricopeptide repeats 3 chr10 Not Cancer Driver No 1 hippie 31 144 10 10 0
IFIT5-201 IFIT5 Q13325 Interferon-induced protein with tetratricopeptide repeats 5 chr10 Not Cancer Driver No 1 hippie 31 19 0 0 0
IRF3-203 IRF3 Q14653 Interferon regulatory factor 3 chr19 Not Cancer Driver No 1 hippie, biogrid 23 205 17 17 1
KCNIP3-201 KCNIP3 Q9Y2W7 Calsenilin chr2 Not Cancer Driver No 1 hippie 28 60 8 8 0
KCNIP4-204 KCNIP4 Q6PIL6 Kv channel-interacting protein 4 chr4 Not Cancer Driver No 1 hippie 43 30 6 6 0
KIF22-201 KIF22 Q14807 Kinesin-like protein KIF22 chr16 Not Cancer Driver No 1 hippie 63 324 31 31 2
LIPF-201 LIPF P07098 Gastric triacylglycerol lipase chr10 Not Cancer Driver No 1 intact, hippie 52 0 0 0 0
MAST1-201 MAST1 Q9Y2H9 Microtubule-associated serine/threonine-protein kinase 1 chr19 Not Cancer Driver No 1 intact, hippie 160 1081 99 99 1
MGARP-201 MGARP Q8TDB4 Protein MGARP chr4 Not Cancer Driver No 1 intact, hippie 15 209 14 14 0
MICAL2-234 MICAL2 O94851 [F-actin]-monooxygenase MICAL2 chr11 Not Cancer Driver No 1 hippie 224 1205 131 131 0
MNDA-201 MNDA P41218 Myeloid cell nuclear differentiation antigen chr1 Not Cancer Driver No 1 intact, hippie 142 173 63 63 0
MRFAP1L1-201 MRFAP1L1 Q96HT8 MORF4 family-associated protein 1-like 1 chr4 Not Cancer Driver No 1 hippie 8 59 4 4 0
NCSTN-201 NCSTN Q92542 Nicastrin chr1 Not Cancer Driver No 1 hippie 69 72 10 10 1
NEBL-202 NEBL O76041 Nebulette chr10 Not Cancer Driver No 1 intact, hippie 184 778 146 146 0
NOS3-201 NOS3 P29474 Nitric oxide synthase 3 chr7 Not Cancer Driver No 1 hippie 143 349 30 30 0
NOTCH1-204 NOTCH1 P46531 Neurogenic locus notch homolog protein 1 chr9 Census, Compendium Yes 1 hippie 312 690 71 71 3
NOTCH2-201 NOTCH2 Q04721 Neurogenic locus notch homolog protein 2 chr1 Census, Compendium Yes 1 hippie 191 631 61 61 1
NOTCH3-201 NOTCH3 Q9UM47 Neurogenic locus notch homolog protein 3 chr19 Not Cancer Driver No 1 hippie 241 560 61 61 89
NOTCH4-201 NOTCH4 Q99466 Neurogenic locus notch homolog protein 4 chr6 Not Cancer Driver No 1 hippie 287 464 71 71 0
NPLOC4-201 NPLOC4 Q8TAT6 Nuclear protein localization protein 4 homolog chr17 Not Cancer Driver No 1 intact, hippie, biogrid 58 48 6 6 0
OGA-202 OGA O60502 Protein O-GlcNAcase chr10 Not Cancer Driver No 1 hippie 60 241 11 11 0
PDCD4-201 PDCD4 Q53EL6 Programmed cell death protein 4 chr10 Not Cancer Driver No 1 intact, hippie 49 188 25 25 0
PDZK1IP1-201 PDZK1IP1 Q13113 PDZK1-interacting protein 1 chr1 Not Cancer Driver No 1 hippie 13 21 0 0 0
PIK3R1-211 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 Census, Compendium Yes 1 intact, hippie 122 271 50 50 2
PPP5C-201 PPP5C P53041 Serine/threonine-protein phosphatase 5 chr19 Not Cancer Driver No 1 hippie 58 73 10 10 0
PSEN1-201 PSEN1 P49768 Presenilin-1 chr14 Not Cancer Driver No 2 intact, hippie 43 134 18 18 69
PSEN2-202 PSEN2 P49810 Presenilin-2 chr1 Not Cancer Driver No 1 hippie 58 91 13 13 4
PSENEN-202 PSENEN Q9NZ42 Gamma-secretase subunit PEN-2 chr19 Not Cancer Driver No 1 hippie 14 0 0 0 0
RAB11A-201 RAB11A P62491 Ras-related protein Rab-11A chr15 Not Cancer Driver No 1 intact, hippie 12 43 2 2 0
RHEB-201 RHEB Q15382 GTP-binding protein Rheb chr7 Not Cancer Driver No 1 hippie 25 0 0 0 0
RNF115-202 RNF115 Q9Y4L5 E3 ubiquitin-protein ligase RNF115 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 23 136 11 11 0
RNF2-202 RNF2 Q99496 E3 ubiquitin-protein ligase RING2 chr1 Not Cancer Driver No 1 hippie 26 203 15 15 1
RNF32-202 RNF32 Q9H0A6 RING finger protein 32 chr7 Not Cancer Driver No 1 intact, hippie 43 109 9 9 0
RYBP-201 RYBP Q8N488 RING1 and YY1-binding protein chr3 Not Cancer Driver No 1 hippie 23 202 22 22 0
SGSM1-202 SGSM1 Q2NKQ1 Small G protein signaling modulator 1 chr22 Not Cancer Driver No 1 intact, hippie 151 421 50 50 0
SKIC8-201 SKIC8 Q9GZS3 Superkiller complex protein 8 chr15 Not Cancer Driver No 1 intact 18 7 1 1 0
SLC6A13-201 SLC6A13 Q9NSD5 Sodium- and chloride-dependent GABA transporter 2 chr12 Not Cancer Driver No 1 intact, hippie 110 37 9 9 0
SOX14-201 SOX14 O95416 Transcription factor SOX-14 chr3 Not Cancer Driver No 1 hippie 45 129 30 30 0
SP6-202 SP6 Q3SY56 Transcription factor Sp6 chr17 Not Cancer Driver No 1 intact, hippie 45 296 31 31 1
SPC24-206 SPC24 Q8NBT2 Kinetochore protein Spc24 chr19 Not Cancer Driver No 1 hippie 7 88 3 3 0
SRI-201 SRI P30626 Sorcin chr7 Not Cancer Driver No 1 hippie 8 32 0 0 0
TMBIM6-201 TMBIM6 P55061 Bax inhibitor 1 chr12 Not Cancer Driver No 1 hippie 12 3 0 0 0
TRAF6-202 TRAF6 Q9Y4K3 TNF receptor-associated factor 6 chr11 Not Cancer Driver No 1 hippie 51 62 5 5 0
TSPAN5-201 TSPAN5 P62079 Tetraspanin-5 chr4 Not Cancer Driver No 1 hippie, biogrid 32 0 0 0 0
UBAC1-201 UBAC1 Q9BSL1 Ubiquitin-associated domain-containing protein 1 chr9 Not Cancer Driver No 1 hippie 31 245 21 21 0
UBQLN1-202 UBQLN1 Q9UMX0 Ubiquilin-1 chr9 Not Cancer Driver No 1 hippie 40 545 38 38 0
ZMAT2-201 ZMAT2 Q96NC0 Zinc finger matrin-type protein 2 chr5 Not Cancer Driver No 1 intact, hippie 14 148 9 9 0
ZNF366-201 ZNF366 Q8N895 Zinc finger protein 366 chr5 Not Cancer Driver No 1 intact, hippie 115 387 69 69 0
ZSCAN1-201 ZSCAN1 Q8NBB4 Zinc finger and SCAN domain-containing protein 1 chr19 Not Cancer Driver No 1 intact, hippie 105 299 76 76 0
ZXDC-202 ZXDC Q2QGD7 Zinc finger protein ZXDC chr3 Not Cancer Driver No 1 intact, hippie 60 554 36 36 0