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FLG-201 ,FLG ,P20930
  • Number of Interaction partner in intact: 17
  • Number of Interaction partner in biogrid: 61
  • Number of Interaction partner in hippie: 98
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACAD9-201 ACAD9 Q9H845 Complex I assembly factor ACAD9, mitochondrial chr3 Not Cancer Driver No 1 hippie, biogrid 54 28 2 2 12
ALDH3A1-201 ALDH3A1 P30838 Aldehyde dehydrogenase, dimeric NADP-preferring chr17 Not Cancer Driver No 1 hippie, biogrid 55 36 5 5 0
ANXA2-204 ANXA2 P07355 Annexin A2 chr15 Not Cancer Driver No 1 hippie, biogrid 38 21 2 2 0
APTX-203 APTX Q7Z2E3 Aprataxin chr9 Not Cancer Driver No 1 hippie, biogrid 19 113 6 6 9
AQP12B-206 AQP12B A6NM10 Aquaporin-12B chr2 Not Cancer Driver No 1 hippie, biogrid 32 37 0 0 0
ATG5-204 ATG5 Q9H1Y0 Autophagy protein 5 chr6 Not Cancer Driver No 1 hippie 33 25 6 6 1
ATP6AP2-217 ATP6AP2 O75787 Renin receptor chrX Not Cancer Driver No 1 hippie, biogrid 36 0 0 0 2
BLMH-201 BLMH Q13867 Bleomycin hydrolase chr17 Not Cancer Driver No 1 hippie, biogrid 38 15 1 1 0
BMI1-201 BMI1 P35226 Polycomb complex protein BMI-1 chr10 Not Cancer Driver No 1 intact, hippie 34 150 23 23 0
C18orf21-205 C18orf21 Q32NC0 UPF0711 protein C18orf21 chr18 Not Cancer Driver No 1 hippie, biogrid 12 113 4 4 0
CASP14-201 CASP14 P31944 Caspase-14 chr19 Not Cancer Driver No 1 hippie, biogrid 42 84 10 10 0
CCNC-210 CCNC P24863 Cyclin-C chr6 Census Yes 1 hippie, biogrid 23 33 1 1 0
CCR1-201 CCR1 P32246 C-C chemokine receptor type 1 chr3 Not Cancer Driver No 1 hippie, biogrid 47 14 0 0 0
CFAP298-201 CFAP298 P57076 Cilia- and flagella-associated protein 298 chr21 Not Cancer Driver No 2 intact, hippie 18 111 5 5 0
CHD4-206 CHD4 Q14839 Chromodomain-helicase-DNA-binding protein 4 chr12 Census, Compendium Yes 1 hippie 312 978 118 118 6
CSNK2A1-201 CSNK2A1 P68400 Casein kinase II subunit alpha chr20 Not Cancer Driver No 1 hippie 47 75 6 6 4
CUL2-203 CUL2 Q13617 Cullin-2 chr10 Not Cancer Driver No 1 intact, hippie 64 66 2 2 0
CYLD-203 CYLD Q9NQC7 Ubiquitin carboxyl-terminal hydrolase CYLD chr16 Census, Compendium Yes 1 hippie 76 213 21 21 3
DDR2-201 DDR2 Q16832 Discoidin domain-containing receptor 2 chr1 Census Yes 1 biogrid 129 120 25 25 7
DDX3X-244 DDX3X O00571 ATP-dependent RNA helicase DDX3X chrX Census, Compendium Yes 1 hippie 91 302 32 32 18
DPPA4-201 DPPA4 Q7L190 Developmental pluripotency-associated protein 4 chr3 Not Cancer Driver No 1 hippie, biogrid 76 183 39 39 0
DSG1-201 DSG1 Q02413 Desmoglein-1 chr18 Not Cancer Driver No 1 hippie, biogrid 197 504 106 106 0
DTL-201 DTL Q9NZJ0 Denticleless protein homolog chr1 Not Cancer Driver No 1 hippie, biogrid 53 333 38 38 0
E2F6-202 E2F6 O75461 Transcription factor E2F6 chr2 Not Cancer Driver No 1 hippie, biogrid 7 105 2 2 0
ENST00000635511 PCLAF Q15004 PCNA-associated factor chr15 Not Cancer Driver No 1 hippie 0 0 0 0 0
ENST00000651531 TGM3 Q08188 Protein-glutamine gamma-glutamyltransferase E chr20 Not Cancer Driver No 1 hippie, biogrid 111 77 14 14 0
ERCC3-201 ERCC3 P19447 General transcription and DNA repair factor IIH helicase subunit XPB chr2 Census, Compendium Yes 1 hippie, biogrid 67 208 14 14 2
ERP27-201 ERP27 Q96DN0 Endoplasmic reticulum resident protein 27 chr12 Not Cancer Driver No 1 hippie, biogrid 25 28 7 7 0
ESR2-202 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 2 intact, hippie 69 92 10 10 1
EZH2-203 EZH2 Q15910 Histone-lysine N-methyltransferase EZH2 chr7 Census, Compendium Yes 1 hippie 74 284 32 32 11
FBXW7-201 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 Census, Compendium Yes 1 hippie 289 232 15 15 17
FCF1-201 FCF1 Q9Y324 rRNA-processing protein FCF1 homolog chr14 Not Cancer Driver No 2 intact, hippie, biogrid 19 46 3 3 0
FIBIN-201 FIBIN Q8TAL6 Fin bud initiation factor homolog chr11 Not Cancer Driver No 1 hippie, biogrid 33 51 11 11 0
FLG2-201 FLG2 Q5D862 Filaggrin-2 chr1 Not Cancer Driver No 1 hippie, biogrid 89 2255 60 60 0
FLNC-201 FLNC Q14315 Filamin-C chr7 Not Cancer Driver No 1 hippie 436 1451 234 234 7
FNDC5-201 FNDC5 Q8NAU1 Fibronectin type III domain-containing protein 5 chr1 Not Cancer Driver No 1 hippie, biogrid 13 74 6 6 0
FRMD1-201 FRMD1 Q8N878 FERM domain-containing protein 1 chr6 Not Cancer Driver No 1 hippie, biogrid 74 266 37 37 0
FTH1-201 FTH1 P02794 Ferritin heavy chain chr11 Not Cancer Driver No 2 hippie, biogrid 18 57 7 7 0
GALNT9-201 GALNT9 Q9HCQ5 Polypeptide N-acetylgalactosaminyltransferase 9 chr12 Not Cancer Driver No 1 hippie, biogrid 60 32 2 2 0
GMCL1-201 GMCL1 Q96IK5 Germ cell-less protein-like 1 chr2 Not Cancer Driver No 2 hippie, biogrid 23 80 2 2 0
GOT1-201 GOT1 P17174 Aspartate aminotransferase, cytoplasmic chr10 Not Cancer Driver No 1 hippie, biogrid 36 35 5 5 0
GPR18-202 GPR18 Q14330 N-arachidonyl glycine receptor chr13 Not Cancer Driver No 2 hippie, biogrid 27 0 0 0 0
HNRNPA1-202 HNRNPA1 P09651 Heterogeneous nuclear ribonucleoprotein A1 chr12 Not Cancer Driver No 1 hippie 33 290 22 22 4
HTN3-206 HTN3 P15516 Histatin-3 chr4 Not Cancer Driver No 1 hippie 8 13 2 2 0
INPP5A-203 INPP5A Q14642 Inositol polyphosphate-5-phosphatase A chr10 Not Cancer Driver No 1 hippie, biogrid 46 7 3 3 0
KIF23-201 KIF23 Q02241 Kinesin-like protein KIF23 chr15 Not Cancer Driver No 1 hippie 74 561 45 45 1
KLF5-201 KLF5 Q13887 Krueppel-like factor 5 chr13 Compendium Yes 1 hippie 68 367 34 34 0
KLK5-201 KLK5 Q9Y337 Kallikrein-5 chr19 Not Cancer Driver No 1 intact, hippie 54 75 14 14 0
LARP7-201 LARP7 Q4G0J3 La-related protein 7 chr4 Not Cancer Driver No 1 hippie 39 353 28 28 0
LRRC10-201 LRRC10 Q5BKY1 Leucine-rich repeat-containing protein 10 chr12 Not Cancer Driver No 1 hippie, biogrid 42 38 8 8 0
LRRK2-201 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 402 91 13 13 20
MAK-201 MAK P20794 Serine/threonine-protein kinase MAK chr6 Not Cancer Driver No 2 intact, hippie 48 324 30 30 5
MAP1LC3B-201 MAP1LC3B Q9GZQ8 Microtubule-associated proteins 1A/1B light chain 3B chr16 Not Cancer Driver No 1 intact, hippie 4 17 0 0 0
MAPT-212 MAPT P10636 Microtubule-associated protein tau chr17 Not Cancer Driver No 1 intact, hippie 100 750 99 99 17
MCL1-202 MCL1 Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 chr1 Not Cancer Driver No 2 hippie, biogrid 27 204 19 19 0
METTL14-201 METTL14 Q9HCE5 N6-adenosine-methyltransferase non-catalytic subunit chr4 Not Cancer Driver No 1 hippie 37 224 14 14 0
MLLT6-211 MLLT6 P55198 Protein AF-17 chr17 Census Yes 1 hippie, biogrid 42 842 39 39 0
MPG-201 MPG P29372 DNA-3-methyladenine glycosylase chr16 Not Cancer Driver No 1 hippie 31 143 18 18 0
MRM1-204 MRM1 Q6IN84 rRNA methyltransferase 1, mitochondrial chr17 Not Cancer Driver No 1 hippie, biogrid 27 106 8 8 0
NCAPD3-212 NCAPD3 P42695 Condensin-2 complex subunit D3 chr11 Not Cancer Driver No 1 hippie 145 305 35 35 1
NPHP1-203 NPHP1 O15259 Nephrocystin-1 chr2 Not Cancer Driver No 1 hippie, biogrid 83 260 24 24 1
OR13C3-201 OR13C3 Q8NGS6 Olfactory receptor 13C3 chr9 Not Cancer Driver No 1 hippie, biogrid 75 0 0 0 0
OR2A4-201 OR2A4 O95047 Olfactory receptor 2A4 chr6 Not Cancer Driver No 1 hippie, biogrid 36 0 0 0 0
P2RX6-202 P2RX6 O15547 P2X purinoceptor 6 chr22 Not Cancer Driver No 1 hippie, biogrid 22 43 1 1 0
PCLAF-201 PCLAF Q15004 PCNA-associated factor chr15 Not Cancer Driver No 1 hippie 15 112 16 16 0
PCSK6-214 PCSK6 P29122 Proprotein convertase subtilisin/kexin type 6 chr15 Not Cancer Driver No 1 hippie 113 207 41 41 0
PI4KA-201 PI4KA P42356 Phosphatidylinositol 4-kinase alpha chr22 Not Cancer Driver No 1 hippie, biogrid 198 142 10 10 7
PINK1-201 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 Not Cancer Driver No 1 hippie 46 99 8 8 24
PKP1-202 PKP1 Q13835 Plakophilin-1 chr1 Not Cancer Driver No 1 hippie, biogrid 82 192 20 20 0
PPP2R2B-203 PPP2R2B Q00005 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform chr5 Not Cancer Driver No 1 hippie, biogrid 66 76 11 11 1
PRSS16-201 PRSS16 Q9NQE7 Thymus-specific serine protease chr6 Not Cancer Driver No 1 hippie, biogrid 63 26 5 5 0
PSMD14-201 PSMD14 O00487 26S proteasome non-ATPase regulatory subunit 14 chr2 Not Cancer Driver No 1 hippie 14 68 3 3 0
PTDSS1-202 PTDSS1 P48651 Phosphatidylserine synthase 1 chr8 Not Cancer Driver No 1 hippie, biogrid 56 44 4 4 3
RIPPLY3-201 RIPPLY3 P57055 Protein ripply3 chr21 Not Cancer Driver No 1 hippie, biogrid 42 192 42 42 0
SAMD12-201 SAMD12 Q8N8I0 Sterile alpha motif domain-containing protein 12 chr8 Not Cancer Driver No 1 hippie 34 60 7 7 0
SARAF-201 SARAF Q96BY9 Store-operated calcium entry-associated regulatory factor chr8 Not Cancer Driver No 1 hippie, biogrid 23 75 8 8 0
SCN3B-201 SCN3B Q9NY72 Sodium channel subunit beta-3 chr11 Not Cancer Driver No 1 hippie, biogrid 45 16 2 2 3
SH2D3A-201 SH2D3A Q9BRG2 SH2 domain-containing protein 3A chr19 Not Cancer Driver No 1 hippie, biogrid 52 308 30 30 0
SLC25A6-201 SLC25A6 P12236 ADP/ATP translocase 3 chrX Not Cancer Driver No 1 hippie, biogrid 29 0 0 0 0
SLC35F2-204 SLC35F2 Q8IXU6 Solute carrier family 35 member F2 chr11 Not Cancer Driver No 1 hippie, biogrid 37 12 0 0 0
SLX4-201 SLX4 Q8IY92 Structure-specific endonuclease subunit SLX4 chr16 Not Cancer Driver No 1 intact, hippie 201 1586 175 175 0
ST6GALNAC6-205 ST6GALNAC6 Q969X2 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 chr9 Not Cancer Driver No 1 hippie, biogrid 29 87 7 7 0
STK11-201 STK11 Q15831 Serine/threonine-protein kinase STK11 chr19 Census, Compendium Yes 1 hippie, biogrid 63 135 12 12 9
STK16-201 STK16 O75716 Serine/threonine-protein kinase 16 chr2 Not Cancer Driver No 2 intact, hippie, biogrid 25 48 2 2 0
STK4-202 STK4 Q13043 Serine/threonine-protein kinase 4 chr20 Not Cancer Driver No 1 intact, hippie 49 233 20 20 0
STX17-201 STX17 P56962 Syntaxin-17 chr9 Not Cancer Driver No 1 hippie, biogrid 24 81 6 6 0
TBC1D22B-201 TBC1D22B Q9NU19 TBC1 domain family member 22B chr6 Not Cancer Driver No 1 hippie, biogrid 43 206 23 23 0
TGM3-201 TGM3 Q08188 Protein-glutamine gamma-glutamyltransferase E chr20 Not Cancer Driver No 1 hippie, biogrid 111 86 15 15 0
TMEM79-203 TMEM79 Q9BSE2 Transmembrane protein 79 chr1 Not Cancer Driver No 1 hippie 40 149 12 12 0
TNFRSF19-202 TNFRSF19 Q9NS68 Tumor necrosis factor receptor superfamily member 19 chr13 Not Cancer Driver No 2 intact, hippie, biogrid 52 103 12 12 0
TUBG1-201 TUBG1 P23258 Tubulin gamma-1 chain chr17 Not Cancer Driver No 1 hippie 42 44 9 9 3
TXNIP-204 TXNIP Q9H3M7 Thioredoxin-interacting protein chr1 Not Cancer Driver No 1 hippie 46 77 10 10 0
UCHL5-206 UCHL5 Q9Y5K5 Ubiquitin carboxyl-terminal hydrolase isozyme L5 chr1 Not Cancer Driver No 1 hippie 23 41 2 2 0
UCP2-211 UCP2 P55851 Dicarboxylate carrier SLC25A8 chr11 Not Cancer Driver No 3 hippie, biogrid 23 12 4 4 0
USP1-201 USP1 O94782 Ubiquitin carboxyl-terminal hydrolase 1 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 45 405 20 20 0
VHL-201 VHL P40337 von Hippel-Lindau disease tumor suppressor chr3 Census, Compendium Yes 1 intact, hippie 85 117 15 15 84
ZC3HC1-202 ZC3HC1 Q86WB0 Zinc finger C3HC-type protein 1 chr7 Not Cancer Driver No 1 hippie, biogrid 44 252 19 19 0
ZDHHC19-201 ZDHHC19 Q8WVZ1 Palmitoyltransferase ZDHHC19 chr3 Not Cancer Driver No 1 hippie, biogrid 40 35 9 9 0
ZSCAN12-203 ZSCAN12 O43309 Zinc finger and SCAN domain-containing protein 12 chr6 Not Cancer Driver No 2 intact, hippie, biogrid 33 262 19 19 0