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FLG2-201 ,FLG2 ,Q5D862
  • Number of Interaction partner in intact: 18
  • Number of Interaction partner in biogrid: 31
  • Number of Interaction partner in hippie: 101
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AGO1-201 AGO1 Q9UL18 Protein argonaute-1 chr1 Not Cancer Driver No 1 intact, hippie 94 87 10 10 1
ANXA2-204 ANXA2 P07355 Annexin A2 chr15 Not Cancer Driver No 1 hippie, biogrid 38 21 2 2 0
ARG1-203 ARG1 P05089 Arginase-1 chr6 Not Cancer Driver No 1 hippie, biogrid 27 83 8 8 9
ARMC12-202 ARMC12 Q5T9G4 Armadillo repeat-containing protein 12 chr6 Not Cancer Driver No 1 hippie 40 8 0 0 0
ATP6AP2-217 ATP6AP2 O75787 Renin receptor chrX Not Cancer Driver No 1 hippie, biogrid 36 0 0 0 2
BTF3-202 BTF3 P20290 Transcription factor BTF3 chr5 Not Cancer Driver No 1 hippie 20 192 18 18 0
CASP14-201 CASP14 P31944 Caspase-14 chr19 Not Cancer Driver No 1 hippie, biogrid 42 84 10 10 0
CCNC-210 CCNC P24863 Cyclin-C chr6 Census Yes 1 hippie, biogrid 23 33 1 1 0
CCNF-202 CCNF P41002 Cyclin-F chr16 Not Cancer Driver No 1 hippie, biogrid 77 221 16 16 3
CD274-202 CD274 Q9NZQ7 Programmed cell death 1 ligand 1 chr9 Census Yes 1 hippie 26 54 9 9 0
CDC73-201 CDC73 Q6P1J9 Parafibromin chr1 Census, Compendium Yes 1 hippie 78 210 32 32 2
CDK1-203 CDK1 P06493 Cyclin-dependent kinase 1 chr10 Not Cancer Driver No 1 hippie, biogrid 26 1 0 0 0
CDK2-201 CDK2 P24941 Cyclin-dependent kinase 2 chr12 Not Cancer Driver No 1 hippie 17 0 0 0 0
CDK5-204 CDK5 Q00535 Cyclin-dependent kinase 5 chr7 Not Cancer Driver No 1 hippie 38 5 0 0 0
CFTR-201 CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 Not Cancer Driver No 3 intact, hippie 216 145 9 9 130
CHD3-201 CHD3 Q12873 Chromodomain-helicase-DNA-binding protein 3 chr17 Not Cancer Driver No 1 hippie 187 1017 92 92 17
CHD4-206 CHD4 Q14839 Chromodomain-helicase-DNA-binding protein 4 chr12 Census, Compendium Yes 1 hippie 312 978 118 118 6
CIC-206 CIC Q96RK0 Protein capicua homolog chr19 Census, Compendium Yes 1 hippie 216 1552 207 207 0
COPS5-201 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 Not Cancer Driver No 1 hippie 27 32 4 4 0
CSNK1E-203 CSNK1E P49674 Casein kinase I isoform epsilon chr22 Not Cancer Driver No 1 hippie 44 133 13 13 0
CUL2-203 CUL2 Q13617 Cullin-2 chr10 Not Cancer Driver No 1 intact, hippie 64 66 2 2 0
CUL4A-202 CUL4A Q13619 Cullin-4A chr13 Not Cancer Driver No 1 hippie 54 102 2 2 0
CYLD-203 CYLD Q9NQC7 Ubiquitin carboxyl-terminal hydrolase CYLD chr16 Census, Compendium Yes 1 hippie 76 213 21 21 3
DCPS-201 DCPS Q96C86 m7GpppX diphosphatase chr11 Not Cancer Driver No 1 hippie 32 55 5 5 1
DCUN1D1-201 DCUN1D1 Q96GG9 DCN1-like protein 1 chr3 Not Cancer Driver No 1 intact, hippie 24 13 1 1 0
DDX39B-202 DDX39B Q13838 Spliceosome RNA helicase DDX39B chr6 Not Cancer Driver No 1 hippie 36 34 6 6 0
DDX3X-244 DDX3X O00571 ATP-dependent RNA helicase DDX3X chrX Census, Compendium Yes 1 hippie 91 302 32 32 18
DHFR2-201 DHFR2 Q86XF0 Dihydrofolate reductase 2, mitochondrial chr3 Not Cancer Driver No 1 hippie 13 20 0 0 0
DSC1-202 DSC1 Q08554 Desmocollin-1 chr18 Not Cancer Driver No 1 hippie, biogrid 161 268 53 53 0
DSG1-201 DSG1 Q02413 Desmoglein-1 chr18 Not Cancer Driver No 1 hippie, biogrid 197 504 106 106 0
DSP-201 DSP P15924 Desmoplakin chr6 Not Cancer Driver No 1 hippie, biogrid 354 1127 146 146 6
EFTUD2-202 EFTUD2 Q15029 116 kDa U5 small nuclear ribonucleoprotein component chr17 Compendium Yes 1 hippie 100 179 22 22 3
ENST00000635511 PCLAF Q15004 PCNA-associated factor chr15 Not Cancer Driver No 1 hippie 0 0 0 0 0
ENST00000651531 TGM3 Q08188 Protein-glutamine gamma-glutamyltransferase E chr20 Not Cancer Driver No 1 hippie, biogrid 111 77 14 14 0
ESR1-201 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 hippie 92 198 19 19 2
ESR2-202 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 intact, hippie 69 92 10 10 1
FASTKD3-201 FASTKD3 Q14CZ7 FAST kinase domain-containing protein 3, mitochondrial chr5 Not Cancer Driver No 1 hippie, biogrid 83 6 1 1 0
FBP1-201 FBP1 P09467 Fructose-1,6-bisphosphatase 1 chr9 Not Cancer Driver No 1 hippie 24 19 0 0 4
FBXO6-201 FBXO6 Q9NRD1 F-box only protein 6 chr1 Not Cancer Driver No 1 hippie 25 27 3 3 0
FGFRL1-205 FGFRL1 Q8N441 Fibroblast growth factor receptor-like 1 chr4 Not Cancer Driver No 1 hippie, biogrid 50 279 25 25 0
FHIP1A-201 FHIP1A Q05DH4 FHF complex subunit HOOK-interacting protein 1A chr4 Not Cancer Driver No 1 intact 32 341 7 7 0
FHIP1B-202 FHIP1B Q8N612 FHF complex subunit HOOK-interacting protein 1B chr11 Not Cancer Driver No 1 intact 97 420 42 42 0
FHIP2A-202 FHIP2A Q5W0V3 FHF complex subunit HOOK interacting protein 2A chr10 Not Cancer Driver No 1 intact 63 130 11 11 0
FLG-201 FLG P20930 Filaggrin chr1 Not Cancer Driver No 1 hippie, biogrid 1351 4059 1373 1373 0
FTH1-201 FTH1 P02794 Ferritin heavy chain chr11 Not Cancer Driver No 1 hippie, biogrid 18 57 7 7 0
FZR1-202 FZR1 Q9UM11 Fizzy-related protein homolog chr19 Not Cancer Driver No 1 hippie 64 184 24 24 2
GABARAPL1-201 GABARAPL1 Q9H0R8 Gamma-aminobutyric acid receptor-associated protein-like 1 chr12 Not Cancer Driver No 1 hippie 10 10 1 1 0
GABARAPL2-201 GABARAPL2 P60520 Gamma-aminobutyric acid receptor-associated protein-like 2 chr16 Not Cancer Driver No 1 hippie 4 2 1 1 0
GMCL1-201 GMCL1 Q96IK5 Germ cell-less protein-like 1 chr2 Not Cancer Driver No 1 hippie, biogrid 23 80 2 2 0
HNRNPA1-202 HNRNPA1 P09651 Heterogeneous nuclear ribonucleoprotein A1 chr12 Not Cancer Driver No 1 hippie 33 290 22 22 4
HRNR-201 HRNR Q86YZ3 Hornerin chr1 Not Cancer Driver No 1 hippie, biogrid 27 2773 23 23 0
HSP90AA1-201 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 hippie 44 258 15 15 0
IQCB1-201 IQCB1 Q15051 IQ calmodulin-binding motif-containing protein 1 chr3 Not Cancer Driver No 1 hippie 46 89 6 6 0
JAK1-201 JAK1 P23458 Tyrosine-protein kinase JAK1 chr1 Census, Compendium Yes 1 intact, hippie 109 120 6 6 2
JUP-203 JUP P14923 Junction plakoglobin chr17 Not Cancer Driver No 1 hippie, biogrid 81 242 24 24 0
KCNJ2-201 KCNJ2 P63252 Inward rectifier potassium channel 2 chr17 Not Cancer Driver No 1 hippie 85 49 7 7 12
KIF23-201 KIF23 Q02241 Kinesin-like protein KIF23 chr15 Not Cancer Driver No 1 hippie 74 561 45 45 1
KLF5-201 KLF5 Q13887 Krueppel-like factor 5 chr13 Compendium Yes 1 hippie 68 367 34 34 0
KPRP-201 KPRP Q5T749 Keratinocyte proline-rich protein chr1 Not Cancer Driver No 1 hippie, biogrid 162 196 52 52 0
KRT17-201 KRT17 Q04695 Keratin, type I cytoskeletal 17 chr17 Not Cancer Driver No 1 hippie 68 162 28 28 13
LARP7-201 LARP7 Q4G0J3 La-related protein 7 chr4 Not Cancer Driver No 1 hippie 39 353 28 28 0
LRRK2-201 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 402 91 13 13 20
MAD2L1-201 MAD2L1 Q13257 Mitotic spindle assembly checkpoint protein MAD2A chr4 Not Cancer Driver No 1 intact, hippie 21 12 1 1 0
MAGEA3-201 MAGEA3 P43357 Melanoma-associated antigen 3 chrX Not Cancer Driver No 1 hippie 74 104 16 16 0
MAP1LC3A-201 MAP1LC3A Q9H492 Microtubule-associated proteins 1A/1B light chain 3A chr20 Not Cancer Driver No 1 hippie 19 24 1 1 0
MAP1LC3B-201 MAP1LC3B Q9GZQ8 Microtubule-associated proteins 1A/1B light chain 3B chr16 Not Cancer Driver No 1 intact, hippie 4 17 0 0 0
MAPT-212 MAPT P10636 Microtubule-associated protein tau chr17 Not Cancer Driver No 1 intact, hippie 100 750 99 99 17
METTL14-201 METTL14 Q9HCE5 N6-adenosine-methyltransferase non-catalytic subunit chr4 Not Cancer Driver No 1 hippie 37 224 14 14 0
METTL3-201 METTL3 Q86U44 N6-adenosine-methyltransferase catalytic subunit chr14 Not Cancer Driver No 1 hippie 60 274 24 24 0
NCAPD3-212 NCAPD3 P42695 Condensin-2 complex subunit D3 chr11 Not Cancer Driver No 1 hippie 145 305 35 35 1
NEK2-202 NEK2 P51955 Serine/threonine-protein kinase Nek2 chr1 Not Cancer Driver No 1 hippie 44 93 12 12 0
NLRP7-207 NLRP7 Q8WX94 NACHT, LRR and PYD domains-containing protein 7 chr19 Not Cancer Driver No 1 hippie 203 71 11 11 7
NUPR1-201 NUPR1 O60356 Nuclear protein 1 chr16 Not Cancer Driver No 1 hippie 10 82 10 10 0
PCLAF-201 PCLAF Q15004 PCNA-associated factor chr15 Not Cancer Driver No 1 hippie 15 112 16 16 0
PHKG2-204 PHKG2 P15735 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform chr16 Not Cancer Driver No 1 hippie 36 50 4 4 4
PINK1-201 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 Not Cancer Driver No 1 hippie 46 99 8 8 24
PKP1-202 PKP1 Q13835 Plakophilin-1 chr1 Not Cancer Driver No 1 hippie, biogrid 82 192 20 20 0
PRKN-206 PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 Not Cancer Driver No 1 hippie 96 78 14 14 30
PRPF8-201 PRPF8 Q6P2Q9 Pre-mRNA-processing-splicing factor 8 chr17 Not Cancer Driver No 1 hippie 202 226 24 24 6
PRSS16-201 PRSS16 Q9NQE7 Thymus-specific serine protease chr6 Not Cancer Driver No 1 hippie, biogrid 63 26 5 5 0
PTDSS1-202 PTDSS1 P48651 Phosphatidylserine synthase 1 chr8 Not Cancer Driver No 1 hippie, biogrid 56 44 4 4 3
RNF130-205 RNF130 Q86XS8 E3 ubiquitin-protein ligase RNF130 chr5 Not Cancer Driver No 1 biogrid 32 43 2 2 0
RPS19BP1-201 RPS19BP1 Q86WX3 Active regulator of SIRT1 chr22 Not Cancer Driver No 1 hippie, biogrid 3 112 3 3 0
RYBP-201 RYBP Q8N488 RING1 and YY1-binding protein chr3 Not Cancer Driver No 1 hippie 23 202 22 22 0
SERPINB12-201 SERPINB12 Q96P63 Serpin B12 chr18 Not Cancer Driver No 1 hippie, biogrid 59 21 6 6 0
SH2D3A-201 SH2D3A Q9BRG2 SH2 domain-containing protein 3A chr19 Not Cancer Driver No 1 hippie, biogrid 52 308 30 30 0
SMIM26-201 SMIM26 A0A096LP01 Small integral membrane protein 26 chr20 Not Cancer Driver No 1 intact 0 17 0 0 0
SOAT1-201 SOAT1 P35610 Sterol O-acyltransferase 1 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 55 51 1 1 0
STAG1-202 STAG1 Q8WVM7 Cohesin subunit SA-1 chr3 Census Yes 1 hippie 166 391 48 48 8
STK24-201 STK24 Q9Y6E0 Serine/threonine-protein kinase 24 chr13 Not Cancer Driver No 1 hippie 42 118 13 13 0
STK26-202 STK26 Q9P289 Serine/threonine-protein kinase 26 chrX Not Cancer Driver No 1 hippie 44 119 14 14 0
STK4-202 STK4 Q13043 Serine/threonine-protein kinase 4 chr20 Not Cancer Driver No 1 hippie 49 233 20 20 0
STX17-201 STX17 P56962 Syntaxin-17 chr9 Not Cancer Driver No 1 hippie, biogrid 24 81 6 6 0
TBC1D22B-201 TBC1D22B Q9NU19 TBC1 domain family member 22B chr6 Not Cancer Driver No 1 hippie, biogrid 43 206 23 23 0
TCF3-201 TCF3 P15923 Transcription factor E2-alpha chr19 Census Yes 1 hippie 40 658 40 40 0
TGM3-201 TGM3 Q08188 Protein-glutamine gamma-glutamyltransferase E chr20 Not Cancer Driver No 1 hippie, biogrid 111 86 15 15 0
TPTEP2-CSNK1E-201 CSNK1E P49674 Casein kinase I isoform epsilon chr22 Not Cancer Driver No 1 hippie 44 133 13 13 0
UBD-203 UBD O15205 Ubiquitin D chr6 Not Cancer Driver No 1 hippie 24 8 1 1 0
UCHL1-201 UCHL1 P09936 Ubiquitin carboxyl-terminal hydrolase isozyme L1 chr4 Not Cancer Driver No 1 hippie 23 34 5 5 4
UFL1-201 UFL1 O94874 E3 UFM1-protein ligase 1 chr6 Not Cancer Driver No 1 hippie 77 141 19 19 0
VDAC1-201 VDAC1 P21796 Voltage-dependent anion-selective channel protein 1 chr5 Not Cancer Driver No 1 intact, hippie, biogrid 25 36 4 4 0
VIRMA-201 VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 157 634 73 73 0
WAPL-201 WAPL Q7Z5K2 Wings apart-like protein homolog chr10 Not Cancer Driver No 1 hippie 104 623 49 49 0
WTAP-206 WTAP Q15007 Pre-mRNA-splicing regulator WTAP chr6 Not Cancer Driver No 1 hippie 52 307 44 44 0
YAP1-201 YAP1 P46937 Transcriptional coactivator YAP1 chr11 Not Cancer Driver No 1 hippie 41 491 41 41 0
YWHAE-201 YWHAE P62258 14-3-3 protein epsilon chr17 Census Yes 1 intact 24 41 1 1 0
ZNF808-201 ZNF808 Q8N4W9 Zinc finger protein 808 chr19 Not Cancer Driver No 1 intact 128 186 21 21 0
ZUP1-202 ZUP1 Q96AP4 Zinc finger-containing ubiquitin peptidase 1 chr6 Not Cancer Driver No 1 hippie 48 204 13 13 0