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HECTD3-202 ,HECTD3 ,Q5T447
  • Number of Interaction partner in intact: 3
  • Number of Interaction partner in biogrid: 67
  • Number of Interaction partner in hippie: 109
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ANGPT2-201 ANGPT2 O15123 Angiopoietin-2 chr8 Not Cancer Driver No 1 hippie, biogrid 44 96 7 7 1
BAG6-237 BAG6 P46379 Large proline-rich protein BAG6 chr6 Not Cancer Driver No 1 hippie 73 856 59 59 0
BRCA1-203 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 Census, Compendium Yes 1 hippie 167 1466 127 127 34
BRD1-202 BRD1 O95696 Bromodomain-containing protein 1 chr22 Not Cancer Driver No 1 hippie, biogrid 117 424 47 47 0
CASP8-218 CASP8 Q14790 Caspase-8 chr2 Census, Compendium Yes 1 hippie 116 106 11 11 1
CASP9-201 CASP9 P55211 Caspase-9 chr1 Census Yes 1 hippie 26 71 7 7 0
CAVIN1-201 CAVIN1 Q6NZI2 Caveolae-associated protein 1 chr17 Not Cancer Driver No 1 hippie 48 281 34 34 0
CCNG1-201 CCNG1 P51959 Cyclin-G1 chr5 Not Cancer Driver No 1 hippie, biogrid 15 0 0 0 0
CCT2-201 CCT2 P78371 T-complex protein 1 subunit beta chr12 Not Cancer Driver No 1 hippie, biogrid 51 46 4 4 0
CCT4-201 CCT4 P50991 T-complex protein 1 subunit delta chr2 Not Cancer Driver No 1 hippie, biogrid 37 93 1 1 0
CCT6A-201 CCT6A P40227 T-complex protein 1 subunit zeta chr7 Not Cancer Driver No 1 hippie, biogrid 54 5 1 1 0
CCT6B-201 CCT6B Q92526 T-complex protein 1 subunit zeta-2 chr17 Not Cancer Driver No 1 hippie, biogrid 60 1 0 0 0
CCT7-201 CCT7 Q99832 T-complex protein 1 subunit eta chr2 Not Cancer Driver No 1 hippie, biogrid 45 36 3 3 0
CEP192-202 CEP192 Q8TEP8 Centrosomal protein of 192 kDa chr18 Not Cancer Driver No 1 hippie, biogrid 198 1220 81 81 0
CHRDL1-203 CHRDL1 Q9BU40 Chordin-like protein 1 chrX Not Cancer Driver No 2 hippie, biogrid 72 68 8 8 1
CLEC3A-201 CLEC3A O75596 C-type lectin domain family 3 member A chr16 Not Cancer Driver No 2 hippie, biogrid 53 21 3 3 0
CNR2-201 CNR2 P34972 Cannabinoid receptor 2 chr1 Not Cancer Driver No 1 hippie 44 21 4 4 0
COPS7B-201 COPS7B Q9H9Q2 COP9 signalosome complex subunit 7b chr2 Not Cancer Driver No 2 hippie, biogrid 19 74 6 6 0
COX7B2-201 COX7B2 Q8TF08 Cytochrome c oxidase subunit 7B2, mitochondrial chr4 Not Cancer Driver No 1 hippie, biogrid 15 6 0 0 0
CPA6-201 CPA6 Q8N4T0 Carboxypeptidase A6 chr8 Not Cancer Driver No 1 hippie, biogrid 76 8 0 0 2
DKK2-201 DKK2 Q9UBU2 Dickkopf-related protein 2 chr4 Not Cancer Driver No 1 hippie, biogrid 84 71 17 17 0
DNAJC28-202 DNAJC28 Q9NX36 DnaJ homolog subfamily C member 28 chr21 Not Cancer Driver No 1 hippie, biogrid 37 139 7 7 0
EBI3-201 EBI3 Q14213 Interleukin-27 subunit beta chr19 Not Cancer Driver No 1 hippie, biogrid 19 10 0 0 0
EGFL6-201 EGFL6 Q8IUX8 Epidermal growth factor-like protein 6 chrX Not Cancer Driver No 2 hippie, biogrid 56 104 17 17 0
EMILIN3-201 EMILIN3 Q9NT22 EMILIN-3 chr20 Not Cancer Driver No 1 hippie, biogrid 76 339 33 33 0
FAM81A-201 FAM81A Q8TBF8 Protein FAM81A chr15 Not Cancer Driver No 1 hippie, biogrid 36 157 9 9 0
FEZF1-203 FEZF1 A0PJY2 Fez family zinc finger protein 1 chr7 Not Cancer Driver No 1 hippie, biogrid 52 152 10 10 1
FGFR3-205 FGFR3 P22607 Fibroblast growth factor receptor 3 chr4 Census, Compendium Yes 1 intact, hippie 134 241 18 18 32
FOSL2-201 FOSL2 P15408 Fos-related antigen 2 chr2 Not Cancer Driver No 3 hippie, biogrid 39 323 39 39 0
FST-201 FST P19883 Follistatin chr5 Not Cancer Driver No 1 hippie, biogrid 33 20 3 3 0
GADD45GIP1-201 GADD45GIP1 Q8TAE8 Large ribosomal subunit protein mL64 chr19 Not Cancer Driver No 1 hippie, biogrid 9 193 9 9 0
GAS2L1-208 GAS2L1 Q99501 GAS2-like protein 1 chr22 Not Cancer Driver No 2 hippie, biogrid 30 477 11 11 0
GAST-201 GAST P01350 Gastrin chr17 Not Cancer Driver No 2 hippie, biogrid 14 82 11 11 0
GREM2-201 GREM2 Q9H772 Gremlin-2 chr1 Not Cancer Driver No 1 hippie, biogrid 47 22 8 8 3
GRIN2C-201 GRIN2C Q14957 Glutamate receptor ionotropic, NMDA 2C chr17 Not Cancer Driver No 1 intact, hippie 78 278 3 3 0
GSN-204 GSN P06396 Gelsolin chr9 Not Cancer Driver No 1 intact, hippie 51 318 18 18 1
HASPIN-201 HASPIN Q8TF76 Serine/threonine-protein kinase haspin chr17 Not Cancer Driver No 1 hippie 46 376 13 13 0
HECTD3-202 HECTD3 Q5T447 E3 ubiquitin-protein ligase HECTD3 chr1 Not Cancer Driver No 1 hippie 66 55 3 3 0
HLA-DPB1-211 HLA-DPB1 P04440 HLA class II histocompatibility antigen, DP beta 1 chain chr6 Not Cancer Driver No 1 hippie, biogrid 14 39 4 4 0
HSP90AA1-201 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 hippie 44 258 15 15 0
HSP90AB1-203 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 hippie 70 255 29 29 0
LAD1-202 LAD1 O00515 Ladinin-1 chr1 Not Cancer Driver No 1 hippie, biogrid 75 511 75 75 0
LMBR1L-201 LMBR1L Q6UX01 Protein LMBR1L chr12 Not Cancer Driver No 1 hippie 46 4 0 0 0
LRRC17-202 LRRC17 Q8N6Y2 Leucine-rich repeat-containing protein 17 chr7 Not Cancer Driver No 1 hippie, biogrid 43 90 7 7 0
LYZL1-203 LYZL1 Q6UWQ5 Lysozyme-like protein 1 chr10 Not Cancer Driver No 2 hippie, biogrid 17 0 0 0 0
LYZL2-202 LYZL2 Q7Z4W2 Lysozyme-like protein 2 chr10 Not Cancer Driver No 2 hippie, biogrid 33 0 0 0 0
MALT1-208 MALT1 Q9UDY8 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 chr18 Census, Compendium Yes 1 hippie 55 139 9 9 1
MAPK1-201 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 Census, Compendium Yes 1 hippie 52 2 0 0 6
MAVS-202 MAVS Q7Z434 Mitochondrial antiviral-signaling protein chr20 Not Cancer Driver No 1 hippie 55 415 44 44 0
MRM1-204 MRM1 Q6IN84 rRNA methyltransferase 1, mitochondrial chr17 Not Cancer Driver No 3 hippie, biogrid 27 106 8 8 0
MRM2-201 MRM2 Q9UI43 rRNA methyltransferase 2, mitochondrial chr7 Not Cancer Driver No 1 hippie 33 15 1 1 1
MRPL30-201 MRPL30 Q8TCC3 Large ribosomal subunit protein uL30m chr2 Not Cancer Driver No 1 hippie, biogrid 20 76 8 8 0
MRPS24-201 MRPS24 Q96EL2 Small ribosomal subunit protein uS3m chr7 Not Cancer Driver No 2 hippie, biogrid 16 2 0 0 0
MRPS26-201 MRPS26 Q9BYN8 Small ribosomal subunit protein mS26 chr20 Not Cancer Driver No 1 hippie, biogrid 12 102 4 4 0
MRPS34-202 MRPS34 P82930 Small ribosomal subunit protein mS34 chr16 Not Cancer Driver No 2 hippie, biogrid 9 56 2 2 1
MRPS7-201 MRPS7 Q9Y2R9 Small ribosomal subunit protein uS7m chr17 Not Cancer Driver No 1 hippie, biogrid 28 26 1 1 1
MRPS9-201 MRPS9 P82933 Small ribosomal subunit protein uS9m chr2 Not Cancer Driver No 1 hippie, biogrid 39 75 5 5 0
NCAPH-201 NCAPH Q15003 Condensin complex subunit 2 chr2 Not Cancer Driver No 1 hippie 73 465 45 45 1
NKAP-201 NKAP Q8N5F7 NF-kappa-B-activating protein chrX Not Cancer Driver No 1 hippie, biogrid 58 409 57 57 2
NR3C1-203 NR3C1 P04150 Glucocorticoid receptor chr5 Not Cancer Driver No 1 hippie 55 364 20 20 11
NTRK1-206 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 133 57 8 8 23
OVOL2-201 OVOL2 Q9BRP0 Transcription factor Ovo-like 2 chr20 Not Cancer Driver No 1 hippie, biogrid 28 141 5 5 0
PARD6B-201 PARD6B Q9BYG5 Partitioning defective 6 homolog beta chr20 Not Cancer Driver No 3 hippie, biogrid 41 166 18 18 0
PATE1-201 PATE1 Q8WXA2 Prostate and testis expressed protein 1 chr11 Not Cancer Driver No 1 hippie, biogrid 23 0 0 0 0
PCBP3-222 PCBP3 P57721 Poly(rC)-binding protein 3 chr21 Not Cancer Driver No 1 hippie, biogrid 52 232 38 38 0
PLA2G2D-201 PLA2G2D Q9UNK4 Group IID secretory phospholipase A2 chr1 Not Cancer Driver No 1 hippie, biogrid 24 0 0 0 0
PLEKHA4-201 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 115 690 110 110 0
POGLUT1-201 POGLUT1 Q8NBL1 Protein O-glucosyltransferase 1 chr3 Not Cancer Driver No 2 hippie, biogrid 44 0 0 0 3
PPL-201 PPL O60437 Periplakin chr16 Not Cancer Driver No 1 hippie 160 1143 100 100 0
PRR27-201 PRR27 Q6MZM9 Proline-rich protein 27 chr4 Not Cancer Driver No 1 hippie, biogrid 19 115 4 4 0
RBFA-202 RBFA Q8N0V3 Putative ribosome-binding factor A, mitochondrial chr18 Not Cancer Driver No 2 hippie, biogrid 34 161 18 18 0
RPL3-201 RPL3 P39023 Large ribosomal subunit protein uL3 chr22 Not Cancer Driver No 1 hippie, biogrid 28 80 4 4 0
RPS4X-201 RPS4X P62701 Small ribosomal subunit protein eS4, X isoform chrX Not Cancer Driver No 3 hippie, biogrid 27 35 6 6 0
RPS4Y1-201 RPS4Y1 P22090 Small ribosomal subunit protein eS4, Y isoform 1 chrY Not Cancer Driver No 1 hippie, biogrid 9 34 0 0 0
RSPO1-201 RSPO1 Q2MKA7 R-spondin-1 chr1 Not Cancer Driver No 3 hippie, biogrid 46 82 10 10 0
SCCPDH-201 SCCPDH Q8NBX0 Saccharopine dehydrogenase-like oxidoreductase chr1 Not Cancer Driver No 2 hippie, biogrid 50 26 1 1 0
SERPINA5-201 SERPINA5 P05154 Plasma serine protease inhibitor chr14 Not Cancer Driver No 2 hippie, biogrid 84 25 16 16 0
SLC2A1-203 SLC2A1 P11166 Solute carrier family 2, facilitated glucose transporter member 1 chr1 Not Cancer Driver No 1 hippie 43 13 2 2 44
SLC7A11-201 SLC7A11 Q9UPY5 Cystine/glutamate transporter chr4 Not Cancer Driver No 1 hippie, biogrid 55 15 1 1 0
SMAD2-201 SMAD2 Q15796 Mothers against decapentaplegic homolog 2 chr18 Census, Compendium Yes 1 hippie 58 137 11 11 3
SMAD4-201 SMAD4 Q13485 Mothers against decapentaplegic homolog 4 chr18 Census, Compendium Yes 1 hippie 172 195 16 16 6
SPINK14-201 SPINK14 Q6IE38 Serine protease inhibitor Kazal-type 14 chr5 Not Cancer Driver No 1 hippie, biogrid 9 0 0 0 0
STX8-201 STX8 Q9UNK0 Syntaxin-8 chr17 Not Cancer Driver No 1 hippie 16 99 5 5 0
SULF2-213 SULF2 Q8IWU5 Extracellular sulfatase Sulf-2 chr20 Not Cancer Driver No 1 hippie, biogrid 126 142 16 16 0
TCP1-201 TCP1 P17987 T-complex protein 1 subunit alpha chr6 Not Cancer Driver No 1 hippie, biogrid 34 55 7 7 0
TEFM-205 TEFM Q96QE5 Transcription elongation factor, mitochondrial chr17 Not Cancer Driver No 1 hippie, biogrid 19 26 3 3 0
TIFAB-201 TIFAB Q6ZNK6 TRAF-interacting protein with FHA domain-containing protein B chr5 Not Cancer Driver No 1 hippie 27 26 4 4 0
TIMP3-201 TIMP3 P35625 Metalloproteinase inhibitor 3 chr22 Not Cancer Driver No 1 hippie, biogrid 31 3 0 0 5
TP53-201 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 hippie 2742 282 1364 1364 60
TRAF3-202 TRAF3 Q13114 TNF receptor-associated factor 3 chr14 Compendium Yes 1 hippie 49 101 8 8 1
TRIOBP-211 TRIOBP Q9H2D6 TRIO and F-actin-binding protein chr22 Not Cancer Driver No 1 hippie 278 2194 258 258 1
TRMT10C-201 TRMT10C Q7L0Y3 tRNA methyltransferase 10 homolog C chr3 Not Cancer Driver No 3 hippie, biogrid 37 59 8 8 2
UBE2A-202 UBE2A P49459 Ubiquitin-conjugating enzyme E2 A chrX Compendium Yes 1 hippie 23 67 11 11 2
UBE2C-204 UBE2C O00762 Ubiquitin-conjugating enzyme E2 C chr20 Not Cancer Driver No 1 hippie 13 40 0 0 0
UBE2D2-201 UBE2D2 P62837 Ubiquitin-conjugating enzyme E2 D2 chr5 Compendium Yes 1 hippie 14 13 1 1 0
UBE2D3-210 UBE2D3 P61077 Ubiquitin-conjugating enzyme E2 D3 chr4 Not Cancer Driver No 1 hippie 15 13 3 3 0
UBE2Q2-201 UBE2Q2 Q8WVN8 Ubiquitin-conjugating enzyme E2 Q2 chr15 Not Cancer Driver No 1 hippie 28 122 8 8 0
UBE2S-201 UBE2S Q16763 Ubiquitin-conjugating enzyme E2 S chr19 Not Cancer Driver No 1 hippie 15 102 5 5 0
UBQLN1-202 UBQLN1 Q9UMX0 Ubiquilin-1 chr9 Not Cancer Driver No 1 hippie 40 545 38 38 0
UBXN10-201 UBXN10 Q96LJ8 UBX domain-containing protein 10 chr1 Not Cancer Driver No 1 hippie 39 254 35 35 0
UBXN6-201 UBXN6 Q9BZV1 UBX domain-containing protein 6 chr19 Not Cancer Driver No 1 hippie, biogrid 50 135 21 21 0
VWA8-203 VWA8 A3KMH1 von Willebrand factor A domain-containing protein 8 chr13 Not Cancer Driver No 1 hippie, biogrid 153 384 24 24 0
WFDC10A-201 WFDC10A Q9H1F0 WAP four-disulfide core domain protein 10A chr20 Not Cancer Driver No 2 hippie, biogrid 9 0 0 0 0
WNT9B-201 WNT9B O14905 Protein Wnt-9b chr17 Not Cancer Driver No 3 hippie, biogrid 42 11 6 6 0
ZBBX-205 ZBBX A8MT70 Zinc finger B-box domain-containing protein 1 chr3 Not Cancer Driver No 2 hippie, biogrid 207 469 132 132 0
ZDHHC17-201 ZDHHC17 Q8IUH5 Palmitoyltransferase ZDHHC17 chr12 Not Cancer Driver No 1 hippie 61 50 6 6 0
ZNF317-201 ZNF317 Q96PQ6 Zinc finger protein 317 chr19 Not Cancer Driver No 2 hippie, biogrid 66 204 17 17 0
ZRANB1-201 ZRANB1 Q9UGI0 Ubiquitin thioesterase ZRANB1 chr10 Not Cancer Driver No 1 hippie 65 158 16 16 0
ZZEF1-201 ZZEF1 O43149 Zinc finger ZZ-type and EF-hand domain-containing protein 1 chr17 Not Cancer Driver No 1 hippie 235 583 60 60 0