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IARS2-201 ,IARS2 ,Q9NSE4
  • Number of Interaction partner in intact: 54
  • Number of Interaction partner in biogrid: 150
  • Number of Interaction partner in hippie: 227
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AARS2-201 AARS2 Q5JTZ9 Alanine--tRNA ligase, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 91 203 23 23 5
ACAD9-201 ACAD9 Q9H845 Complex I assembly factor ACAD9, mitochondrial chr3 Not Cancer Driver No 1 hippie, biogrid 54 28 2 2 12
ACSM5-201 ACSM5 Q6NUN0 Acyl-coenzyme A synthetase ACSM5, mitochondrial chr16 Not Cancer Driver No 2 intact, hippie, biogrid 133 87 24 24 0
ACTR3-201 ACTR3 P61158 Actin-related protein 3 chr2 Not Cancer Driver No 1 hippie, biogrid 24 16 2 2 0
AGR2-203 AGR2 O95994 Anterior gradient protein 2 homolog chr7 Not Cancer Driver No 1 hippie 14 20 1 1 1
AIFM1-201 AIFM1 O95831 Apoptosis-inducing factor 1, mitochondrial chrX Not Cancer Driver No 2 intact, hippie, biogrid 61 166 20 20 10
AKAP1-202 AKAP1 Q92667 A-kinase anchor protein 1, mitochondrial chr17 Not Cancer Driver No 1 hippie, biogrid 77 541 50 50 0
ALDH1B1-201 ALDH1B1 P30837 Aldehyde dehydrogenase X, mitochondrial chr9 Not Cancer Driver No 1 hippie, biogrid 74 54 13 13 0
ALDH2-201 ALDH2 P05091 Aldehyde dehydrogenase, mitochondrial chr12 Census Yes 1 hippie, biogrid 43 44 1 1 1
APP-201 APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 94 419 52 52 12
ARF6-201 ARF6 P62330 ADP-ribosylation factor 6 chr14 Not Cancer Driver No 1 hippie, biogrid 16 5 0 0 0
ASB8-201 ASB8 Q9H765 Ankyrin repeat and SOCS box protein 8 chr12 Not Cancer Driver No 2 intact, hippie, biogrid 26 7 0 0 0
ASPM-203 ASPM Q8IZT6 Abnormal spindle-like microcephaly-associated protein chr1 Not Cancer Driver No 2 intact, hippie, biogrid 380 427 47 47 0
ATAD3A-202 ATAD3A Q9NVI7 ATPase family AAA domain-containing protein 3A chr1 Not Cancer Driver No 1 intact, hippie 49 275 16 16 2
ATG12-208 ATG12 O94817 Ubiquitin-like protein ATG12 chr5 Not Cancer Driver No 1 hippie, biogrid 13 61 6 6 0
AUH-202 AUH Q13825 Methylglutaconyl-CoA hydratase, mitochondrial chr9 Not Cancer Driver No 1 hippie, biogrid 28 29 0 0 1
AURKAIP1-202 AURKAIP1 Q9NWT8 Small ribosomal subunit protein mS38 chr1 Not Cancer Driver No 1 hippie 17 104 8 8 0
BBS1-201 BBS1 Q8NFJ9 Bardet-Biedl syndrome 1 protein chr11 Not Cancer Driver No 2 intact, hippie, biogrid 52 100 9 9 11
BCL2L14-203 BCL2L14 Q9BZR8 Apoptosis facilitator Bcl-2-like protein 14 chr12 Not Cancer Driver No 1 hippie 20 40 4 4 0
BIRC3-201 BIRC3 Q13489 Baculoviral IAP repeat-containing protein 3 chr11 Census, Compendium Yes 1 hippie 53 98 10 10 0
C17orf80-205 C17orf80 Q9BSJ5 Uncharacterized protein C17orf80 chr17 Not Cancer Driver No 1 hippie, biogrid 44 458 37 37 0
C1QBP-201 C1QBP Q07021 Complement component 1 Q subcomponent-binding protein, mitochondrial chr17 Not Cancer Driver No 1 hippie, biogrid 14 103 5 5 2
C8orf82-202 C8orf82 Q6P1X6 UPF0598 protein C8orf82 chr8 Not Cancer Driver No 1 hippie, biogrid 9 11 0 0 0
CALU-201 CALU O43852 Calumenin chr7 Not Cancer Driver No 1 hippie, biogrid 15 130 9 9 0
CAPNS1-201 CAPNS1 P04632 Calpain small subunit 1 chr19 Not Cancer Driver No 1 hippie, biogrid 21 59 5 5 0
CCDC90B-214 CCDC90B Q9GZT6 Coiled-coil domain-containing protein 90B, mitochondrial chr11 Not Cancer Driver No 1 hippie, biogrid 23 77 4 4 0
CDH2-201 CDH2 P19022 Cadherin-2 chr18 Not Cancer Driver No 1 hippie, biogrid 182 464 107 107 7
CELF5-201 CELF5 Q8N6W0 CUGBP Elav-like family member 5 chr19 Not Cancer Driver No 2 intact, hippie, biogrid 34 166 15 15 0
CFTR-201 CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 Not Cancer Driver No 1 intact 216 145 9 9 130
CHCHD1-201 CHCHD1 Q96BP2 Small ribosomal subunit protein mS37 chr10 Not Cancer Driver No 1 hippie, biogrid 8 67 6 6 0
CHMP4C-201 CHMP4C Q96CF2 Charged multivesicular body protein 4c chr8 Not Cancer Driver No 1 hippie 33 226 31 31 0
CHORDC1-201 CHORDC1 Q9UHD1 Cysteine and histidine-rich domain-containing protein 1 chr11 Not Cancer Driver No 1 hippie 37 119 12 12 0
CHP1-201 CHP1 Q99653 Calcineurin B homologous protein 1 chr15 Not Cancer Driver No 1 intact 22 70 13 13 0
CLIP1-219 CLIP1 P30622 CAP-Gly domain-containing linker protein 1 chr12 Census, Compendium Yes 1 hippie, biogrid 98 1200 72 72 0
CLPB-201 CLPB Q9H078 Mitochondrial disaggregase chr11 Not Cancer Driver No 1 hippie, biogrid 54 224 22 22 20
CLPP-201 CLPP Q16740 ATP-dependent Clp protease proteolytic subunit, mitochondrial chr19 Not Cancer Driver No 1 hippie 15 83 7 7 3
COX14-203 COX14 Q96I36 Cytochrome c oxidase assembly protein COX14 chr12 Not Cancer Driver No 1 intact, hippie 4 7 0 0 1
COX15-201 COX15 Q7KZN9 Cytochrome c oxidase assembly protein COX15 homolog chr10 Not Cancer Driver No 1 hippie, biogrid 33 0 0 0 2
COX4I1-201 COX4I1 P13073 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial chr16 Not Cancer Driver No 2 intact, hippie, biogrid 13 5 1 1 1
COX8A-201 COX8A P10176 Cytochrome c oxidase subunit 8A, mitochondrial chr11 Not Cancer Driver No 1 hippie, biogrid 10 1 0 0 0
CRYZ-201 CRYZ Q08257 Quinone oxidoreductase chr1 Not Cancer Driver No 1 hippie, biogrid 35 0 0 0 0
CS-201 CS O75390 Citrate synthase, mitochondrial chr12 Not Cancer Driver No 2 hippie, biogrid 38 13 2 2 0
DCTN2-209 DCTN2 Q13561 Dynactin subunit 2 chr12 Not Cancer Driver No 1 hippie, biogrid 34 254 23 23 0
DDX11-229 DDX11 Q96FC9 ATP-dependent DNA helicase DDX11 chr12 Not Cancer Driver No 2 intact, hippie, biogrid 95 282 32 32 1
DERL1-201 DERL1 Q9BUN8 Derlin-1 chr8 Not Cancer Driver No 1 hippie, biogrid 17 12 0 0 0
DHX30-205 DHX30 Q7L2E3 ATP-dependent RNA helicase DHX30 chr3 Not Cancer Driver No 1 hippie, biogrid 107 260 29 29 5
DHX40-201 DHX40 Q8IX18 Probable ATP-dependent RNA helicase DHX40 chr17 Not Cancer Driver No 2 intact, hippie, biogrid 64 167 17 17 0
DIABLO-207 DIABLO Q9NR28 Diablo IAP-binding mitochondrial protein chr12 Not Cancer Driver No 2 hippie, biogrid 20 54 2 2 1
DNA2-201 DNA2 P51530 DNA replication ATP-dependent helicase/nuclease DNA2 chr10 Not Cancer Driver No 1 hippie, biogrid 72 52 4 4 3
DNAJA2-201 DNAJA2 O60884 DnaJ homolog subfamily A member 2 chr16 Not Cancer Driver No 1 hippie, biogrid 34 174 18 18 0
DNAJA3-201 DNAJA3 Q96EY1 DnaJ homolog subfamily A member 3, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 44 152 19 19 0
DNAJC15-201 DNAJC15 Q9Y5T4 DnaJ homolog subfamily C member 15 chr13 Not Cancer Driver No 1 hippie, biogrid 15 25 2 2 0
DNAJC19-201 DNAJC19 Q96DA6 Mitochondrial import inner membrane translocase subunit TIM14 chr3 Not Cancer Driver No 1 hippie, biogrid 14 27 3 3 0
DNAJC28-202 DNAJC28 Q9NX36 DnaJ homolog subfamily C member 28 chr21 Not Cancer Driver No 1 hippie, biogrid 37 139 7 7 0
DNAJC30-201 DNAJC30 Q96LL9 DnaJ homolog subfamily C member 30, mitochondrial chr7 Not Cancer Driver No 1 hippie, biogrid 13 83 3 3 3
DNAJC4-212 DNAJC4 Q9NNZ3 DnaJ homolog subfamily C member 4 chr11 Not Cancer Driver No 1 hippie, biogrid 15 180 11 11 0
DNAJC7-203 DNAJC7 Q99615 DnaJ homolog subfamily C member 7 chr17 Not Cancer Driver No 1 hippie, biogrid 26 102 8 8 0
DRG2-201 DRG2 P55039 Developmentally-regulated GTP-binding protein 2 chr17 Not Cancer Driver No 1 hippie, biogrid 31 11 0 0 0
ECSIT-202 ECSIT Q9BQ95 Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial chr19 Not Cancer Driver No 1 hippie 50 146 25 25 0
ENST00000419755 BBS1 Q8NFJ9 Bardet-Biedl syndrome 1 protein chr11 Not Cancer Driver No 2 intact, hippie, biogrid 52 132 7 7 11
EPHA4-201 EPHA4 P54764 Ephrin type-A receptor 4 chr2 Not Cancer Driver No 2 intact, hippie, biogrid 132 141 16 16 0
EPHA7-202 EPHA7 Q15375 Ephrin type-A receptor 7 chr6 Census, Compendium Yes 1 intact, hippie, biogrid 226 71 10 10 0
ERCC6-201 ERCC6 Q03468 DNA excision repair protein ERCC-6 chr10 Not Cancer Driver No 1 hippie 142 837 82 82 9
ESPL1-201 ESPL1 Q14674 Separin chr12 Not Cancer Driver No 2 intact, hippie, biogrid 172 383 27 27 0
EXD2-214 EXD2 Q9NVH0 Exonuclease 3'-5' domain-containing protein 2 chr14 Not Cancer Driver No 1 hippie, biogrid 47 178 12 12 0
FANCA-202 FANCA O15360 Fanconi anemia group A protein chr16 Census, Compendium Yes 1 intact, hippie, biogrid 121 157 13 13 26
FASTKD2-202 FASTKD2 Q9NYY8 FAST kinase domain-containing protein 2, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 49 30 2 2 0
FASTKD3-201 FASTKD3 Q14CZ7 FAST kinase domain-containing protein 3, mitochondrial chr5 Not Cancer Driver No 2 intact, hippie, biogrid 83 6 1 1 0
FASTKD5-201 FASTKD5 Q7L8L6 FAST kinase domain-containing protein 5, mitochondrial chr20 Not Cancer Driver No 1 hippie, biogrid 58 94 3 3 0
FGFR3-205 FGFR3 P22607 Fibroblast growth factor receptor 3 chr4 Census, Compendium Yes 1 intact, biogrid 134 241 18 18 32
FH-201 FH P07954 Fumarate hydratase, mitochondrial chr1 Census, Compendium Yes 1 hippie, biogrid 54 76 4 4 13
FHIP2B-201 FHIP2B Q86V87 FHF complex subunit HOOK-interacting protein 2B chr8 Not Cancer Driver No 1 intact 46 140 10 10 0
FLOT1-201 FLOT1 O75955 Flotillin-1 chr6 Not Cancer Driver No 1 hippie, biogrid 31 122 10 10 0
FOXM1-202 FOXM1 Q08050 Forkhead box protein M1 chr12 Not Cancer Driver No 1 hippie 73 605 57 57 0
FOXS1-201 FOXS1 O43638 Forkhead box protein S1 chr20 Not Cancer Driver No 1 hippie 51 229 34 34 0
GAK-201 GAK O14976 Cyclin-G-associated kinase chr4 Not Cancer Driver No 2 intact, hippie, biogrid 110 592 57 57 0
GBF1-223 GBF1 Q92538 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 chr10 Not Cancer Driver No 1 hippie 161 670 62 62 0
GFAP-214 GFAP P14136 Glial fibrillary acidic protein chr17 Not Cancer Driver No 1 hippie, biogrid 45 290 27 27 41
GFM1-210 GFM1 Q96RP9 Elongation factor G, mitochondrial chr3 Not Cancer Driver No 1 hippie, biogrid 49 79 5 5 4
GFM2-201 GFM2 Q969S9 Ribosome-releasing factor 2, mitochondrial chr5 Not Cancer Driver No 1 hippie, biogrid 61 100 6 6 2
GJA1-201 GJA1 P17302 Gap junction alpha-1 protein chr6 Not Cancer Driver No 1 hippie, biogrid 62 111 20 20 43
GRPEL1-201 GRPEL1 Q9HAV7 GrpE protein homolog 1, mitochondrial chr4 Not Cancer Driver No 1 hippie, biogrid 13 88 5 5 0
GRSF1-201 GRSF1 Q12849 G-rich sequence factor 1 chr4 Not Cancer Driver No 2 hippie, biogrid 33 147 15 15 0
GSK3B-201 GSK3B P49841 Glycogen synthase kinase-3 beta chr3 Not Cancer Driver No 1 hippie 34 148 6 6 0
HINT2-201 HINT2 Q9BX68 Adenosine 5'-monophosphoramidase HINT2 chr9 Not Cancer Driver No 1 hippie, biogrid 6 29 1 1 0
HLA-B-249 HLA-B P01889 HLA class I histocompatibility antigen, B alpha chain chr6 Compendium Yes 1 hippie 49 169 18 18 0
HNRNPH1-203 HNRNPH1 P31943 Heterogeneous nuclear ribonucleoprotein H chr5 Not Cancer Driver No 1 hippie, biogrid 44 169 20 20 1
HNRNPH2-201 HNRNPH2 P55795 Heterogeneous nuclear ribonucleoprotein H2 chrX Not Cancer Driver No 1 hippie, biogrid 47 168 21 21 2
HNRNPH3-201 HNRNPH3 P31942 Heterogeneous nuclear ribonucleoprotein H3 chr10 Not Cancer Driver No 1 hippie, biogrid 10 188 3 3 0
HOOK3-201 HOOK3 Q86VS8 Protein Hook homolog 3 chr8 Census Yes 1 hippie 65 493 44 44 0
HSCB-201 HSCB Q8IWL3 Iron-sulfur cluster co-chaperone protein HscB chr22 Not Cancer Driver No 2 intact, hippie, biogrid 23 25 3 3 0
HSD17B11-201 HSD17B11 Q8NBQ5 Estradiol 17-beta-dehydrogenase 11 chr4 Not Cancer Driver No 1 hippie, biogrid 23 2 0 0 0
HSFX1-201 HSFX2 Q9UBD0 Heat shock transcription factor, X-linked chrX Not Cancer Driver No 1 hippie 0 262 0 0 0
HSFX2-201 HSFX2 Q9UBD0 Heat shock transcription factor, X-linked chrX Not Cancer Driver No 1 hippie 0 262 0 0 0
HSP90AA1-201 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 hippie 44 258 15 15 0
HSP90AB1-203 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 intact, hippie 70 255 29 29 0
HSPA9-201 HSPA9 P38646 Stress-70 protein, mitochondrial chr5 Not Cancer Driver No 1 hippie, biogrid 47 284 19 19 2
HSPB1-201 HSPB1 P04792 Heat shock protein beta-1 chr7 Not Cancer Driver No 1 intact, hippie 10 118 8 8 19
HSPD1-202 HSPD1 P10809 60 kDa heat shock protein, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 45 83 1 1 2
HTRA2-201 HTRA2 O43464 Serine protease HTRA2, mitochondrial chr2 Compendium Yes 1 hippie 33 127 7 7 2
HYAL4-201 HYAL4 Q2M3T9 Hyaluronidase-4 chr7 Not Cancer Driver No 1 hippie, biogrid 80 0 0 0 0
IFT122-203 IFT122 Q9HBG6 Intraflagellar transport protein 122 homolog chr3 Not Cancer Driver No 1 hippie, biogrid 108 54 5 5 5
ILF2-201 ILF2 Q12905 Interleukin enhancer-binding factor 2 chr1 Not Cancer Driver No 1 hippie, biogrid 24 92 2 2 0
ILF3-218 ILF3 Q12906 Interleukin enhancer-binding factor 3 chr19 Not Cancer Driver No 1 hippie, biogrid 57 676 39 39 0
IMMP1L-209 IMMP1L Q96LU5 Mitochondrial inner membrane protease subunit 1 chr11 Not Cancer Driver No 1 hippie 15 3 0 0 0
IMMP2L-202 IMMP2L Q96T52 Mitochondrial inner membrane protease subunit 2 chr7 Not Cancer Driver No 1 hippie 32 29 6 6 0
INS-202 INS P01308 Insulin chr11 Not Cancer Driver No 1 hippie 7 5 1 1 19
IRF2-201 IRF2 P14316 Interferon regulatory factor 2 chr4 Not Cancer Driver No 1 intact, hippie 60 290 52 52 0
ITM2B-204 ITM2B Q9Y287 Integral membrane protein 2B chr13 Not Cancer Driver No 1 intact 15 12 0 0 1
JUP-203 JUP P14923 Junction plakoglobin chr17 Not Cancer Driver No 1 hippie, biogrid 81 242 24 24 0
KIF14-201 KIF14 Q15058 Kinesin-like protein KIF14 chr1 Not Cancer Driver No 1 hippie 145 777 65 65 2
KLC4-202 KLC4 Q9NSK0 Kinesin light chain 4 chr6 Not Cancer Driver No 1 hippie 62 387 38 38 0
LACTB-201 LACTB P83111 Serine beta-lactamase-like protein LACTB, mitochondrial chr15 Not Cancer Driver No 1 intact, hippie 29 123 2 2 0
LAMTOR1-201 LAMTOR1 Q6IAA8 Ragulator complex protein LAMTOR1 chr11 Not Cancer Driver No 1 hippie, biogrid 10 96 6 6 0
LONP1-201 LONP1 P36776 Lon protease homolog, mitochondrial chr19 Not Cancer Driver No 1 hippie, biogrid 75 178 16 16 10
LRPPRC-201 LRPPRC P42704 Leucine-rich PPR motif-containing protein, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 99 18 0 0 1
LRRK2-201 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 402 91 13 13 20
LZTS2-205 LZTS2 Q9BRK4 Leucine zipper putative tumor suppressor 2 chr10 Not Cancer Driver No 1 hippie 63 511 51 51 0
MALSU1-202 MALSU1 Q96EH3 Mitochondrial assembly of ribosomal large subunit protein 1 chr7 Not Cancer Driver No 1 hippie, biogrid 17 34 1 1 0
MAPRE3-201 MAPRE3 Q9UPY8 Microtubule-associated protein RP/EB family member 3 chr2 Not Cancer Driver No 1 hippie, biogrid 24 120 11 11 0
MATR3-201 MATR3 P43243 Matrin-3 chr5 Not Cancer Driver No 1 hippie, biogrid 81 613 61 61 3
MBNL1-201 MBNL1 Q9NR56 Muscleblind-like protein 1 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 39 154 14 14 0
MCU-202 MCU Q8NE86 Calcium uniporter protein, mitochondrial chr10 Not Cancer Driver No 1 hippie, biogrid 25 13 0 0 0
MCUB-201 MCUB Q9NWR8 Calcium uniporter regulatory subunit MCUb, mitochondrial chr4 Not Cancer Driver No 1 hippie 22 24 0 0 0
MCUR1-201 MCUR1 Q96AQ8 Mitochondrial calcium uniporter regulator 1 chr6 Not Cancer Driver No 1 hippie, biogrid 22 66 0 0 0
MDH2-201 MDH2 P40926 Malate dehydrogenase, mitochondrial chr7 Not Cancer Driver No 1 hippie, biogrid 26 8 1 1 3
METTL15-204 METTL15 A6NJ78 12S rRNA N4-methylcytidine (m4C) methyltransferase chr11 Not Cancer Driver No 1 hippie, biogrid 35 92 11 11 0
METTL17-201 METTL17 Q9H7H0 Methyltransferase-like protein 17, mitochondrial chr14 Not Cancer Driver No 1 hippie, biogrid 48 95 10 10 0
MGST3-205 MGST3 O14880 Glutathione S-transferase 3, mitochondrial chr1 Not Cancer Driver No 1 intact, hippie 17 0 0 0 0
MRM1-204 MRM1 Q6IN84 rRNA methyltransferase 1, mitochondrial chr17 Not Cancer Driver No 1 hippie 27 106 8 8 0
MRPL11-201 MRPL11 Q9Y3B7 Large ribosomal subunit protein uL11m chr11 Not Cancer Driver No 1 hippie, biogrid 20 12 2 2 0
MRPL21-201 MRPL21 Q7Z2W9 Large ribosomal subunit protein bL21m chr11 Not Cancer Driver No 2 intact, hippie, biogrid 20 20 0 0 0
MRPL58-201 MRPL58 Q14197 Large ribosomal subunit protein mL62 chr17 Not Cancer Driver No 1 hippie 26 106 11 11 0
MRPS12-201 MRPS12 O15235 Small ribosomal subunit protein uS12m chr19 Not Cancer Driver No 1 hippie, biogrid 14 59 8 8 0
MRPS26-201 MRPS26 Q9BYN8 Small ribosomal subunit protein mS26 chr20 Not Cancer Driver No 1 hippie, biogrid 12 102 4 4 0
MRRF-202 MRRF Q96E11 Ribosome-recycling factor, mitochondrial chr9 Not Cancer Driver No 1 hippie, biogrid 13 118 6 6 0
MTERF3-201 MTERF3 Q96E29 Transcription termination factor 3, mitochondrial chr8 Not Cancer Driver No 1 hippie, biogrid 35 62 4 4 0
MTFMT-201 MTFMT Q96DP5 Methionyl-tRNA formyltransferase, mitochondrial chr15 Not Cancer Driver No 1 hippie, biogrid 29 56 3 3 3
MTG1-201 MTG1 Q9BT17 Mitochondrial ribosome-associated GTPase 1 chr10 Not Cancer Driver No 1 hippie, biogrid 29 16 2 2 0
MTG2-201 MTG2 Q9H4K7 Mitochondrial ribosome-associated GTPase 2 chr20 Not Cancer Driver No 1 hippie, biogrid 43 48 7 7 0
MTHFD1-220 MTHFD1 P11586 C-1-tetrahydrofolate synthase, cytoplasmic chr14 Not Cancer Driver No 1 hippie, biogrid 78 129 11 11 6
MTIF2-201 MTIF2 P46199 Translation initiation factor IF-2, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 71 114 7 7 0
MTIF3-202 MTIF3 Q9H2K0 Translation initiation factor IF-3, mitochondrial chr13 Not Cancer Driver No 1 hippie, biogrid 15 180 11 11 0
MTO1-201 MTO1 Q9Y2Z2 Protein MTO1 homolog, mitochondrial chr6 Not Cancer Driver No 2 hippie, biogrid 51 61 2 2 1
MTRF1-203 MTRF1 O75570 Peptide chain release factor 1, mitochondrial chr13 Not Cancer Driver No 1 hippie, biogrid 33 72 4 4 0
MTRF1L-203 MTRF1L Q9UGC7 Peptide chain release factor 1-like, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 17 185 5 5 0
NAA38-205 NAA38 Q9BRA0 N-alpha-acetyltransferase 38, NatC auxiliary subunit chr17 Not Cancer Driver No 1 hippie, biogrid 7 79 2 2 0
NAA40-202 NAA40 Q86UY6 N-alpha-acetyltransferase 40 chr11 Not Cancer Driver No 1 hippie 16 31 1 1 0
NDUFS7-201 NDUFS7 O75251 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial chr19 Not Cancer Driver No 2 hippie, biogrid 30 31 2 2 1
NEDD8-201 NEDD8 Q15843 NEDD8 chr14 Not Cancer Driver No 1 hippie 9 36 4 4 0
NEURL4-202 NEURL4 Q96JN8 Neuralized-like protein 4 chr17 Not Cancer Driver No 1 intact, hippie 145 753 83 83 0
NGRN-202 NGRN Q9NPE2 Neugrin chr15 Not Cancer Driver No 1 hippie, biogrid 16 216 14 14 0
NT5C3A-209 NT5C3A Q9H0P0 Cytosolic 5'-nucleotidase 3A chr7 Compendium Yes 1 intact, hippie 26 0 0 0 8
NTRK1-206 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 133 57 8 8 23
OMA1-201 OMA1 Q96E52 Metalloendopeptidase OMA1, mitochondrial chr1 Not Cancer Driver No 1 intact, hippie 39 35 3 3 0
OPA3-201 OPA3 Q9H6K4 Optic atrophy 3 protein chr19 Not Cancer Driver No 1 intact, hippie 3 44 0 0 2
OTC-201 OTC P00480 Ornithine transcarbamylase, mitochondrial chrX Not Cancer Driver No 1 hippie, biogrid 53 24 3 3 92
PAFAH2-201 PAFAH2 Q99487 Platelet-activating factor acetylhydrolase 2, cytoplasmic chr1 Not Cancer Driver No 1 hippie, biogrid 45 41 4 4 0
PANX1-201 PANX1 Q96RD7 Pannexin-1 chr11 Not Cancer Driver No 1 hippie, biogrid 40 45 5 5 2
PARD6B-201 PARD6B Q9BYG5 Partitioning defective 6 homolog beta chr20 Not Cancer Driver No 1 intact, hippie 41 166 18 18 0
PARL-202 PARL Q9H300 Presenilin-associated rhomboid-like protein, mitochondrial chr3 Not Cancer Driver No 1 intact, hippie 38 28 5 5 0
PDHA1-205 PDHA1 P08559 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial chrX Not Cancer Driver No 1 hippie, biogrid 40 43 4 4 19
PDK1-201 PDK1 Q15118 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 32 49 7 7 0
PEX3-201 PEX3 P56589 Peroxisomal biogenesis factor 3 chr6 Not Cancer Driver No 1 hippie, biogrid 18 24 0 0 2
PFDN4-201 PFDN4 Q9NQP4 Prefoldin subunit 4 chr20 Not Cancer Driver No 1 hippie, biogrid 13 41 3 3 0
PFDN5-202 PFDN5 Q99471 Prefoldin subunit 5 chr12 Not Cancer Driver No 1 hippie, biogrid 16 3 0 0 0
PHB2-203 PHB2 Q99623 Prohibitin-2 chr12 Not Cancer Driver No 1 hippie, biogrid 25 26 4 4 0
PINK1-201 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 Not Cancer Driver No 1 hippie 46 99 8 8 24
PLEKHA4-201 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 115 690 110 110 0
PLGRKT-201 PLGRKT Q9HBL7 Plasminogen receptor (KT) chr9 Not Cancer Driver No 1 intact, hippie 11 0 0 0 0
PMPCA-201 PMPCA Q10713 Mitochondrial-processing peptidase subunit alpha chr9 Not Cancer Driver No 1 hippie, biogrid 48 23 3 3 4
PMPCB-201 PMPCB O75439 Mitochondrial-processing peptidase subunit beta chr7 Not Cancer Driver No 1 hippie, biogrid 36 22 2 2 4
POC5-202 POC5 Q8NA72 Centrosomal protein POC5 chr5 Not Cancer Driver No 1 hippie 35 356 26 26 0
PPT2-244 PPT2 Q9UMR5 Lysosomal thioesterase PPT2 chr6 Compendium Yes 1 hippie, biogrid 31 0 0 0 0
PRPH-201 PRPH P41219 Peripherin chr12 Not Cancer Driver No 1 hippie, biogrid 37 242 20 20 0
PTRH2-201 PTRH2 Q9Y3E5 Peptidyl-tRNA hydrolase 2, mitochondrial chr17 Not Cancer Driver No 1 hippie 7 19 1 1 1
QPRT-202 QPRT Q15274 Nicotinate-nucleotide pyrophosphorylase [carboxylating] chr16 Not Cancer Driver No 1 hippie, biogrid 23 7 1 1 0
RAD23A-203 RAD23A P54725 UV excision repair protein RAD23 homolog A chr19 Not Cancer Driver No 1 hippie, biogrid 41 284 34 34 0
RAF1-201 RAF1 P04049 RAF proto-oncogene serine/threonine-protein kinase chr3 Census, Compendium Yes 1 intact, hippie 64 169 30 30 18
RBM47-201 RBM47 A0AV96 RNA-binding protein 47 chr4 Not Cancer Driver No 1 hippie 113 131 25 25 0
RHOG-201 RHOG P84095 Rho-related GTP-binding protein RhoG chr11 Not Cancer Driver No 1 hippie 20 22 3 3 0
RMND1-202 RMND1 Q9NWS8 Required for meiotic nuclear division protein 1 homolog chr6 Not Cancer Driver No 1 hippie, biogrid 34 85 7 7 1
RNASEH2A-201 RNASEH2A O75792 Ribonuclease H2 subunit A chr19 Not Cancer Driver No 1 intact, hippie 29 31 1 1 7
RNF126-201 RNF126 Q9BV68 E3 ubiquitin-protein ligase RNF126 chr19 Not Cancer Driver No 1 hippie 28 184 19 19 0
RPUSD3-201 RPUSD3 Q6P087 Mitochondrial mRNA pseudouridine synthase RPUSD3 chr3 Not Cancer Driver No 1 hippie, biogrid 26 81 5 5 0
RPUSD4-201 RPUSD4 Q96CM3 Pseudouridylate synthase RPUSD4, mitochondrial chr11 Not Cancer Driver No 1 hippie, biogrid 44 98 15 15 0
SCO1-201 SCO1 O75880 Protein SCO1 homolog, mitochondrial chr17 Not Cancer Driver No 1 intact, hippie 27 79 6 6 1
SFXN1-201 SFXN1 Q9H9B4 Sideroflexin-1 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 21 29 0 0 0
SIRT4-201 SIRT4 Q9Y6E7 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial chr12 Not Cancer Driver No 1 hippie 31 4 0 0 0
SIRT7-201 SIRT7 Q9NRC8 NAD-dependent protein deacetylase sirtuin-7 chr17 Not Cancer Driver No 1 hippie 34 163 10 10 0
SLIRP-209 SLIRP Q9GZT3 SRA stem-loop-interacting RNA-binding protein, mitochondrial chr14 Not Cancer Driver No 1 hippie, biogrid 2 41 0 0 0
SMG8-201 SMG8 Q8ND04 Nonsense-mediated mRNA decay factor SMG8 chr17 Not Cancer Driver No 2 intact, hippie, biogrid 110 415 45 45 1
SNRPA-201 SNRPA P09012 U1 small nuclear ribonucleoprotein A chr19 Not Cancer Driver No 1 intact, hippie 37 165 22 22 0
SOCS6-201 SOCS6 O14544 Suppressor of cytokine signaling 6 chr18 Not Cancer Driver No 1 hippie 65 302 44 44 0
SPRTN-202 SPRTN Q9H040 DNA-dependent metalloprotease SPRTN chr1 Not Cancer Driver No 1 hippie 53 254 26 26 1
SQSTM1-202 SQSTM1 Q13501 Sequestosome-1 chr5 Not Cancer Driver No 1 hippie, biogrid 41 271 24 24 30
SSBP1-201 SSBP1 Q04837 Single-stranded DNA-binding protein, mitochondrial chr7 Not Cancer Driver No 1 hippie, biogrid 20 0 0 0 6
STAT2-201 STAT2 P52630 Signal transducer and activator of transcription 2 chr12 Not Cancer Driver No 2 hippie, biogrid 60 178 17 17 1
STK11-201 STK11 Q15831 Serine/threonine-protein kinase STK11 chr19 Census, Compendium Yes 1 intact 63 135 12 12 9
SUMO1-203 SUMO1 P63165 Small ubiquitin-related modifier 1 chr2 Not Cancer Driver No 1 hippie 10 76 7 7 0
SUMO2-202 SUMO2 P61956 Small ubiquitin-related modifier 2 chr17 Not Cancer Driver No 1 hippie 8 70 6 6 0
SUMO3-201 SUMO3 P55854 Small ubiquitin-related modifier 3 chr21 Not Cancer Driver No 1 hippie 6 86 4 4 0
SURF1-201 SURF1 Q15526 Surfeit locus protein 1 chr9 Not Cancer Driver No 1 hippie, biogrid 14 82 5 5 9
TACO1-201 TACO1 Q9BSH4 Translational activator of cytochrome c oxidase 1 chr17 Not Cancer Driver No 1 hippie, biogrid 20 111 2 2 0
TBRG4-201 TBRG4 Q969Z0 FAST kinase domain-containing protein 4 chr7 Not Cancer Driver No 1 hippie, biogrid 56 61 1 1 0
TEFM-205 TEFM Q96QE5 Transcription elongation factor, mitochondrial chr17 Not Cancer Driver No 1 hippie, biogrid 19 26 3 3 0
TFAM-204 TFAM Q00059 Transcription factor A, mitochondrial chr10 Not Cancer Driver No 1 hippie, biogrid 19 110 11 11 1
TMEM25-201 TMEM25 Q86YD3 Transmembrane protein 25 chr11 Not Cancer Driver No 3 intact, hippie, biogrid 29 129 8 8 0
TMEM70-201 TMEM70 Q9BUB7 Transmembrane protein 70, mitochondrial chr8 Not Cancer Driver No 2 intact, hippie, biogrid 17 24 1 1 1
TNFRSF10A-201 TNFRSF10A O00220 Tumor necrosis factor receptor superfamily member 10A chr8 Not Cancer Driver No 1 hippie 39 175 14 14 0
TOMM20-201 TOMM20 Q15388 Mitochondrial import receptor subunit TOM20 homolog chr1 Not Cancer Driver No 1 hippie 6 25 0 0 0
TP53-201 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 hippie 2742 282 1364 1364 60
TRAP1-201 TRAP1 Q12931 Heat shock protein 75 kDa, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 51 110 6 6 0
TRIM28-201 TRIM28 Q13263 Transcription intermediary factor 1-beta chr19 Not Cancer Driver No 1 hippie 67 431 32 32 0
TRMT61B-201 TRMT61B Q9BVS5 tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 40 124 11 11 0
TRUB2-201 TRUB2 O95900 Pseudouridylate synthase TRUB2, mitochondrial chr9 Not Cancer Driver No 1 hippie, biogrid 28 73 6 6 0
TSFM-212 TSFM P43897 Elongation factor Ts, mitochondrial chr12 Not Cancer Driver No 1 hippie, biogrid 21 74 4 4 2
TUFM-201 TUFM P49411 Elongation factor Tu, mitochondrial chr16 Not Cancer Driver No 2 hippie, biogrid 36 51 4 4 1
UBA1-201 UBA1 P22314 Ubiquitin-like modifier-activating enzyme 1 chrX Not Cancer Driver No 1 hippie, biogrid 82 166 14 14 4
UFL1-201 UFL1 O94874 E3 UFM1-protein ligase 1 chr6 Not Cancer Driver No 1 hippie 77 141 19 19 0
UGGT1-201 UGGT1 Q9NYU2 UDP-glucose:glycoprotein glucosyltransferase 1 chr2 Not Cancer Driver No 1 intact, hippie 113 162 14 14 0
UNK-205 UNK Q9C0B0 RING finger protein unkempt homolog chr17 Not Cancer Driver No 1 hippie 60 513 33 33 0
UQCRFS1-201 UQCRFS1 P47985 Cytochrome b-c1 complex subunit Rieske, mitochondrial chr19 Not Cancer Driver No 1 hippie, biogrid 27 47 1 1 1
VBP1-201 VBP1 P61758 Prefoldin subunit 3 chrX Not Cancer Driver No 1 hippie, biogrid 16 47 5 5 0
VWA8-203 VWA8 A3KMH1 von Willebrand factor A domain-containing protein 8 chr13 Not Cancer Driver No 1 hippie, biogrid 153 384 24 24 0
WDR62-201 WDR62 O43379 WD repeat-containing protein 62 chr19 Not Cancer Driver No 1 intact, hippie 136 801 71 71 5
YARS2-201 YARS2 Q9Y2Z4 Tyrosine--tRNA ligase, mitochondrial chr12 Not Cancer Driver No 1 hippie, biogrid 47 63 8 8 2
YBEY-206 YBEY P58557 Endoribonuclease YbeY chr21 Not Cancer Driver No 2 intact, hippie, biogrid 13 9 1 1 0
YWHAE-201 YWHAE P62258 14-3-3 protein epsilon chr17 Census Yes 1 hippie, biogrid 24 41 1 1 0
YWHAG-201 YWHAG P61981 14-3-3 protein gamma chr7 Not Cancer Driver No 1 hippie, biogrid 21 78 4 4 3
YWHAH-201 YWHAH Q04917 14-3-3 protein eta chr22 Not Cancer Driver No 1 hippie, biogrid 10 55 0 0 0
YWHAQ-201 YWHAQ P27348 14-3-3 protein theta chr2 Not Cancer Driver No 1 hippie 23 41 2 2 0
ZDHHC5-201 ZDHHC5 Q9C0B5 Palmitoyltransferase ZDHHC5 chr11 Not Cancer Driver No 1 hippie 66 463 46 46 0