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JAK1-201 ,JAK1 ,P23458
  • Number of Interaction partner in intact: 37
  • Number of Interaction partner in biogrid: 71
  • Number of Interaction partner in hippie: 211
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABL1-201 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 Census, Compendium Yes 1 hippie 106 609 53 53 2
ABL2-203 ABL2 P42684 Tyrosine-protein kinase ABL2 chr1 Census, Compendium Yes 1 hippie 125 644 53 53 0
ACAD10-201 ACAD10 Q6JQN1 Acyl-CoA dehydrogenase family member 10 chr12 Not Cancer Driver No 1 biogrid 113 91 12 12 0
ACAD11-201 ACAD11 Q709F0 Acyl-CoA dehydrogenase family member 11 chr3 Not Cancer Driver No 1 biogrid 77 33 5 5 0
ADAM11-201 ADAM11 O75078 Disintegrin and metalloproteinase domain-containing protein 11 chr17 Not Cancer Driver No 1 hippie, biogrid 84 163 15 15 0
AGO4-201 AGO4 Q9HCK5 Protein argonaute-4 chr1 Not Cancer Driver No 1 intact, hippie 83 183 22 22 0
AGTR1-201 AGTR1 P30556 Type-1 angiotensin II receptor chr3 Not Cancer Driver No 1 intact, hippie 70 0 0 0 1
AIFM1-201 AIFM1 O95831 Apoptosis-inducing factor 1, mitochondrial chrX Not Cancer Driver No 1 biogrid 61 166 20 20 10
AK2-214 AK2 P54819 Adenylate kinase 2, mitochondrial chr1 Not Cancer Driver No 1 biogrid 17 76 8 8 2
AMHR2-201 AMHR2 Q16671 Anti-Muellerian hormone type-2 receptor chr12 Not Cancer Driver No 1 hippie, biogrid 67 118 9 9 8
APLNR-202 APLNR P35414 Apelin receptor chr11 Not Cancer Driver No 2 intact, hippie, biogrid 76 29 7 7 0
ARL15-202 ARL15 Q9NXU5 ADP-ribosylation factor-like protein 15 chr5 Not Cancer Driver No 1 hippie, biogrid 18 9 2 2 0
ARRB1-202 ARRB1 P49407 Beta-arrestin-1 chr11 Not Cancer Driver No 1 hippie, biogrid 37 154 11 11 0
ATIC-201 ATIC P31939 Bifunctional purine biosynthesis protein ATIC chr2 Census Yes 1 hippie, biogrid 49 25 1 1 1
BRCA1-203 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 Census, Compendium Yes 1 intact, hippie 167 1466 127 127 34
BSND-201 BSND Q8WZ55 Barttin chr1 Not Cancer Driver No 1 hippie, biogrid 48 210 31 31 3
BTK-201 BTK Q06187 Tyrosine-protein kinase BTK chrX Census, Compendium Yes 1 hippie 109 114 21 21 83
BTN2A1-201 BTN2A1 Q7KYR7 Butyrophilin subfamily 2 member A1 chr6 Not Cancer Driver No 1 hippie, biogrid 57 38 5 5 0
CACNA1C-220 CACNA1C Q13936 Voltage-dependent L-type calcium channel subunit alpha-1C chr12 Not Cancer Driver No 1 intact 350 708 123 123 25
CBL-201 CBL P22681 E3 ubiquitin-protein ligase CBL chr11 Census, Compendium Yes 1 hippie 84 513 44 44 4
CCR1-201 CCR1 P32246 C-C chemokine receptor type 1 chr3 Not Cancer Driver No 1 hippie 47 14 0 0 0
CCR5-201 CCR5 P51681 C-C chemokine receptor type 5 chr3 Not Cancer Driver No 1 hippie 34 0 0 0 0
CD83-201 CD83 Q01151 CD83 antigen chr6 Not Cancer Driver No 1 hippie, biogrid 23 49 8 8 0
CDC42-208 CDC42 P60953 Cell division control protein 42 homolog chr1 Not Cancer Driver No 1 hippie 21 23 1 1 1
CFTR-201 CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 Not Cancer Driver No 2 intact, hippie 216 145 9 9 130
CHMP4B-201 CHMP4B Q9H444 Charged multivesicular body protein 4b chr20 Not Cancer Driver No 1 hippie 21 201 20 20 2
CIC-206 CIC Q96RK0 Protein capicua homolog chr19 Census, Compendium Yes 1 hippie 216 1552 207 207 0
CLDND1-201 CLDND1 Q9NY35 Claudin domain-containing protein 1 chr3 Not Cancer Driver No 1 hippie, biogrid 23 0 0 0 0
CLEC4A-201 CLEC4A Q9UMR7 C-type lectin domain family 4 member A chr12 Not Cancer Driver No 1 hippie, biogrid 24 22 4 4 0
CMKLR1-204 CMKLR1 Q99788 Chemerin-like receptor 1 chr12 Not Cancer Driver No 1 hippie, biogrid 91 24 10 10 0
CRLF2-202 CRLF2 Q9HC73 Cytokine receptor-like factor 2 chrX Census Yes 1 hippie, biogrid 37 62 0 0 0
CSF2RB-201 CSF2RB P32927 Cytokine receptor common subunit beta chr22 Not Cancer Driver No 2 intact, hippie 164 547 102 102 0
CSF3R-203 CSF3R Q99062 Granulocyte colony-stimulating factor receptor chr1 Census, Compendium Yes 1 hippie 108 210 27 27 3
CSNK1G2-201 CSNK1G2 P78368 Casein kinase I isoform gamma-2 chr19 Not Cancer Driver No 1 hippie, biogrid 32 112 10 10 0
CTDSPL2-201 CTDSPL2 Q05D32 CTD small phosphatase-like protein 2 chr15 Not Cancer Driver No 1 hippie 32 256 17 17 0
CX3CL1-201 CX3CL1 P78423 Fractalkine chr16 Not Cancer Driver No 1 hippie, biogrid 53 259 36 36 0
CXCR4-201 CXCR4 P61073 C-X-C chemokine receptor type 4 chr2 Census, Compendium Yes 2 hippie, biogrid 45 5 0 0 0
CYLD-203 CYLD Q9NQC7 Ubiquitin carboxyl-terminal hydrolase CYLD chr16 Census, Compendium Yes 1 hippie 76 213 21 21 3
DISC1-209 DISC1 Q9NRI5 Disrupted in schizophrenia 1 protein chr1 Not Cancer Driver No 1 intact, hippie 106 520 65 65 0
DLK1-202 DLK1 P80370 Protein delta homolog 1 chr14 Not Cancer Driver No 1 hippie, biogrid 67 0 0 0 0
DSP-201 DSP P15924 Desmoplakin chr6 Not Cancer Driver No 1 intact, hippie 354 1127 146 146 6
DTX3L-201 DTX3L Q8TDB6 E3 ubiquitin-protein ligase DTX3L chr3 Not Cancer Driver No 1 hippie 60 260 19 19 0
EDAR-201 EDAR Q9UNE0 Tumor necrosis factor receptor superfamily member EDAR chr2 Not Cancer Driver No 1 hippie, biogrid 65 117 16 16 17
EFNB1-201 EFNB1 P98172 Ephrin-B1 chrX Not Cancer Driver No 1 hippie, biogrid 35 126 10 10 14
EGFR-201 EGFR P00533 Epidermal growth factor receptor chr7 Census, Compendium Yes 1 hippie 346 223 30 30 1
EID1-201 EID1 Q9Y6B2 EP300-interacting inhibitor of differentiation 1 chr15 Not Cancer Driver No 1 hippie 14 159 11 11 0
EIF2AK2-201 EIF2AK2 P19525 Interferon-induced, double-stranded RNA-activated protein kinase chr2 Not Cancer Driver No 1 hippie 36 188 15 15 1
EIF4A3-209 EIF4A3 P38919 Eukaryotic initiation factor 4A-III chr17 Not Cancer Driver No 1 hippie 40 57 6 6 1
ELF3-203 ELF3 P78545 ETS-related transcription factor Elf-3 chr1 Census, Compendium Yes 1 hippie, biogrid 84 147 31 31 0
ELOVL5-201 ELOVL5 Q9NYP7 Elongation of very long chain fatty acids protein 5 chr6 Not Cancer Driver No 1 hippie, biogrid 33 25 2 2 2
ELP2-203 ELP2 Q6IA86 Elongator complex protein 2 chr18 Not Cancer Driver No 1 hippie 43 16 2 2 0
EMC4-202 EMC4 Q5J8M3 ER membrane protein complex subunit 4 chr15 Not Cancer Driver No 1 hippie 8 17 1 1 0
ENST00000646106 IL2RG P31785 Cytokine receptor common subunit gamma chrX Not Cancer Driver No 1 hippie 0 0 0 0 0
ENST00000695856 CDC42 P60953 Cell division control protein 42 homolog chr1 Not Cancer Driver No 1 hippie 21 23 1 1 1
ERBB2-201 ERBB2 P04626 Receptor tyrosine-protein kinase erbB-2 chr17 Census, Compendium Yes 1 hippie 249 315 32 32 1
ESR1-201 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 hippie 92 198 19 19 2
FAM174A-201 FAM174A Q8TBP5 Membrane protein FAM174A chr5 Not Cancer Driver No 1 hippie, biogrid 22 140 17 17 0
FBXW7-201 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 Census, Compendium Yes 1 hippie 289 232 15 15 17
FER-201 FER P16591 Tyrosine-protein kinase Fer chr5 Not Cancer Driver No 1 hippie 70 145 13 13 0
FES-201 FES P07332 Tyrosine-protein kinase Fes/Fps chr15 Census Yes 1 hippie 70 246 24 24 0
FFAR1-201 FFAR1 O14842 Free fatty acid receptor 1 chr19 Not Cancer Driver No 1 hippie, biogrid 30 2 0 0 0
FGFR3-205 FGFR3 P22607 Fibroblast growth factor receptor 3 chr4 Census, Compendium Yes 1 intact 134 241 18 18 32
FLG2-201 FLG2 Q5D862 Filaggrin-2 chr1 Not Cancer Driver No 1 intact, hippie 89 2255 60 60 0
FN3KRP-201 FN3KRP Q9HA64 Ketosamine-3-kinase chr17 Not Cancer Driver No 1 biogrid 25 75 4 4 0
FYN-202 FYN P06241 Tyrosine-protein kinase Fyn chr6 Not Cancer Driver No 1 hippie 64 71 11 11 0
GAB1-201 GAB1 Q13480 GRB2-associated-binding protein 1 chr4 Not Cancer Driver No 1 hippie 54 570 46 46 1
GHR-201 GHR P10912 Growth hormone receptor chr5 Not Cancer Driver No 1 hippie 139 229 59 59 19
GPR182-201 GPR182 O15218 G-protein coupled receptor 182 chr12 Not Cancer Driver No 1 hippie, biogrid 38 33 5 5 0
GPR45-201 GPR45 Q9Y5Y3 Probable G-protein coupled receptor 45 chr2 Not Cancer Driver No 1 hippie, biogrid 75 0 0 0 0
GPRC5B-201 GPRC5B Q9NZH0 G-protein coupled receptor family C group 5 member B chr16 Not Cancer Driver No 1 hippie, biogrid 72 76 19 19 0
GRB2-202 GRB2 P62993 Growth factor receptor-bound protein 2 chr17 Not Cancer Driver No 1 hippie 21 10 0 0 0
HAVCR2-201 HAVCR2 Q8TDQ0 Hepatitis A virus cellular receptor 2 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 45 17 1 1 3
HCN1-201 HCN1 O60741 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 chr5 Not Cancer Driver No 1 intact 378 366 163 163 15
HCST-201 HCST Q9UBK5 Hematopoietic cell signal transducer chr19 Not Cancer Driver No 1 hippie, biogrid 5 12 0 0 0
HNRNPD-201 HNRNPD Q14103 Heterogeneous nuclear ribonucleoprotein D0 chr4 Not Cancer Driver No 1 intact, hippie 28 206 12 12 0
HSP90AA1-201 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 hippie 44 258 15 15 0
HSP90AB1-203 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 intact, hippie 70 255 29 29 0
HSPB8-201 HSPB8 Q9UJY1 Heat shock protein beta-8 chr12 Not Cancer Driver No 1 hippie, biogrid 36 131 27 27 3
IFI16-201 IFI16 Q16666 Gamma-interferon-inducible protein 16 chr1 Not Cancer Driver No 1 hippie 102 422 61 61 0
IFITM3-201 IFITM3 Q01628 Interferon-induced transmembrane protein 3 chr11 Not Cancer Driver No 1 hippie, biogrid 7 19 2 2 0
IFNAR1-201 IFNAR1 P17181 Interferon alpha/beta receptor 1 chr21 Compendium Yes 2 hippie, biogrid 36 50 4 4 0
IFNAR2-202 IFNAR2 P48551 Interferon alpha/beta receptor 2 chr21 Not Cancer Driver No 2 intact, hippie 41 199 19 19 0
IFNAR2-IL10RB-205 IFNAR2 P48551 Interferon alpha/beta receptor 2 chr21 Not Cancer Driver No 2 intact, hippie 0 0 0 0 0
IFNGR1-201 IFNGR1 P15260 Interferon gamma receptor 1 chr6 Compendium Yes 3 intact, hippie, biogrid 38 176 13 13 9
IFNLR1-201 IFNLR1 Q8IU57 Interferon lambda receptor 1 chr1 Not Cancer Driver No 1 hippie, biogrid 43 256 30 30 0
IFT88-202 IFT88 Q13099 Intraflagellar transport protein 88 homolog chr13 Not Cancer Driver No 1 hippie 70 281 23 23 0
IGF1R-217 IGF1R P08069 Insulin-like growth factor 1 receptor chr15 Not Cancer Driver No 1 hippie 143 265 30 30 6
IL10RA-201 IL10RA Q13651 Interleukin-10 receptor subunit alpha chr11 Not Cancer Driver No 1 hippie 64 223 26 26 7
IL13RA2-201 IL13RA2 Q14627 Interleukin-13 receptor subunit alpha-2 chrX Not Cancer Driver No 2 intact, hippie, biogrid 56 0 0 0 0
IL20RB-201 IL20RB Q6UXL0 Interleukin-20 receptor subunit beta chr3 Not Cancer Driver No 1 hippie, biogrid 31 0 0 0 0
IL21R-201 IL21R Q9HBE5 Interleukin-21 receptor chr16 Census Yes 1 hippie 113 184 38 38 1
IL27RA-201 IL27RA Q6UWB1 Interleukin-27 receptor subunit alpha chr19 Not Cancer Driver No 1 hippie 70 167 17 17 0
IL2RB-201 IL2RB P14784 Interleukin-2 receptor subunit beta chr22 Not Cancer Driver No 1 hippie 66 184 26 26 1
IL2RG-202 IL2RG P31785 Cytokine receptor common subunit gamma chrX Not Cancer Driver No 1 hippie 42 32 6 6 29
IL3RA-201 IL3RA P26951 Interleukin-3 receptor subunit alpha chrX Not Cancer Driver No 1 hippie 58 9 2 2 0
IL4R-202 IL4R P24394 Interleukin-4 receptor subunit alpha chr16 Not Cancer Driver No 3 intact, hippie, biogrid 105 426 48 48 0
IL5RA-209 IL5RA Q01344 Interleukin-5 receptor subunit alpha chr3 Not Cancer Driver No 1 intact, hippie 67 23 2 2 0
IL6R-202 IL6R P08887 Interleukin-6 receptor subunit alpha chr1 Not Cancer Driver No 1 intact, hippie 43 166 19 19 1
IL6ST-204 IL6ST P40189 Interleukin-6 receptor subunit beta chr5 Census, Compendium Yes 2 intact, hippie 76 315 26 26 3
IL7R-201 IL7R P16871 Interleukin-7 receptor subunit alpha chr5 Census, Compendium Yes 1 hippie 140 89 40 40 1
IL9R-201 IL9R Q01113 Interleukin-9 receptor chrX Not Cancer Driver No 1 hippie 77 79 16 16 0
INPP5D-204 INPP5D Q92835 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 chr2 Not Cancer Driver No 1 hippie 140 579 75 75 0
INSR-201 INSR P06213 Insulin receptor chr19 Not Cancer Driver No 1 hippie 139 282 37 37 63
INSRR-201 INSRR P14616 Insulin receptor-related protein chr1 Not Cancer Driver No 1 hippie, biogrid 213 229 34 34 0
IRS1-201 IRS1 P35568 Insulin receptor substrate 1 chr2 Not Cancer Driver No 1 hippie 118 1075 104 104 2
IRS2-201 IRS2 Q9Y4H2 Insulin receptor substrate 2 chr13 Not Cancer Driver No 1 hippie 44 1117 34 34 0
ISG15-203 ISG15 P05161 Ubiquitin-like protein ISG15 chr1 Not Cancer Driver No 1 hippie 12 24 2 2 0
JAK1-201 JAK1 P23458 Tyrosine-protein kinase JAK1 chr1 Census, Compendium Yes 1 hippie 109 120 6 6 2
JAK2-201 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 Census, Compendium Yes 1 hippie 81 59 4 4 4
JAK3-201 JAK3 P52333 Tyrosine-protein kinase JAK3 chr19 Census, Compendium Yes 1 hippie 131 63 4 4 7
JAKMIP1-201 JAKMIP1 Q96N16 Janus kinase and microtubule-interacting protein 1 chr4 Not Cancer Driver No 1 hippie 118 389 95 95 0
KCNC3-203 KCNC3 Q14003 Potassium voltage-gated channel subfamily C member 3 chr19 Not Cancer Driver No 1 hippie, biogrid 51 405 20 20 4
KCNE3-201 KCNE3 Q9Y6H6 Potassium voltage-gated channel subfamily E member 3 chr11 Not Cancer Driver No 1 hippie, biogrid 25 25 2 2 0
KIF24-202 KIF24 Q5T7B8 Kinesin-like protein KIF24 chr9 Not Cancer Driver No 1 hippie 95 903 62 62 0
LAMP2-201 LAMP2 P13473 Lysosome-associated membrane glycoprotein 2 chrX Not Cancer Driver No 2 intact, hippie, biogrid 29 55 4 4 1
LAMP3-201 LAMP3 Q9UQV4 Lysosome-associated membrane glycoprotein 3 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 57 223 34 34 0
LPAR6-209 LPAR6 P43657 Lysophosphatidic acid receptor 6 chr13 Not Cancer Driver No 3 intact, hippie, biogrid 31 0 0 0 3
LRRIQ1-202 LRRIQ1 Q96JM4 Leucine-rich repeat and IQ domain-containing protein 1 chr12 Not Cancer Driver No 2 intact, hippie, biogrid 284 887 143 143 0
LTN1-201 LTN1 O94822 E3 ubiquitin-protein ligase listerin chr21 Not Cancer Driver No 1 hippie 139 125 15 15 0
MAGOH-202 MAGOH P61326 Protein mago nashi homolog chr1 Not Cancer Driver No 1 hippie 11 6 0 0 0
MANSC1-202 MANSC1 Q9H8J5 MANSC domain-containing protein 1 chr12 Not Cancer Driver No 2 intact, hippie, biogrid 38 209 14 14 0
MAS1-202 MAS1 P04201 Proto-oncogene Mas chr6 Not Cancer Driver No 2 intact, hippie, biogrid 36 5 2 2 0
MDK-203 MDK P21741 Midkine chr11 Not Cancer Driver No 1 hippie 13 20 1 1 0
MDM2-224 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 Census, Compendium Yes 1 hippie 39 298 24 24 0
MFSD4A-201 MFSD4A Q8N468 Major facilitator superfamily domain-containing protein 4A chr1 Not Cancer Driver No 1 hippie 33 29 2 2 0
MGARP-201 MGARP Q8TDB4 Protein MGARP chr4 Not Cancer Driver No 1 hippie, biogrid 15 209 14 14 0
MRAP2-201 MRAP2 Q96G30 Melanocortin-2 receptor accessory protein 2 chr6 Not Cancer Driver No 1 hippie, biogrid 40 76 11 11 0
NOC2L-201 NOC2L Q9Y3T9 Nucleolar complex protein 2 homolog chr1 Not Cancer Driver No 1 hippie 54 281 22 22 0
NPM1-201 NPM1 P06748 Nucleophosmin chr5 Census, Compendium Yes 1 hippie 25 249 19 19 0
NTRK1-206 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 133 57 8 8 23
OPALIN-201 OPALIN Q96PE5 Opalin chr10 Not Cancer Driver No 1 hippie, biogrid 27 86 16 16 0
OSMR-201 OSMR Q99650 Oncostatin-M-specific receptor subunit beta chr5 Not Cancer Driver No 3 hippie, biogrid 115 145 15 15 5
OSTM1-201 OSTM1 Q86WC4 Osteopetrosis-associated transmembrane protein 1 chr6 Not Cancer Driver No 1 hippie, biogrid 19 24 4 4 0
P2RY10-201 P2RY10 O00398 Putative P2Y purinoceptor 10 chrX Not Cancer Driver No 1 hippie, biogrid 90 0 0 0 0
PAGE4-201 PAGE4 O60829 P antigen family member 4 chrX Not Cancer Driver No 1 hippie 13 102 13 13 0
PARP9-201 PARP9 Q8IXQ6 Protein mono-ADP-ribosyltransferase PARP9 chr3 Not Cancer Driver No 1 hippie 85 45 3 3 0
PCDHA8-202 PCDHA8 Q9Y5H6 Protocadherin alpha-8 chr5 Not Cancer Driver No 1 hippie, biogrid 260 274 55 55 0
PDCD1-201 PDCD1 Q15116 Programmed cell death protein 1 chr2 Not Cancer Driver No 1 hippie, biogrid 45 141 31 31 0
PDGFRA-201 PDGFRA P16234 Platelet-derived growth factor receptor alpha chr4 Census, Compendium Yes 1 hippie 213 173 36 36 2
PDGFRB-201 PDGFRB P09619 Platelet-derived growth factor receptor beta chr5 Census, Compendium Yes 1 hippie 134 233 40 40 7
PEBP1-201 PEBP1 P30086 Phosphatidylethanolamine-binding protein 1 chr12 Not Cancer Driver No 1 hippie 17 77 11 11 0
PIK3R1-211 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 Census, Compendium Yes 1 hippie 122 271 50 50 2
PLA2G4A-201 PLA2G4A P47712 Cytosolic phospholipase A2 chr1 Not Cancer Driver No 1 hippie 106 129 20 20 1
PLAUR-203 PLAUR Q03405 Urokinase plasminogen activator surface receptor chr19 Not Cancer Driver No 1 hippie 38 18 4 4 0
PLCG1-202 PLCG1 P19174 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 chr20 Census, Compendium Yes 1 hippie 129 187 15 15 0
PLCG2-206 PLCG2 P16885 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 chr16 Not Cancer Driver No 1 hippie 183 144 18 18 1
PML-201 PML P29590 Protein PML chr15 Census, Compendium Yes 1 hippie 87 312 28 28 0
PRKCA-202 PRKCA P17252 Protein kinase C alpha type chr17 Not Cancer Driver No 1 intact, hippie 70 155 17 17 0
PRKCZ-201 PRKCZ Q05513 Protein kinase C zeta type chr1 Not Cancer Driver No 1 hippie 47 117 11 11 0
PRMT5-202 PRMT5 O14744 Protein arginine N-methyltransferase 5 chr14 Not Cancer Driver No 1 hippie 62 72 3 3 0
PTH2R-201 PTH2R P49190 Parathyroid hormone 2 receptor chr2 Not Cancer Driver No 1 hippie, biogrid 97 50 13 13 0
PTK2B-201 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 Not Cancer Driver No 1 hippie 117 263 23 23 0
PTPN11-201 PTPN11 Q06124 Tyrosine-protein phosphatase non-receptor type 11 chr12 Census, Compendium Yes 1 hippie 92 260 27 27 44
PTPN2-201 PTPN2 P17706 Tyrosine-protein phosphatase non-receptor type 2 chr18 Not Cancer Driver No 1 hippie 39 120 10 10 0
PTPN6-201 PTPN6 P29350 Tyrosine-protein phosphatase non-receptor type 6 chr12 Census, Compendium Yes 1 hippie 52 194 20 20 0
RAC1-201 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 Census, Compendium Yes 1 hippie 61 2 0 0 6
RAC3-201 RAC3 P60763 Ras-related C3 botulinum toxin substrate 3 chr17 Not Cancer Driver No 1 hippie 20 0 0 0 4
RACK1-227 RACK1 P63244 Small ribosomal subunit protein RACK1 chr5 Not Cancer Driver No 1 hippie 27 13 0 0 0
RAF1-201 RAF1 P04049 RAF proto-oncogene serine/threonine-protein kinase chr3 Census, Compendium Yes 1 hippie 64 169 30 30 18
RARA-201 RARA P10276 Retinoic acid receptor alpha chr17 Census, Compendium Yes 1 hippie 60 167 14 14 0
RELT-201 RELT Q969Z4 Tumor necrosis factor receptor superfamily member 19L chr11 Not Cancer Driver No 1 hippie, biogrid 30 239 12 12 0
RHOA-202 RHOA P61586 Transforming protein RhoA chr3 Census, Compendium Yes 1 hippie 92 46 12 12 2
RHOB-201 RHOB P62745 Rho-related GTP-binding protein RhoB chr2 Not Cancer Driver No 1 hippie 50 20 1 1 0
RHOC-202 RHOC P08134 Rho-related GTP-binding protein RhoC chr1 Not Cancer Driver No 1 hippie 23 53 4 4 0
RHOG-201 RHOG P84095 Rho-related GTP-binding protein RhoG chr11 Not Cancer Driver No 1 hippie 20 22 3 3 0
RHOH-201 RHOH Q15669 Rho-related GTP-binding protein RhoH chr4 Census Yes 1 hippie 32 12 3 3 0
RHOJ-201 RHOJ Q9H4E5 Rho-related GTP-binding protein RhoJ chr14 Not Cancer Driver No 1 hippie 31 0 0 0 0
RHOQ-201 RHOQ P17081 Rho-related GTP-binding protein RhoQ chr2 Not Cancer Driver No 1 hippie 19 0 0 0 0
RHOU-201 RHOU Q7L0Q8 Rho-related GTP-binding protein RhoU chr1 Not Cancer Driver No 1 hippie 28 63 6 6 0
RND1-201 RND1 Q92730 Rho-related GTP-binding protein Rho6 chr12 Not Cancer Driver No 1 hippie 35 9 1 1 0
RND2-202 RND2 P52198 Rho-related GTP-binding protein RhoN chr17 Not Cancer Driver No 1 hippie 17 54 4 4 0
RNF125-201 RNF125 Q96EQ8 E3 ubiquitin-protein ligase RNF125 chr18 Not Cancer Driver No 1 hippie 23 27 1 1 3
RNF149-201 RNF149 Q8NC42 E3 ubiquitin-protein ligase RNF149 chr2 Not Cancer Driver No 1 hippie, biogrid 30 103 12 12 0
S100B-201 S100B P04271 Protein S100-B chr21 Not Cancer Driver No 1 hippie, biogrid 8 14 0 0 0
SH2B2-201 SH2B2 O14492 SH2B adapter protein 2 chr7 Not Cancer Driver No 1 hippie 32 356 12 12 0
SHB-201 SHB Q15464 SH2 domain-containing adapter protein B chr9 Not Cancer Driver No 1 hippie 42 338 29 29 0
SIRT1-201 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 Not Cancer Driver No 1 hippie 43 435 19 19 0
SLC15A1-202 SLC15A1 P46059 Solute carrier family 15 member 1 chr13 Not Cancer Driver No 2 intact, hippie, biogrid 83 26 1 1 0
SLC18A2-202 SLC18A2 Q05940 Synaptic vesicular amine transporter chr10 Not Cancer Driver No 1 hippie, biogrid 80 24 4 4 1
SLC1A1-201 SLC1A1 P43005 Excitatory amino acid transporter 3 chr9 Not Cancer Driver No 1 hippie, biogrid 50 17 3 3 1
SMURF1-201 SMURF1 Q9HCE7 E3 ubiquitin-protein ligase SMURF1 chr7 Not Cancer Driver No 1 hippie 60 257 19 19 0
SNAI1-201 SNAI1 O95863 Zinc finger protein SNAI1 chr20 Not Cancer Driver No 1 hippie 41 98 8 8 0
SOCS1-201 SOCS1 O15524 Suppressor of cytokine signaling 1 chr16 Census, Compendium Yes 1 hippie 20 66 3 3 2
SOCS3-201 SOCS3 O14543 Suppressor of cytokine signaling 3 chr17 Not Cancer Driver No 1 hippie 24 111 11 11 0
SPTAN1-202 SPTAN1 Q13813 Spectrin alpha chain, non-erythrocytic 1 chr9 Not Cancer Driver No 1 intact, hippie 236 983 84 84 0
STAM-202 STAM Q92783 Signal transducing adapter molecule 1 chr10 Not Cancer Driver No 1 hippie 50 361 26 26 0
STAM2-201 STAM2 O75886 Signal transducing adapter molecule 2 chr2 Not Cancer Driver No 2 intact, hippie 49 292 25 25 0
STAT1-201 STAT1 P42224 Signal transducer and activator of transcription 1-alpha/beta chr2 Not Cancer Driver No 4 intact, hippie 100 144 16 16 23
STAT2-201 STAT2 P52630 Signal transducer and activator of transcription 2 chr12 Not Cancer Driver No 1 hippie 60 178 17 17 1
STAT3-201 STAT3 P40763 Signal transducer and activator of transcription 3 chr17 Census, Compendium Yes 1 hippie 93 152 16 16 15
STAT5A-209 STAT5A P42229 Signal transducer and activator of transcription 5A chr17 Not Cancer Driver No 1 hippie 64 125 7 7 0
STAT5B-201 STAT5B P51692 Signal transducer and activator of transcription 5B chr17 Census, Compendium Yes 1 hippie 73 145 17 17 5
STAT6-201 STAT6 P42226 Signal transducer and activator of transcription 6 chr12 Census, Compendium Yes 1 hippie 86 325 39 39 0
SYK-204 SYK P43405 Tyrosine-protein kinase SYK chr9 Census Yes 1 hippie 75 131 20 20 4
SYT11-201 SYT11 Q9BT88 Synaptotagmin-11 chr1 Not Cancer Driver No 1 hippie, biogrid 51 106 19 19 0
SYVN1-203 SYVN1 Q86TM6 E3 ubiquitin-protein ligase synoviolin chr11 Not Cancer Driver No 1 hippie 25 284 0 0 0
TAGLN-202 TAGLN Q01995 Transgelin chr11 Not Cancer Driver No 1 hippie 12 94 8 8 0
TEC-201 TEC P42680 Tyrosine-protein kinase Tec chr4 Census, Compendium Yes 1 hippie 66 57 11 11 0
TENT5A-201 TENT5A Q96IP4 Terminal nucleotidyltransferase 5A chr6 Not Cancer Driver No 1 intact, hippie 33 0 0 0 0
TGFBR2-201 TGFBR2 P37173 TGF-beta receptor type-2 chr3 Census, Compendium Yes 3 intact, hippie, biogrid 93 61 15 15 21
TICAM2-201 TICAM2 Q86XR7 TIR domain-containing adapter molecule 2 chr5 Not Cancer Driver No 1 biogrid 19 90 6 6 0
TIRAP-202 TIRAP P58753 Toll/interleukin-1 receptor domain-containing adapter protein chr11 Not Cancer Driver No 1 hippie 14 80 5 5 0
TMEM192-201 TMEM192 Q8IY95 Transmembrane protein 192 chr4 Not Cancer Driver No 1 hippie 23 5 1 1 0
TMEM9-201 TMEM9 Q9P0T7 Proton-transporting V-type ATPase complex assembly regulator TMEM9 chr1 Not Cancer Driver No 1 hippie, biogrid 18 24 1 1 0
TNF-208 TNF P01375 Tumor necrosis factor chr6 Not Cancer Driver No 1 hippie 22 45 2 2 0
TNFRSF1A-201 TNFRSF1A P19438 Tumor necrosis factor receptor superfamily member 1A chr12 Not Cancer Driver No 1 hippie 38 111 14 14 9
TOP1-201 TOP1 P11387 DNA topoisomerase 1 chr20 Census, Compendium Yes 1 hippie 50 391 19 19 0
TP53-201 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 hippie 2742 282 1364 1364 60
TRIM11-201 TRIM11 Q96F44 E3 ubiquitin-protein ligase TRIM11 chr1 Not Cancer Driver No 1 hippie 46 132 16 16 0
TRIM66-208 TRIM66 O15016 Tripartite motif-containing protein 66 chr11 Not Cancer Driver No 1 hippie 32 773 20 20 0
TSHR-201 TSHR P16473 Thyrotropin receptor chr14 Census Yes 1 hippie 100 38 7 7 36
TTC3-206 TTC3 P53804 E3 ubiquitin-protein ligase TTC3 chr21 Not Cancer Driver No 1 intact 167 727 54 54 0
TYK2-204 TYK2 P29597 Non-receptor tyrosine-protein kinase TYK2 chr19 Not Cancer Driver No 1 hippie 118 213 20 20 0
UBL4A-202 UBL4A P11441 Ubiquitin-like protein 4A chrX Not Cancer Driver No 1 hippie 17 16 4 4 0
UFL1-201 UFL1 O94874 E3 UFM1-protein ligase 1 chr6 Not Cancer Driver No 1 hippie 77 141 19 19 0
UPF3B-201 UPF3B Q9BZI7 Regulator of nonsense transcripts 3B chrX Not Cancer Driver No 1 biogrid 67 428 61 61 1
USP16-204 USP16 Q9Y5T5 Ubiquitin carboxyl-terminal hydrolase 16 chr21 Not Cancer Driver No 1 hippie 68 396 27 27 0
USP6-205 USP6 P35125 Ubiquitin carboxyl-terminal hydrolase 6 chr17 Census, Compendium Yes 1 hippie 154 540 49 49 0
VIRMA-201 VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 157 634 73 73 0
VSIG4-201 VSIG4 Q9Y279 V-set and immunoglobulin domain-containing protein 4 chrX Not Cancer Driver No 1 hippie, biogrid 59 70 10 10 0
YWHAE-201 YWHAE P62258 14-3-3 protein epsilon chr17 Census Yes 1 hippie 24 41 1 1 0
ZRANB1-201 ZRANB1 Q9UGI0 Ubiquitin thioesterase ZRANB1 chr10 Not Cancer Driver No 1 hippie 65 158 16 16 0