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KPNA6-201 ,KPNA6 ,O60684
  • Number of Interaction partner in intact: 45
  • Number of Interaction partner in biogrid: 36
  • Number of Interaction partner in hippie: 130
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACTC1-201 ACTC1 P68032 Actin, alpha cardiac muscle 1 chr15 Not Cancer Driver No 1 hippie 90 48 14 14 11
ANKRD11-201 ANKRD11 Q6UB99 Ankyrin repeat domain-containing protein 11 chr16 Not Cancer Driver No 1 intact, hippie 285 2300 230 230 0
ANP32A-203 ANP32A P39687 Acidic leucine-rich nuclear phosphoprotein 32 family member A chr15 Not Cancer Driver No 1 intact, hippie 17 165 6 6 0
ANP32B-201 ANP32B Q92688 Acidic leucine-rich nuclear phosphoprotein 32 family member B chr9 Not Cancer Driver No 1 hippie 8 117 1 1 0
ANP32E-208 ANP32E Q9BTT0 Acidic leucine-rich nuclear phosphoprotein 32 family member E chr1 Not Cancer Driver No 1 hippie, biogrid 15 135 0 0 0
ARMC8-210 ARMC8 Q8IUR7 Armadillo repeat-containing protein 8 chr3 Not Cancer Driver No 1 hippie 42 7 0 0 0
ARNT-202 ARNT P27540 Aryl hydrocarbon receptor nuclear translocator chr1 Census Yes 1 hippie 61 511 47 47 0
BCOR-202 BCOR Q6W2J9 BCL-6 corepressor chrX Census, Compendium Yes 1 hippie 219 1289 174 174 1
BIRC3-201 BIRC3 Q13489 Baculoviral IAP repeat-containing protein 3 chr11 Census, Compendium Yes 1 hippie 53 98 10 10 0
BRCA1-203 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 Census, Compendium Yes 1 hippie 167 1466 127 127 34
CACNA1C-220 CACNA1C Q13936 Voltage-dependent L-type calcium channel subunit alpha-1C chr12 Not Cancer Driver No 1 intact 350 708 123 123 25
CBX1-201 CBX1 P83916 Chromobox protein homolog 1 chr17 Not Cancer Driver No 1 intact, hippie 17 155 14 14 0
CBX3-202 CBX3 Q13185 Chromobox protein homolog 3 chr7 Not Cancer Driver No 1 intact, hippie 18 119 13 13 0
CCNF-202 CCNF P41002 Cyclin-F chr16 Not Cancer Driver No 1 hippie, biogrid 77 221 16 16 3
CD2BP2-201 CD2BP2 O95400 CD2 antigen cytoplasmic tail-binding protein 2 chr16 Not Cancer Driver No 1 hippie, biogrid 35 260 28 28 0
CDC34-201 CDC34 P49427 Ubiquitin-conjugating enzyme E2 R1 chr19 Not Cancer Driver No 1 hippie 19 96 7 7 0
CDK2AP1-201 CDK2AP1 O14519 Cyclin-dependent kinase 2-associated protein 1 chr12 Not Cancer Driver No 1 hippie 8 76 7 7 0
CDKN1B-201 CDKN1B P46527 Cyclin-dependent kinase inhibitor 1B chr12 Census, Compendium Yes 1 hippie 14 199 14 14 0
CENPA-202 CENPA P49450 Histone H3-like centromeric protein A chr2 Not Cancer Driver No 1 hippie, biogrid 12 50 1 1 0
CENPU-201 CENPU Q71F23 Centromere protein U chr4 Not Cancer Driver No 1 intact, hippie 23 302 19 19 0
CFTR-201 CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 Not Cancer Driver No 2 intact, hippie 216 145 9 9 130
CHD4-206 CHD4 Q14839 Chromodomain-helicase-DNA-binding protein 4 chr12 Census, Compendium Yes 1 hippie 312 978 118 118 6
CHD8-224 CHD8 Q9HCK8 Chromodomain-helicase-DNA-binding protein 8 chr14 Not Cancer Driver No 1 hippie 234 1413 107 107 0
CHMP4B-201 CHMP4B Q9H444 Charged multivesicular body protein 4b chr20 Not Cancer Driver No 1 hippie 21 201 20 20 2
COPS5-201 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 Not Cancer Driver No 1 hippie 27 32 4 4 0
CREBBP-201 CREBBP Q92793 CREB-binding protein chr16 Census, Compendium Yes 1 hippie 217 1801 91 91 30
CSE1L-201 CSE1L P55060 Exportin-2 chr20 Not Cancer Driver No 1 hippie 77 32 4 4 0
CUL3-201 CUL3 Q13618 Cullin-3 chr2 Census, Compendium Yes 1 intact, hippie 98 168 18 18 3
DCPS-201 DCPS Q96C86 m7GpppX diphosphatase chr11 Not Cancer Driver No 1 intact, hippie 32 55 5 5 1
EFTUD2-202 EFTUD2 Q15029 116 kDa U5 small nuclear ribonucleoprotein component chr17 Compendium Yes 1 hippie 100 179 22 22 3
ELAVL1-201 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 54 43 5 5 0
EPAS1-201 EPAS1 Q99814 Endothelial PAS domain-containing protein 1 chr2 Census, Compendium Yes 1 hippie 109 451 54 54 4
EXOSC4-201 EXOSC4 Q9NPD3 Exosome complex component RRP41 chr8 Not Cancer Driver No 1 hippie, biogrid 26 23 0 0 0
FAM90A1-203 FAM90A1 Q86YD7 Protein FAM90A1 chr12 Not Cancer Driver No 1 intact, hippie 91 476 91 91 0
FBL-201 FBL P22087 rRNA 2'-O-methyltransferase fibrillarin chr19 Not Cancer Driver No 1 hippie, biogrid 21 145 3 3 0
FOXE1-201 FOXE1 O00358 Forkhead box protein E1 chr9 Not Cancer Driver No 1 hippie 30 134 3 3 4
G3BP1-201 G3BP1 Q13283 Ras GTPase-activating protein-binding protein 1 chr5 Not Cancer Driver No 2 intact, hippie 55 352 38 38 0
GABARAPL2-201 GABARAPL2 P60520 Gamma-aminobutyric acid receptor-associated protein-like 2 chr16 Not Cancer Driver No 1 hippie 4 2 1 1 0
GEMIN2-202 GEMIN2 O14893 Gem-associated protein 2 chr14 Not Cancer Driver No 1 intact, hippie 17 97 4 4 0
GFPT1-201 GFPT1 Q06210 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 chr2 Not Cancer Driver No 1 hippie 59 75 5 5 12
HASPIN-201 HASPIN Q8TF76 Serine/threonine-protein kinase haspin chr17 Not Cancer Driver No 1 intact, hippie 46 376 13 13 0
HDAC1-201 HDAC1 Q13547 Histone deacetylase 1 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 30 135 5 5 0
HIF1A-202 HIF1A Q16665 Hypoxia-inducible factor 1-alpha chr14 Census Yes 1 hippie 54 436 28 28 0
HMGB1-203 HMGB1 P09429 High mobility group protein B1 chr13 Not Cancer Driver No 1 hippie, biogrid 10 202 7 7 0
IKBKG-206 IKBKG Q9Y6K9 NF-kappa-B essential modulator chrX Not Cancer Driver No 1 hippie 5 301 4 4 21
IL1A-201 IL1A P01583 Interleukin-1 alpha chr2 Not Cancer Driver No 1 intact, hippie 23 35 6 6 0
IPO5-230 IPO5 O00410 Importin-5 chr13 Not Cancer Driver No 1 hippie, biogrid 82 52 2 2 0
IRF3-203 IRF3 Q14653 Interferon regulatory factor 3 chr19 Not Cancer Driver No 1 intact, hippie 23 205 17 17 1
JRK-211 JRK O75564 Jerky protein homolog chr8 Not Cancer Driver No 1 intact, hippie 0 140 0 0 0
KAT5-203 KAT5 Q92993 Histone acetyltransferase KAT5 chr11 Not Cancer Driver No 1 intact, hippie 45 174 16 16 3
KBTBD4-204 KBTBD4 Q9NVX7 Kelch repeat and BTB domain-containing protein 4 chr11 Not Cancer Driver No 2 hippie, biogrid 47 8 1 1 0
KEAP1-201 KEAP1 Q14145 Kelch-like ECH-associated protein 1 chr19 Census, Compendium Yes 1 hippie 217 57 7 7 0
KPNA1-201 KPNA1 P52294 Importin subunit alpha-5 chr3 Not Cancer Driver No 2 hippie, biogrid 48 122 16 16 0
KPNA2-201 KPNA2 P52292 Importin subunit alpha-1 chr17 Not Cancer Driver No 2 hippie, biogrid 54 130 14 14 0
KPNA3-201 KPNA3 O00505 Importin subunit alpha-4 chr13 Not Cancer Driver No 1 hippie 47 108 7 7 5
KPNB1-201 KPNB1 Q14974 Importin subunit beta-1 chr17 Not Cancer Driver No 2 hippie, biogrid 79 95 9 9 0
KSR1-219 KSR1 Q8IVT5 Kinase suppressor of Ras 1 chr17 Not Cancer Driver No 1 intact, hippie 88 408 46 46 0
LARP7-201 LARP7 Q4G0J3 La-related protein 7 chr4 Not Cancer Driver No 2 intact, hippie 39 353 28 28 0
LIN28A-202 LIN28A Q9H9Z2 Protein lin-28 homolog A chr1 Not Cancer Driver No 1 intact 30 86 11 11 0
LMBR1L-201 LMBR1L Q6UX01 Protein LMBR1L chr12 Not Cancer Driver No 1 hippie 46 4 0 0 0
LMNA-205 LMNA P02545 Prelamin-A/C chr1 Census Yes 3 intact, hippie, biogrid 50 547 34 34 117
LMNB1-201 LMNB1 P20700 Lamin-B1 chr5 Not Cancer Driver No 1 intact, hippie 39 407 27 27 4
LYAR-201 LYAR Q9NX58 Cell growth-regulating nucleolar protein chr4 Not Cancer Driver No 2 intact, hippie, biogrid 34 250 19 19 0
MAGED1-201 MAGED1 Q9Y5V3 Melanoma-associated antigen D1 chrX Not Cancer Driver No 1 hippie 42 457 37 37 0
MAP1LC3B-201 MAP1LC3B Q9GZQ8 Microtubule-associated proteins 1A/1B light chain 3B chr16 Not Cancer Driver No 1 hippie 4 17 0 0 0
MCM2-201 MCM2 P49736 DNA replication licensing factor MCM2 chr3 Not Cancer Driver No 1 hippie 77 277 33 33 1
MDM2-224 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 Census, Compendium Yes 1 hippie 39 298 24 24 0
MEAF6-201 MEAF6 Q9HAF1 Chromatin modification-related protein MEAF6 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 14 171 13 13 0
MEPCE-201 MEPCE Q7L2J0 7SK snRNA methylphosphate capping enzyme chr7 Not Cancer Driver No 1 hippie, biogrid 46 449 29 29 0
METTL16-201 METTL16 Q86W50 RNA N6-adenosine-methyltransferase METTL16 chr17 Not Cancer Driver No 1 hippie 34 173 13 13 0
MORF4L1-201 MORF4L1 Q9UBU8 Mortality factor 4-like protein 1 chr15 Not Cancer Driver No 1 hippie, biogrid 32 163 11 11 0
MORF4L2-206 MORF4L2 Q15014 Mortality factor 4-like protein 2 chrX Not Cancer Driver No 1 hippie, biogrid 30 136 17 17 0
MTHFR-204 MTHFR P42898 Methylenetetrahydrofolate reductase (NADPH) chr1 Not Cancer Driver No 1 hippie, biogrid 70 125 17 17 50
NAF1-201 NAF1 Q96HR8 H/ACA ribonucleoprotein complex non-core subunit NAF1 chr4 Not Cancer Driver No 1 intact, hippie 48 388 33 33 0
NCBP1-202 NCBP1 Q09161 Nuclear cap-binding protein subunit 1 chr9 Not Cancer Driver No 1 intact 66 89 7 7 0
NCBP2-201 NCBP2 P52298 Nuclear cap-binding protein subunit 2 chr3 Not Cancer Driver No 1 hippie 18 35 3 3 0
NCBP3-201 NCBP3 Q53F19 Nuclear cap-binding protein subunit 3 chr17 Not Cancer Driver No 1 hippie 26 510 22 22 0
NLRC5-229 NLRC5 Q86WI3 Protein NLRC5 chr16 Not Cancer Driver No 1 intact, hippie 194 114 17 17 0
NMNAT1-201 NMNAT1 Q9HAN9 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 chr1 Not Cancer Driver No 1 intact, hippie 31 49 5 5 26
NOP2-201 NOP2 P46087 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase chr12 Not Cancer Driver No 1 intact, hippie 88 513 52 52 0
NOP56-201 NOP56 O00567 Nucleolar protein 56 chr20 Not Cancer Driver No 2 hippie, biogrid 56 194 26 26 0
NOP58-201 NOP58 Q9Y2X3 Nucleolar protein 58 chr2 Not Cancer Driver No 1 hippie, biogrid 40 156 13 13 0
NR2C2-206 NR2C2 P49116 Nuclear receptor subfamily 2 group C member 2 chr3 Not Cancer Driver No 1 hippie 41 187 13 13 0
NR4A1-204 NR4A1 P22736 Nuclear receptor subfamily 4 group A member 1 chr12 Not Cancer Driver No 1 hippie 52 252 24 24 0
NTRK1-206 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 133 57 8 8 23
NUP153-201 NUP153 P49790 Nuclear pore complex protein Nup153 chr6 Not Cancer Driver No 1 hippie 125 1149 101 101 0
NUP50-201 NUP50 Q9UKX7 Nuclear pore complex protein Nup50 chr22 Not Cancer Driver No 5 intact, hippie, biogrid 43 335 30 30 0
NUPR1-201 NUPR1 O60356 Nuclear protein 1 chr16 Not Cancer Driver No 1 hippie 10 82 10 10 0
OGT-202 OGT O15294 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit chrX Not Cancer Driver No 1 hippie 111 90 9 9 2
PHB2-203 PHB2 Q99623 Prohibitin-2 chr12 Not Cancer Driver No 1 hippie 25 26 4 4 0
PLEKHA4-201 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 115 690 110 110 0
POLR3C-201 POLR3C Q9BUI4 DNA-directed RNA polymerase III subunit RPC3 chr1 Not Cancer Driver No 1 intact, hippie 47 161 19 19 0
POM121-202 POM121 Q96HA1 Nuclear envelope pore membrane protein POM 121 chr7 Not Cancer Driver No 1 intact, hippie 100 1075 80 80 0
POU6F2-201 POU6F2 P78424 POU domain, class 6, transcription factor 2 chr7 Not Cancer Driver No 1 intact, hippie 49 572 32 32 1
PPM1D-201 PPM1D O15297 Protein phosphatase 1D chr17 Census, Compendium Yes 1 hippie 32 370 17 17 0
PPM1G-201 PPM1G O15355 Protein phosphatase 1G chr2 Not Cancer Driver No 1 hippie, biogrid 35 359 28 28 0
PPP1CC-201 PPP1CC P36873 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit chr12 Not Cancer Driver No 1 hippie 19 23 3 3 0
PRKAR2A-201 PRKAR2A P13861 cAMP-dependent protein kinase type II-alpha regulatory subunit chr3 Not Cancer Driver No 1 hippie 27 150 8 8 0
PRMT1-202 PRMT1 Q99873 Protein arginine N-methyltransferase 1 chr19 Not Cancer Driver No 1 hippie, biogrid 37 18 0 0 0
PSMC2-201 PSMC2 P35998 26S proteasome regulatory subunit 7 chr7 Not Cancer Driver No 1 hippie, biogrid 53 120 14 14 0
PTPN2-201 PTPN2 P17706 Tyrosine-protein phosphatase non-receptor type 2 chr18 Not Cancer Driver No 1 intact, hippie 39 120 10 10 0
RAC1-201 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 Census, Compendium Yes 1 intact, hippie 61 2 0 0 6
RAN-212 RAN P62826 GTP-binding nuclear protein Ran chr12 Not Cancer Driver No 1 hippie, biogrid 18 14 0 0 0
RANBP6-201 RANBP6 O60518 Ran-binding protein 6 chr9 Not Cancer Driver No 1 hippie, biogrid 99 46 3 3 0
RBBP4-202 RBBP4 Q09028 Histone-binding protein RBBP4 chr1 Not Cancer Driver No 1 hippie 40 169 19 19 0
RBBP7-203 RBBP7 Q16576 Histone-binding protein RBBP7 chrX Not Cancer Driver No 1 intact, hippie 42 138 8 8 0
RECQL4-209 RECQL4 O94761 ATP-dependent DNA helicase Q4 chr8 Census, Compendium Yes 1 hippie 105 612 54 54 1
RELA-202 RELA Q04206 Transcription factor p65 chr11 Compendium Yes 1 hippie 53 401 32 32 0
RELB-201 RELB Q01201 Transcription factor RelB chr19 Not Cancer Driver No 1 intact, hippie 45 348 27 27 0
RNMT-202 RNMT O43148 mRNA cap guanine-N7 methyltransferase chr18 Not Cancer Driver No 2 intact, hippie, biogrid 41 161 13 13 0
RPL11-206 RPL11 P62913 Large ribosomal subunit protein uL5 chr1 Not Cancer Driver No 1 hippie, biogrid 19 12 1 1 1
SF1-204 SF1 Q15637 Splicing factor 1 chr11 Not Cancer Driver No 1 hippie 72 627 68 68 0
SIRT1-201 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 Not Cancer Driver No 1 hippie, biogrid 43 435 19 19 0
SIRT6-202 SIRT6 Q8N6T7 NAD-dependent protein deacylase sirtuin-6 chr19 Not Cancer Driver No 1 hippie 24 165 6 6 0
SKP2-202 SKP2 Q13309 S-phase kinase-associated protein 2 chr5 Not Cancer Driver No 1 hippie 37 52 5 5 0
SMARCB1-213 SMARCB1 Q12824 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 chr22 Census, Compendium Yes 1 intact, hippie 55 141 26 26 3
SP110-203 SP110 Q9HB58 Sp110 nuclear body protein chr2 Not Cancer Driver No 1 hippie, biogrid 49 374 28 28 0
SPOP-206 SPOP O43791 Speckle-type POZ protein chr17 Census, Compendium Yes 1 hippie, biogrid 136 25 1 1 6
SREK1IP1-204 SREK1IP1 Q8N9Q2 Protein SREK1IP1 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 5 132 3 3 0
STAT1-201 STAT1 P42224 Signal transducer and activator of transcription 1-alpha/beta chr2 Not Cancer Driver No 2 intact, hippie 100 144 16 16 23
STAT3-201 STAT3 P40763 Signal transducer and activator of transcription 3 chr17 Census, Compendium Yes 1 hippie 93 152 16 16 15
SURF2-201 SURF2 Q15527 Surfeit locus protein 2 chr9 Not Cancer Driver No 2 intact, hippie, biogrid 19 146 15 15 0
TAF9-201 TAF9 Q16594 Transcription initiation factor TFIID subunit 9 chr5 Not Cancer Driver No 1 hippie 19 203 14 14 0
TRIM28-201 TRIM28 Q13263 Transcription intermediary factor 1-beta chr19 Not Cancer Driver No 1 hippie 67 431 32 32 0
TRIM33-201 TRIM33 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 chr1 Census, Compendium Yes 1 hippie 71 618 34 34 0
TRIP12-201 TRIP12 Q14669 E3 ubiquitin-protein ligase TRIP12 chr2 Not Cancer Driver No 1 intact, hippie 154 847 82 82 4
TTC1-201 TTC1 Q99614 Tetratricopeptide repeat protein 1 chr5 Not Cancer Driver No 1 hippie 21 213 18 18 0
UBE2O-201 UBE2O Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme chr17 Not Cancer Driver No 1 hippie, biogrid 94 717 54 54 0
UNK-205 UNK Q9C0B0 RING finger protein unkempt homolog chr17 Not Cancer Driver No 1 hippie 60 513 33 33 0
VIRMA-201 VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 157 634 73 73 0
VPS35-201 VPS35 Q96QK1 Vacuolar protein sorting-associated protein 35 chr16 Not Cancer Driver No 1 hippie 55 99 7 7 1
XRN2-201 XRN2 Q9H0D6 5'-3' exoribonuclease 2 chr20 Not Cancer Driver No 2 intact, hippie 91 428 48 48 0
ZNF131-221 ZNF131 P52739 Zinc finger protein 131 chr5 Not Cancer Driver No 1 hippie 56 267 34 34 0