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MAP3K21-203 ,MAP3K21 ,Q5TCX8
  • Number of Interaction partner in intact: 52
  • Number of Interaction partner in biogrid: 0
  • Number of Interaction partner in hippie: 105
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AGAP1-201 AGAP1 Q9UPQ3 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 chr2 Not Cancer Driver No 1 hippie 121 407 59 59 0
ANKRD34A-201 ANKRD34A Q69YU3 Ankyrin repeat domain-containing protein 34A chr1 Not Cancer Driver No 2 intact, hippie 80 411 69 69 0
BASP1-201 BASP1 P80723 Brain acid soluble protein 1 chr5 Not Cancer Driver No 1 intact, hippie 12 227 12 12 0
BRCA1-203 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 Census, Compendium Yes 1 hippie 167 1466 127 127 34
C11orf52-201 C11orf52 Q96A22 Uncharacterized protein C11orf52 chr11 Not Cancer Driver No 1 hippie 14 109 11 11 0
CAMSAP2-201 CAMSAP2 Q08AD1 Calmodulin-regulated spectrin-associated protein 2 chr1 Not Cancer Driver No 1 hippie 128 1025 92 92 0
CBY1-201 CBY1 Q9Y3M2 Protein chibby homolog 1 chr22 Not Cancer Driver No 2 intact, hippie 9 98 7 7 0
CCT8L2-201 CCT8L2 Q96SF2 T-complex protein 1 subunit theta-like 2 chr22 Not Cancer Driver No 1 hippie 196 104 41 41 0
CDC25B-201 CDC25B P30305 M-phase inducer phosphatase 2 chr20 Not Cancer Driver No 1 hippie 61 329 33 33 0
CDC25C-201 CDC25C P30307 M-phase inducer phosphatase 3 chr5 Not Cancer Driver No 2 intact, hippie 48 226 19 19 0
CDC37-201 CDC37 Q16543 Hsp90 co-chaperone Cdc37 chr19 Not Cancer Driver No 1 intact, hippie 43 214 29 29 0
CDK16-202 CDK16 Q00536 Cyclin-dependent kinase 16 chrX Not Cancer Driver No 1 hippie 42 140 21 21 0
CGN-201 CGN Q9P2M7 Cingulin chr1 Not Cancer Driver No 2 intact, hippie 113 1182 111 111 0
CHODL-201 CHODL Q9H9P2 Chondrolectin chr21 Not Cancer Driver No 1 hippie 44 45 5 5 0
CHUK-201 CHUK O15111 Inhibitor of nuclear factor kappa-B kinase subunit alpha chr10 Not Cancer Driver No 1 intact, hippie 49 116 7 7 0
CLINT1-201 CLINT1 Q14677 Clathrin interactor 1 chr5 Not Cancer Driver No 1 intact, hippie 43 476 39 39 0
CLK1-201 CLK1 P49759 Dual specificity protein kinase CLK1 chr2 Not Cancer Driver No 1 hippie 51 131 16 16 0
CLTB-201 CLTB P09497 Clathrin light chain B chr5 Not Cancer Driver No 1 intact, hippie 19 193 15 15 0
CXADR-201 CXADR P78310 Coxsackievirus and adenovirus receptor chr21 Not Cancer Driver No 1 hippie 40 99 15 15 0
DCLK1-202 DCLK1 O15075 Serine/threonine-protein kinase DCLK1 chr13 Not Cancer Driver No 1 hippie 148 253 49 49 0
DENND1A-203 DENND1A Q8TEH3 DENN domain-containing protein 1A chr9 Not Cancer Driver No 1 hippie 98 591 63 63 0
DENND4C-209 DENND4C Q5VZ89 DENN domain-containing protein 4C chr9 Not Cancer Driver No 2 intact, hippie 121 709 40 40 0
DIRAS3-202 DIRAS3 O95661 GTP-binding protein Di-Ras3 chr1 Not Cancer Driver No 1 hippie 27 21 2 2 0
DNAJC10-201 DNAJC10 Q8IXB1 DnaJ homolog subfamily C member 10 chr2 Not Cancer Driver No 1 intact, hippie 77 37 3 3 0
DVL2-201 DVL2 O14641 Segment polarity protein dishevelled homolog DVL-2 chr17 Not Cancer Driver No 1 hippie 72 515 52 52 0
EFNB1-201 EFNB1 P98172 Ephrin-B1 chrX Not Cancer Driver No 1 hippie 35 126 10 10 14
EIF4E2-201 EIF4E2 O60573 Eukaryotic translation initiation factor 4E type 2 chr2 Not Cancer Driver No 2 intact, hippie 24 80 5 5 0
EXOSC9-201 EXOSC9 Q06265 Exosome complex component RRP45 chr4 Not Cancer Driver No 1 intact, hippie 30 155 11 11 1
FAM110A-204 FAM110A Q9BQ89 Protein FAM110A chr20 Not Cancer Driver No 2 intact, hippie 16 248 11 11 0
FAM110B-203 FAM110B Q8TC76 Protein FAM110B chr8 Not Cancer Driver No 2 intact, hippie 64 299 56 56 0
FAM53C-201 FAM53C Q9NYF3 Protein FAM53C chr5 Not Cancer Driver No 2 intact, hippie 40 296 35 35 0
FKBP5-201 FKBP5 Q13451 Peptidyl-prolyl cis-trans isomerase FKBP5 chr6 Not Cancer Driver No 1 intact, hippie 47 150 15 15 0
GIGYF1-207 GIGYF1 O75420 GRB10-interacting GYF protein 1 chr7 Not Cancer Driver No 1 hippie 111 860 94 94 0
GIGYF2-201 GIGYF2 Q6Y7W6 GRB10-interacting GYF protein 2 chr2 Not Cancer Driver No 1 hippie 73 1098 62 62 6
H1-2-201 H1-2 P16403 Histone H1.2 chr6 Not Cancer Driver No 1 intact 28 214 28 28 0
HAVCR2-201 HAVCR2 Q8TDQ0 Hepatitis A virus cellular receptor 2 chr5 Not Cancer Driver No 1 intact, hippie 45 17 1 1 3
HDAC4-201 HDAC4 P56524 Histone deacetylase 4 chr2 Not Cancer Driver No 2 intact, hippie 145 751 95 95 3
HIF1AN-201 HIF1AN Q9NWT6 Hypoxia-inducible factor 1-alpha inhibitor chr10 Not Cancer Driver No 1 hippie 24 78 5 5 0
HOOK2-202 HOOK2 Q96ED9 Protein Hook homolog 2 chr19 Not Cancer Driver No 1 intact 70 489 49 49 0
HPCA-201 HPCA P84074 Neuron-specific calcium-binding protein hippocalcin chr1 Not Cancer Driver No 1 hippie 19 42 4 4 3
HPCAL1-201 HPCAL1 P37235 Hippocalcin-like protein 1 chr2 Not Cancer Driver No 1 hippie 28 46 8 8 0
HSP90AA1-201 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 intact, hippie 44 258 15 15 0
HSP90AB1-203 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 intact, hippie 70 255 29 29 0
HSPA1A-201 HSPA1A P0DMV8 Heat shock 70 kDa protein 1A chr6 Not Cancer Driver No 1 hippie 20 200 10 10 0
HSPA1B-201 HSPA1A P0DMV8 Heat shock 70 kDa protein 1A chr6 Not Cancer Driver No 1 hippie 19 200 7 7 0
IGHM-202 IGHM P01871 Immunoglobulin heavy constant mu chr14 Not Cancer Driver No 1 hippie 0 0 0 0 0
IKBKB-216 IKBKB O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta chr8 Census, Compendium Yes 1 intact, hippie 83 211 22 22 1
IL17RB-201 IL17RB Q9NRM6 Interleukin-17 receptor B chr3 Not Cancer Driver No 1 hippie 35 30 2 2 0
INPP5E-201 INPP5E Q9NRR6 Phosphatidylinositol polyphosphate 5-phosphatase type IV chr9 Not Cancer Driver No 2 intact, hippie 32 273 9 9 15
KCNE3-201 KCNE3 Q9Y6H6 Potassium voltage-gated channel subfamily E member 3 chr11 Not Cancer Driver No 1 hippie 25 25 2 2 0
KCTD3-201 KCTD3 Q9Y597 BTB/POZ domain-containing protein KCTD3 chr1 Not Cancer Driver No 2 intact, hippie 90 326 39 39 0
KIF13B-206 KIF13B Q9NQT8 Kinesin-like protein KIF13B chr8 Not Cancer Driver No 1 hippie 131 970 56 56 0
KIF1C-201 KIF1C O43896 Kinesin-like protein KIF1C chr17 Not Cancer Driver No 2 intact, hippie 97 700 69 69 1
KRAS-201 KRAS P01116 GTPase KRas chr12 Census, Compendium Yes 1 hippie 771 7 2 2 22
KSR1-219 KSR1 Q8IVT5 Kinase suppressor of Ras 1 chr17 Not Cancer Driver No 2 intact, hippie 88 408 46 46 0
LAMP2-201 LAMP2 P13473 Lysosome-associated membrane glycoprotein 2 chrX Not Cancer Driver No 1 hippie 29 55 4 4 1
LAMTOR1-201 LAMTOR1 Q6IAA8 Ragulator complex protein LAMTOR1 chr11 Not Cancer Driver No 1 hippie 10 96 6 6 0
LCK-202 LCK P06239 Tyrosine-protein kinase Lck chr1 Census Yes 1 hippie 76 95 12 12 1
LIMA1-201 LIMA1 Q9UHB6 LIM domain and actin-binding protein 1 chr12 Not Cancer Driver No 1 hippie 64 688 60 60 0
LRFN1-201 LRFN1 Q9P244 Leucine-rich repeat and fibronectin type III domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie 77 278 31 31 0
LYN-202 LYN P07948 Tyrosine-protein kinase Lyn chr8 Census Yes 1 hippie 78 85 10 10 0
MAGI1-202 MAGI1 Q96QZ7 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 chr3 Not Cancer Driver No 2 intact, hippie 173 1181 140 140 0
MAP3K10-201 MAP3K10 Q02779 Mitogen-activated protein kinase kinase kinase 10 chr19 Not Cancer Driver No 2 intact, hippie 84 591 45 45 0
MAP3K11-201 MAP3K11 Q16584 Mitogen-activated protein kinase kinase kinase 11 chr11 Not Cancer Driver No 1 hippie 84 466 50 50 0
MAP3K9-205 MAP3K9 P80192 Mitogen-activated protein kinase kinase kinase 9 chr14 Not Cancer Driver No 1 intact, hippie 134 685 85 85 0
MAPKAP1-201 MAPKAP1 Q9BPZ7 Target of rapamycin complex 2 subunit MAPKAP1 chr9 Not Cancer Driver No 1 hippie 57 173 17 17 0
MAST3-201 MAST3 O60307 Microtubule-associated serine/threonine-protein kinase 3 chr19 Not Cancer Driver No 2 intact, hippie 133 785 77 77 5
NADK-201 NADK O95544 NAD kinase chr1 Not Cancer Driver No 1 hippie 46 91 8 8 0
NCALD-201 NCALD P61601 Neurocalcin-delta chr8 Not Cancer Driver No 1 hippie 24 34 3 3 0
NCS1-201 NCS1 P62166 Neuronal calcium sensor 1 chr9 Not Cancer Driver No 1 hippie 15 26 0 0 0
NF1-202 NF1 P21359 Neurofibromin chr17 Census, Compendium Yes 2 intact, hippie 285 406 36 36 75
OPALIN-201 OPALIN Q96PE5 Opalin chr10 Not Cancer Driver No 1 hippie 27 86 16 16 0
PCNA-201 PCNA P12004 Proliferating cell nuclear antigen chr20 Not Cancer Driver No 1 intact, hippie 19 22 2 2 1
PHLDB2-204 PHLDB2 Q86SQ0 Pleckstrin homology-like domain family B member 2 chr3 Not Cancer Driver No 1 hippie 168 1037 130 130 0
PLEKHA7-202 PLEKHA7 Q6IQ23 Pleckstrin homology domain-containing family A member 7 chr11 Not Cancer Driver No 2 intact, hippie 129 925 106 106 0
PPM1H-201 PPM1H Q9ULR3 Protein phosphatase 1H chr12 Not Cancer Driver No 1 hippie 60 141 25 25 0
RAB11A-201 RAB11A P62491 Ras-related protein Rab-11A chr15 Not Cancer Driver No 1 hippie 12 43 2 2 0
RAB35-201 RAB35 Q15286 Ras-related protein Rab-35 chr12 Not Cancer Driver No 1 hippie 16 26 1 1 0
RAC3-201 RAC3 P60763 Ras-related C3 botulinum toxin substrate 3 chr17 Not Cancer Driver No 1 hippie 20 0 0 0 4
RALGPS2-204 RALGPS2 Q86X27 Ras-specific guanine nucleotide-releasing factor RalGPS2 chr1 Not Cancer Driver No 2 intact, hippie 67 184 17 17 0
RASAL2-203 RASAL2 Q9UJF2 Ras GTPase-activating protein nGAP chr1 Not Cancer Driver No 2 intact, hippie 134 607 69 69 0
RHOB-201 RHOB P62745 Rho-related GTP-binding protein RhoB chr2 Not Cancer Driver No 1 hippie 50 20 1 1 0
RHOV-201 RHOV Q96L33 Rho-related GTP-binding protein RhoV chr15 Not Cancer Driver No 1 hippie 17 48 5 5 0
RTKN-202 RTKN Q9BST9 Rhotekin chr2 Not Cancer Driver No 1 hippie 53 265 30 30 0
SH3PXD2A-203 SH3PXD2A Q5TCZ1 SH3 and PX domain-containing protein 2A chr10 Not Cancer Driver No 1 hippie 111 802 86 86 0
SIPA1L1-211 SIPA1L1 O43166 Signal-induced proliferation-associated 1-like protein 1 chr14 Not Cancer Driver No 2 intact, hippie 231 1176 166 166 0
SLC31A1-201 SLC31A1 O15431 High affinity copper uptake protein 1 chr9 Not Cancer Driver No 1 hippie 12 28 3 3 0
SRGAP2-203 SRGAP2 O75044 SLIT-ROBO Rho GTPase-activating protein 2 chr1 Not Cancer Driver No 1 hippie 98 543 57 57 0
SRSF12-201 SRSF12 Q8WXF0 Serine/arginine-rich splicing factor 12 chr6 Not Cancer Driver No 2 intact, hippie 24 205 20 20 0
STUB1-201 STUB1 Q9UNE7 E3 ubiquitin-protein ligase CHIP chr16 Not Cancer Driver No 1 hippie 29 113 11 11 11
STX7-202 STX7 O15400 Syntaxin-7 chr6 Not Cancer Driver No 1 hippie 21 165 9 9 0
SYDE1-201 SYDE1 Q6ZW31 Rho GTPase-activating protein SYDE1 chr19 Not Cancer Driver No 2 intact, hippie 52 412 25 25 0
TACC3-201 TACC3 Q9Y6A5 Transforming acidic coiled-coil-containing protein 3 chr4 Not Cancer Driver No 1 hippie 76 719 67 67 0
TESK2-202 TESK2 Q96S53 Dual specificity testis-specific protein kinase 2 chr1 Not Cancer Driver No 2 intact, hippie 57 243 31 31 0
TIAM1-206 TIAM1 Q13009 Rho guanine nucleotide exchange factor TIAM1 chr21 Not Cancer Driver No 2 intact, hippie 263 813 147 147 0
TNIP2-201 TNIP2 Q8NFZ5 TNFAIP3-interacting protein 2 chr4 Not Cancer Driver No 1 hippie 28 318 21 21 0
USP21-203 USP21 Q9UK80 Ubiquitin carboxyl-terminal hydrolase 21 chr1 Not Cancer Driver No 2 intact, hippie 86 230 44 44 0
USP9X-202 USP9X Q93008 Probable ubiquitin carboxyl-terminal hydrolase FAF-X chrX Census, Compendium Yes 1 intact, hippie 243 405 33 33 1
VIRMA-201 VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 157 634 73 73 0
YWHAB-201 YWHAB P31946 14-3-3 protein beta/alpha chr20 Not Cancer Driver No 5 intact, hippie 19 110 3 3 0
YWHAE-201 YWHAE P62258 14-3-3 protein epsilon chr17 Census Yes 2 intact, hippie 24 41 1 1 0
YWHAG-201 YWHAG P61981 14-3-3 protein gamma chr7 Not Cancer Driver No 3 intact, hippie 21 78 4 4 3
YWHAH-201 YWHAH Q04917 14-3-3 protein eta chr22 Not Cancer Driver No 3 intact, hippie 10 55 0 0 0
YWHAQ-201 YWHAQ P27348 14-3-3 protein theta chr2 Not Cancer Driver No 3 intact, hippie 23 41 2 2 0
YWHAZ-207 YWHAZ P63104 14-3-3 protein zeta/delta chr8 Not Cancer Driver No 3 intact, hippie 19 81 7 7 0
ZBTB21-201 ZBTB21 Q9ULJ3 Zinc finger and BTB domain-containing protein 21 chr21 Not Cancer Driver No 2 intact, hippie 91 649 48 48 0
ZNF638-201 ZNF638 Q14966 Zinc finger protein 638 chr2 Not Cancer Driver No 2 intact, hippie 173 1674 153 153 0