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MED8-203 ,MED8 ,Q96G25
  • Number of Interaction partner in intact: 29
  • Number of Interaction partner in biogrid: 73
  • Number of Interaction partner in hippie: 106
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACAD11-201 ACAD11 Q709F0 Acyl-CoA dehydrogenase family member 11 chr3 Not Cancer Driver No 1 hippie, biogrid 77 33 5 5 0
ACTL6A-202 ACTL6A O96019 Actin-like protein 6A chr3 Not Cancer Driver No 1 biogrid 39 74 8 8 1
APOA2-201 APOA2 P02652 Apolipoprotein A-II chr1 Not Cancer Driver No 1 hippie, biogrid 7 0 0 0 0
APP-201 APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 94 419 52 52 12
AR-201 AR P10275 Androgen receptor chrX Census, Compendium Yes 1 hippie, biogrid 116 443 38 38 144
ARRB2-201 ARRB2 P32121 Beta-arrestin-2 chr17 Not Cancer Driver No 1 hippie, biogrid 39 122 19 19 0
ATG16L1-203 ATG16L1 Q676U5 Autophagy-related protein 16-1 chr2 Not Cancer Driver No 1 hippie 54 240 19 19 1
BIRC5-202 BIRC5 O15392 Baculoviral IAP repeat-containing protein 5 chr17 Not Cancer Driver No 2 hippie, biogrid 16 51 4 4 0
BRD4-213 BRD4 O60885 Bromodomain-containing protein 4 chr19 Census, Compendium Yes 1 hippie 143 1184 132 132 0
BRD9-202 BRD9 Q9H8M2 Bromodomain-containing protein 9 chr5 Not Cancer Driver No 1 biogrid 57 391 31 31 0
CCL3-204 CCL3 P10147 C-C motif chemokine 3 chr17 Not Cancer Driver No 1 hippie, biogrid 13 0 0 0 0
CCNC-210 CCNC P24863 Cyclin-C chr6 Census Yes 5 intact, hippie, biogrid 23 33 1 1 0
CCNH-201 CCNH P51946 Cyclin-H chr5 Not Cancer Driver No 1 hippie 23 28 1 1 0
CDK19-202 CDK19 Q9BWU1 Cyclin-dependent kinase 19 chr6 Not Cancer Driver No 8 intact, hippie, biogrid 46 191 18 18 6
CDK8-201 CDK8 P49336 Cyclin-dependent kinase 8 chr13 Not Cancer Driver No 10 intact, hippie, biogrid 53 152 14 14 7
CPSF1-212 CPSF1 Q10570 Cleavage and polyadenylation specificity factor subunit 1 chr8 Not Cancer Driver No 1 hippie, biogrid 155 298 36 36 0
CSN3-201 CSN3 P07498 Kappa-casein chr4 Not Cancer Driver No 1 intact 36 87 13 13 0
CTDP1-208 CTDP1 Q9Y5B0 RNA polymerase II subunit A C-terminal domain phosphatase chr18 Not Cancer Driver No 1 hippie 96 627 68 68 0
CUL2-203 CUL2 Q13617 Cullin-2 chr10 Not Cancer Driver No 1 hippie 64 66 2 2 0
CXXC1-201 CXXC1 Q9P0U4 CXXC-type zinc finger protein 1 chr18 Not Cancer Driver No 1 biogrid 89 368 51 51 0
DISC1-209 DISC1 Q9NRI5 Disrupted in schizophrenia 1 protein chr1 Not Cancer Driver No 1 intact, hippie 106 520 65 65 0
ELOB-203 ELOB Q15370 Elongin-B chr16 Not Cancer Driver No 1 intact, hippie 5 69 3 3 0
ELOC-206 ELOC Q15369 Elongin-C chr8 Not Cancer Driver No 1 intact, hippie 13 25 3 3 0
ENST00000684631 MED20 Q9H944 Mediator of RNA polymerase II transcription subunit 20 chr6 Not Cancer Driver No 4 hippie, biogrid 13 0 0 0 0
EPAS1-201 EPAS1 Q99814 Endothelial PAS domain-containing protein 1 chr2 Census, Compendium Yes 1 hippie 109 451 54 54 4
ESR1-201 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 intact, hippie 92 198 19 19 2
EWSR1-206 EWSR1 Q01844 RNA-binding protein EWS chr22 Census, Compendium Yes 1 hippie 21 646 21 21 0
FBXL19-204 FBXL19 Q6PCT2 F-box/LRR-repeat protein 19 chr16 Not Cancer Driver No 1 hippie, biogrid 54 350 30 30 0
FBXW7-201 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 Census, Compendium Yes 1 hippie 289 232 15 15 17
FOS-201 FOS P01100 Protein c-Fos chr14 Not Cancer Driver No 1 hippie 37 247 28 28 0
GAPDH-201 GAPDH P04406 Glyceraldehyde-3-phosphate dehydrogenase chr12 Not Cancer Driver No 1 intact, hippie 36 24 3 3 0
HDAC1-201 HDAC1 Q13547 Histone deacetylase 1 chr1 Not Cancer Driver No 1 biogrid 30 135 5 5 0
HNF4A-201 HNF4A P41235 Hepatocyte nuclear factor 4-alpha chr20 Not Cancer Driver No 1 hippie 113 127 44 44 5
HSPB3-201 HSPB3 Q12988 Heat shock protein beta-3 chr5 Not Cancer Driver No 1 hippie, biogrid 22 21 1 1 1
INO80E-207 INO80E Q8NBZ0 INO80 complex subunit E chr16 Not Cancer Driver No 1 biogrid 15 211 15 15 0
INTS9-211 INTS9 Q9NV88 Integrator complex subunit 9 chr8 Not Cancer Driver No 1 biogrid 44 50 5 5 0
KMT2A-201 KMT2A Q03164 Histone-lysine N-methyltransferase 2A chr11 Census, Compendium Yes 1 biogrid 342 3148 263 263 0
KRT40-201 KRT40 Q6A162 Keratin, type I cytoskeletal 40 chr17 Not Cancer Driver No 1 intact, hippie 50 7 2 2 0
KSR1-219 KSR1 Q8IVT5 Kinase suppressor of Ras 1 chr17 Not Cancer Driver No 1 intact, hippie 88 408 46 46 0
LMO2-202 LMO2 P25791 Rhombotin-2 chr11 Census Yes 1 hippie, biogrid 24 14 0 0 0
MED1-201 MED1 Q15648 Mediator of RNA polymerase II transcription subunit 1 chr17 Not Cancer Driver No 6 hippie, biogrid 81 1104 50 50 0
MED10-201 MED10 Q9BTT4 Mediator of RNA polymerase II transcription subunit 10 chr5 Not Cancer Driver No 9 intact, hippie, biogrid 15 13 3 3 0
MED11-201 MED11 Q9P086 Mediator of RNA polymerase II transcription subunit 11 chr17 Not Cancer Driver No 4 hippie, biogrid 10 24 3 3 0
MED12-202 MED12 Q93074 Mediator of RNA polymerase II transcription subunit 12 chrX Census, Compendium Yes 5 hippie, biogrid 300 975 129 129 5
MED12L-206 MED12L Q86YW9 Mediator of RNA polymerase II transcription subunit 12-like protein chr3 Not Cancer Driver No 1 hippie, biogrid 287 825 123 123 0
MED13-201 MED13 Q9UHV7 Mediator of RNA polymerase II transcription subunit 13 chr17 Not Cancer Driver No 2 hippie, biogrid 207 906 90 90 2
MED13L-201 MED13L Q71F56 Mediator of RNA polymerase II transcription subunit 13-like chr12 Not Cancer Driver No 1 hippie, biogrid 128 1077 73 73 0
MED14-201 MED14 O60244 Mediator of RNA polymerase II transcription subunit 14 chrX Not Cancer Driver No 4 hippie, biogrid 129 318 35 35 0
MED15-201 MED15 Q96RN5 Mediator of RNA polymerase II transcription subunit 15 chr22 Not Cancer Driver No 2 hippie, biogrid 30 558 15 15 0
MED16-202 MED16 Q9Y2X0 Mediator of RNA polymerase II transcription subunit 16 chr19 Not Cancer Driver No 3 hippie, biogrid 74 88 5 5 0
MED17-201 MED17 Q9NVC6 Mediator of RNA polymerase II transcription subunit 17 chr11 Not Cancer Driver No 4 hippie, biogrid 48 185 8 8 1
MED18-201 MED18 Q9BUE0 Mediator of RNA polymerase II transcription subunit 18 chr1 Not Cancer Driver No 6 intact, hippie, biogrid 23 10 1 1 0
MED19-202 MED19 A0JLT2 Mediator of RNA polymerase II transcription subunit 19 chr11 Not Cancer Driver No 10 intact, hippie, biogrid 7 230 5 5 0
MED20-201 MED20 Q9H944 Mediator of RNA polymerase II transcription subunit 20 chr6 Not Cancer Driver No 4 hippie, biogrid 13 0 0 0 0
MED21-201 MED21 Q13503 Mediator of RNA polymerase II transcription subunit 21 chr12 Not Cancer Driver No 4 hippie, biogrid 8 46 2 2 0
MED22-201 MED22 Q15528 Mediator of RNA polymerase II transcription subunit 22 chr9 Not Cancer Driver No 3 hippie, biogrid 18 97 10 10 0
MED23-205 MED23 Q9ULK4 Mediator of RNA polymerase II transcription subunit 23 chr6 Not Cancer Driver No 2 intact, hippie, biogrid 109 28 3 3 1
MED24-204 MED24 O75448 Mediator of RNA polymerase II transcription subunit 24 chr17 Not Cancer Driver No 4 hippie, biogrid 77 75 0 0 0
MED25-201 MED25 Q71SY5 Mediator of RNA polymerase II transcription subunit 25 chr19 Not Cancer Driver No 1 hippie 72 432 41 41 2
MED26-201 MED26 O95402 Mediator of RNA polymerase II transcription subunit 26 chr19 Not Cancer Driver No 2 hippie, biogrid 49 541 44 44 0
MED27-201 MED27 Q6P2C8 Mediator of RNA polymerase II transcription subunit 27 chr9 Not Cancer Driver No 3 hippie, biogrid 17 61 3 3 0
MED28-201 MED28 Q9H204 Mediator of RNA polymerase II transcription subunit 28 chr4 Not Cancer Driver No 3 hippie, biogrid 24 101 17 17 0
MED29-201 MED29 Q9NX70 Mediator of RNA polymerase II transcription subunit 29 chr19 Not Cancer Driver No 7 intact, hippie, biogrid 13 119 4 4 0
MED30-201 MED30 Q96HR3 Mediator of RNA polymerase II transcription subunit 30 chr8 Not Cancer Driver No 2 hippie, biogrid 17 94 8 8 0
MED31-201 MED31 Q9Y3C7 Mediator of RNA polymerase II transcription subunit 31 chr17 Not Cancer Driver No 2 hippie, biogrid 9 15 1 1 0
MED4-201 MED4 Q9NPJ6 Mediator of RNA polymerase II transcription subunit 4 chr13 Not Cancer Driver No 4 hippie, biogrid 23 161 13 13 0
MED6-201 MED6 O75586 Mediator of RNA polymerase II transcription subunit 6 chr14 Not Cancer Driver No 3 hippie, biogrid 17 79 6 6 0
MED7-201 MED7 O43513 Mediator of RNA polymerase II transcription subunit 7 chr5 Not Cancer Driver No 6 intact, hippie, biogrid 21 132 15 15 0
MED8-203 MED8 Q96G25 Mediator of RNA polymerase II transcription subunit 8 chr1 Not Cancer Driver No 1 hippie 20 191 15 15 0
MED9-201 MED9 Q9NWA0 Mediator of RNA polymerase II transcription subunit 9 chr17 Not Cancer Driver No 3 intact, hippie, biogrid 13 127 12 12 0
MOV10-203 MOV10 Q9HCE1 Helicase MOV-10 chr1 Not Cancer Driver No 1 hippie 90 103 6 6 0
MRGBP-201 MRGBP Q9NV56 MRG/MORF4L-binding protein chr20 Not Cancer Driver No 1 biogrid 21 147 19 19 0
MYC-206 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 72 325 41 41 0
MYOD1-201 MYOD1 P15172 Myoblast determination protein 1 chr11 Census Yes 1 hippie 35 246 26 26 0
NR3C1-203 NR3C1 P04150 Glucocorticoid receptor chr5 Not Cancer Driver No 1 hippie 55 364 20 20 11
NUDCD1-201 NUDCD1 Q96RS6 NudC domain-containing protein 1 chr8 Not Cancer Driver No 1 intact, hippie 49 38 2 2 0
NXF1-201 NXF1 Q9UBU9 Nuclear RNA export factor 1 chr11 Compendium Yes 1 hippie 85 163 28 28 0
PAF1-201 PAF1 Q8N7H5 RNA polymerase II-associated factor 1 homolog chr19 Not Cancer Driver No 1 biogrid 36 378 23 23 0
PEX14-201 PEX14 O75381 Peroxisomal membrane protein PEX14 chr1 Not Cancer Driver No 1 hippie, biogrid 28 268 19 19 0
PHYHIP-202 PHYHIP Q92561 Phytanoyl-CoA hydroxylase-interacting protein chr8 Not Cancer Driver No 1 hippie, biogrid 37 25 3 3 0
PNMA1-201 PNMA1 Q8ND90 Paraneoplastic antigen Ma1 chr14 Not Cancer Driver No 1 intact, hippie 32 56 7 7 0
POLR2A-210 POLR2A P24928 DNA-directed RNA polymerase II subunit RPB1 chr17 Census Yes 1 hippie, biogrid 138 847 36 36 2
POLR2B-201 POLR2B P30876 DNA-directed RNA polymerase II subunit RPB2 chr4 Not Cancer Driver No 1 hippie, biogrid 116 173 17 17 0
POLR2C-201 POLR2C P19387 DNA-directed RNA polymerase II subunit RPB3 chr16 Not Cancer Driver No 1 hippie, biogrid 26 108 9 9 0
POLR2D-201 POLR2D O15514 DNA-directed RNA polymerase II subunit RPB4 chr2 Not Cancer Driver No 1 intact, hippie, biogrid 11 55 2 2 0
POLR2E-213 POLR2E P19388 DNA-directed RNA polymerases I, II, and III subunit RPABC1 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 22 36 3 3 0
POLR2F-205 POLR2F P61218 DNA-directed RNA polymerases I, II, and III subunit RPABC2 chr22 Not Cancer Driver No 1 hippie, biogrid 10 57 4 4 0
POLR2G-201 POLR2G P62487 DNA-directed RNA polymerase II subunit RPB7 chr11 Not Cancer Driver No 1 hippie, biogrid 13 15 2 2 0
POLR2H-208 POLR2H P52434 DNA-directed RNA polymerases I, II, and III subunit RPABC3 chr3 Not Cancer Driver No 1 hippie, biogrid 16 14 2 2 0
POLR2I-201 POLR2I P36954 DNA-directed RNA polymerase II subunit RPB9 chr19 Not Cancer Driver No 1 hippie, biogrid 16 22 3 3 0
POLR2J-201 POLR2J P52435 DNA-directed RNA polymerase II subunit RPB11-a chr7 Not Cancer Driver No 1 hippie, biogrid 9 0 0 0 0
POLR2K-201 POLR2K P53803 DNA-directed RNA polymerases I, II, and III subunit RPABC4 chr8 Not Cancer Driver No 1 hippie, biogrid 8 11 1 1 0
POLR2L-201 POLR2L P62875 DNA-directed RNA polymerases I, II, and III subunit RPABC5 chr11 Not Cancer Driver No 1 hippie, biogrid 10 0 0 0 0
POLR2M-201 POLR2M P0CAP2 DNA-directed RNA polymerase II subunit GRINL1A chr15 Not Cancer Driver No 1 intact, hippie, biogrid 19 302 14 14 0
PRKAR1B-211 PRKAR1B P31321 cAMP-dependent protein kinase type I-beta regulatory subunit chr7 Not Cancer Driver No 1 intact, hippie 42 72 12 12 2
PTBP3-204 PTBP3 O95758 Polypyrimidine tract-binding protein 3 chr9 Not Cancer Driver No 1 intact, hippie 39 114 8 8 0
RBX1-201 RBX1 P62877 E3 ubiquitin-protein ligase RBX1 chr22 Not Cancer Driver No 1 intact, hippie 9 18 1 1 0
RECQL5-201 RECQL5 O94762 ATP-dependent DNA helicase Q5 chr17 Not Cancer Driver No 1 hippie, biogrid 101 499 57 57 0
RPAP2-203 RPAP2 Q8IXW5 Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 chr1 Not Cancer Driver No 1 hippie, biogrid 43 294 23 23 0
RPRD2-202 RPRD2 Q5VT52 Regulation of nuclear pre-mRNA domain-containing protein 2 chr1 Not Cancer Driver No 1 hippie, biogrid 131 1226 111 111 0
SCAF4-201 SCAF4 O95104 SR-related and CTD-associated factor 4 chr21 Not Cancer Driver No 1 hippie, biogrid 37 939 23 23 0
SNTA1-201 SNTA1 Q13424 Alpha-1-syntrophin chr20 Not Cancer Driver No 1 hippie 39 239 13 13 2
STN1-201 STN1 Q9H668 CST complex subunit STN1 chr10 Not Cancer Driver No 1 hippie 34 27 3 3 2
SUMO2-202 SUMO2 P61956 Small ubiquitin-related modifier 2 chr17 Not Cancer Driver No 1 hippie 8 70 6 6 0
TADA2A-205 TADA2A O75478 Transcriptional adapter 2-alpha chr17 Not Cancer Driver No 1 hippie 39 70 4 4 0
TBXT-201 TBXT O15178 T-box transcription factor T chr6 Not Cancer Driver No 1 intact, hippie 85 255 52 52 1
TCL1B-201 TCL1B O95988 T-cell leukemia/lymphoma protein 1B chr14 Not Cancer Driver No 3 hippie, biogrid 31 11 1 1 0
THOC7-201 THOC7 Q6I9Y2 THO complex subunit 7 homolog chr3 Not Cancer Driver No 1 hippie 17 63 4 4 0
THRA-201 THRA P10827 Thyroid hormone receptor alpha chr17 Not Cancer Driver No 1 hippie 47 207 21 21 2
TNIP2-201 TNIP2 Q8NFZ5 TNFAIP3-interacting protein 2 chr4 Not Cancer Driver No 1 hippie 28 318 21 21 0
TP53BP1-201 TP53BP1 Q12888 TP53-binding protein 1 chr15 Not Cancer Driver No 1 intact, hippie 159 1638 131 131 0
TRIP4-201 TRIP4 Q15650 Activating signal cointegrator 1 chr15 Not Cancer Driver No 1 hippie 53 176 18 18 0
UBALD1-201 UBALD1 Q8TB05 UBA-like domain-containing protein 1 chr16 Not Cancer Driver No 1 intact, hippie 1 127 1 1 0
USP49-206 USP49 Q70CQ1 Ubiquitin carboxyl-terminal hydrolase 49 chr6 Not Cancer Driver No 1 hippie 56 190 15 15 0
WDR5-201 WDR5 P61964 WD repeat-containing protein 5 chr9 Not Cancer Driver No 1 biogrid 18 37 1 1 0
ZC3H13-201 ZC3H13 Q5T200 Zinc finger CCCH domain-containing protein 13 chr13 Not Cancer Driver No 1 hippie 33 1444 30 30 0
ZCCHC10-207 ZCCHC10 Q8TBK6 Zinc finger CCHC domain-containing protein 10 chr5 Not Cancer Driver No 1 hippie, biogrid 3 144 2 2 0