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MFN2-201 ,MFN2 ,O95140
  • Number of Interaction partner in intact: 9
  • Number of Interaction partner in biogrid: 99
  • Number of Interaction partner in hippie: 127
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACTBL2-201 ACTBL2 Q562R1 Beta-actin-like protein 2 chr5 Not Cancer Driver No 1 hippie, biogrid 60 29 3 3 0
ADSL-208 ADSL P30566 Adenylosuccinate lyase chr22 Not Cancer Driver No 1 hippie, biogrid 48 36 8 8 26
AIP-201 AIP O00170 AH receptor-interacting protein chr11 Not Cancer Driver No 1 hippie, biogrid 26 64 7 7 1
AKAP1-202 AKAP1 Q92667 A-kinase anchor protein 1, mitochondrial chr17 Not Cancer Driver No 2 hippie, biogrid 77 541 50 50 0
ALDH3A2-201 ALDH3A2 P51648 Aldehyde dehydrogenase family 3 member A2 chr17 Not Cancer Driver No 1 hippie, biogrid 30 5 1 1 25
ATXN3-251 ATXN3 P54252 Ataxin-3 chr14 Not Cancer Driver No 1 hippie, biogrid 25 183 12 12 0
BAG2-201 BAG2 O95816 BAG family molecular chaperone regulator 2 chr6 Not Cancer Driver No 1 hippie, biogrid 13 112 7 7 0
BAK1-201 BAK1 Q16611 Bcl-2 homologous antagonist/killer chr6 Not Cancer Driver No 1 hippie 25 58 5 5 0
C3orf18-201 C3orf18 Q9UK00 Uncharacterized protein C3orf18 chr3 Not Cancer Driver No 1 hippie, biogrid 14 112 9 9 0
C9orf72-203 C9orf72 Q96LT7 Guanine nucleotide exchange factor C9orf72 chr9 Not Cancer Driver No 1 hippie, biogrid 41 11 0 0 0
CACYBP-201 CACYBP Q9HB71 Calcyclin-binding protein chr1 Not Cancer Driver No 1 hippie, biogrid 22 92 10 10 0
CDC34-201 CDC34 P49427 Ubiquitin-conjugating enzyme E2 R1 chr19 Not Cancer Driver No 1 hippie 19 96 7 7 0
CDC37-201 CDC37 Q16543 Hsp90 co-chaperone Cdc37 chr19 Not Cancer Driver No 1 hippie, biogrid 43 214 29 29 0
CFAP36-202 CFAP36 Q96G28 Cilia- and flagella-associated protein 36 chr2 Not Cancer Driver No 1 hippie, biogrid 33 227 18 18 0
CIP2A-201 CIP2A Q8TCG1 Protein CIP2A chr3 Not Cancer Driver No 1 hippie 89 242 27 27 0
CLTC-201 CLTC Q00610 Clathrin heavy chain 1 chr17 Census, Compendium Yes 1 hippie, biogrid 132 71 5 5 1
CRYBG3-201 CRYBG3 Q68DQ2 Very large A-kinase anchor protein chr3 Not Cancer Driver No 1 hippie, biogrid 117 1780 40 40 0
CYP2C19-201 CYP2C19 P33261 Cytochrome P450 2C19 chr10 Not Cancer Driver No 1 hippie, biogrid 125 33 10 10 0
DIP2A-202 DIP2A Q14689 Disco-interacting protein 2 homolog A chr21 Not Cancer Driver No 1 hippie, biogrid 139 399 36 36 0
DIPK2A-201 DIPK2A Q8NDZ4 Divergent protein kinase domain 2A chr3 Not Cancer Driver No 1 hippie 44 9 0 0 0
DNM1L-219 DNM1L O00429 Dynamin-1-like protein chr12 Not Cancer Driver No 1 hippie, biogrid 44 211 15 15 7
EDEM1-201 EDEM1 Q92611 ER degradation-enhancing alpha-mannosidase-like protein 1 chr3 Not Cancer Driver No 1 hippie 44 141 5 5 0
EGLN3-201 EGLN3 Q9H6Z9 Prolyl hydroxylase EGLN3 chr14 Not Cancer Driver No 1 hippie 21 13 0 0 0
ENST00000442788 PSMA2 P25787 Proteasome subunit alpha type-2 chr7 Not Cancer Driver No 1 hippie, biogrid 0 0 0 0 0
EXD2-214 EXD2 Q9NVH0 Exonuclease 3'-5' domain-containing protein 2 chr14 Not Cancer Driver No 1 hippie, biogrid 47 178 12 12 0
FKBP4-201 FKBP4 Q02790 Peptidyl-prolyl cis-trans isomerase FKBP4 chr12 Not Cancer Driver No 1 hippie, biogrid 39 134 11 11 0
FKBP8-206 FKBP8 Q14318 Peptidyl-prolyl cis-trans isomerase FKBP8 chr19 Not Cancer Driver No 1 hippie, biogrid 50 161 19 19 0
GHITM-201 GHITM Q9H3K2 Growth hormone-inducible transmembrane protein chr10 Not Cancer Driver No 2 intact, hippie, biogrid 34 8 0 0 0
GLMN-201 GLMN Q92990 Glomulin chr1 Not Cancer Driver No 1 hippie, biogrid 40 37 6 6 0
GOLGA3-202 GOLGA3 Q08378 Golgin subfamily A member 3 chr12 Not Cancer Driver No 1 hippie, biogrid 181 1283 156 156 0
GYPA-213 GYPA P02724 Glycophorin-A chr4 Not Cancer Driver No 1 hippie, biogrid 28 90 23 23 0
HDAC6-201 HDAC6 Q9UBN7 Histone deacetylase 6 chrX Not Cancer Driver No 1 hippie 122 409 35 35 0
HSCB-201 HSCB Q8IWL3 Iron-sulfur cluster co-chaperone protein HscB chr22 Not Cancer Driver No 1 intact, hippie 23 25 3 3 0
HUWE1-202 HUWE1 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 chrX Not Cancer Driver No 1 hippie 263 2091 107 107 20
IBTK-201 IBTK Q9P2D0 Inhibitor of Bruton tyrosine kinase chr6 Not Cancer Driver No 1 hippie, biogrid 107 364 33 33 0
IPO5-230 IPO5 O00410 Importin-5 chr13 Not Cancer Driver No 1 hippie, biogrid 82 52 2 2 0
KDF1-201 KDF1 Q8NAX2 Keratinocyte differentiation factor 1 chr1 Not Cancer Driver No 1 hippie 43 279 35 35 0
KIF14-201 KIF14 Q15058 Kinesin-like protein KIF14 chr1 Not Cancer Driver No 1 hippie 145 777 65 65 2
LARP4-203 LARP4 Q71RC2 La-related protein 4 chr12 Not Cancer Driver No 1 hippie, biogrid 65 486 43 43 0
LRRC49-201 LRRC49 Q8IUZ0 Leucine-rich repeat-containing protein 49 chr15 Not Cancer Driver No 1 hippie, biogrid 82 124 15 15 0
LRRK2-201 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 402 91 13 13 20
MAPK9-207 MAPK9 P45984 Mitogen-activated protein kinase 9 chr5 Not Cancer Driver No 1 hippie 37 90 3 3 0
MAVS-202 MAVS Q7Z434 Mitochondrial antiviral-signaling protein chr20 Not Cancer Driver No 2 hippie, biogrid 55 415 44 44 0
MFN1-205 MFN1 Q8IWA4 Mitofusin-1 chr3 Not Cancer Driver No 2 hippie, biogrid 63 64 2 2 0
MFN2-201 MFN2 O95140 Mitofusin-2 chr1 Not Cancer Driver No 2 intact, hippie 60 82 7 7 19
MTCH1-202 MTCH1 Q9NZJ7 Mitochondrial carrier homolog 1 chr6 Not Cancer Driver No 1 hippie, biogrid 21 102 1 1 0
MYH10-201 MYH10 P35580 Myosin-10 chr17 Not Cancer Driver No 1 hippie, biogrid 197 1135 103 103 1
MYO19-213 MYO19 Q96H55 Unconventional myosin-XIX chr17 Not Cancer Driver No 1 hippie, biogrid 80 147 11 11 0
NAA15-201 NAA15 Q9BXJ9 N-alpha-acetyltransferase 15, NatA auxiliary subunit chr4 Not Cancer Driver No 1 hippie, biogrid 61 115 15 15 0
NAXE-203 NAXE Q8NCW5 NAD(P)H-hydrate epimerase chr1 Not Cancer Driver No 1 hippie 14 5 0 0 2
NBR1-206 NBR1 Q14596 Next to BRCA1 gene 1 protein chr17 Not Cancer Driver No 1 hippie, biogrid 88 562 41 41 0
NIPSNAP1-201 NIPSNAP1 Q9BPW8 Protein NipSnap homolog 1 chr22 Not Cancer Driver No 1 hippie, biogrid 26 9 0 0 0
NIPSNAP2-201 NIPSNAP2 O75323 Protein NipSnap homolog 2 chr7 Not Cancer Driver No 1 hippie 24 6 1 1 0
NSFL1C-201 NSFL1C Q9UNZ2 NSFL1 cofactor p47 chr20 Not Cancer Driver No 1 hippie, biogrid 33 267 22 22 0
NTRK1-206 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 133 57 8 8 23
NUDC-201 NUDC Q9Y266 Nuclear migration protein nudC chr1 Not Cancer Driver No 1 hippie, biogrid 29 237 23 23 0
NUDCD3-202 NUDCD3 Q8IVD9 NudC domain-containing protein 3 chr7 Not Cancer Driver No 1 hippie, biogrid 22 199 12 12 0
NXF1-201 NXF1 Q9UBU9 Nuclear RNA export factor 1 chr11 Compendium Yes 1 hippie 85 163 28 28 0
OCIAD1-201 OCIAD1 Q9NX40 OCIA domain-containing protein 1 chr4 Not Cancer Driver No 1 hippie, biogrid 25 169 19 19 0
OCRL-202 OCRL Q01968 Inositol polyphosphate 5-phosphatase OCRL chrX Not Cancer Driver No 1 hippie, biogrid 105 126 18 18 36
PIH1D1-201 PIH1D1 Q9NWS0 PIH1 domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie, biogrid 24 160 13 13 0
PINK1-201 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 Not Cancer Driver No 1 intact, hippie 46 99 8 8 24
PLEKHA4-201 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 115 690 110 110 0
PRKAR2A-201 PRKAR2A P13861 cAMP-dependent protein kinase type II-alpha regulatory subunit chr3 Not Cancer Driver No 1 hippie, biogrid 27 150 8 8 0
PRKAR2B-201 PRKAR2B P31323 cAMP-dependent protein kinase type II-beta regulatory subunit chr7 Not Cancer Driver No 1 hippie, biogrid 43 127 5 5 0
PRKCI-201 PRKCI P41743 Protein kinase C iota type chr3 Not Cancer Driver No 1 hippie, biogrid 79 120 12 12 0
PRKN-206 PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 Not Cancer Driver No 2 intact, hippie 96 78 14 14 30
PSMA1-201 PSMA1 P25786 Proteasome subunit alpha type-1 chr11 Not Cancer Driver No 1 hippie, biogrid 33 51 7 7 0
PSMA2-201 PSMA2 P25787 Proteasome subunit alpha type-2 chr7 Not Cancer Driver No 1 hippie, biogrid 14 0 0 0 0
PSMA3-201 PSMA3 P25788 Proteasome subunit alpha type-3 chr14 Not Cancer Driver No 1 hippie, biogrid 15 30 1 1 0
PSMA5-201 PSMA5 P28066 Proteasome subunit alpha type-5 chr1 Not Cancer Driver No 1 hippie, biogrid 18 23 1 1 0
PSMA6-201 PSMA6 P60900 Proteasome subunit alpha type-6 chr14 Not Cancer Driver No 1 hippie, biogrid 33 3 0 0 0
PSMA7-203 PSMA7 O14818 Proteasome subunit alpha type-7 chr20 Not Cancer Driver No 1 hippie, biogrid 18 23 0 0 0
PSMB1-201 PSMB1 P20618 Proteasome subunit beta type-1 chr6 Not Cancer Driver No 1 hippie, biogrid 20 15 2 2 0
PSMB3-211 PSMB3 P49720 Proteasome subunit beta type-3 chr17 Not Cancer Driver No 1 hippie, biogrid 22 0 0 0 0
PSMB4-201 PSMB4 P28070 Proteasome subunit beta type-4 chr1 Not Cancer Driver No 1 hippie, biogrid 19 18 2 2 0
PSMB5-202 PSMB5 P28074 Proteasome subunit beta type-5 chr14 Not Cancer Driver No 1 hippie, biogrid 31 9 0 0 0
PSMB6-201 PSMB6 P28072 Proteasome subunit beta type-6 chr17 Not Cancer Driver No 1 hippie, biogrid 16 22 1 1 0
PSMB7-201 PSMB7 Q99436 Proteasome subunit beta type-7 chr9 Not Cancer Driver No 1 hippie, biogrid 19 26 3 3 0
PSMC1-201 PSMC1 P62191 26S proteasome regulatory subunit 4 chr14 Not Cancer Driver No 1 hippie, biogrid 29 165 8 8 0
PSMC2-201 PSMC2 P35998 26S proteasome regulatory subunit 7 chr7 Not Cancer Driver No 1 hippie, biogrid 53 120 14 14 0
PSMC3-201 PSMC3 P17980 26S proteasome regulatory subunit 6A chr11 Not Cancer Driver No 1 hippie, biogrid 38 131 8 8 0
PSMC4-201 PSMC4 P43686 26S proteasome regulatory subunit 6B chr19 Not Cancer Driver No 1 hippie, biogrid 38 21 2 2 0
PSMC5-201 PSMC5 P62195 26S proteasome regulatory subunit 8 chr17 Not Cancer Driver No 1 hippie, biogrid 35 64 5 5 0
PSMC6-201 PSMC6 P62333 26S proteasome regulatory subunit 10B chr14 Not Cancer Driver No 1 hippie, biogrid 39 69 6 6 0
PSMD1-201 PSMD1 Q99460 26S proteasome non-ATPase regulatory subunit 1 chr2 Not Cancer Driver No 1 hippie, biogrid 77 201 14 14 0
PSMD11-201 PSMD11 O00231 26S proteasome non-ATPase regulatory subunit 11 chr17 Not Cancer Driver No 1 hippie, biogrid 38 0 0 0 0
PSMD13-212 PSMD13 Q9UNM6 26S proteasome non-ATPase regulatory subunit 13 chr11 Not Cancer Driver No 1 hippie, biogrid 20 13 2 2 0
PSMD2-201 PSMD2 Q13200 26S proteasome non-ATPase regulatory subunit 2 chr3 Not Cancer Driver No 1 hippie, biogrid 71 136 11 11 0
PSMD4-202 PSMD4 P55036 26S proteasome non-ATPase regulatory subunit 4 chr1 Not Cancer Driver No 1 hippie, biogrid 31 243 19 19 0
PSMD6-201 PSMD6 Q15008 26S proteasome non-ATPase regulatory subunit 6 chr3 Not Cancer Driver No 1 hippie, biogrid 25 40 2 2 0
PSMD7-201 PSMD7 P51665 26S proteasome non-ATPase regulatory subunit 7 chr16 Not Cancer Driver No 1 hippie, biogrid 24 70 3 3 0
REEP5-202 REEP5 Q00765 Receptor expression-enhancing protein 5 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 23 0 0 0 0
RHOT2-201 RHOT2 Q8IXI1 Mitochondrial Rho GTPase 2 chr16 Not Cancer Driver No 1 hippie, biogrid 40 81 4 4 0
RNF4-201 RNF4 P78317 E3 ubiquitin-protein ligase RNF4 chr4 Not Cancer Driver No 1 hippie 9 120 5 5 0
RTL5-202 RTL5 Q5HYW3 Retrotransposon Gag-like protein 5 chrX Not Cancer Driver No 1 hippie 47 312 15 15 0
SAMM50-201 SAMM50 Q9Y512 Sorting and assembly machinery component 50 homolog chr22 Not Cancer Driver No 1 intact, hippie 32 35 0 0 0
SLC25A38-209 SLC25A38 Q96DW6 Mitochondrial glycine transporter chr3 Not Cancer Driver No 1 hippie 30 0 0 0 4
SLC25A46-201 SLC25A46 Q96AG3 Mitochondrial outer membrane protein SLC25A46 chr5 Not Cancer Driver No 2 hippie, biogrid 28 98 2 2 4
SMAD2-201 SMAD2 Q15796 Mothers against decapentaplegic homolog 2 chr18 Census, Compendium Yes 1 hippie 58 137 11 11 3
SMCR8-201 SMCR8 Q8TEV9 Guanine nucleotide exchange protein SMCR8 chr17 Not Cancer Driver No 1 hippie, biogrid 76 357 30 30 0
SNAP47-213 SNAP47 Q5SQN1 Synaptosomal-associated protein 47 chr1 Not Cancer Driver No 1 hippie, biogrid 38 151 15 15 0
SQSTM1-202 SQSTM1 Q13501 Sequestosome-1 chr5 Not Cancer Driver No 2 hippie, biogrid 41 271 24 24 30
ST13-201 ST13 P50502 Hsc70-interacting protein chr22 Not Cancer Driver No 1 hippie, biogrid 27 298 21 21 0
STIP1-201 STIP1 P31948 Stress-induced-phosphoprotein 1 chr11 Not Cancer Driver No 1 hippie, biogrid 54 270 28 28 0
TCHP-202 TCHP Q9BT92 Trichoplein keratin filament-binding protein chr12 Not Cancer Driver No 1 hippie 37 358 33 33 0
TDRKH-203 TDRKH Q9Y2W6 Tudor and KH domain-containing protein chr1 Not Cancer Driver No 1 hippie, biogrid 53 185 19 19 0
THY1-201 THY1 P04216 Thy-1 membrane glycoprotein chr11 Not Cancer Driver No 1 hippie, biogrid 23 5 0 0 0
TMEM160-201 TMEM160 Q9NX00 Transmembrane protein 160 chr19 Not Cancer Driver No 1 hippie, biogrid 3 46 0 0 0
TPGS1-201 TPGS1 Q6ZTW0 Tubulin polyglutamylase complex subunit 1 chr19 Not Cancer Driver No 1 hippie, biogrid 2 64 0 0 0
TPM3-224 TPM3 P06753 Tropomyosin alpha-3 chain chr1 Census Yes 1 hippie, biogrid 17 230 13 13 18
TPM4-218 TPM4 P67936 Tropomyosin alpha-4 chain chr19 Census Yes 1 hippie, biogrid 21 216 21 21 0
TRAK2-201 TRAK2 O60296 Trafficking kinesin-binding protein 2 chr2 Not Cancer Driver No 1 hippie, biogrid 82 577 50 50 0
TTC1-201 TTC1 Q99614 Tetratricopeptide repeat protein 1 chr5 Not Cancer Driver No 1 hippie, biogrid 21 213 18 18 0
TTC4-201 TTC4 O95801 Tetratricopeptide repeat protein 4 chr1 Not Cancer Driver No 1 hippie, biogrid 36 101 10 10 0
TXNL1-201 TXNL1 O43396 Thioredoxin-like protein 1 chr18 Not Cancer Driver No 1 hippie, biogrid 19 90 3 3 0
UBB-201 UBB P0CG47 Polyubiquitin-B chr17 Not Cancer Driver No 1 hippie, biogrid 15 103 6 6 0
UBE2N-201 UBE2N P61088 Ubiquitin-conjugating enzyme E2 N chr12 Not Cancer Driver No 1 hippie 19 24 1 1 0
UBR4-204 UBR4 Q5T4S7 E3 ubiquitin-protein ligase UBR4 chr1 Not Cancer Driver No 1 hippie, biogrid 433 1069 97 97 0
UBXN4-201 UBXN4 Q92575 UBX domain-containing protein 4 chr2 Not Cancer Driver No 1 hippie, biogrid 53 303 32 32 0
VCP-201 VCP P55072 Transitional endoplasmic reticulum ATPase chr9 Not Cancer Driver No 2 intact, hippie, biogrid 74 186 14 14 12
VCPIP1-201 VCPIP1 Q96JH7 Deubiquitinating protein VCPIP1 chr8 Not Cancer Driver No 1 hippie, biogrid 103 543 45 45 0
VPS13D-214 VPS13D Q5THJ4 Intermembrane lipid transfer protein VPS13D chr1 Not Cancer Driver No 1 hippie, biogrid 367 975 94 94 8
VSIG1-201 VSIG1 Q86XK7 V-set and immunoglobulin domain-containing protein 1 chrX Not Cancer Driver No 2 hippie, biogrid 27 137 5 5 0
WDR41-201 WDR41 Q9HAD4 WD repeat-containing protein 41 chr5 Not Cancer Driver No 1 hippie, biogrid 34 23 2 2 0
YKT6-201 YKT6 O15498 Synaptobrevin homolog YKT6 chr7 Not Cancer Driver No 1 hippie, biogrid 11 21 1 1 0
ZZEF1-201 ZZEF1 O43149 Zinc finger ZZ-type and EF-hand domain-containing protein 1 chr17 Not Cancer Driver No 1 hippie, biogrid 235 583 60 60 0