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MTHFR-204 ,MTHFR ,P42898
  • Uniprot Accession= P42898
  • Ensembl Transcript= ENST00000376590.9
  • Uniprot Name= MTHFR
  • Name= Methylenetetrahydrofolate reductase (NADPH)
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 15
  • Number of Interaction partner in biogrid: 36
  • Number of Interaction partner in hippie: 43
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ANKLE2-201 ANKLE2 Q86XL3 Ankyrin repeat and LEM domain-containing protein 2 chr12 Not Cancer Driver No 1 hippie, biogrid 105 524 62 62 2
BCL2-201 BCL2 P10415 Apoptosis regulator Bcl-2 chr18 Census, Compendium Yes 1 hippie, biogrid 21 73 5 5 0
BCL2L11-204 BCL2L11 O43521 Bcl-2-like protein 11 chr2 Not Cancer Driver No 3 intact, hippie, biogrid 37 131 16 16 0
BTN3A1-202 BTN3A1 O00481 Butyrophilin subfamily 3 member A1 chr6 Not Cancer Driver No 1 hippie, biogrid 59 72 13 13 0
CDCA8-202 CDCA8 Q53HL2 Borealin chr1 Not Cancer Driver No 3 hippie, biogrid 18 171 10 10 0
COX4I2-201 COX4I2 Q96KJ9 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial chr20 Not Cancer Driver No 1 hippie, biogrid 20 36 4 4 1
CUL4A-202 CUL4A Q13619 Cullin-4A chr13 Not Cancer Driver No 1 hippie 54 102 2 2 0
CXorf66-201 CXorf66 Q5JRM2 Uncharacterized protein CXorf66 chrX Not Cancer Driver No 1 hippie, biogrid 73 248 59 59 0
DCLRE1C-209 DCLRE1C Q96SD1 Protein artemis chr10 Not Cancer Driver No 1 intact, hippie, biogrid 56 277 21 21 3
EPHA1-201 EPHA1 P21709 Ephrin type-A receptor 1 chr7 Not Cancer Driver No 2 intact, hippie, biogrid 109 211 29 29 0
EPHA8-201 EPHA8 P29322 Ephrin type-A receptor 8 chr1 Not Cancer Driver No 1 intact, biogrid 156 122 16 16 0
G0S2-201 G0S2 P27469 G0/G1 switch protein 2 chr1 Not Cancer Driver No 1 hippie, biogrid 7 28 5 5 0
GDF10-201 GDF10 P55107 Growth/differentiation factor 10 chr10 Not Cancer Driver No 1 intact, hippie, biogrid 81 254 54 54 0
GNAI1-228 GNAI1 P63096 Guanine nucleotide-binding protein G(i) subunit alpha-1 chr7 Not Cancer Driver No 3 intact, hippie, biogrid 39 11 2 2 9
GNAZ-203 GNAZ P19086 Guanine nucleotide-binding protein G(z) subunit alpha chr22 Not Cancer Driver No 3 hippie, biogrid 64 30 10 10 0
HSD3B2-201 HSD3B2 P26439 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 67 24 7 7 23
JUN-201 JUN P05412 Transcription factor Jun chr1 Census Yes 1 hippie 26 283 17 17 0
KCNF1-201 KCNF1 Q9H3M0 Potassium voltage-gated channel subfamily F member 1 chr2 Not Cancer Driver No 1 hippie, biogrid 86 73 9 9 0
KCNV2-201 KCNV2 Q8TDN2 Potassium voltage-gated channel subfamily V member 2 chr9 Not Cancer Driver No 2 intact, hippie, biogrid 85 123 18 18 6
KPNA6-201 KPNA6 O60684 Importin subunit alpha-7 chr1 Not Cancer Driver No 1 hippie, biogrid 50 97 13 13 0
LSM8-201 LSM8 O95777 U6 snRNA-associated Sm-like protein LSm8 chr7 Not Cancer Driver No 1 intact, hippie 9 3 0 0 0
MTHFR-204 MTHFR P42898 Methylenetetrahydrofolate reductase (NADPH) chr1 Not Cancer Driver No 1 hippie 70 125 17 17 50
NOX5-201 NOX5 Q96PH1 NADPH oxidase 5 chr15 Not Cancer Driver No 2 intact, hippie, biogrid 94 95 7 7 0
PCDHB16-201 PCDHB16 Q9NRJ7 Protocadherin beta-16 chr5 Not Cancer Driver No 2 hippie, biogrid 175 248 58 58 0
PRPF31-201 PRPF31 Q8WWY3 U4/U6 small nuclear ribonucleoprotein Prp31 chr19 Not Cancer Driver No 2 intact, hippie, biogrid 37 213 9 9 2
RASSF1-202 RASSF1 Q9NS23 Ras association domain-containing protein 1 chr3 Not Cancer Driver No 3 hippie, biogrid 21 79 2 2 0
RECQL4-209 RECQL4 O94761 ATP-dependent DNA helicase Q4 chr8 Census, Compendium Yes 1 hippie 105 612 54 54 1
RFX1-201 RFX1 P22670 MHC class II regulatory factor RFX1 chr19 Not Cancer Driver No 1 hippie 83 537 41 41 0
SIRT1-201 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 Not Cancer Driver No 1 hippie, biogrid 43 435 19 19 0
SMPD2-201 SMPD2 O60906 Sphingomyelin phosphodiesterase 2 chr6 Not Cancer Driver No 3 intact, hippie, biogrid 34 49 4 4 0
SP110-203 SP110 Q9HB58 Sp110 nuclear body protein chr2 Not Cancer Driver No 1 hippie, biogrid 49 374 28 28 0
SPATA19-201 SPATA19 Q7Z5L4 Spermatogenesis-associated protein 19, mitochondrial chr11 Not Cancer Driver No 2 hippie, biogrid 39 85 19 19 0
SYT2-202 SYT2 Q8N9I0 Synaptotagmin-2 chr1 Not Cancer Driver No 1 hippie, biogrid 50 142 14 14 3
TIGD6-201 TIGD6 Q17RP2 Tigger transposable element-derived protein 6 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 20 64 3 3 0
TLR10-201 TLR10 Q9BXR5 Toll-like receptor 10 chr4 Not Cancer Driver No 1 hippie, biogrid 82 9 1 1 0
TLR9-201 TLR9 Q9NR96 Toll-like receptor 9 chr3 Not Cancer Driver No 1 hippie, biogrid 107 35 3 3 0
TMEM223-201 TMEM223 A0PJW6 Transmembrane protein 223 chr11 Not Cancer Driver No 2 intact, hippie, biogrid 17 6 0 0 0
TMPRSS4-201 TMPRSS4 Q9NRS4 Transmembrane protease serine 4 chr11 Not Cancer Driver No 1 hippie, biogrid 41 34 1 1 0
TULP3-202 TULP3 O75386 Tubby-related protein 3 chr12 Not Cancer Driver No 1 hippie 54 218 26 26 1
TYROBP-201 TYROBP O43914 TYRO protein tyrosine kinase-binding protein chr19 Not Cancer Driver No 1 hippie, biogrid 19 29 6 6 0
UBA52-202 UBA52 P62987 Ubiquitin-ribosomal protein eL40 fusion protein chr19 Not Cancer Driver No 1 hippie, biogrid 17 45 8 8 0
VIRMA-201 VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 157 634 73 73 0
ZNF263-201 ZNF263 O14978 Zinc finger protein 263 chr16 Not Cancer Driver No 1 hippie, biogrid 61 403 39 39 0
ZNF556-201 ZNF556 Q9HAH1 Zinc finger protein 556 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 82 178 23 23 0