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S1PR1-201 ,S1PR1 ,P21453
  • Number of Interaction partner in intact: 21
  • Number of Interaction partner in biogrid: 91
  • Number of Interaction partner in hippie: 108
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACAD9-201 ACAD9 Q9H845 Complex I assembly factor ACAD9, mitochondrial chr3 Not Cancer Driver No 1 hippie, biogrid 54 28 2 2 12
ACP2-206 ACP2 P11117 Lysosomal acid phosphatase chr11 Not Cancer Driver No 2 intact, hippie, biogrid 35 78 8 8 0
AKT1-218 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 Census, Compendium Yes 1 hippie 99 158 19 19 4
APP-201 APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 94 419 52 52 12
ARL10-201 ARL10 Q8N8L6 ADP-ribosylation factor-like protein 10 chr5 Not Cancer Driver No 1 intact, hippie, biogrid 14 19 0 0 0
ATP12A-202 ATP12A P54707 Potassium-transporting ATPase alpha chain 2 chr13 Not Cancer Driver No 2 intact, hippie, biogrid 139 118 14 14 0
ATP1A3-214 ATP1A3 P13637 Sodium/potassium-transporting ATPase subunit alpha-3 chr19 Not Cancer Driver No 2 hippie, biogrid 151 116 21 21 41
ATP2A3-205 ATP2A3 Q93084 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 chr17 Not Cancer Driver No 1 hippie, biogrid 92 147 13 13 0
ATP2B2-202 ATP2B2 Q01814 Plasma membrane calcium-transporting ATPase 2 chr3 Not Cancer Driver No 1 hippie, biogrid 206 362 68 68 0
ATP2B3-201 ATP2B3 Q16720 Plasma membrane calcium-transporting ATPase 3 chrX Census Yes 1 intact, hippie, biogrid 176 328 51 51 2
ATP2C1-218 ATP2C1 P98194 Calcium-transporting ATPase type 2C member 1 chr3 Not Cancer Driver No 1 hippie, biogrid 84 44 6 6 19
B4GAT1-201 B4GAT1 O43505 Beta-1,4-glucuronyltransferase 1 chr11 Not Cancer Driver No 1 hippie, biogrid 38 4 0 0 2
BTAF1-201 BTAF1 O14981 TATA-binding protein-associated factor 172 chr10 Not Cancer Driver No 1 hippie, biogrid 158 360 33 33 0
CAV1-201 CAV1 Q03135 Caveolin-1 chr7 Not Cancer Driver No 1 hippie 23 2 0 0 0
CD47-202 CD47 Q08722 Leukocyte surface antigen CD47 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 23 0 0 0 0
CD69-201 CD69 Q07108 Early activation antigen CD69 chr12 Not Cancer Driver No 1 intact, hippie 23 18 3 3 0
CERS6-201 CERS6 Q6ZMG9 Ceramide synthase 6 chr2 Not Cancer Driver No 1 hippie, biogrid 33 32 6 6 0
CHCHD6-201 CHCHD6 Q9BRQ6 MICOS complex subunit MIC25 chr3 Not Cancer Driver No 1 hippie, biogrid 22 196 21 21 0
CKAP4-201 CKAP4 Q07065 Cytoskeleton-associated protein 4 chr12 Not Cancer Driver No 1 hippie, biogrid 44 412 36 36 0
CKAP5-210 CKAP5 Q14008 Cytoskeleton-associated protein 5 chr11 Not Cancer Driver No 1 hippie, biogrid 149 634 48 48 0
CLEC2D-203 CLEC2D Q9UHP7 C-type lectin domain family 2 member D chr12 Not Cancer Driver No 1 intact, hippie, biogrid 16 14 1 1 0
CMSS1-201 CMSS1 Q9BQ75 Protein CMSS1 chr3 Not Cancer Driver No 1 intact, hippie 40 98 14 14 0
CMTM6-201 CMTM6 Q9NX76 CKLF-like MARVEL transmembrane domain-containing protein 6 chr3 Not Cancer Driver No 1 hippie, biogrid 8 30 1 1 0
CNNM4-201 CNNM4 Q6P4Q7 Metal transporter CNNM4 chr2 Not Cancer Driver No 1 hippie, biogrid 82 116 21 21 4
COLEC12-201 COLEC12 Q5KU26 Collectin-12 chr18 Not Cancer Driver No 1 hippie, biogrid 60 450 28 28 0
COX16-201 COX16 Q9P0S2 Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial chr14 Not Cancer Driver No 1 hippie, biogrid 11 39 7 7 0
CYBA-201 CYBA P13498 Cytochrome b-245 light chain chr16 Not Cancer Driver No 1 hippie, biogrid 17 66 1 1 10
DYM-201 DYM Q7RTS9 Dymeclin chr18 Not Cancer Driver No 1 hippie, biogrid 57 22 0 0 3
ECSIT-202 ECSIT Q9BQ95 Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial chr19 Not Cancer Driver No 1 hippie, biogrid 50 146 25 25 0
ENST00000644613 ATP1A3 P13637 Sodium/potassium-transporting ATPase subunit alpha-3 chr19 Not Cancer Driver No 2 hippie, biogrid 151 115 21 21 39
ERGIC2-201 ERGIC2 Q96RQ1 Endoplasmic reticulum-Golgi intermediate compartment protein 2 chr12 Not Cancer Driver No 1 hippie, biogrid 25 25 3 3 0
EXTL3-201 EXTL3 O43909 Exostosin-like 3 chr8 Not Cancer Driver No 1 hippie, biogrid 101 111 17 17 5
FAM241B-201 FAM241B Q96D05 Protein FAM241B chr10 Not Cancer Driver No 1 hippie 21 53 10 10 0
FANCD2-212 FANCD2 Q9BXW9 Fanconi anemia group D2 protein chr3 Census, Compendium Yes 1 hippie, biogrid 116 182 9 9 3
FRMD5-202 FRMD5 Q7Z6J6 FERM domain-containing protein 5 chr15 Not Cancer Driver No 1 hippie, biogrid 48 134 14 14 2
GBF1-223 GBF1 Q92538 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 chr10 Not Cancer Driver No 1 hippie, biogrid 161 670 62 62 0
GNA13-201 GNA13 Q14344 Guanine nucleotide-binding protein subunit alpha-13 chr17 Compendium Yes 1 intact, hippie, biogrid 45 32 4 4 0
GNAI1-228 GNAI1 P63096 Guanine nucleotide-binding protein G(i) subunit alpha-1 chr7 Not Cancer Driver No 1 hippie 39 11 2 2 9
GNAI3-201 GNAI3 P08754 Guanine nucleotide-binding protein G(i) subunit alpha-3 chr1 Not Cancer Driver No 1 hippie 36 12 0 0 1
GNAQ-201 GNAQ P50148 Guanine nucleotide-binding protein G(q) subunit alpha chr9 Census, Compendium Yes 1 intact, hippie, biogrid 82 14 1 1 1
GNG5-202 GNG5 P63218 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 3 9 0 0 0
GOLPH3L-201 GOLPH3L Q9H4A5 Golgi phosphoprotein 3-like chr1 Not Cancer Driver No 1 intact, hippie, biogrid 16 81 9 9 0
GPAT4-201 GPAT4 Q86UL3 Glycerol-3-phosphate acyltransferase 4 chr8 Not Cancer Driver No 1 hippie 33 3 0 0 0
GPR180-201 GPR180 Q86V85 Integral membrane protein GPR180 chr13 Not Cancer Driver No 1 hippie, biogrid 23 11 1 1 0
GPRIN1-201 GPRIN1 Q7Z2K8 G protein-regulated inducer of neurite outgrowth 1 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 83 1001 82 82 0
HK3-201 HK3 P52790 Hexokinase-3 chr5 Not Cancer Driver No 1 intact, hippie, biogrid 132 71 12 12 0
HRAS-201 HRAS P01112 GTPase HRas chr11 Census, Compendium Yes 1 intact, hippie, biogrid 129 16 2 2 10
HTR1A-201 HTR1A P08908 5-hydroxytryptamine receptor 1A chr5 Not Cancer Driver No 1 hippie 134 100 36 36 0
HTR1D-201 HTR1D P28221 5-hydroxytryptamine receptor 1D chr1 Not Cancer Driver No 1 hippie 47 25 1 1 0
IPO7-201 IPO7 O95373 Importin-7 chr11 Not Cancer Driver No 1 hippie, biogrid 108 202 25 25 0
IPO8-201 IPO8 O15397 Importin-8 chr12 Not Cancer Driver No 1 hippie, biogrid 93 111 10 10 3
IPO9-201 IPO9 Q96P70 Importin-9 chr1 Not Cancer Driver No 1 hippie, biogrid 101 103 15 15 0
ITPRIPL1-204 ITPRIPL1 Q6GPH6 Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 chr2 Not Cancer Driver No 1 hippie, biogrid 47 39 3 3 0
KIAA2013-201 KIAA2013 Q8IYS2 Uncharacterized protein KIAA2013 chr1 Not Cancer Driver No 1 hippie, biogrid 33 78 4 4 0
LMBR1-201 LMBR1 Q8WVP7 Limb region 1 protein homolog chr7 Not Cancer Driver No 1 intact, hippie, biogrid 41 19 0 0 0
MKRN2-201 MKRN2 Q9H000 E3 ubiquitin-protein ligase makorin-2 chr3 Not Cancer Driver No 1 hippie 30 145 7 7 0
MON2-202 MON2 Q7Z3U7 Protein MON2 homolog chr12 Not Cancer Driver No 1 hippie, biogrid 130 151 9 9 0
MRS2-203 MRS2 Q9HD23 Magnesium transporter MRS2 homolog, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 32 0 0 0 0
NDUFAF1-201 NDUFAF1 Q9Y375 Complex I intermediate-associated protein 30, mitochondrial chr15 Not Cancer Driver No 1 hippie, biogrid 26 64 4 4 4
PDGFRB-201 PDGFRB P09619 Platelet-derived growth factor receptor beta chr5 Census, Compendium Yes 1 hippie 134 233 40 40 7
PKD2-201 PKD2 Q13563 Polycystin-2 chr4 Not Cancer Driver No 1 hippie, biogrid 88 376 30 30 9
POMGNT1-201 POMGNT1 Q8WZA1 Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 chr1 Not Cancer Driver No 1 hippie, biogrid 46 90 4 4 20
POTEF-202 POTEF A5A3E0 POTE ankyrin domain family member F chr2 Not Cancer Driver No 1 intact, hippie, biogrid 174 456 63 63 0
PPM1B-201 PPM1B O75688 Protein phosphatase 1B chr2 Not Cancer Driver No 1 hippie, biogrid 53 243 26 26 0
PPP6R1-201 PPP6R1 Q9UPN7 Serine/threonine-protein phosphatase 6 regulatory subunit 1 chr19 Not Cancer Driver No 1 hippie, biogrid 60 473 36 36 0
PTDSS2-201 PTDSS2 Q9BVG9 Phosphatidylserine synthase 2 chr11 Not Cancer Driver No 1 hippie, biogrid 33 93 3 3 0
RAP2A-201 RAP2A P10114 Ras-related protein Rap-2a chr13 Not Cancer Driver No 1 hippie, biogrid 13 9 0 0 0
RER1-209 RER1 O15258 Protein RER1 chr1 Not Cancer Driver No 1 hippie, biogrid 12 15 1 1 0
RHOT2-201 RHOT2 Q8IXI1 Mitochondrial Rho GTPase 2 chr16 Not Cancer Driver No 1 hippie, biogrid 40 81 4 4 0
RMDN3-202 RMDN3 Q96TC7 Regulator of microtubule dynamics protein 3 chr15 Not Cancer Driver No 1 hippie, biogrid 33 198 14 14 0
S1PR2-201 S1PR2 O95136 Sphingosine 1-phosphate receptor 2 chr19 Not Cancer Driver No 1 intact, hippie 31 16 3 3 2
SAAL1-202 SAAL1 Q96ER3 Protein SAAL1 chr11 Not Cancer Driver No 1 hippie, biogrid 36 75 8 8 0
SACM1L-201 SACM1L Q9NTJ5 Phosphatidylinositol-3-phosphatase SAC1 chr3 Not Cancer Driver No 1 hippie, biogrid 33 0 0 0 0
SLC38A10-202 SLC38A10 Q9HBR0 Putative sodium-coupled neutral amino acid transporter 10 chr17 Not Cancer Driver No 1 hippie, biogrid 108 725 68 68 0
SLC39A10-201 SLC39A10 Q9ULF5 Zinc transporter ZIP10 chr2 Not Cancer Driver No 1 hippie, biogrid 74 417 41 41 0
SLC39A4-202 SLC39A4 Q6P5W5 Zinc transporter ZIP4 chr8 Not Cancer Driver No 1 hippie, biogrid 58 116 9 9 9
SORT1-201 SORT1 Q99523 Sortilin chr1 Not Cancer Driver No 1 hippie, biogrid 54 110 0 0 0
SP1-201 SP1 P08047 Transcription factor Sp1 chr12 Not Cancer Driver No 1 intact, hippie 67 601 53 53 0
SRC-204 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 Census Yes 1 intact, hippie, biogrid 40 130 10 10 1
STX17-201 STX17 P56962 Syntaxin-17 chr9 Not Cancer Driver No 1 hippie, biogrid 24 81 6 6 0
STXBP3-201 STXBP3 O00186 Syntaxin-binding protein 3 chr1 Not Cancer Driver No 1 hippie, biogrid 44 65 8 8 0
SYNJ2BP-201 SYNJ2BP P57105 Synaptojanin-2-binding protein chr14 Not Cancer Driver No 1 hippie, biogrid 21 12 1 1 0
TBC1D15-217 TBC1D15 Q8TC07 TBC1 domain family member 15 chr12 Not Cancer Driver No 1 hippie, biogrid 62 135 15 15 0
THADA-207 THADA Q6YHU6 Thyroid adenoma-associated protein chr2 Not Cancer Driver No 1 hippie, biogrid 142 63 4 4 0
THEM6-201 THEM6 Q8WUY1 Protein THEM6 chr8 Not Cancer Driver No 1 hippie, biogrid 3 7 0 0 0
TM9SF1-201 TM9SF1 O15321 Transmembrane 9 superfamily member 1 chr14 Not Cancer Driver No 1 hippie, biogrid 46 15 2 2 0
TM9SF3-201 TM9SF3 Q9HD45 Transmembrane 9 superfamily member 3 chr10 Not Cancer Driver No 1 hippie, biogrid 39 2 0 0 0
TMCO1-207 TMCO1 Q9UM00 Calcium load-activated calcium channel chr1 Not Cancer Driver No 1 hippie, biogrid 22 49 2 2 0
TMED1-201 TMED1 Q13445 Transmembrane emp24 domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie, biogrid 15 26 2 2 0
TMED5-202 TMED5 Q9Y3A6 Transmembrane emp24 domain-containing protein 5 chr1 Not Cancer Driver No 1 hippie, biogrid 14 1 0 0 0
TMEM126A-201 TMEM126A Q9H061 Transmembrane protein 126A chr11 Not Cancer Driver No 1 hippie, biogrid 9 7 0 0 0
TMEM160-201 TMEM160 Q9NX00 Transmembrane protein 160 chr19 Not Cancer Driver No 1 hippie, biogrid 3 46 0 0 0
TMEM259-202 TMEM259 Q4ZIN3 Membralin chr19 Not Cancer Driver No 1 hippie, biogrid 30 193 5 5 0
TNPO2-202 TNPO2 O14787 Transportin-2 chr19 Not Cancer Driver No 1 hippie, biogrid 77 76 9 9 10
TNPO3-201 TNPO3 Q9Y5L0 Transportin-3 chr7 Not Cancer Driver No 1 hippie, biogrid 95 12 1 1 1
TRIP6-201 TRIP6 Q15654 Thyroid receptor-interacting protein 6 chr7 Not Cancer Driver No 1 hippie 48 270 14 14 0
TSG101-201 TSG101 Q99816 Tumor susceptibility gene 101 protein chr11 Not Cancer Driver No 1 hippie, biogrid 31 160 15 15 0
TSPAN15-201 TSPAN15 O95858 Tetraspanin-15 chr10 Not Cancer Driver No 1 hippie, biogrid 18 0 0 0 0
TSPAN3-201 TSPAN3 O60637 Tetraspanin-3 chr15 Not Cancer Driver No 1 hippie, biogrid 18 0 0 0 0
TTI1-201 TTI1 O43156 TELO2-interacting protein 1 homolog chr20 Not Cancer Driver No 1 hippie, biogrid 104 94 12 12 0
TTYH2-201 TTYH2 Q9BSA4 Protein tweety homolog 2 chr17 Not Cancer Driver No 1 hippie, biogrid 43 69 14 14 0
TTYH3-201 TTYH3 Q9C0H2 Protein tweety homolog 3 chr7 Not Cancer Driver No 2 intact, hippie, biogrid 37 92 8 8 0
VPS28-201 VPS28 Q9UK41 Vacuolar protein sorting-associated protein 28 homolog chr8 Not Cancer Driver No 1 hippie, biogrid 17 31 5 5 0
VPS37A-201 VPS37A Q8NEZ2 Vacuolar protein sorting-associated protein 37A chr8 Not Cancer Driver No 1 hippie, biogrid 33 153 17 17 1
WWP2-202 WWP2 O00308 NEDD4-like E3 ubiquitin-protein ligase WWP2 chr16 Not Cancer Driver No 1 hippie 87 423 46 46 0
XPO4-201 XPO4 Q9C0E2 Exportin-4 chr13 Not Cancer Driver No 1 hippie, biogrid 80 66 2 2 0
YIPF3-202 YIPF3 Q9GZM5 Protein YIPF3 chr6 Not Cancer Driver No 1 hippie, biogrid 26 88 8 8 0
ZMYM3-201 ZMYM3 Q14202 Zinc finger MYM-type protein 3 chrX Census Yes 1 hippie, biogrid 158 538 76 76 0