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SPEN-201 ,SPEN ,Q96T58
  • Number of Interaction partner in intact: 0
  • Number of Interaction partner in biogrid: 38
  • Number of Interaction partner in hippie: 107
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABT1-201 ABT1 Q9ULW3 Activator of basal transcription 1 chr6 Not Cancer Driver No 1 hippie, biogrid 40 157 17 17 0
ANKRD36B-202 ANKRD36B Q8N2N9 Ankyrin repeat domain-containing protein 36B chr2 Not Cancer Driver No 1 hippie, biogrid 0 812 0 0 0
ASF1A-201 ASF1A Q9Y294 Histone chaperone ASF1A chr6 Not Cancer Driver No 1 hippie, biogrid 11 69 2 2 0
ATXN1-202 ATXN1 P54253 Ataxin-1 chr6 Not Cancer Driver No 1 hippie 111 608 91 91 0
BAG2-201 BAG2 O95816 BAG family molecular chaperone regulator 2 chr6 Not Cancer Driver No 1 hippie, biogrid 13 112 7 7 0
BAG4-201 BAG4 O95429 BAG family molecular chaperone regulator 4 chr8 Not Cancer Driver No 1 hippie, biogrid 40 402 36 36 0
BCL6-202 BCL6 P41182 B-cell lymphoma 6 protein chr3 Census, Compendium Yes 1 hippie 91 328 45 45 0
BCLAF1-214 BCLAF1 Q9NYF8 Bcl-2-associated transcription factor 1 chr6 Census, Compendium Yes 1 hippie 245 900 236 236 0
BIRC3-201 BIRC3 Q13489 Baculoviral IAP repeat-containing protein 3 chr11 Census, Compendium Yes 1 hippie 53 98 10 10 0
BMI1-201 BMI1 P35226 Polycomb complex protein BMI-1 chr10 Not Cancer Driver No 1 hippie 34 150 23 23 0
BPGM-201 BPGM P07738 Bisphosphoglycerate mutase chr7 Not Cancer Driver No 1 hippie, biogrid 27 15 0 0 2
CAMKV-209 CAMKV Q8NCB2 CaM kinase-like vesicle-associated protein chr3 Not Cancer Driver No 2 hippie, biogrid 67 226 22 22 0
CBX3-202 CBX3 Q13185 Chromobox protein homolog 3 chr7 Not Cancer Driver No 1 hippie, biogrid 18 119 13 13 0
CCNC-210 CCNC P24863 Cyclin-C chr6 Census Yes 3 hippie, biogrid 23 33 1 1 0
CCT8L2-201 CCT8L2 Q96SF2 T-complex protein 1 subunit theta-like 2 chr22 Not Cancer Driver No 1 hippie, biogrid 196 104 41 41 0
CDC5L-201 CDC5L Q99459 Cell division cycle 5-like protein chr6 Not Cancer Driver No 1 hippie 60 621 46 46 0
CHD4-206 CHD4 Q14839 Chromodomain-helicase-DNA-binding protein 4 chr12 Census, Compendium Yes 1 hippie 312 978 118 118 6
CLK1-201 CLK1 P49759 Dual specificity protein kinase CLK1 chr2 Not Cancer Driver No 1 hippie 51 131 16 16 0
CRK-201 CRK P46108 Adapter molecule crk chr17 Not Cancer Driver No 1 hippie 24 197 19 19 0
CTBP1-201 CTBP1 Q13363 C-terminal-binding protein 1 chr4 Not Cancer Driver No 1 hippie 30 123 8 8 1
CUL7-201 CUL7 Q14999 Cullin-7 chr6 Not Cancer Driver No 1 hippie 141 373 31 31 3
DAXX-202 DAXX Q9UER7 Death domain-associated protein 6 chr6 Census, Compendium Yes 2 hippie, biogrid 79 549 57 57 0
DHX8-201 DHX8 Q14562 ATP-dependent RNA helicase DHX8 chr17 Not Cancer Driver No 1 hippie, biogrid 92 490 40 40 0
DLX5-203 DLX5 P56178 Homeobox protein DLX-5 chr7 Not Cancer Driver No 1 hippie 64 223 54 54 1
DPPA4-201 DPPA4 Q7L190 Developmental pluripotency-associated protein 4 chr3 Not Cancer Driver No 1 hippie 76 183 39 39 0
DYNLT1-203 DYNLT1 P63172 Dynein light chain Tctex-type 1 chr6 Not Cancer Driver No 1 hippie 7 1 0 0 0
EED-201 EED O75530 Polycomb protein EED chr11 Census Yes 1 hippie 42 79 10 10 4
EGFR-201 EGFR P00533 Epidermal growth factor receptor chr7 Census, Compendium Yes 1 hippie 346 223 30 30 1
ESR1-201 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 hippie 92 198 19 19 2
EZH2-203 EZH2 Q15910 Histone-lysine N-methyltransferase EZH2 chr7 Census, Compendium Yes 1 hippie 74 284 32 32 11
FERMT3-201 FERMT3 Q86UX7 Fermitin family homolog 3 chr11 Not Cancer Driver No 1 hippie 75 108 13 13 0
FHL2-211 FHL2 Q14192 Four and a half LIM domains protein 2 chr2 Not Cancer Driver No 1 hippie, biogrid 17 0 0 0 0
GRB2-202 GRB2 P62993 Growth factor receptor-bound protein 2 chr17 Not Cancer Driver No 1 hippie 21 10 0 0 0
HDAC1-201 HDAC1 Q13547 Histone deacetylase 1 chr1 Not Cancer Driver No 1 hippie 30 135 5 5 0
HDAC2-205 HDAC2 Q92769 Histone deacetylase 2 chr6 Not Cancer Driver No 1 hippie 34 145 11 11 0
HIF1AN-201 HIF1AN Q9NWT6 Hypoxia-inducible factor 1-alpha inhibitor chr10 Not Cancer Driver No 1 hippie 24 78 5 5 0
HMGA1-201 HMGA1 P17096 High mobility group protein HMG-I/HMG-Y chr6 Census Yes 1 hippie 3 107 3 3 0
HNF4A-201 HNF4A P41235 Hepatocyte nuclear factor 4-alpha chr20 Not Cancer Driver No 1 hippie 113 127 44 44 5
HSPA1A-201 HSPA1A P0DMV8 Heat shock 70 kDa protein 1A chr6 Not Cancer Driver No 1 hippie, biogrid 20 200 10 10 0
HSPA1B-201 HSPA1A P0DMV8 Heat shock 70 kDa protein 1A chr6 Not Cancer Driver No 1 hippie, biogrid 19 200 7 7 0
HSPA2-201 HSPA2 P54652 Heat shock-related 70 kDa protein 2 chr14 Not Cancer Driver No 1 hippie, biogrid 68 286 30 30 0
HSPA8-224 HSPA8 P11142 Heat shock cognate 71 kDa protein chr11 Not Cancer Driver No 1 hippie, biogrid 82 252 28 28 0
IRF2BP2-201 IRF2BP2 Q7Z5L9 Interferon regulatory factor 2-binding protein 2 chr1 Not Cancer Driver No 1 hippie 36 453 24 24 1
KCNE3-201 KCNE3 Q9Y6H6 Potassium voltage-gated channel subfamily E member 3 chr11 Not Cancer Driver No 1 hippie, biogrid 25 25 2 2 0
KDR-201 KDR P35968 Vascular endothelial growth factor receptor 2 chr4 Census, Compendium Yes 1 biogrid 276 276 40 40 2
KLF8-204 KLF8 O95600 Krueppel-like factor 8 chrX Not Cancer Driver No 1 hippie 44 271 32 32 0
MBD3-202 MBD3 O95983 Methyl-CpG-binding domain protein 3 chr19 Not Cancer Driver No 1 hippie 38 247 35 35 0
MED23-205 MED23 Q9ULK4 Mediator of RNA polymerase II transcription subunit 23 chr6 Not Cancer Driver No 1 hippie 109 28 3 3 1
MKI67-202 MKI67 P46013 Proliferation marker protein Ki-67 chr10 Not Cancer Driver No 1 hippie, biogrid 346 3213 343 343 0
MSX2-201 MSX2 P35548 Homeobox protein MSX-2 chr5 Not Cancer Driver No 1 hippie 21 170 10 10 3
MTA2-201 MTA2 O94776 Metastasis-associated protein MTA2 chr11 Not Cancer Driver No 1 hippie 59 283 25 25 0
MYC-206 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 72 325 41 41 0
NCBP2-201 NCBP2 P52298 Nuclear cap-binding protein subunit 2 chr3 Not Cancer Driver No 1 hippie 18 35 3 3 0
NCK1-207 NCK1 P16333 Cytoplasmic protein NCK1 chr3 Not Cancer Driver No 1 hippie 41 111 15 15 0
NCOR1-201 NCOR1 O75376 Nuclear receptor corepressor 1 chr17 Census, Compendium Yes 1 hippie 265 2348 258 258 0
NCOR2-202 NCOR2 Q9Y618 Nuclear receptor corepressor 2 chr12 Census, Compendium Yes 1 hippie 167 2369 167 167 0
NFIX-214 NFIX Q14938 Nuclear factor 1 X-type chr19 Not Cancer Driver No 1 hippie 45 305 26 26 6
NFKBIL1-203 NFKBIL1 Q9UBC1 NF-kappa-B inhibitor-like protein 1 chr6 Not Cancer Driver No 1 hippie, biogrid 30 316 26 26 0
NOTCH2-201 NOTCH2 Q04721 Neurogenic locus notch homolog protein 2 chr1 Census, Compendium Yes 1 hippie, biogrid 191 631 61 61 1
NR3C1-203 NR3C1 P04150 Glucocorticoid receptor chr5 Not Cancer Driver No 1 hippie 55 364 20 20 11
NUP50-201 NUP50 Q9UKX7 Nuclear pore complex protein Nup50 chr22 Not Cancer Driver No 1 hippie, biogrid 43 335 30 30 0
NUP54-201 NUP54 Q7Z3B4 Nucleoporin p54 chr4 Not Cancer Driver No 1 hippie, biogrid 22 234 11 11 0
OBSL1-204 OBSL1 O75147 Obscurin-like protein 1 chr2 Not Cancer Driver No 1 hippie 168 556 38 38 0
PCBP3-222 PCBP3 P57721 Poly(rC)-binding protein 3 chr21 Not Cancer Driver No 1 hippie, biogrid 52 232 38 38 0
PIK3R1-211 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 Census, Compendium Yes 1 hippie 122 271 50 50 2
PIP4K2A-202 PIP4K2A P48426 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha chr10 Not Cancer Driver No 2 hippie, biogrid 41 123 12 12 0
PIR-201 PIR O00625 Pirin chrX Not Cancer Driver No 1 hippie, biogrid 19 186 11 11 0
PLCD3-212 PLCD3 Q8N3E9 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 chr17 Not Cancer Driver No 1 hippie, biogrid 54 231 18 18 0
PLCG1-202 PLCG1 P19174 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 chr20 Census, Compendium Yes 1 hippie 129 187 15 15 0
PPARD-203 PPARD Q03181 Peroxisome proliferator-activated receptor delta chr6 Not Cancer Driver No 1 hippie 51 70 5 5 0
PRC1-202 PRC1 O43663 Protein regulator of cytokinesis 1 chr15 Not Cancer Driver No 1 hippie 44 236 17 17 0
PRDX3-201 PRDX3 P30048 Thioredoxin-dependent peroxide reductase, mitochondrial chr10 Not Cancer Driver No 1 hippie, biogrid 17 23 2 2 2
PYHIN1-203 PYHIN1 Q6K0P9 Pyrin and HIN domain-containing protein 1 chr1 Not Cancer Driver No 1 hippie 139 293 81 81 0
RAD18-201 RAD18 Q9NS91 E3 ubiquitin-protein ligase RAD18 chr3 Not Cancer Driver No 1 hippie 42 330 31 31 0
RARA-201 RARA P10276 Retinoic acid receptor alpha chr17 Census, Compendium Yes 1 hippie 60 167 14 14 0
RBBP4-202 RBBP4 Q09028 Histone-binding protein RBBP4 chr1 Not Cancer Driver No 1 hippie 40 169 19 19 0
RBBP8-201 RBBP8 Q99708 DNA endonuclease RBBP8 chr18 Not Cancer Driver No 1 hippie 72 751 54 54 1
RBPJ-206 RBPJ Q06330 Recombining binding protein suppressor of hairless chr4 Not Cancer Driver No 4 hippie, biogrid 32 151 10 10 2
RHOBTB1-201 RHOBTB1 O94844 Rho-related BTB domain-containing protein 1 chr10 Not Cancer Driver No 1 hippie 83 121 16 16 0
RIDA-201 RIDA P52758 2-iminobutanoate/2-iminopropanoate deaminase chr8 Not Cancer Driver No 1 hippie 13 3 0 0 0
RPL10A-201 RPL10A P62906 Large ribosomal subunit protein uL1 chr6 Not Cancer Driver No 1 hippie 20 16 0 0 0
RRP1B-201 RRP1B Q14684 Ribosomal RNA processing protein 1 homolog B chr21 Not Cancer Driver No 1 hippie 61 517 40 40 0
RUNX1-202 RUNX1 Q01196 Runt-related transcription factor 1 chr21 Census, Compendium Yes 1 hippie 62 361 46 46 2
RUNX1T1-245 RUNX1T1 Q06455 Protein CBFA2T1 chr8 Census, Compendium Yes 1 hippie 216 469 171 171 0
SCYL2-201 SCYL2 Q6P3W7 SCY1-like protein 2 chr12 Not Cancer Driver No 1 hippie, biogrid 77 326 26 26 0
SERTAD1-201 SERTAD1 Q9UHV2 SERTA domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie 20 166 15 15 0
SIRT7-201 SIRT7 Q9NRC8 NAD-dependent protein deacetylase sirtuin-7 chr17 Not Cancer Driver No 1 hippie 34 163 10 10 0
SOX2-201 SOX2 P48431 Transcription factor SOX-2 chr3 Census Yes 1 hippie 32 312 32 32 0
SOX9-201 SOX9 P48436 Transcription factor SOX-9 chr17 Compendium Yes 1 hippie 69 497 66 66 13
SRA1-201 SRA1 Q9HD15 Steroid receptor RNA activator 1 chr5 Not Cancer Driver No 1 hippie 14 174 11 11 0
SRPK2-201 SRPK2 P78362 SRSF protein kinase 2 chr7 Not Cancer Driver No 1 hippie 57 344 31 31 0
SRSF6-201 SRSF6 Q13247 Serine/arginine-rich splicing factor 6 chr20 Not Cancer Driver No 1 hippie, biogrid 29 259 12 12 0
SULF2-213 SULF2 Q8IWU5 Extracellular sulfatase Sulf-2 chr20 Not Cancer Driver No 1 hippie, biogrid 126 142 16 16 0
SUMO1-203 SUMO1 P63165 Small ubiquitin-related modifier 1 chr2 Not Cancer Driver No 1 hippie 10 76 7 7 0
SUPT5H-204 SUPT5H O00267 Transcription elongation factor SPT5 chr19 Not Cancer Driver No 1 hippie 115 574 58 58 0
TBXT-201 TBXT O15178 T-box transcription factor T chr6 Not Cancer Driver No 1 hippie 85 255 52 52 1
TCTE1-202 TCTE1 Q5JU00 Dynein regulatory complex subunit 5 chr6 Not Cancer Driver No 1 hippie 73 126 16 16 0
TERF2IP-201 TERF2IP Q9NYB0 Telomeric repeat-binding factor 2-interacting protein 1 chr16 Not Cancer Driver No 1 hippie, biogrid 20 312 12 12 0
TRIM37-201 TRIM37 O94972 E3 ubiquitin-protein ligase TRIM37 chr17 Not Cancer Driver No 1 hippie 89 493 42 42 3
TRIML2-208 TRIML2 Q8N7C3 Probable E3 ubiquitin-protein ligase TRIML2 chr4 Not Cancer Driver No 2 hippie, biogrid 137 78 21 21 0
TTN-215 TTN Q8WZ42 Titin chr2 Not Cancer Driver No 1 hippie, biogrid 3472 12945 1338 1338 10
UBE2E2-202 UBE2E2 Q96LR5 Ubiquitin-conjugating enzyme E2 E2 chr3 Not Cancer Driver No 1 hippie 23 90 11 11 0
UBE2L6-201 UBE2L6 O14933 Ubiquitin/ISG15-conjugating enzyme E2 L6 chr11 Not Cancer Driver No 1 hippie 13 7 1 1 0
USP37-201 USP37 Q86T82 Ubiquitin carboxyl-terminal hydrolase 37 chr2 Not Cancer Driver No 1 hippie 78 531 43 43 0
VIRMA-201 VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 157 634 73 73 0
WRAP73-201 WRAP73 Q9P2S5 WD repeat-containing protein WRAP73 chr1 Not Cancer Driver No 3 hippie, biogrid 34 5 0 0 0
XRCC6-202 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 Not Cancer Driver No 1 hippie 49 140 8 8 0
ZC3H18-201 ZC3H18 Q86VM9 Zinc finger CCCH domain-containing protein 18 chr16 Not Cancer Driver No 1 hippie, biogrid 36 929 33 33 0