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THEM4-201 ,THEM4 ,Q5T1C6
  • Number of Interaction partner in intact: 20
  • Number of Interaction partner in biogrid: 65
  • Number of Interaction partner in hippie: 83
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AARS2-201 AARS2 Q5JTZ9 Alanine--tRNA ligase, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 91 203 23 23 5
ACAD9-201 ACAD9 Q9H845 Complex I assembly factor ACAD9, mitochondrial chr3 Not Cancer Driver No 1 hippie, biogrid 54 28 2 2 12
ACO2-201 ACO2 Q99798 Aconitate hydratase, mitochondrial chr22 Not Cancer Driver No 1 hippie, biogrid 77 172 16 16 5
AKT1-218 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 Census, Compendium Yes 2 intact, hippie 99 158 19 19 4
ALAS1-205 ALAS1 P13196 5-aminolevulinate synthase, non-specific, mitochondrial chr3 Not Cancer Driver No 2 intact, hippie, biogrid 39 178 9 9 0
ALDH7A1-201 ALDH7A1 P49419 Alpha-aminoadipic semialdehyde dehydrogenase chr5 Not Cancer Driver No 1 hippie, biogrid 41 26 0 0 8
AUH-202 AUH Q13825 Methylglutaconyl-CoA hydratase, mitochondrial chr9 Not Cancer Driver No 1 hippie, biogrid 28 29 0 0 1
AURKAIP1-202 AURKAIP1 Q9NWT8 Small ribosomal subunit protein mS38 chr1 Not Cancer Driver No 1 hippie 17 104 8 8 0
C1QBP-201 C1QBP Q07021 Complement component 1 Q subcomponent-binding protein, mitochondrial chr17 Not Cancer Driver No 1 hippie, biogrid 14 103 5 5 2
CARD9-201 CARD9 Q9H257 Caspase recruitment domain-containing protein 9 chr9 Not Cancer Driver No 1 intact, hippie, biogrid 54 225 26 26 10
CLDN18-201 CLDN18 P56856 Claudin-18 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 28 21 2 2 0
CLPP-201 CLPP Q16740 ATP-dependent Clp protease proteolytic subunit, mitochondrial chr19 Not Cancer Driver No 1 hippie 15 83 7 7 3
CMPK1-207 CMPK1 P30085 UMP-CMP kinase chr1 Not Cancer Driver No 1 hippie, biogrid 15 41 5 5 0
CS-201 CS O75390 Citrate synthase, mitochondrial chr12 Not Cancer Driver No 2 hippie, biogrid 38 13 2 2 0
DBT-202 DBT P11182 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial chr1 Not Cancer Driver No 2 intact, hippie, biogrid 49 82 7 7 3
DNAJC15-201 DNAJC15 Q9Y5T4 DnaJ homolog subfamily C member 15 chr13 Not Cancer Driver No 1 hippie, biogrid 15 25 2 2 0
ENOPH1-201 ENOPH1 Q9UHY7 Enolase-phosphatase E1 chr4 Not Cancer Driver No 2 hippie, biogrid 23 14 2 2 0
FAHD2A-201 FAHD2A Q96GK7 Fumarylacetoacetate hydrolase domain-containing protein 2A chr2 Not Cancer Driver No 1 hippie, biogrid 25 8 1 1 0
FASTKD2-202 FASTKD2 Q9NYY8 FAST kinase domain-containing protein 2, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 49 30 2 2 0
FASTKD5-201 FASTKD5 Q7L8L6 FAST kinase domain-containing protein 5, mitochondrial chr20 Not Cancer Driver No 1 hippie, biogrid 58 94 3 3 0
FGFR3-205 FGFR3 P22607 Fibroblast growth factor receptor 3 chr4 Census, Compendium Yes 1 intact, hippie 134 241 18 18 32
FPGS-203 FPGS Q05932 Folylpolyglutamate synthase, mitochondrial chr9 Not Cancer Driver No 2 intact, hippie, biogrid 50 142 15 15 0
GFM1-210 GFM1 Q96RP9 Elongation factor G, mitochondrial chr3 Not Cancer Driver No 1 hippie, biogrid 49 79 5 5 4
GPT2-201 GPT2 Q8TD30 Alanine aminotransferase 2 chr16 Not Cancer Driver No 2 intact, hippie, biogrid 49 68 5 5 1
GRSF1-201 GRSF1 Q12849 G-rich sequence factor 1 chr4 Not Cancer Driver No 2 hippie, biogrid 33 147 15 15 0
HDHD3-202 HDHD3 Q9BSH5 Haloacid dehalogenase-like hydrolase domain-containing protein 3 chr9 Not Cancer Driver No 1 hippie, biogrid 27 0 0 0 0
HELB-201 HELB Q8NG08 DNA helicase B chr12 Not Cancer Driver No 1 hippie, biogrid 96 302 24 24 0
HINT2-201 HINT2 Q9BX68 Adenosine 5'-monophosphoramidase HINT2 chr9 Not Cancer Driver No 1 hippie, biogrid 6 29 1 1 0
HNRNPL-201 HNRNPL P14866 Heterogeneous nuclear ribonucleoprotein L chr19 Not Cancer Driver No 1 hippie 61 283 23 23 0
HRAS-201 HRAS P01112 GTPase HRas chr11 Census, Compendium Yes 1 intact, hippie 129 16 2 2 10
HSCB-201 HSCB Q8IWL3 Iron-sulfur cluster co-chaperone protein HscB chr22 Not Cancer Driver No 1 hippie, biogrid 23 25 3 3 0
HSPD1-202 HSPD1 P10809 60 kDa heat shock protein, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 45 83 1 1 2
IMMP1L-209 IMMP1L Q96LU5 Mitochondrial inner membrane protease subunit 1 chr11 Not Cancer Driver No 1 hippie 15 3 0 0 0
IMMP2L-202 IMMP2L Q96T52 Mitochondrial inner membrane protease subunit 2 chr7 Not Cancer Driver No 1 hippie 32 29 6 6 0
KLC2-204 KLC2 Q9H0B6 Kinesin light chain 2 chr11 Not Cancer Driver No 1 intact, hippie, biogrid 53 346 38 38 0
LBH-201 LBH Q53QV2 Protein LBH chr2 Not Cancer Driver No 1 hippie, biogrid 11 72 7 7 0
LONP1-201 LONP1 P36776 Lon protease homolog, mitochondrial chr19 Not Cancer Driver No 1 hippie, biogrid 75 178 16 16 10
LRPPRC-201 LRPPRC P42704 Leucine-rich PPR motif-containing protein, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 99 18 0 0 1
MCUR1-201 MCUR1 Q96AQ8 Mitochondrial calcium uniporter regulator 1 chr6 Not Cancer Driver No 1 hippie, biogrid 22 66 0 0 0
MDH2-201 MDH2 P40926 Malate dehydrogenase, mitochondrial chr7 Not Cancer Driver No 1 hippie, biogrid 26 8 1 1 3
METTL17-201 METTL17 Q9H7H0 Methyltransferase-like protein 17, mitochondrial chr14 Not Cancer Driver No 1 hippie, biogrid 48 95 10 10 0
MGST3-205 MGST3 O14880 Glutathione S-transferase 3, mitochondrial chr1 Not Cancer Driver No 1 intact, hippie 17 0 0 0 0
MRM1-204 MRM1 Q6IN84 rRNA methyltransferase 1, mitochondrial chr17 Not Cancer Driver No 1 hippie 27 106 8 8 0
MRPL11-201 MRPL11 Q9Y3B7 Large ribosomal subunit protein uL11m chr11 Not Cancer Driver No 1 hippie, biogrid 20 12 2 2 0
MRPL49-201 MRPL49 Q13405 Large ribosomal subunit protein mL49 chr11 Not Cancer Driver No 1 hippie, biogrid 14 74 7 7 0
MRPS26-201 MRPS26 Q9BYN8 Small ribosomal subunit protein mS26 chr20 Not Cancer Driver No 1 hippie, biogrid 12 102 4 4 0
MRRF-202 MRRF Q96E11 Ribosome-recycling factor, mitochondrial chr9 Not Cancer Driver No 1 hippie, biogrid 13 118 6 6 0
MTERF3-201 MTERF3 Q96E29 Transcription termination factor 3, mitochondrial chr8 Not Cancer Driver No 1 hippie, biogrid 35 62 4 4 0
MTIF2-201 MTIF2 P46199 Translation initiation factor IF-2, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 71 114 7 7 0
MTIF3-202 MTIF3 Q9H2K0 Translation initiation factor IF-3, mitochondrial chr13 Not Cancer Driver No 1 hippie, biogrid 15 180 11 11 0
MTRF1-203 MTRF1 O75570 Peptide chain release factor 1, mitochondrial chr13 Not Cancer Driver No 1 hippie, biogrid 33 72 4 4 0
MTRF1L-203 MTRF1L Q9UGC7 Peptide chain release factor 1-like, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 17 185 5 5 0
NDUFAB1-201 NDUFAB1 O14561 Acyl carrier protein, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 16 0 0 0 0
NENF-201 NENF Q9UMX5 Neudesin chr1 Not Cancer Driver No 1 hippie, biogrid 12 98 6 6 0
PARK7-201 PARK7 Q99497 Parkinson disease protein 7 chr1 Not Cancer Driver No 1 hippie, biogrid 8 30 0 0 6
PARL-202 PARL Q9H300 Presenilin-associated rhomboid-like protein, mitochondrial chr3 Not Cancer Driver No 1 intact, hippie 38 28 5 5 0
PDHA1-205 PDHA1 P08559 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial chrX Not Cancer Driver No 1 hippie, biogrid 40 43 4 4 19
PDK1-201 PDK1 Q15118 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 32 49 7 7 0
PDSS1-201 PDSS1 Q5T2R2 All trans-polyprenyl-diphosphate synthase PDSS1 chr10 Not Cancer Driver No 2 intact, hippie, biogrid 37 52 7 7 1
PDSS2-202 PDSS2 Q86YH6 All trans-polyprenyl-diphosphate synthase PDSS2 chr6 Not Cancer Driver No 2 hippie, biogrid 27 7 0 0 1
PECAM1-203 PECAM1 P16284 Platelet endothelial cell adhesion molecule chr17 Not Cancer Driver No 1 hippie 0 153 0 0 0
PMPCA-201 PMPCA Q10713 Mitochondrial-processing peptidase subunit alpha chr9 Not Cancer Driver No 1 hippie, biogrid 48 23 3 3 4
PMPCB-201 PMPCB O75439 Mitochondrial-processing peptidase subunit beta chr7 Not Cancer Driver No 1 hippie, biogrid 36 22 2 2 4
POMC-203 POMC P01189 Pro-opiomelanocortin chr2 Not Cancer Driver No 1 hippie, biogrid 28 200 23 23 0
RHOG-201 RHOG P84095 Rho-related GTP-binding protein RhoG chr11 Not Cancer Driver No 1 hippie 20 22 3 3 0
RPUSD4-201 RPUSD4 Q96CM3 Pseudouridylate synthase RPUSD4, mitochondrial chr11 Not Cancer Driver No 1 hippie, biogrid 44 98 15 15 0
SIRT5-205 SIRT5 Q9NXA8 NAD-dependent protein deacylase sirtuin-5, mitochondrial chr6 Not Cancer Driver No 2 intact, hippie, biogrid 22 55 2 2 0
SPRED1-201 SPRED1 Q7Z699 Sprouty-related, EVH1 domain-containing protein 1 chr15 Not Cancer Driver No 1 intact, hippie 53 195 28 28 2
TBCA-202 TBCA O75347 Tubulin-specific chaperone A chr5 Not Cancer Driver No 1 hippie, biogrid 7 30 2 2 0
TBRG4-201 TBRG4 Q969Z0 FAST kinase domain-containing protein 4 chr7 Not Cancer Driver No 1 hippie, biogrid 56 61 1 1 0
TFAM-204 TFAM Q00059 Transcription factor A, mitochondrial chr10 Not Cancer Driver No 1 hippie, biogrid 19 110 11 11 1
THEM5-201 THEM5 Q8N1Q8 Acyl-coenzyme A thioesterase THEM5 chr1 Not Cancer Driver No 1 hippie, biogrid 26 1 0 0 0
TMEM70-201 TMEM70 Q9BUB7 Transmembrane protein 70, mitochondrial chr8 Not Cancer Driver No 1 hippie, biogrid 17 24 1 1 1
TOP3A-201 TOP3A Q13472 DNA topoisomerase 3-alpha chr17 Not Cancer Driver No 2 intact, hippie, biogrid 79 293 28 28 2
TRAP1-201 TRAP1 Q12931 Heat shock protein 75 kDa, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 51 110 6 6 0
TRMT61B-201 TRMT61B Q9BVS5 tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 40 124 11 11 0
TRUB2-201 TRUB2 O95900 Pseudouridylate synthase TRUB2, mitochondrial chr9 Not Cancer Driver No 1 hippie, biogrid 28 73 6 6 0
TSFM-212 TSFM P43897 Elongation factor Ts, mitochondrial chr12 Not Cancer Driver No 1 hippie, biogrid 21 74 4 4 2
TUFM-201 TUFM P49411 Elongation factor Tu, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 36 51 4 4 1
UCHL1-201 UCHL1 P09936 Ubiquitin carboxyl-terminal hydrolase isozyme L1 chr4 Not Cancer Driver No 1 hippie, biogrid 23 34 5 5 4
ULBP1-201 ULBP1 Q9BZM6 UL16-binding protein 1 chr6 Not Cancer Driver No 1 hippie, biogrid 26 25 4 4 0
VIM-209 VIM P08670 Vimentin chr10 Not Cancer Driver No 1 intact, hippie 67 316 45 45 1
VWA8-203 VWA8 A3KMH1 von Willebrand factor A domain-containing protein 8 chr13 Not Cancer Driver No 1 hippie, biogrid 153 384 24 24 0