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USP21-203 ,USP21 ,Q9UK80
  • Number of Interaction partner in intact: 42
  • Number of Interaction partner in biogrid: 19
  • Number of Interaction partner in hippie: 146
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ADAMTSL4-201 ADAMTSL4 Q6UY14 ADAMTS-like protein 4 chr1 Not Cancer Driver No 1 hippie 134 566 68 68 0
AFDN-211 AFDN P55196 Afadin chr6 Census Yes 2 intact, hippie 162 1247 123 123 0
AGAP1-201 AGAP1 Q9UPQ3 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 chr2 Not Cancer Driver No 1 hippie 121 407 59 59 0
ANKRD28-201 ANKRD28 O15084 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A chr3 Not Cancer Driver No 1 intact, hippie, biogrid 83 115 14 14 0
ANKRD34A-201 ANKRD34A Q69YU3 Ankyrin repeat domain-containing protein 34A chr1 Not Cancer Driver No 2 intact, hippie 80 411 69 69 0
ARHGEF2-203 ARHGEF2 Q92974 Rho guanine nucleotide exchange factor 2 chr1 Not Cancer Driver No 1 hippie 121 450 64 64 0
ATXN3-251 ATXN3 P54252 Ataxin-3 chr14 Not Cancer Driver No 1 hippie 25 183 12 12 0
AURKA-208 AURKA O14965 Aurora kinase A chr20 Not Cancer Driver No 1 hippie 25 180 17 17 0
BAP1-202 BAP1 Q92560 Ubiquitin carboxyl-terminal hydrolase BAP1 chr3 Census, Compendium Yes 1 hippie 116 419 42 42 4
BAZ2A-214 BAZ2A Q9UIF9 Bromodomain adjacent to zinc finger domain protein 2A chr12 Not Cancer Driver No 1 hippie 137 1287 81 81 0
BEND3-201 BEND3 Q5T5X7 BEN domain-containing protein 3 chr6 Not Cancer Driver No 1 intact, hippie, biogrid 92 311 36 36 0
BHLHE40-201 BHLHE40 O14503 Class E basic helix-loop-helix protein 40 chr3 Not Cancer Driver No 1 hippie 35 243 20 20 0
BRCA2-201 BRCA2 P51587 Breast cancer type 2 susceptibility protein chr13 Census, Compendium Yes 1 hippie 310 1545 152 152 46
CBL-201 CBL P22681 E3 ubiquitin-protein ligase CBL chr11 Census, Compendium Yes 1 hippie 84 513 44 44 4
CBLC-203 CBLC Q9ULV8 E3 ubiquitin-protein ligase CBL-C chr19 Census Yes 1 hippie 43 126 12 12 0
CBY1-201 CBY1 Q9Y3M2 Protein chibby homolog 1 chr22 Not Cancer Driver No 2 intact, hippie 9 98 7 7 0
CDC25B-201 CDC25B P30305 M-phase inducer phosphatase 2 chr20 Not Cancer Driver No 1 hippie 61 329 33 33 0
CDC34-201 CDC34 P49427 Ubiquitin-conjugating enzyme E2 R1 chr19 Not Cancer Driver No 1 hippie 19 96 7 7 0
CDK16-202 CDK16 Q00536 Cyclin-dependent kinase 16 chrX Not Cancer Driver No 1 hippie 42 140 21 21 0
CKAP5-210 CKAP5 Q14008 Cytoskeleton-associated protein 5 chr11 Not Cancer Driver No 1 hippie 149 634 48 48 0
CPSF6-202 CPSF6 Q16630 Cleavage and polyadenylation specificity factor subunit 6 chr12 Not Cancer Driver No 1 intact, hippie 15 485 9 9 0
CTNNB1-201 CTNNB1 P35222 Catenin beta-1 chr3 Census, Compendium Yes 1 hippie 363 288 291 291 11
CUL3-201 CUL3 Q13618 Cullin-3 chr2 Census, Compendium Yes 1 hippie 98 168 18 18 3
DCLK1-202 DCLK1 O15075 Serine/threonine-protein kinase DCLK1 chr13 Not Cancer Driver No 1 hippie 148 253 49 49 0
DENND1A-203 DENND1A Q8TEH3 DENN domain-containing protein 1A chr9 Not Cancer Driver No 1 hippie 98 591 63 63 0
DENND4C-209 DENND4C Q5VZ89 DENN domain-containing protein 4C chr9 Not Cancer Driver No 2 intact, hippie 121 709 40 40 0
DEPDC1B-201 DEPDC1B Q8WUY9 DEP domain-containing protein 1B chr5 Not Cancer Driver No 2 intact, hippie 54 52 3 3 0
DHX58-201 DHX58 Q96C10 ATP-dependent RNA helicase DHX58 chr17 Not Cancer Driver No 1 hippie 50 84 7 7 0
DTX3-201 DTX3 Q8N9I9 Probable E3 ubiquitin-protein ligase DTX3 chr12 Not Cancer Driver No 1 hippie 47 182 25 25 0
EFEMP2-201 EFEMP2 O95967 EGF-containing fibulin-like extracellular matrix protein 2 chr11 Not Cancer Driver No 1 hippie 55 41 2 2 7
EIF4E2-201 EIF4E2 O60573 Eukaryotic translation initiation factor 4E type 2 chr2 Not Cancer Driver No 2 intact, hippie 24 80 5 5 0
ESPL1-201 ESPL1 Q14674 Separin chr12 Not Cancer Driver No 1 hippie 172 383 27 27 0
EXOSC10-202 EXOSC10 Q01780 Exosome component 10 chr1 Not Cancer Driver No 1 hippie 66 378 27 27 0
FAM110A-204 FAM110A Q9BQ89 Protein FAM110A chr20 Not Cancer Driver No 2 intact, hippie 16 248 11 11 0
FAM110B-203 FAM110B Q8TC76 Protein FAM110B chr8 Not Cancer Driver No 2 intact, hippie 64 299 56 56 0
FAM53C-201 FAM53C Q9NYF3 Protein FAM53C chr5 Not Cancer Driver No 2 intact, hippie 40 296 35 35 0
FOXM1-202 FOXM1 Q08050 Forkhead box protein M1 chr12 Not Cancer Driver No 1 hippie 73 605 57 57 0
FUCA1-201 FUCA1 P04066 Tissue alpha-L-fucosidase chr1 Not Cancer Driver No 1 intact, hippie, biogrid 30 13 1 1 3
GAB2-202 GAB2 Q9UQC2 GRB2-associated-binding protein 2 chr11 Not Cancer Driver No 1 hippie 63 540 53 53 0
GATA3-201 GATA3 P23771 Trans-acting T-cell-specific transcription factor GATA-3 chr10 Census, Compendium Yes 1 hippie 99 368 79 79 2
GIGYF1-207 GIGYF1 O75420 GRB10-interacting GYF protein 1 chr7 Not Cancer Driver No 1 hippie 111 860 94 94 0
GLI1-201 GLI1 P08151 Zinc finger protein GLI1 chr12 Census, Compendium Yes 1 hippie 156 1018 138 138 0
GLI2-209 GLI2 P10070 Zinc finger protein GLI2 chr2 Not Cancer Driver No 1 hippie 235 1407 200 200 2
GSC-201 GSC P56915 Homeobox protein goosecoid chr14 Not Cancer Driver No 1 hippie 13 109 9 9 0
HDAC4-201 HDAC4 P56524 Histone deacetylase 4 chr2 Not Cancer Driver No 2 intact, hippie 145 751 95 95 3
HECW2-212 HECW2 Q9P2P5 E3 ubiquitin-protein ligase HECW2 chr2 Not Cancer Driver No 1 hippie 272 848 157 157 4
HOXC10-201 HOXC10 Q9NYD6 Homeobox protein Hox-C10 chr12 Not Cancer Driver No 1 intact, hippie 42 267 32 32 0
IFIH1-206 IFIH1 Q9BYX4 Interferon-induced helicase C domain-containing protein 1 chr2 Not Cancer Driver No 1 hippie 83 288 27 27 9
IL33-206 IL33 O95760 Interleukin-33 chr9 Not Cancer Driver No 1 hippie 31 47 5 5 0
ISG15-203 ISG15 P05161 Ubiquitin-like protein ISG15 chr1 Not Cancer Driver No 1 hippie 12 24 2 2 0
JOSD1-210 JOSD1 Q15040 Josephin-1 chr22 Not Cancer Driver No 1 hippie 12 23 0 0 0
KCTD11-202 KCTD11 Q693B1 BTB/POZ domain-containing protein KCTD11 chr17 Not Cancer Driver No 1 hippie 27 54 3 3 0
KCTD3-201 KCTD3 Q9Y597 BTB/POZ domain-containing protein KCTD3 chr1 Not Cancer Driver No 2 intact, hippie 90 326 39 39 0
KCTD6-202 KCTD6 Q8NC69 BTB/POZ domain-containing protein KCTD6 chr3 Not Cancer Driver No 1 hippie 23 12 0 0 0
KCTD9-201 KCTD9 Q7L273 BTB/POZ domain-containing protein KCTD9 chr8 Not Cancer Driver No 1 intact, hippie 32 27 0 0 0
KIF13B-206 KIF13B Q9NQT8 Kinesin-like protein KIF13B chr8 Not Cancer Driver No 1 hippie 131 970 56 56 0
KIF1C-201 KIF1C O43896 Kinesin-like protein KIF1C chr17 Not Cancer Driver No 2 intact, hippie 97 700 69 69 1
KRT40-201 KRT40 Q6A162 Keratin, type I cytoskeletal 40 chr17 Not Cancer Driver No 1 intact, hippie 50 7 2 2 0
KSR1-219 KSR1 Q8IVT5 Kinase suppressor of Ras 1 chr17 Not Cancer Driver No 2 intact, hippie 88 408 46 46 0
LIMA1-201 LIMA1 Q9UHB6 LIM domain and actin-binding protein 1 chr12 Not Cancer Driver No 1 hippie 64 688 60 60 0
LRFN1-201 LRFN1 Q9P244 Leucine-rich repeat and fibronectin type III domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie 77 278 31 31 0
LRSAM1-201 LRSAM1 Q6UWE0 E3 ubiquitin-protein ligase LRSAM1 chr9 Not Cancer Driver No 1 hippie 71 240 24 24 1
MAGI1-202 MAGI1 Q96QZ7 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 chr3 Not Cancer Driver No 2 intact, hippie 173 1181 140 140 0
MAP3K21-203 MAP3K21 Q5TCX8 Mitogen-activated protein kinase kinase kinase 21 chr1 Not Cancer Driver No 2 intact, hippie 146 665 92 92 0
MAP4-202 MAP4 P27816 Microtubule-associated protein 4 chr3 Not Cancer Driver No 1 hippie 83 1140 80 80 0
MAPK3-201 MAPK3 P27361 Mitogen-activated protein kinase 3 chr16 Not Cancer Driver No 1 hippie 32 49 3 3 0
MAPKAP1-201 MAPKAP1 Q9BPZ7 Target of rapamycin complex 2 subunit MAPKAP1 chr9 Not Cancer Driver No 1 hippie 57 173 17 17 0
MARK1-201 MARK1 Q9P0L2 Serine/threonine-protein kinase MARK1 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 129 454 81 81 0
MARK2-204 MARK2 Q7KZI7 Serine/threonine-protein kinase MARK2 chr11 Compendium Yes 1 hippie, biogrid 84 445 52 52 0
MARK3-205 MARK3 P27448 MAP/microtubule affinity-regulating kinase 3 chr14 Not Cancer Driver No 1 hippie, biogrid 64 376 38 38 1
MARK4-201 MARK4 Q96L34 MAP/microtubule affinity-regulating kinase 4 chr19 Not Cancer Driver No 1 hippie, biogrid 76 403 39 39 0
MAST3-201 MAST3 O60307 Microtubule-associated serine/threonine-protein kinase 3 chr19 Not Cancer Driver No 2 intact, hippie 133 785 77 77 5
MELK-201 MELK Q14680 Maternal embryonic leucine zipper kinase chr9 Not Cancer Driver No 1 hippie 51 164 18 18 0
MPP1-202 MPP1 Q00013 55 kDa erythrocyte membrane protein chrX Not Cancer Driver No 1 hippie 58 194 29 29 0
NADK-201 NADK O95544 NAD kinase chr1 Not Cancer Driver No 1 hippie 46 91 8 8 0
NANOG-201 NANOG Q9H9S0 Homeobox protein NANOG chr12 Not Cancer Driver No 1 hippie 35 171 28 28 0
NF1-202 NF1 P21359 Neurofibromin chr17 Census, Compendium Yes 2 intact, hippie 285 406 36 36 75
OTUB1-208 OTUB1 Q96FW1 Ubiquitin thioesterase OTUB1 chr11 Not Cancer Driver No 1 hippie 25 34 3 3 0
OTUB2-201 OTUB2 Q96DC9 Ubiquitin thioesterase OTUB2 chr14 Not Cancer Driver No 1 hippie 22 0 0 0 0
PCGF6-202 PCGF6 Q9BYE7 Polycomb group RING finger protein 6 chr10 Not Cancer Driver No 1 hippie 19 142 5 5 0
PHLDB2-204 PHLDB2 Q86SQ0 Pleckstrin homology-like domain family B member 2 chr3 Not Cancer Driver No 1 hippie 168 1037 130 130 0
PLEKHA7-202 PLEKHA7 Q6IQ23 Pleckstrin homology domain-containing family A member 7 chr11 Not Cancer Driver No 2 intact, hippie 129 925 106 106 0
PPIB-201 PPIB P23284 Peptidyl-prolyl cis-trans isomerase B chr15 Not Cancer Driver No 1 intact, hippie, biogrid 16 16 0 0 1
PPM1H-201 PPM1H Q9ULR3 Protein phosphatase 1H chr12 Not Cancer Driver No 1 hippie 60 141 25 25 0
PPP6R3-203 PPP6R3 Q5H9R7 Serine/threonine-protein phosphatase 6 regulatory subunit 3 chr11 Not Cancer Driver No 1 intact, hippie, biogrid 77 389 37 37 0
PRKCI-201 PRKCI P41743 Protein kinase C iota type chr3 Not Cancer Driver No 1 hippie, biogrid 79 120 12 12 0
RAB3IP-212 RAB3IP Q96QF0 Rab-3A-interacting protein chr12 Not Cancer Driver No 1 hippie 70 228 31 31 0
RAD51-201 RAD51 Q06609 DNA repair protein RAD51 homolog 1 chr15 Not Cancer Driver No 1 hippie 27 48 3 3 3
RASAL2-203 RASAL2 Q9UJF2 Ras GTPase-activating protein nGAP chr1 Not Cancer Driver No 2 intact, hippie 134 607 69 69 0
RBCK1-202 RBCK1 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 chr20 Not Cancer Driver No 1 hippie 42 141 14 14 2
RBM45-201 RBM45 Q8IUH3 RNA-binding protein 45 chr2 Not Cancer Driver No 1 intact, hippie, biogrid 44 110 19 19 0
RBM8A-204 RBM8A Q9Y5S9 RNA-binding protein 8A chr1 Not Cancer Driver No 1 hippie, biogrid 24 135 21 21 0
RIPK1-201 RIPK1 Q13546 Receptor-interacting serine/threonine-protein kinase 1 chr6 Compendium Yes 1 hippie 59 277 28 28 1
RNF144A-201 RNF144A P50876 E3 ubiquitin-protein ligase RNF144A chr2 Not Cancer Driver No 1 hippie 50 0 0 0 0
RNF185-202 RNF185 Q96GF1 E3 ubiquitin-protein ligase RNF185 chr22 Not Cancer Driver No 1 hippie 18 82 10 10 0
RTKN-202 RTKN Q9BST9 Rhotekin chr2 Not Cancer Driver No 1 hippie 53 265 30 30 0
SENP3-201 SENP3 Q9H4L4 Sentrin-specific protease 3 chr17 Not Cancer Driver No 1 hippie 33 288 17 17 0
SENP8-201 SENP8 Q96LD8 Sentrin-specific protease 8 chr15 Not Cancer Driver No 1 hippie 10 0 0 0 0
SH3BP4-202 SH3BP4 Q9P0V3 SH3 domain-binding protein 4 chr2 Not Cancer Driver No 1 hippie 114 243 36 36 0
SH3PXD2A-203 SH3PXD2A Q5TCZ1 SH3 and PX domain-containing protein 2A chr10 Not Cancer Driver No 1 hippie 111 802 86 86 0
SIPA1L1-211 SIPA1L1 O43166 Signal-induced proliferation-associated 1-like protein 1 chr14 Not Cancer Driver No 2 intact, hippie 231 1176 166 166 0
SLF1-201 SLF1 Q9BQI6 SMC5-SMC6 complex localization factor protein 1 chr5 Not Cancer Driver No 1 hippie 70 167 8 8 0
SNAI1-201 SNAI1 O95863 Zinc finger protein SNAI1 chr20 Not Cancer Driver No 1 hippie 41 98 8 8 0
SRGAP2-203 SRGAP2 O75044 SLIT-ROBO Rho GTPase-activating protein 2 chr1 Not Cancer Driver No 1 hippie 98 543 57 57 0
SRSF12-201 SRSF12 Q8WXF0 Serine/arginine-rich splicing factor 12 chr6 Not Cancer Driver No 2 intact, hippie 24 205 20 20 0
STAMBP-202 STAMBP O95630 STAM-binding protein chr2 Not Cancer Driver No 1 hippie 42 143 15 15 6
SYDE1-201 SYDE1 Q6ZW31 Rho GTPase-activating protein SYDE1 chr19 Not Cancer Driver No 2 intact, hippie 52 412 25 25 0
SYNE1-206 SYNE1 Q8NF91 Nesprin-1 chr6 Not Cancer Driver No 1 hippie 1294 2545 421 421 2
TBC1D25-201 TBC1D25 Q3MII6 TBC1 domain family member 25 chrX Not Cancer Driver No 2 intact, hippie 83 258 25 25 0
TCF7-201 TCF7 P36402 Transcription factor 7 chr5 Not Cancer Driver No 1 hippie 26 307 23 23 0
TESK2-202 TESK2 Q96S53 Dual specificity testis-specific protein kinase 2 chr1 Not Cancer Driver No 2 intact, hippie 57 243 31 31 0
TIAM1-206 TIAM1 Q13009 Rho guanine nucleotide exchange factor TIAM1 chr21 Not Cancer Driver No 2 intact, hippie 263 813 147 147 0
TP53-201 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 hippie 2742 282 1364 1364 60
TRAF6-202 TRAF6 Q9Y4K3 TNF receptor-associated factor 6 chr11 Not Cancer Driver No 1 hippie 51 62 5 5 0
TRIM23-201 TRIM23 P36406 E3 ubiquitin-protein ligase TRIM23 chr5 Not Cancer Driver No 1 hippie 65 39 2 2 0
TRIM5-202 TRIM5 Q9C035 Tripartite motif-containing protein 5 chr11 Not Cancer Driver No 1 hippie 38 78 7 7 0
TRIM54-202 TRIM54 Q9BYV2 Tripartite motif-containing protein 54 chr2 Not Cancer Driver No 1 hippie 47 98 11 11 0
TRIM63-201 TRIM63 Q969Q1 E3 ubiquitin-protein ligase TRIM63 chr1 Not Cancer Driver No 1 hippie 26 71 6 6 0
TRIM8-209 TRIM8 Q9BZR9 E3 ubiquitin-protein ligase TRIM8 chr10 Not Cancer Driver No 1 hippie 52 209 23 23 0
TRIM9-201 TRIM9 Q9C026 E3 ubiquitin-protein ligase TRIM9 chr14 Not Cancer Driver No 1 hippie 110 112 21 21 0
UBE2D1-201 UBE2D1 P51668 Ubiquitin-conjugating enzyme E2 D1 chr10 Not Cancer Driver No 1 hippie 9 14 0 0 0
UBE2S-201 UBE2S Q16763 Ubiquitin-conjugating enzyme E2 S chr19 Not Cancer Driver No 1 hippie 15 102 5 5 0
UCHL1-201 UCHL1 P09936 Ubiquitin carboxyl-terminal hydrolase isozyme L1 chr4 Not Cancer Driver No 1 hippie, biogrid 23 34 5 5 4
UCHL3-201 UCHL3 P15374 Ubiquitin carboxyl-terminal hydrolase isozyme L3 chr13 Not Cancer Driver No 1 hippie 20 61 1 1 0
UPF3B-201 UPF3B Q9BZI7 Regulator of nonsense transcripts 3B chrX Not Cancer Driver No 1 hippie, biogrid 67 428 61 61 1
USP14-201 USP14 P54578 Ubiquitin carboxyl-terminal hydrolase 14 chr18 Not Cancer Driver No 1 hippie 38 86 4 4 0
USP15-201 USP15 Q9Y4E8 Ubiquitin carboxyl-terminal hydrolase 15 chr12 Not Cancer Driver No 1 hippie 103 260 31 31 0
USP2-201 USP2 O75604 Ubiquitin carboxyl-terminal hydrolase 2 chr11 Not Cancer Driver No 1 hippie 65 214 28 28 0
USP20-203 USP20 Q9Y2K6 Ubiquitin carboxyl-terminal hydrolase 20 chr9 Not Cancer Driver No 1 intact, hippie, biogrid 87 296 30 30 0
USP21-203 USP21 Q9UK80 Ubiquitin carboxyl-terminal hydrolase 21 chr1 Not Cancer Driver No 1 hippie 86 230 44 44 0
USP28-201 USP28 Q96RU2 Ubiquitin carboxyl-terminal hydrolase 28 chr11 Not Cancer Driver No 1 hippie 106 311 18 18 0
USP33-203 USP33 Q8TEY7 Ubiquitin carboxyl-terminal hydrolase 33 chr1 Not Cancer Driver No 1 hippie 95 257 33 33 0
USP4-201 USP4 Q13107 Ubiquitin carboxyl-terminal hydrolase 4 chr3 Not Cancer Driver No 1 hippie 80 287 21 21 0
USP48-201 USP48 Q86UV5 Ubiquitin carboxyl-terminal hydrolase 48 chr1 Not Cancer Driver No 1 hippie, biogrid 89 178 13 13 0
USP51-201 USP51 Q70EK9 Ubiquitin carboxyl-terminal hydrolase 51 chrX Not Cancer Driver No 1 hippie 78 246 30 30 0
USP7-201 USP7 Q93009 Ubiquitin carboxyl-terminal hydrolase 7 chr16 Not Cancer Driver No 1 hippie 135 215 34 34 7
USP8-201 USP8 P40818 Ubiquitin carboxyl-terminal hydrolase 8 chr15 Census, Compendium Yes 1 hippie 82 603 49 49 0
UTRN-204 UTRN P46939 Utrophin chr6 Not Cancer Driver No 1 intact, hippie, biogrid 352 1287 137 137 0
WDR47-202 WDR47 O94967 WD repeat-containing protein 47 chr1 Not Cancer Driver No 1 hippie 75 317 22 22 0
XPO1-201 XPO1 O14980 Exportin-1 chr2 Census, Compendium Yes 1 hippie 84 33 5 5 0
YOD1-201 YOD1 Q5VVQ6 Ubiquitin thioesterase OTU1 chr1 Not Cancer Driver No 1 hippie 19 121 3 3 0
YWHAG-201 YWHAG P61981 14-3-3 protein gamma chr7 Not Cancer Driver No 2 intact, hippie, biogrid 21 78 4 4 3
YWHAH-201 YWHAH Q04917 14-3-3 protein eta chr22 Not Cancer Driver No 2 intact, hippie, biogrid 10 55 0 0 0
ZBTB21-201 ZBTB21 Q9ULJ3 Zinc finger and BTB domain-containing protein 21 chr21 Not Cancer Driver No 2 intact, hippie 91 649 48 48 0
ZNF350-201 ZNF350 Q9GZX5 Zinc finger protein 350 chr19 Not Cancer Driver No 1 hippie 51 97 8 8 0
ZNF638-201 ZNF638 Q14966 Zinc finger protein 638 chr2 Not Cancer Driver No 2 intact, hippie 173 1674 153 153 0